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Volumn 10, Issue 10, 2002, Pages 3113-3122
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Design, synthesis and bioactivities of novel diarylthiophenes: Inhibitors of tumor necrosis factor-α (TNF-α) production
a
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Author keywords
[No Author keywords available]
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Indexed keywords
1 [7 (4 FLUOROPHENYL) 1,2,3,4 TETRAHYDRO 8 (4 PYRIDYL)PYRAZOLO[5,1 C][1,2,4]TRIAZIN 2 YL] 2 PHENYLETHANEDIONE;
5 (4 FLUOROPHENYL) 4 (2 HYDROXYETHYLAMINO) 2 METHYL 6 (4 PYRIDYL)THIENO[2,3 D]PYRIMIDINE;
5 (4 PYRIDINYL) 4 (4 FLUOROPHENYL) 1 (3 MORPHOLINOPROPYL)IMIDAZOLE;
6 ACETYL 3 ETHHOXYCARBONYL 4,5,6,7 TETRAHYDROTHIENO[2,3 C]PYRIDINE;
ANTIRHEUMATIC AGENT;
DEXAMETHASONE;
FR 133605;
LIPOPOLYSACCHARIDE;
SYNAPTOPHYSIN;
THIOPHENE DERIVATIVE;
TUMOR NECROSIS FACTOR ALPHA;
UNCLASSIFIED DRUG;
IMMUNOSUPPRESSIVE AGENT;
NONSTEROID ANTIINFLAMMATORY AGENT;
PLASMA PROTEIN;
PYRAZOLE DERIVATIVE;
PYRIDINE DERIVATIVE;
ANIMAL MODEL;
ANIMAL TISSUE;
ARTICLE;
BLOOD LEVEL;
CONTROLLED STUDY;
CYTOKINE PRODUCTION;
DRUG DESIGN;
DRUG SCREENING;
DRUG STRUCTURE;
DRUG SYNTHESIS;
ENZYME INHIBITION;
IN VITRO STUDY;
MALE;
MASS SPECTROMETRY;
NONHUMAN;
NUCLEAR MAGNETIC RESONANCE;
RAT;
STRUCTURE ACTIVITY RELATION;
ANIMAL;
BIOSYNTHESIS;
CHEMISTRY;
DRUG ANTAGONISM;
IC 50;
SYNTHESIS;
ANIMALS;
ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL;
BLOOD PROTEINS;
DRUG DESIGN;
IMMUNOSUPPRESSIVE AGENTS;
INHIBITORY CONCENTRATION 50;
LIPOPOLYSACCHARIDES;
PYRAZOLES;
PYRIDINES;
RATS;
STRUCTURE-ACTIVITY RELATIONSHIP;
THIOPHENES;
TUMOR NECROSIS FACTOR-ALPHA;
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EID: 0036336136
PISSN: 09680896
EISSN: None
Source Type: Journal
DOI: 10.1016/S0968-0896(02)00224-9 Document Type: Article |
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Times cited : (48)
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References (25)
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