The Gewald multicomponent reaction

Molecular Diversity

Volumn 15, Issue 1, 2011, Pages 3-33

  Huang, Yijun ^a   Dömling, Alexander ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

2 Aminothiophene; Cyanoacetamide; Gewald three component reaction; Malonodinitrile; MCR; Multicomponent reaction; Structure activity relationship; Sulfur

Indexed keywords

1,2,4 TRIAZOLE DERIVATIVE; 2 AMINO 4,5 DIMETHYL 3 (3 TRIFLUOROMETHYLBENZOYL)THIOPHENE; ACYLTRANSFERASE INHIBITOR; ALDEHYDE DERIVATIVE; AMINOTHIOPHENE DERIVATIVE; ANTIFUNGAL AGENT; ANTINEOPLASTIC AGENT; CHOLINESTERASE INHIBITOR; DIHYDROFOLATE REDUCTASE INHIBITOR; ESTERASE INHIBITOR; FR 133605; HORMONE RECEPTOR BLOCKING AGENT; HUMAN GLUCAGON RECEPTOR ANTAGONIST; HYDRAZIDE DERIVATIVE; L 695902; LEUKOCYTE ELASTASE INHIBITOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; TETRAHYDROTHIENO(2,3 C)PYRIDINE; TETRAZOLE DERIVATIVE; THIENO(2,3 B)PYRIDINONE DERIVATIVE; THIENO(2,3 D)PYRIMIDIN 4 ONE ACYLHYDRAZIDE DERIVATIVE; THIENO(2,3 D)PYRIMIDINE; THIENOPYRIDINE DERIVATIVE; THIENOPYRIMIDINE UREA; THIOPHENE DERIVATIVE; THYMIDYLATE SYNTHASE INHIBITOR; TRICYCLIC 1,3 OXAZIN 4 ONE DERIVATIVE; TUBERCULOSTATIC AGENT; TUMOR NECROSIS FACTOR ALPHA INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; UREA DERIVATIVE;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; CANCER INHIBITION; CHEMICAL MODIFICATION; CHEMICAL REACTION; CHEMICAL STRUCTURE; COMBINATORIAL CHEMISTRY; DRUG BIOAVAILABILITY; DRUG RECEPTOR BINDING; DRUG RESEARCH; DRUG SCREENING; DRUG STRUCTURE; ENZYME INHIBITION; FIBROSARCOMA; GEWALD REACTION; HIGH THROUGHPUT SCREENING; HUMAN; IC 50; MICROWAVE RADIATION; MOLECULAR LIBRARY; NONHUMAN; ONE POT SYNTHESIS; PRIORITY JOURNAL; REVIEW; SINGLE DRUG DOSE; STRUCTURAL HOMOLOGY; SUBSTITUTION REACTION; SYNTHESIS;

ACETIC ACIDS; AMINO ACID SEQUENCE; ANIMALS; ENZYME INHIBITORS; HUMANS; SULFUR; THIOPHENES;

EID: 79953294223     PISSN: 13811991     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11030-010-9229-6     Document Type: Review

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