Induction of specific T-cell tolerance by adenovirus-transfected, Fas ligand - Producing antigen presenting cells

Nature Biotechnology

Volumn 16, Issue 11, 1998, Pages 1045-1049

  Zhang, Huana Ge ^a   Liu, Di ^a   Heike, Yuji ^b   Yang, Pingar ^a   Wang, Zheng ^a   Wang, Xiaoyun ^a   Curiel, David T ^b   Zhou, Tong ^a   Mountz, John D ^a,c  

^a Center for Palliative Care   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c Kveterans Admin Medical Center   (United States)

Author keywords

Apoptosis; Gene therapy; Immune response

Indexed keywords

FAS LIGAND; VIRUS ANTIGEN; VIRUS VECTOR;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS; GENE THERAPY; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENE;

ADENOVIRIDAE; ANIMALS; ANTIGEN-PRESENTING CELLS; BIOTECHNOLOGY; CELL MOVEMENT; CYTOMEGALOVIRUS; FAS LIGAND PROTEIN; FEMALE; GENE EXPRESSION; GENE THERAPY; GENETIC VECTORS; IMMUNE TOLERANCE; LAC OPERON; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, INBRED MRL LPR; SPLEEN; T-LYMPHOCYTES; TRANSFECTION;

ADENOVIRIDAE; ANIMALIA; CYTOMEGALOVIRUS; MOUSE CYTOMEGALOVIRUS 1; MURINAE;

EID: 0031767338     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/3488     Document Type: Article

References (35)

