Conformational and structural features of HIV-1 gp120 underlying the dual receptor antagonism by cross-reactive neutralizing antibody m18

Biochemistry

Volumn 50, Issue 14, 2011, Pages 2756-2768

  Gift, Syna Kuriakose ^a   Zentner, Isaac J ^a   Schön, Arne ^b   McFadden, Karyn ^a   Umashankara, M ^a   Rajagopal, Srivats ^a   Contarino, Mark ^a   Duffy, Caitlin ^a   Courter, Joel R ^c   Zhang, Mei Yun ^d   Gershoni, Jonathan M ^e   Cocklin, Simon ^a   Dimitrov, Dimiter S ^f   Smith, Amos B ^c   Freire, Ernesto ^b   Chaiken, Irwin M ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d UNIVERSITY OF HONG KONG   (Hong Kong)

^e TEL AVIV UNIVERSITY   (Israel)

^f NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING CAVITY; COMMON MODE; CORECEPTOR BINDING; ENVELOPE PROTEINS; HIGH AFFINITY; INHIBITION EFFECT; ISOTHERMAL TITRATION CALORIMETRY; MINIMAL EFFECTS; NEUTRALIZING ANTIBODIES; RECEPTOR BINDING SITE; RECEPTOR SITES; SATURATING CONCENTRATION; SMALL MOLECULES; SPR ANALYSIS; STRUCTURAL FEATURE; THERMO DYNAMIC ANALYSIS;

ANTIGENS; CONFORMATIONS; DISEASES; MONOCLONAL ANTIBODIES; THERMOANALYSIS; VIRUSES;

SURFACE PLASMON RESONANCE;

CD4 ANTIBODY; EPITOPE; GLYCOPROTEIN GP 120; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY;

ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; CROSS REACTION; HUMAN IMMUNODEFICIENCY VIRUS 1; ISOTHERMAL TITRATION CALORIMETRY; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN INTERACTION; PROTEIN STRUCTURE; SURFACE PLASMON RESONANCE; THERMODYNAMICS;

ANTIBODIES, MONOCLONAL; ANTIBODIES, NEUTRALIZING; ANTIGENS, CD4; BINDING SITES; BINDING, COMPETITIVE; CALORIMETRY; EPITOPES; HIV ANTIBODIES; HIV ENVELOPE PROTEIN GP120; HIV-1; HUMANS; MODELS, MOLECULAR; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SURFACE PLASMON RESONANCE; THERMODYNAMICS;

CITRUS MAXIMA; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 79953699072     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi101160r     Document Type: Article

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