Activation-induced CD4+ T cell death in HIV-positive individuals correlates with Fas susceptibility, CD4+ T cell count, and HIV plasma viral copy number

AIDS Research and Human Retroviruses

Volumn 15, Issue 17, 1999, Pages 1509-1518

  Dockrell, D H ^a,b   Badley, A D ^a,c   Algeciras Schimnich, A ^f   Simpson, M ^d   Schut, R ^d   Lynch, D H ^e   Paya, C V ^a,f  

^a MAYO CLINIC   (United States)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

^c UNIVERSITY OF OTTAWA   (Canada)

^d HENNEPIN COUNTY MEDICAL CENTER   (United States)

^e AMGEN INC   (United States)

^f MAYO GRADUATE SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; FAS ANTIGEN; FAS LIGAND; POKEWEED MITOGEN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; HELPER CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE DEPLETION; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ANTI-HIV AGENTS; ANTIGENS, CD95; APOPTOSIS; BIOLOGICAL MARKERS; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; COHORT STUDIES; HIV; HIV SERONEGATIVITY; HIV SEROPOSITIVITY; HUMANS; IMMUNITY, CELLULAR; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; POKEWEED MITOGENS; POLYMERASE CHAIN REACTION; RNA, VIRAL; VIRAL LOAD;

EID: 0033589664     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/088922299309793     Document Type: Article

References (50)

