Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel

Molecular Pharmacology

Volumn 73, Issue 3, 2008, Pages 758-768

  De La Fuente, Ricardo ^a   Namkung, Wan ^a   Mills, Aaron ^a   Verkman, Alan S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM; CALCIUM ACTIVATED CHLORIDE CHANNEL; CALCIUM DERIVATIVE; CALCIUM ELEVATING AGONIST; CHLORIDE CHANNEL; IODIDE; PROTEIN KINASE (CALCIUM,CALMODULIN) II; THAPSIGARGIN; TRANSMEMBRANE CONDUCTANCE REGULATOR; UNCLASSIFIED DRUG;

ARTICLE; CELL LINE; CELL STRAIN HT 29; CHANNEL GATING; HUMAN; HUMAN CELL; IC 50; INTESTINE EPITHELIUM; KINETICS; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN ANALYSIS; SCREENING; STRUCTURE ACTIVITY RELATION;

ADENOSINE TRIPHOSPHATE; CALCIUM; CARBACHOL; CHLORIDE CHANNELS; CHLORIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; FLUORESCENT DYES; FURA-2; GENETIC VECTORS; HT29 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; INTESTINES; ION CHANNEL GATING; KINETICS; LENTIVIRUS; MODELS, BIOLOGICAL; MOLECULAR STRUCTURE; PATCH-CLAMP TECHNIQUES; REPRODUCIBILITY OF RESULTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 40849100330     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.107.043208     Document Type: Article

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