Distribution and three-dimensional structure of AIDS virus envelope spikes

Nature

Volumn 441, Issue 7095, 2006, Pages 847-852

  Zhu, Ping ^a   Liu, Jun ^a   Bess Jr , Julian ^b   Chertova, Elena ^b   Lifson, Jeffrey D ^b   Grisé, Henry ^a   Ofek, Gilad A ^c   Taylor, Kenneth A ^a   Roux, Kenneth H ^a  

^a FLORIDA STATE UNIVERSITY   (United States)

^b SAIC FREDERICK INC   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CRYSTAL STRUCTURE; DISEASES; IMMUNOLOGY; VACCINES;

CRYOELECTRON MICROSCOPY; IMMUNODEFICIENCY VIRUS; SURFACE GLYCOPROTEIN;

VIRUSES;

GLYCOPROTEIN GP 120; MEMBRANE PROTEIN; PROTEIN SUBUNIT; VIRUS ENVELOPE PROTEIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; CRYSTAL STRUCTURE; DISTRIBUTION SYSTEM; HOST SPECIFICITY; PROTEIN; THREE-DIMENSIONAL MODELING; VACCINATION; VIRUS;

ARTICLE; ATOM; CELL ULTRASTRUCTURE; CRYOELECTRON MICROSCOPY; CRYSTAL STRUCTURE; HUMAN IMMUNODEFICIENCY VIRUS 1; MEMBRANE STRUCTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN STRUCTURE; RETROVIRUS; SIMIAN IMMUNODEFICIENCY VIRUS; STATISTICAL DISTRIBUTION; VIRION; VIRUS ENVELOPE; VIRUS MUTANT; WILD TYPE;

AIDS VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 33745203490     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature04817     Document Type: Article

References (48)