1. Meuer SC, Hodgdon JC, Hussey RE, Protentis JP, Schlossman SF, and Reinherz EL: Antigen-like effects of monoclonal antibodies directed at receptors on human T cell clones. J Exp Med 1983;158:988-993.
2. Brunner T, Mogil RJ, LaFace D, Yoo NJ, Mahboubi A, Echeverri F, Martin SJ, Force WR, Lynch DH, and Ware CF: Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas. Nature (London) 1995;373:441-444.
3. Ju S-T, Panka DJ, Cui H, Ettinger R, el-Khatib M, Sherr DH, Stanger BZ, and Marshak-Rothstein A: Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation. Nature (London) 1995;373:444-448.
4. Dhein J, Walczak H, Bäumler C, Debatin K-M, and Krammer PH: Autocrine T-cell suicide mediated by APO-1/(Fas/CD95). Nature (London) 1995;373:438-440.
5. Alderson MR, Tough TW, Davis-Smith T, Braddy S, Falk B, Schooley KA, Goodwin RG, Smith CA, Ramsdell F, and Lynch DH: Fas ligand mediates activation-induced cell death in human T lymphocytes. J Exp Med 1995;181:71-77.
6. Kabelitz D, Pohl T, and Pechhold K: Activation-induced cell death (apoptosis) of mature peripheral T lymphocytes. Immunol Today 1993;14:338-339.
7. Hanabuchi S, Koyanagi M, Kawasaki A, Shinohara N, Matsuzawa A, Nishimura Y, Kobayashi Y, Yonehara S, Yagita H, and Okumura K: Fas and its ligand in a general mechanism of T-cell-mediated cytotoxicity. Proc Natl Acad Sci USA 1994;91:4930-4934.
8. Itoh N, Yonehara S, Ishii A, Yonehara M, Mizushima S, Sameshima M, Hase A, Seto Y, and Nagata S: The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell 1991;66:233-243.
9. Kischkel FC, Hellbardt S, Behrmann I, Germer M, Pawlita M, Krammer PH, and Peter ME: Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. EMBO J 1995;14:5579-5588.
10. Suda T, Takahashi T, Golstein P, Nagata S, Yokota T, Arai N, Ozaki S, Nakao K, and Nagata S: Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell 1993;75:1169-1178.
11. Suda T and Nagata S: Purification and characterization of the Fas-ligand that induces apoptosis. J Exp Med 1994;179:873-879.
12. Suda T, Okazaki T, Naito Y, et al.: Expression of the Fas ligand in cells of T cell lineage. J Immunol 1995;154:3806-3813.
13. Trauth BC, Klaus C, Peters AMJ, Matzku S, Moller P, Falk W, Debatin KM, and Krammer PH: Monoclonal antibody-mediated tumor regression by induction of apoptosis. Science 1989;245: 301-305.
14. Klas C, Debatin K-M, Jonker RR, and Krammer PH: Activation interferes with the APO-1 pathway in mature human T cells. Int Immunol 1993;5:625-630.
15. Miyawaki T, Uehara T, Nibu R, Tsuji T, Yachie A, Yonehara S, and Taniguchi N: Differential expression of apoptosis-related Fas antigen on lymphocytes subpopulations in human peripheral blood. J Immunol 1992;149:3753-3758.
16. Singer GG and Abbas AK: The Fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice. Immunity 1994;1:365-371.
17. Boise LH and Thompson CB: Hierarchical control of lymphocyte survival. Science 1996;274:67-68.
18. Laurence J: CD4+ and CD8+ T lymphocyte activation in HIV infection. In: Cell Activation and Apoptosis in HIV Infection (Andrieu J-M and Lu W, eds.). Plenum Press, New York, 1995, pp. 1-15.
19. Debatin K-M, Fahrig-Faissner A, Enenkel-Stoodt S, Kreuz W, Benner A, and Krammer PH: High expression of APO-1 (CD95) on T lymphocytes from human immunodeficiency virus-1-infected children. Blood 1994;83:3101-3103.
20. + T cells in vitro and in vivo: Association with Fas-mediated apoptosis and modulation by aurintricarboxylic acid. Immunology 1996;87:581-585.
21. Badley AD, Dockrell DH, and Paya CV: Apoptosis in AIDS. In: Advances in Pharmacology (Kauffman SH, ed.), Vol. 41: Apoptosis. Academic Press, San Diego, California, 1997, pp. 271-294.
22. + T cells from human immunodeficiency virus-infected asymptomatic individuals. J Exp Med 1992;175:331-340.
23. Oyaizu N, McCloskey TW, Coronesi M, Chirmule N, Kalyanaraman VS, and Pahwa S: Accelerated apoptosis in peripheral blood mononuclear cells (PBMCs) from human immunodeficiency virus type-1 infected patients and in CD4 cross-linked PBMCs from normal individuals. Blood 1993;82:3392-3400.
24. Meyaard L, Otto SA, Jonker RR, Mijnster MJ, Keet RPM, and Miedema F: Programmed death of T cells in HIV-1 infection. Science 1992;257:217-219.
25. + donors by cysteine protease inhibitors. J Immunol 1994;153: 862-872.
26. Katsikis PD, Wunderlich ES, Smith CA, Herzenberg LA, and Herzenberg LA: Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals. J Exp Med 1995;181:2029-2036.
27. Katsikis PD, García-Ojeda ME, Wunderlich ES, Smith CA, Yagita H, Okumura K, Kayagaki N, Alderson M, Herzenberg LA, and Herzenberg HA: Activation-induced peripheral blood T cell apoptosis is Fas independent in HIV-infected individuals. Int Immunol 1996;8:1311-1317.
