Mode of Action for Linear Peptide Inhibitors of HIV-1 gp120 Interactions

Biochemistry

Volumn 43, Issue 7, 2004, Pages 1928-1938

  Biorn, Alyssa C ^a,f   Cocklin, Simon ^a   Madani, Navid ^b   Si, Zhihai ^b   Ivanovic, Tijana ^b   Samanen, James ^c   Van Ryk, Donald I ^a,g   Pantophlet, Ralph ^e   Burton, Dennis R ^e   Freire, Ernesto ^d   Sodroski, Joseph ^b   Chaiken, Irwin M ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c GLAXOSMITHKLINE   (United States)

^d JOHNS HOPKINS UNIVERSITY   (United States)

^e SCRIPPS RESEARCH INSTITUTE   (United States)

^f MAYO CLINIC   (United States)

^g NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CONFORMATIONS; PROTEINS; STOICHIOMETRY; VIRUSES;

BINDING SITES; MUTANTS;

BIOCHEMISTRY;

ANTIRETROVIRUS AGENT; ARGINYLISOLEUCYLASPARAGINYLASPARAGINYLISOLEUCYLPROLYLTRYPTOPHYLSERYLGLUTAMY LALANYLMETHIONYLMETHIONINE; CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR5; GLYCOPROTEIN; GLYCOPROTEIN GP 120; PEPTIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIGEN BINDING; ARTICLE; BINDING SITE; COMPETITIVE INHIBITION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG SCREENING; EMBRYO; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IC 50; IN VITRO STUDY; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN TARGETING; STOICHIOMETRY; TARGET CELL; VIRUS ENVELOPE;

ALLOSTERIC REGULATION; ANIMALS; ANTI-HIV AGENTS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD4; BINDING SITES, ANTIBODY; CELL LINE; DOGS; HIV ENVELOPE PROTEIN GP120; HIV-1; HUMANS; OLIGOPEPTIDES; PROTEIN BINDING; RECEPTORS, CCR5; SOLUBILITY; SURFACE PLASMON RESONANCE; T-LYMPHOCYTES;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

EID: 10744224401     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi035088i     Document Type: Article

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