Caspase inhibition blocks human T cell proliferation by suppressing appropriate regulation of IL-2, CD25, and cell cycle-associated proteins

Journal of Immunology

Volumn 173, Issue 8, 2004, Pages 5077-5085

  Falk, Markus ^a   Ussat, Sandra ^a   Reiling, Norbert ^b   Wesch, Daniela ^a   Kabelitz, Dieter ^a   Adam Klages, Sabine ^a  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^b RESEARCH CENTER BORSTEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; CASPASE 8; CD69 ANTIGEN; CELL CYCLE PROTEIN; HLA DR ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; TRANSCRIPTION FACTOR AP 1;

ARTICLE; CELL CYCLE; CONTROLLED STUDY; CYTOKINE RELEASE; DNA RESPONSIVE ELEMENT; ENZYME INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; LYMPHOCYTE PROLIFERATION; MACROPHAGE ACTIVATION; MONOCYTE; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN SYNTHESIS REGULATION; T LYMPHOCYTE; UPREGULATION;

EID: 6344279932     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.173.8.5077     Document Type: Article

References (44)

1. Earnshaw, W. C., L. M. Martins, and S. H. Kaufmann. 1999. Mammalian caspases: structure, activation, substrates, and functions during apoptosis. Annu. Rev. Biochem. 68:383.
2. Elkon, K. B. 1999. Caspases: multifunctional proteases. J. Exp. Med. 190:1725.
3. Los, M., C Stroh, R. U. Jänicke, I. H. Engels, and K. Schulze-Osthoff. 2001. Caspases: more than just killers? Trends Immunol. 22:31.
4. Budd, R. C. 2002. Death receptors couple to both cell proliferation and apoptosis. J. Clin. Invest. 109:437.
5. Algeciras-Schimnich, A., B. C. Barnhart, and M. E. Peter. 2002. Apoptosis-independent functions of killer caspases. Curr. Opin. Cell Biol. 14:721.
6. Miossec, C., V. Dutilleul, F. Fassy, and A. Diu-Hercend. 1997. Evidence for CPP32 activation in the absence of apoptosis during T lymphocyte stimulation. J. Biol. Chem. 272:13459.
7. Wilhelm, S., H. Wagner, and G. Häcker. 1998. Activation of caspase-3-like enzymes in non-apoptotic T cells. Eur. J. Immunol. 28:891.
8. Alam, A., L. Y. Cohen, S. Aouad, and R. P. Sékaly. 1999. Early activation of caspases during T lymphocyte stimulation results in selective substrate cleavage in nonapoptotic cells. J. Exp. Med. 190:1879.
9. Kennedy, N. J., T. Kataoka, J. Tschopp, and R. C. Budd. 1999. Caspase activation is required for T cell proliferation. J. Exp. Med. 190:1891.
10. Chun, H. J., L. Zheng, M. Ahmad, J. Wang, C. K. Speirs, R. M. Siegel, J. K. Dale, J. Puck, J. Davis, C. G. Hall, et al. 2002. Pleiotropic effects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency. Nature 419:395.
11. Salmena, L., B. Lemmers, A. Hakem, E. Matysiak-Zablocki, K. Murakami, P. Y. Au, D. M. Berry, L Tamblyn, A. Shehabeldin, E. Migon, et al. 2003. Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity. Genes Dev. 17:883.
12. Strasser, A., and K. Newton. 1999. FADD/MORT1, a signal transducer that can promote cell death or growth. Int. J. Biochem. Cell Biol. 31:533.
13. Zhang, J., D. Cado, S. Chen, N. H. Kabra, and A. Winoto. 1998. Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1. Nature 392:296.
14. Yeh, W. C., J. L. Pompa, M. E. McCurrach, H. B. Shu, A. J. Elia, A. Shahinian, M. Ng, A. Wakeham, W. Khoo, K. Mitchell, et al. 1998. FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis. Science 279:1954.
15. Newton, K., A. W. Harris, M. L. Bath, K. G. C. Smith, and A. Strasser. 1998. A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes. EMBO J. 17:706.
16. Zörnig, M., A.-O. Hueber, and G. Evan. 1998. p53-dependent impairment of T-cell proliferation in FADD dominant-negative transgenic mice. Curr. Biol. 8:467.
17. Hueber, A.-O., M. Zörnig, A.-M. Bernard, M. Chautan, and G. Evan. 2000. A dominant negative Fas-associated death domain protein mutant inhibits proliferation and leads to impaired calcium mobilization in both T-cells and fibroblasts. J. Biol. Chem. 275:10453.
18. Alderson, M. R., R. J. Armitage, E. Maraskovsky, T. W. Tough, E. Roux, K. Schooley, F. Ramsdell, and D. H. Lynch. 1993. Fas transduces activation signals in normal human T lymphocytes. J. Exp. Med. 178:2231.
19. Aggarwal, B. B., S. Singh, R. LaPushin, and K. Totpal. 1995. Fas antigen signals proliferation of normal human diploid fibroblast and its mechanism is different from tumor necrosis factor receptor. FEBS Lett. 364:5.
