Mutation in Fas ligand impairs maturation of thymocytes bearing moderate affinity T cell receptors

Journal of Experimental Medicine

Volumn 198, Issue 2, 2003, Pages 349-360

  Boursalian, Tamar E ^a   Fink, Pamela J ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Fas ligand; Gld; Reverse signaling; T cell development; TNF family

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; FAS LIGAND; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL DEATH; CELL MATURATION; GENE MUTATION; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; THYMOCYTE; TRANSGENIC MOUSE;

ANIMALS; BONE MARROW CELLS; FAS LIGAND PROTEIN; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MUTAGENESIS; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES;

EID: 0042161809     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20030220     Document Type: Article

References (53)

1. von Boehmer, H. 1994. Positive selection of lymphocytes. Cell. 76:219-228.
2. Jameson, S.C., K.A. Hogquist, and M.J. Bevan. 1995. Positive selection of thymocytes. Annu. Rev. Immunol. 13:93-125.
3. Godfrey, D.I., and A. Zlotnik. 1993.Control points in early T-cell development. Immunol. Today. 14:547-553.
4. von Boehmer, H., and H.J. Fehling. 1997. Structure and function of the pre-T cell receptor. Annu. Rev. Immunol. 15:433-452.
5. Nossal, G.J.V. 1994. Negative selection of lymphocytes. Cell. 76:229-239.
6. Sprent, J., and H. Kishimoto. 2001. The thymus and central tolerance. Transplantation. 72:S25-S28.
7. Daniels, M.A., K.A. Hogquist, and S.C. Jameson. 2002. Sweet 'n' sour: The impact of differential glycosylation on T cell responses. Nat. Immunol. 3:903-910.
8. Singer, A. 2002. New perspectives on a developmental dilemma: the kinetic signaling model and the importance of signal duration for the CD4/CD8 lineage decision. Curr. Opin. Immunol. 14:207-215.
9. Nagata, S. 1997. Apoptosis by death factor. Cell. 88:355-365.
10. Green, D.R. 2000. Apoptotic pathways: paper wraps stone blunts scissors. Cell. 102:1-4.
11. Suzuki, I., and P.J. Fink. 1998. Maximal proliferation of cytotoxic T lymphocytes requires reverse signaling through Fas ligand. J. Exp. Med. 187:123-128.
12. + T cells. J. Immunol. 165:5537-5543.
13. + T cells. Proc. Natl. Acad. Sci. USA. 97:1707-1712.
14. , French, L.E., M. Hahne, I. Viard, G. Radlgruber, R. Zanone, K. Becker, C. Muller, and J. Tschopp. 1996. Fas and Fas ligand in embryos and adult mice: Ligand expression in several immune-privileged tissues and coexpression in adult tissues characterized by apoptotic turnover. J. Cell Biol. 133:335-343.
15. Brunner, T., N.J. Yoo, T.S. Griffith, T.A. Ferguson, and D.R. Green. 1996. Regulation of CD95 ligand expression: a key element in immune regulation? Behring Inst. Mitt. 97:161-174.
16. Sidman, C.L., J.D. Marshall, and H. von Boehmer. 1992. Transgenic T cell receptor interactions in the lymphoproliferative and autoimmune syndromes of lpr and gld mutant mice. Eur. J. Immunol. 22:499-504.
17. Singer, G.G., and A.K. Abbas. 1994. The Fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice. Immunity. 1:365-371.
18. Adachi, M., S. Suematsu, T. Suda, D. Watanabe, H. Fukuyama, J. Ogasawara, T. Tanaka, N. Yoshida, and S. Nagata. 1996. Enhanced and accelerated lymphoproliferation in Fas-null mice. Proc. Natl. Acad. Sci. USA. 93:2131-2136.
19. Kishimoto, H., C.D. Surh, and J. Sprent. 1998. A role for Fas in negative selection of thymocytes in vivo. J. Exp. Med. 187:1427-1438.
20. Pircher, H., D. Moskophidis, U. Rohrer, K. Burki, H. Hengartner, and R.M. Zinkernagel. 1990. Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo. Nature. 346:629-633.
21. Hogquist, K.A., S.C. Jameson, W.R. Heath, J.L. Howard, M.J. Bevan, and F.R. Carbone. 1994. T cell receptor antagonist peptides induce positive selection. Cell. 76:17-27.
22. + thymocytes. Nature. 333:742-746.
23. + T cells in transgenic mice expressing a class II MHC-restricted antigen receptor. Nature. 341:746-749.
24. Grubin, C.E., S. Kovats, P. deRoos, and A.Y. Rudensky. 1997. Deficient positive selection of CD4 T cells in mice displaying altered repertoires of MHC class II-bound self-peptides. Immunity. 7:197-208.
25. Dillon, S.R., and P.J. Fink. 1995. Thymic selection events mediated by the pre-TCR do not depend upon a limiting ligand. Int. Immunol. 7:1363-1373.
26. Lynch, D.H., M.L. Watson, M.R. Alderson, P.R. Baum, R.E. Miller, T. Tough, M. Gibson, T. Davis-Smith, C.A. Smith, K. Hunter, et al. 1994. The mouse Fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster. Immunity. 1:131-136.
27. Takahashi, T., M. Tanaka, C.I. Brannan, N.A. Jenkins, N.G. Copeland, T. Suda, and S. Nagata. 1994. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell. 76:969-976.