1. Yahg, Y. and Wilson, J.M. 1995. Clearance of adenovirus-infected hepatocytes by MHC class I-restricted CD4+ GTLs In vivo. J. Immunol. 165:2564-2570.
2. Christ, M., Lusky, W., Stoeckel, F., Dreyer, D., Dieterie, A., Michou, A.I. et al. 1997. Gene therapy with recombinant adenovirus vectors: evaluation of the host immune response Immunol Lett. 57:9-25.
3. Yang, Y., Li, Q., Ertl, H.C., and Wilson, J.M.1995 Cellular and humoral immune responses to Viral antigens, create barriers to lung-directed gene therapy with recombinant adenoviruses. J. Virol. 60:2004-2015.
4. Gilgenkrantz, H., Duboc, D., Juillard, V., Couton, D., Pavirani, A., Guillet, J.G. et al 1995. Transient expression of genes transferred in vivo into heart using first-generation adenoviral vectors: role of the immune response, Hum. Gene Ther. 6:1265-1274.
5. Yang, Y., Nunes, F.A., Berencsi, K., Furth, E.E., Gonczol, E., and Wilson, J.M. 1994. Cellular immunity to viral antigens limits E1 -deleted adenoviruses for gene therapy. Proc. Natl. Acad. Sci. USA 91:4407-4411.
6. Juillard, V., Villefroy, P., Godfrin, D., Pavirani, A., Venet, A., and Guillet, J.G. 1995. Long-term humoral and cellular immunity induced by a single Immunization with replication-defective adenovirus recombinant vector. Eur. J. Immunol. 25:3467-3473.
7. Yang, Y., Su, Q., Grewal, I.S., Schilz, R., Flavell, R.A., and Wilson, J.M. 1996. Transient subversion of CD40 ligand function diminishes immune responses to adenovirus vectors in mouse liver and lung tissues. J. Virol. 70:6370-6377.
8. Schowalter, D.B., Meuse, L., Wilson, C.B., Linsley, P.S., and Kay, MA. 1997. Constitutive expression of murine CTLA4Ig from a recombinant adenovirus vector results in prolonged transgene expression. Gene Ther. 4:853-060.
9. Qin, L., Ding, Y., Pahud, D.R., Robson, N.D., Shaked, A., and Bromberg, J.S. 1997. Adenovirus-mediated gene transfer of viral interleukin-10 inhibits the immune response to both alloantigen and adenoviral antigen. Hum. Gene Ther, 8:1365-1374.
10. Zsengeller, Z.K., Boivin, G.P., Sawchuk, S.S., Trapnell, B.C., Whitsett, J.A., and Hirsch, R. 1997. Anti-T cell receptor antibody prolongs transgene expression and reduces lung Inflammation after adenovirus-mediated gene transfer. Hum. Gene Ther. 8:935-941.
11. Bellgrau, D., Gold, D., Selawry, H., Moore, J., Franzusoff, A., and Duke, R.C. 1995. A role for CD95 ligand in preventing graft rejection, Nature 377:630-632.
12. French, L.E., Hahne, M., Viard, I., Radlgruber, G., Zanone, R., Becker, K. et al. 1996. Fas and Fas ligand in embryos and adult mice: ligand expression In several immune-privileged tissues and coexpresslon in adult tissues characterized by apoptotic cell turnover. J. Cell Biol. 199:335-343.
13. Lee, J., Richburg, J.H., Younkin, S.C., and Boekelheide, K. The Fas system is a key regulator of germ cell apoptosis in the testis. 1997. Endocrinology 138:2081-2088.
14. Griffith, T.S., Yu, X., Herndon, J.M., Green, D.R., and Ferguson, T.A. 1996. CD95induced apoptosis of lymphocytes in an immune privileged site induces immunological tolerance. Immunity. 5:7-16.
15. Watanabe-Fukunaga, R., Brannan, C.I., Copeland, N.G., Jenkins, N.A., and Nagata, S. 1992. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature, 356:314-317.
16. Zhou, T, Bluethmann, H., Zhang, J., Edwards, C.K., and Mountz, J.D. 1992. Defective maintenance of T cell tolerance to a superantigen in MRL-lpr/lpr mice. J. Exp. Med. 176:1063-1072.
17. Suda, T., Takahashi, T., Golstein, P., and Nagata, S. 1993. Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell 75:1169-1178.
18. Wu, J., Zhou, T., Zhang, J., He, J., Gause, W.C., and Mountz, J.D. 1994. Correction of accelerated autoimmune disease by early replacement of the mutated Ipr gene with the normal Fas apoptosis gene in the T cells of transgenic MRL-lpr/lpr mice. Proc. Natl. Acad, Sci, USA 91:2344-2348.
19. Suda, T., Okazaki, T., Naito, Y., Yokota, T., Arai, N., Ozaki, S. et al 1995. Expression of the Fas ligand in cells of T cell lineage. J. Immunol. 154:3806-3813.
20. Cheng, J., Liu, C., Yang, P., Zhou, T., and Mountz, J.D. 1997. Increased lymphocyte apoptosis in Fas ligand transgenic mice. J. Immunol. 159:674-684.
21. DeMatteo, R.P., Raper, S.E., Ahn, M., Fisher, K.J., Burke, C., Radu, A. et al. 1995. Gene transfer to the thymus. A means of abrogating the immune response to recombinant adenovirus. Ann. Surg. 222:229-239.
22. Zhang, H.G., Bilbao, G., Zhou, T., Contreras, J.L., Gomez-Navarro, J., Feng, M. et al. 1998. Application of a Fas ligand encoding a recombinant adenovirus vector for prolongation of transgene expression. J. Virol. 72:2483-2490.
23. Zsengeller, Z.K., Wert, S.E., Hull, W.M., Hu, X., Yei, S., Trapneli, B.C. et al. 1995. Persistence of replication-deficient adenovirus-mediated gene transfer in lungs of Immune-deficient (nu/nu) mice. Hum. Gene Ther. 6:457-467.
24. Zhang, H.-G., Zhou, T., Yang, P., Edwards, C.K., Curiel, D.T., and Mountz, J.D. 1998. Inhibition of tumor necrosis factor alpha decreases inflammation and prolongs adenovirus gene expression in lung and liver. Hum. Gene Ther. 9:1875-1884.
25. Lau, H.T., Yu, M., Fontana, A., and Stoeckert, C.J. Jr. Prevention of Islet allograft rejection with engineered myoblasts expressing FasL in mice. 1995. Science 273:109-112.
26. Griffith, T.S., Brunner, T., Fletcher, S.M., Green, D.R., and Ferguson, T.A. 1995. Fas ligand-induced apoptosis as a mechanism of Immune privilege. Science 270:1189-1192.
27. Kondo, T., Suda, T., Fukuyama, H., Adachi, M., and Nagata, S. 1997. Essential roles of the Fas ligand in the development of hepatitis. Nat. Med. 3:409-419.
28. Giordano, C., Stassi, G., De Maria, R., Todaro, M., Richlusa, P., Papoff, G. et al. 1997. Potential involvement of Fas and its ligand in the pathogenesis of Hashimoto's thyroiditis. Science 275:960-963.
29. Larsen, C.P., Alexander, D.Z., Hendrix, R., Ritchie, S.C., and Pearson, T.C. 1995. Fas-mediated cytotoxicity. Transplantation 80:221-224.
30. Muruve, D.A., Nicolson, A.G., Manfro, R.C., Strom, T.B., Sukhatme, V.P., and Libermann, T.A. 1997. Adenovirus-mediated expression of Fas ligand induces hepatic apoptosis after systemic administration and apoptosis of ex vivo-infected pancreatic islet allografts and isografts. Hum. Gene Ther. 8:955-963.
31. Muruve, D.A., Manfro, R.O., Strorn, T.B., and Libermann, T.A. 1997. Ex vivo adenovirus-mediated gene delivery leads to long-term expression In pancreatic islet transplants. Transplantation 64:542-546.
32. Sigalla J., David A., Anegon I., Fiche, M., Huvelin JM., Boeffard F. et al. 1997. Adenovirus-mediated gene transfer into isolated mouse adult pancreatic islets: normal beta-cell function despite induction of an anti-adenovirus immune response. Hum. Gene Ther. 8:1625-1634.
33. Piche, A., Grim, J., Rancourt, C., Gomez-Navarro, J., Reed, J.C., and Curiel, D.T. 1998. Modulation of Bcl-2 protein levels by an intracellular anti-Bcl-2 singlechain antibody Increases drug-induced cytotoxicity in the breast cancer cell line MCF-7 cancer Res. 58:2134-2140.
34. Grim, J., Deshane, J., Siegal, G.F., Alvarez, R.D., DiFiore, P.; and Curiel, D.T. 1998. The level of erbB2. expression predicts sensitivity to the cytotoxic effects of an intacellular anti-erbB2 sFv. J. Mol. Med. 76:451-458.
35. Young, D.C., Kingsley, S.D., Ryan, K.A., and DutkO, F.J. 1993. Selective inactiva-tion of eukaryotic β-galactosidase in assays for using bacteria β-galactosidase as a reporter enzyme. Anal. biochem. 215:24-30.