20. Yokota, S., T. D. Geppert, and P. E. Lipsky. 1988. Enhancement of antigen- and mitogen-induced human T lymphocyte proliferation by tumor necrosis factor-α. J. Immunol. 140:531.
21. Mackay, F., J. Rothe, H. Bluethmann, H. Loetscher, and W. Lesslauer. 1994. Differential responses of fibroblasts from wild-type and TNF-R55-deficient mice to mouse and human TNF-α activation. J. Immunol. 153:5274.
22. Beisner, D. R., I. H. Chu, A. F. Arechiga, S. M. Hedrick, and C. M. Walsh. 2003. The requirements for Fas-associated death domain signaling in mature T cell activation and survival. J. Immunol. 171:247.
23. Newton, K., C. Kurts, A. W. Harris, and A. Strasser. 2001. Effects of dominant interfering mutant of FADD on signal transduction in activated T cells. Curr. Biol. 20:273.
24. Mack, A., and G. Häcker. 2002. Inhibition of caspase or FADD function blocks proliferation but not MAP kinase-activation and interleukin-2-production during primary stimulation of T cells. Eur. J. Immunol. 32:1986.
25. Zhang, J., N. H. Kabra, D. Cado, C. Kang, and A. Winoto. 2001. FADD-deficient T cells exhibit a disaccord in regulation of the cell cycle machinery. J. Biol. Chem. 276:29815.
26. Lüschen, S., S. Ussat, G. Scherer, D. Kabelitz, and S. Adam-Klages. 2000. Sensitization to death receptor cytotoxicity by inhibition of FADD/caspase signaling: requirement of cell cycle progression. J. Biol. Chem. 275:24670.
27. Grage-Griebenow, E., D. Lorenzen, R. Fetting, H.-D. Flad, and M. Ernst. 1993. Phenotypical and functional characterization of Fcγ receptor I (CD64)-negative monocytes, a minor human monocyte subpopulation with high accessory and antiviral activity. Eur. J. Immunol. 23:3126.
28. 2 and 3,3′,5,5′-tetramethylbenzidine. J. Clin. Chem. Clin. Biochem. 23:453.
29. Fischer, U., R. U. Jänicke, and K. Schulze-Osthoff. 2003. Many cuts to ruin: a comprehensive update of caspase substrates. Cell Death Differ. 10:76.
30. Waldmann, T. A. 1993. The IL-2/IL-2 receptor system: a target for rational immune intervention. Immunol. Today 14:264.
31. Posmantur, R., K. K. W. Wang, and R. B. Gilbertsen. 1998. Caspase-3-like activity is necessary for IL-2 release in activated Jurkat cells. Exp. Cell Res. 244:302.
32. Juo, P., C. J. Kuo, J. Yuan, and J. Blenis. 1998. Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade. Curr. Biol. 8:1001.
33. Jain, J., C. Loh, and A. Rao. 1995. Transcriptional regulation of the IL-2 gene. Curr. Opin. Immunol. 7:333.
34. Schuh, K., T. Twardzig, B. Kneitz, J. Heyer, A. Schimpl, and E. Serfling. 1998. The interleukin 2 receptor α chain/CD25 promoter is a target for nuclear factor of activated T cells. J. Exp. Med. 188:1369.
35. Shapiro, V. S., K. E. Truitt, J. B. Imboden, and A. Weiss. 1997. CD28 mediates transcriptional up-regulation of the interleukin-2 (IL-2) promoter through a composite element containing the CD28RE and NF-IL-2B AP-1 sites. Mol. Cell. Biol. 17:4051.
36. McGuire, K. L., and M. Iacobelli. 1997. Involvement of Rel, Fos, and Jun proteins in binding activity of the IL-2 promoter CD28 response element/AP-1 sequence in human T cells. J. Immunol. 159:1319.
37. Tibbetts, M. D., L. Zheng, and M. J. Lenardo. 2003. The death effector domain protein family: regulators of cellular homeostasis. Nat. Immunol. 4:404.
38. Datta, R., H. Kojima, K. Yoshida, and D. Kufe. 1997. Caspase-3-mediated cleavage of protein kinase C Θ in induction of apoptosis. J. Biol. Chem. 272:20317.
39. Kontgen, F., R. J. Grumont, A. Strasser, D. Metcalf, R. Li, D. Tarlington, and S. Gerondakis. 1995. Mice lacking the c-rel gene proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and IL-2 expression. Genes Dev. 9:1965.
40. Mukerjee, N., K. M. McGinnis, M. E. Gnegy, and K. K. Wang. 2001. Caspase-mediated calcineurin activation contributes to IL-2 release during T cell activation. Biochem. Biophys. Res. Commun. 285:1192.
41. Boissonas, A., O. Bonduelle, B. Lucas, P. Debre, B. Autran, and B. Combadiere. 2002. Differential requirement of caspases during naive T cell proliferation. Eur. J. Immunol. 32:3007.
42. + T-cell population. Scand. J. Immunol. 57:254.
43. Park, D. R., A. R. Thomsen, C. W. Frevert, U. Pham, S. J. Skerrett, P. A. Kiener, and W. C. Liles. 2003. Fas (CD95) induces proinflammatory cytokine responses by human monocytes and monocyte-derived macrophages. J. Immunol. 170:6209.
44. Kim, S. O., K. Ono, P. S. Tobias, and J. Han. 2003. Orphan nuclear receptor Nur77 is involved in caspase-independent macrophage cell death. J. Exp. Med. 197:1441.