28. Rozzo, S.J., R.A. Eisenberg, P.L. Cohen, and B.L. Kotzin. 1994. Development of the T cell receptor repertoire in lpr mice. Semin. Immunol. 6:19-26.
29. Budd, R.C., N. Van Houten, J. Clements, and P.F. Mixter. 1994. Parallels in T lymphocyte development between lpr and normal mice. Semin. Immunol. 6:43-48.
30. Kaplan, D., and D. Smith. 2000. Enzymatic amplification staining for flow cytometric analysis of cell surface molecules. Cytometry. 40:81-85.
31. Clarke, S.R., M. Barnden, C. Kurts, F.R. Carbone, J.F. Miller, and W.R. Heath. 2000. Characterization of the oval-bumin-specific TCR transgenic line OT-I: MHC elements for positive and negative selection. Immunol. Cell Biol. 78:110-117.
32. Kaye, J., N.J. Vasquez, and S.M. Hedrick. 1992. Involvement of the same region of the T cell antigen receptor in thymic selection and foreign peptide recognition. J. Immunol. 148:3342-3353.
33. Matechak, E.O., N. Killeen, S.M. Hedrick, and B.J. Fowlkes. 1996. MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent. Immunity. 4:337-347.
34. Azzam, H.S., A. Grinberg, K. Lui, H. Shen, E.W. Shores, and P.E. Love. 1998. CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity. J. Exp. Med. 188:2301-2311.
35. Alderson, M.R., R.J. Armitage, E. Maraskovsky, T.W. Tough, E. Roux, K. Schooley, F. Ramsdell, and D.H. Lynch. 1993. Fas transduces activation signals in normal human T lymphocytes. J. Exp. Med. 178:2231-2235.
36. Kennedy, N.J., T. Kataoka, J. Tschopp, and R.C. Budd. 1999. Caspase activation is required for T cell proliferation. J. Exp. Med. 190:1891-1896.
37. Kurasawa, K., Y. Hashimoto, M. Kasai, and I. Iwamoto. 2000. The fas antigen is involved in thymic T-cell development as a costimulatory molecule, but not in the deletion of neglected thymocytes. J. Allergy Clin. Immunol. 106:S19-S31.
38. Drappa, J., N. Brot, and K.B. Elkon. 1993. The Fas protein is expressed at high levels on CD4+CD8+ thymocytes and activated mature lymphocytes in normal mice but not in the lupus-prone strain, MRL 1pr/1pr. Proc. Natl. Acad. Sci. USA. 90:10340-10344.
39. + thymocytes by the anti-fas antibody. J. Exp. Med. 181:485-491.
40. Nishimura, Y., A. Ishii, Y. Kobayashi, Y. Yamasaki, and S. Yonehara. 1995. Expression and function of mouse Fis antigen on immature and mature T cells. J. Immunol. 154:4395-4403.
41. French, L.E., A. Wilson, M. Hahne, V. Isabelle, J. Tschopp, and H.R. MacDonald. 1997. Fas ligand expression is restricted to nonlymphoid thymic components in situ. J. Immunol. 159:2196-2202.
42. Blott, E.J., G. Bossi, R. Clark, M. Zvelebil, and G.M. Griffiths. 2001. Fas ligand is targeted to secretory lysosomes via a proline-rich domain in its cytoplasmic tail. J. Cell Sci. 114:2405-2416.
43. Hughes, D.P., and I.N. Crispe. 1995. A naturally occurring soluble isoform of murine Fas generated by alternative splicing. J. Exp. Med. 182:1395-1401.
44. + T cells. Nat. Med. 4:1377-1382.
45. von Boehmer, H. 1990. Developmental biology of T cells in T cell-receptor transgenic mice. Annu. Rev. Immunol. 8:531-556.
46. Dudley, E.C., H.T. Petrie, L.M. Shah, M.J. Owen, and A.C. Hayday. 1994. T cell receptor β chain gene rearrangement and selection during thymocyte development in adult mice. Immunity. 1:83-93.
47. Lacorazza, H.D., C. Tucek-Szabo, L.V. Vasovic, K. Remus, and J. Nikolich-Zugich. 2001. Premature TCRαβ expression and signaling in early thymocytes impair thymocyte expansion and partially block their development. J. Immunol. 166:3184-3193.
48. Hane, M., B. Lowin, M. Peitsch, K. Becker, and J. Tschopp. 1995. Interaction of peptides derived from the Fas ligand with the Fyn-SH3 domain. FEBS Lett. 373:265-268.
49. Watts, A.D., N.H. Hunt, Y. Wanigasekara, G. Bloomfield, D. Wallach, B.D. Roufogalis, and G. Chaudhri. 1999. A casein kinase I motif present in the cytoplasmic domain of members of the tumour necrosis factor ligand family is implicated in 'reverse signalling'. EMBO J. 18:2119-2126.
50. Wenzel, J., R. Sanzenbacher, M. Ghadimi, M. Lewitzky, Q. Zhou, D.R. Kaplan, D. Kabelitz, S.M. Feller, and O. Janssen. 2001. Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factor. FEBS Lett. 509:255-262.
51. Spencer, D.M., T.J. Wandless, S.L. Schreiber, and G.R. Crabtree. 1993. Controlling signal tansduction with synthetic ligands. Science. 262:1019-1024.
52. Werlen, G., B. Hausmann, and E. Palmer. 2000. A motif in the αβ T-cell receptor controls positive selection by modulating ERK activity. Nature. 406:422-426.
53. Berg, L.J., and J. Kang. 2001. Molecular determinants of TCR expression and selection. Curr. Opin. Immunol. 13:232-241.