28. Badley AD, McElhinny JA, Leibson PJ, Lynch DH, Alderson MR, and Paya CV: Upregulation of Fas ligand expression by human immunodeficiency virus in human macrophages mediates apoptosis of uninfected T lymphocytes. J Virol 1996;70:199-206.
29. + T lymphocytes from HIV-infected individuals is mediated by FasL and tumor necrosis factor. J Exp Med 1997;185:55-64.
30. Mellors JW, Rinaldo CR Jr, Gupta P, White RM, Todd JA, and Kingsley LA: Prognosis in HIV-1 infection predicted by the quantity of virus in plasma. Science 1996;272:1167-1170.
31. Cavert W, Notermans DW, Staskus K, Wietgrefe SW, Zupancic M, Gebhard K, Henry K, Zhang ZQ, Mills R, McDade H, Schuwirth CM, Goudsmit J, Danner SA, and Haase AT: Kinetics of response in lymphoid tissues to antiretroviral therapy of HIV-1 infection. Science 1997;276:960-964.
32. + T cell homeostasis and function in advanced HIV disease. Science 1997;277:112-116.
33. Gougeon ML, Lecoeur H, Dulioust A, Enouf MG, Crouvoiser M, Goujard C, Debord T, and Montagnier L: Programmed cell death in peripheral lymphocytes from HIV-infected persons: increased susceptibility to apoptosis of CD4 and CD8 T cells correlates with lymphocyte activation and with disease progression. J Immunol 1996;156:3509-3520.
34. Baumler CB, Gohler T, Herr I, Benner A, Krammer PH, and Debatin KM: Activation of the CD95 (APO-1/Fas) system in T cells from human immunodeficiency virus type 1-infected children. Blood 1996;88:1741-1746.
35. Westendorp MO, Frank R, Ochsenbauer C, Stricker K, Dhein J, Walczak H, Debatin KM, and Krammer PH: Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120. Nature (London) 1995;375:497-500.
36. Algeciras A, Dockrell DH, Lynch DH, and Paya CV: CD4 regulates susceptibility to Fas ligand- and tumor necrosis factor-mediated apoptosis. J Exp Med 1998;187:711-720.
37. Banda NK, Bernier J, Kurahara DK, Kurde R, Haigwood N, Sekaly RP, and Finkel TH: Crosslinking CD4 by human immunodeficiency virus gp120 primers T cells for activation-induced apoptosis. J Exp Med 1992;176:1099-1106.
38. + T cell apoptosis. J Immunol 1997;158:2456-2463.
39. Mogil RJ, Radvanyi L, Gonzalez-Quintial R, Miller R, Mills G, Theofilopoulos AN, and Green DR: Fas (CD95) participates in peripheral T cell deletion and associated apoptosis in vivo. Int Immunol 1995;7:1451-1458.
40. Aggarwahl S and Gupta S: Increased apoptosis of T cell subsets in aging humans: Altered expression of Fas, FasL, Bcl-2 and Bax. J Immunol 1998;160:1627-1637.
41. + T cells. Int Immunol 1995;7:1212-1223.
42. Sloand EM, Young NS, Kumar P, Weichold FF, Sato T, and Maciejewski JP: Role of Fas ligand and receptor in the mechanism of T-cell depletion in acquired immunodeficiency syndrome: Effect on CD4+ lymphocyte depletion and human immunodeficiency virus replication. Blood 1997;89:1357-1363.
43. Yang Y, Liu Z-H, Ware CV, and Ashwell JD: A cysteine protease inhibitor prevents activation-induced T-cell apoptosis and death of peripheral blood cells from human immunodeficiency virus-infected individuals by inhibiting upregulation of Fas ligand. Blood 1997;89:550-557.
44. Böhler T, Nedel S, and Debatin K-M: CD95-induced apoptosis contributes to loss of primed/memory but not resting/naive T cells in children infected with human immunodeficiency virus type 1. Pediatr Res 1997;41:878-885.
45. Böhler T, Baumler C, Herr I, Groll A, Kurz M, and Debatin KM: Activation of the CD95 system increases with disease progression in human immunodeficiency virus type 1-infected children and adolescents. Pediatr Infect Dis J 1997;16:754-759.
46. Badley AD, Dockrell DH, Ziesmer S, Landay A, Lederman MM, Connick E, Kessler H, Kuritzkes D, Lynch DH, Roche P, Yagita H, and Paya CV: In vivo analysis of Fas/FasL interactions in HIV-infected patients. J Clin Invest 1998;102(2):79-87.
47. Zheng L, Fisher G, Miller RE, Peschon J, Lynch DH, and Lenoardo MJ: Induction of apoptosis in mature T cells by tumor necrosis factor. Nature (London) 1995;377:348-351.
48. Herbein G, Mahlknecht U, Batliwalla F, Gregersen P, Pappas T, Butler J, O'Brien WA, and Verdin E: Apoptosis of CD8 T cells is mediated by macrophages through interaction of HIV g120 with chemokine receptor CXCR4. Nature (London) 1998;395:189-194.
49. Sloand EM, Maciejewski JP, Sato T, Bruny J, Kumar P, Kim S, Weichold FF, and Young NS: The role of interleukin-converting enzyme in Fas-mediated apoptosis in HIV-1 infection. J Clin Invest 1998;101:195-201.
50. Katsikis PD, Garcia-Ojeda ME, Torres-Roca JF, Tijoe IM, Smith CA, Herzenberg LA, and Herzenberg LA: Interleukin-1β converting enzyme-like protease involvement in Fas-induced and activation-induced peripheral blood T cell apoptosis in HIV infection, TNF-related apoptosis-inducing ligand can mediate activation-induced T cell death in HIV infection. J Exp Med 1997;186: 1365-1372.