1. Wei, X. et al. Antibody neutralization and escape by HIV-1. Nature 422, 307-312 (2003).
2. Richman, D. D., Wrin, T., Little, S. J. & Petropoulos, C. J. Rapid evolution of the neutralizing antibody response to HIV type 1 infection. Proc. Natl Acad. Sci. USA 100, 4144-4149 (2003).
3. Poignard, P., Saphire, E. O., Parren, P. & Burton, D. Gp120: biologic aspects of structural features. Annu. Rev. Immunol. 19, 253-274 (2001).
4. Parren, P. W. & Burton, D. R. The antiviral activity of antibodies in vitro and in vivo. Adv. Immunol. 77, 195-262 (2001).
5. Burton, D. R. et al. HIV vaccine design and the neutralizing antibody problem. Nature Immunol. 5, 233-236 (2004).
6. Mascola, J. R. et al. Protection of macaques against pathogenic simian/human immunodeficiency virus 89.6PD by passive transfer of neutralizing antibodies. J. Virol. 73, 4009-4018 (1999).
7. Chan, D. C., Fass, D., Berger, J. M. & Kim, P. S. Core structure of gp41 from the HIV envelope glycoprotein. Cell 89, 263-273 (1997).
8. Weissenhorn, W., Dessen, A., Harrison, S. C., Skehel, J. J. & Wiley, D. C. Atomic structure of the ectodomain from HIV-1 gp41. Nature 387, 426-430 (1997).
9. Caffrey, M. et al. Three-dimensional solution structure of the 44 kDa ectodomain of SIV gp41. EMBO J. 17, 4572-4584 (1998).
10. Doms, R. W. Beyond receptor expression: the influence of receptor conformation, density, and affinity in HIV-1 infection. Virology 276, 229-237 (2000).
11. Kwong, P. D. et al. Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody. Nature 393, 648-659 (1998).
12. Kwong, P. D., Wyatt, R., Sattentau, Q. J., Sodroski, J. & Hendrickson, W. A. Oligomeric modeling and electrostatic analysis of the gp120 envelope glycoprotein of human immunodeficiency virus. J. Virol. 74, 1961-1972 (2000).
13. Chen, B. et al. Structure of an unliganded simian immunodeficiency virus gp120 core. Nature 433, 834-841 (2005).
14. Zhu, P. et al. Electron tomography analysis of envelope glycoprotein trimers on HIV and simian immunodeficiency virus virions. Proc. Natl Acad. Sci. USA 100, 15812-15817 (2003).
15. Lucic, V., Forster, F. & Baumeister, W. Structural studies by electron tomography: from cells to molecules. Annu. Rev. Biochem. 74, 833-865 (2005).
16. LaBranche, C. C. et al. A single acid change in the cytoplasmic domain of the simian immunodeficiency virus transmembrane molecule increases envelope glycoprotein expression on infected cells. J. Virol. 69, 5217-5227 (1995).
17. Kodama, T. et al. Significance of premature stop codons in env of simian immunodeficiency virus. J. Virol. 63, 4709-4714 (1989).
18. Yuste, E., Reeves, J. D., Doms, R. W. & Desrosiers, R. C. Modulation of Env content in virions of simian immunodeficiency virus: correlation with cell surface expression and virion infectivity. J. Virol. 78, 6775-6785 (2004).
19. Doms, R. W. & Moore, J. P. HIV-1 membrane fusion: targets of opportunity. J. Cell Biol. 151, F9-F13 (2000).
20. Kuhmann, S. E., Platt, E. J., Kozak, S. L. & Kabat, D. Cooperation of multiple CCR5 coreceptors is required for infections by human immunodeficiency virus type 1. J. Virol. 74, 7005-7015 (2000).
21. Cavacini, L. A., Ernes, C. L., Power, J., Duval, M. & Posner, M. R. Effect of antibody valency on interaction with cell-surface expressed HIV-1 and viral neutralization. J. Immunol. 152, 2538-2545 (1994).
22. Klasse, P. J. & Sattentau, Q. J. Mechanisms of virus neutralization by antibody. Curr. Top. Microbiol. Immunol. 260, 87-108 (2001).
23. Yuste, E., Johnson, W., Pavlakis, G. N. & Desrosiers, R. C. Virion envelope content, infectivity, and neutralization sensitivity of simian immunodeficiency virus. J. Virol. 79, 12455-12463 (2005).
24. Forster, M. J., Mulloy, B. & Nermut, M. V. Molecular modelling study of HIV p17gag (MA) protein shell utilising data from electron microscopy and X-ray crystallography. J. Mol. Biol. 298, 841-857 (2000).
25. Hill, C. P., Worthylake, D., Bancroft, D. P. & Christensen, A. M. Crystal structures of the trimeric human immunodeficiency virus type 1 matrix protein: Implications for membrane association and assembly. Proc. Natl Acad. Sci. USA 93, 3099-3104 (1996).
26. Förster, F., Medalia, O., Zauberman, N., Baumeister, W. & Fass, D. Retrovirus envelope protein complex structure in situ studied by cryo-electron tomography. Proc. Natl Acad. Sci. USA 102, 4729-4734 (2005).
27. Zwick, M. B. et al. Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41. J. Virol. 75, 10892-10905 (2001).
28. Huang, C. et al. Structure of a V3-containing HIV-1 gp120 core. Science 310, 1025-1028 (2005).
29. Tan, K., Liu, J.-H., Wang, J.-H., Shen, S. & Lu, M. Atomic structure of a thermostable subdomain of HIV-1 gp41. Proc. Natl Acad. Sci. USA 94, 12303-12308 (1997).
30. Qiao, Z. et al. Design, expression, and immunogenicity of a soluble HIV trimeric envelope fragment adopting a prefusion gp41 configuration. J. Biol. Chem. 280, 23138-23146 (2005).
31. Salzwedel, K., West, J. T. & Hunter, E. A conserved tryptophan-rich motif in the membrane-proximal region of the human immunodeficiency virus type 1 gp41 ectodomain is important for Env-mediated fusion and virus infectivity. J. Virol. 73, 2469-2480 (1999).
32. Saez-Cirion, A. et al. Structural and functional roles of HIV-1 gp41 pretransmembrane sequence segmentation. Biophys. J. 85, 3769-3780 (2003).
33. Grundner, C., Mirzabekov, T., Sodroski, J. & Wyatt, R. Solid-phase proteoliposomes containing human immunodeficiency virus envelope glycoproteins. J. Virol. 76, 3511-3521 (2002).
34. Ofek, G. et al. Structure and mechanistic analysis of the anti-human immunodeficiency virus type 1 antibody 2F5 in complex with its gp41 epitope. J. Virol. 78, 10724-10737 (2004).
35. Cardoso, R. M. et al. Broadly neutralizing anti-HIV antibody 4E10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41. Immunity 22, 163-173 (2005).
36. Yuste, E. et al. Simian immunodeficiency virus engrafted with human immunodeficiency virus type 1 (HIV-1)-specific epitopes: replication, neutralization, and survey of HIV-1-positive plasma. J. Virol. 80, 3030-3041 (2006).
37. Binley, J. M. et al. Comprehensive cross-clade neutralization analysis of a panel of anti-human immunodeficiency virus type 1 monoclonal antibodies. J. Virol. 78, 13232-13252 (2004).
38. West, J. T., Johnston, P. B., Dubay, S. R. & Hunter, E. Mutations within the putative membrane-spanning domain of the simian immunodeficiency virus transmembrane glycoprotein define the minimal requirements for fusion, incorporation, and infectivity. J. Virol. 75, 9601-9612 (2001).
39. Yang, X., Kurteva, S., Ren, X., Lee, S. & Sodroski, J. Stoichiometry of envelope glycoprotein trimers in the entry of human immunodeficiency virus type 1. J. Virol. 79, 12132-12147 (2005).
40. Blumenthal, R., Sarkar, D. P., Durell, S., Howard, D. E. & Morris, S. J. Dilation of the influenza hemagglutinin fusion pore revealed by the kinetics of individual cell-cell fusion events. J. Cell Biol. 135, 63-71 (1996).
41. Danieli, T., Pelletier, S. L., Henis, Y. I. & White, J. M. Membrane fusion mediated by the influenza virus hemagglutinin requires the concerted action of at least three hemagglutinin trimers. J. Cell Biol. 133, 559-569 (1996).
42. Freed, E. O. & Martin, M. A. Domains of the human immunodeficiency virus type 1 matrix and gp41 cytoplasmic tail required for envelope incorporation into virions. J. Virol. 70, 341-351 (1996).
43. Rao, Z. et al. Crystal structure of SIV matrix antigen and implications for virus assembly. Nature 378, 743-747 (1995).
44. Moore, P. L. et al. Nature of nonfunctional envelope proteins on the surface of human immunodeficiency virus type 1. J. Virol. 80, 2515-2528 (2006).
45. Chertova, E. et al. Sites, mechanism of action and lack of reversibility of primate lentivirus inactivation by preferential covalent modification of virion internal proteins. Curr. Mol. Med. 3, 265-272 (2003).
46. Rossio, J. L. et al. Inactivation of human immunodeficiency virus type 1 infectivity with preservation of conformational and functional integrity of virion surface proteins. J. Virol. 72, 7992-8001 (1998).
47. Winkler, H. & Taylor, K. A. Accurate marker-free alignment with simultaneous geometry determination and reconstruction of tilt series in electron tomography. Ultramicroscopy 106, 240-254 (2006).
48. Winkler, H. & Taylor, K. A. Multivariate statistical analysis of three-dimensional cross-bridge motifs in insect flight muscle. Ultramicroscopy 77, 141-152 (1999).