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Volumn 40, Issue 49, 2001, Pages 14812-14820

Steric hindrance as a basis for structure-based design of selective inhibitors of protein-tyrosine phosphatases

(13) Iversen, L F a Andersen, H S a Moller K B a Olsen, O H a Peters, G H b Branner, S a Mortensen, S B a Hansen, T K a Lau, J a Ge, Y c Holsworth, D D c Newman, M J c Moller N P H a

a NOVO NORDISK A S (Denmark)

b TECHNICAL UNIVERSITY OF DENMARK (Denmark)

c Ontogen Corporation (United States)

Author keywords

[No Author keywords available]

Indexed keywords

STERIC HINDRANCE;

ENZYME KINETICS; MOLECULAR WEIGHT; SUBSTRATES; X RAY CRYSTALLOGRAPHY;

ENZYMES;

PROTEIN TYROSINE PHOSPHATASE INHIBITOR;

ARTICLE; ENZYME ACTIVE SITE; ENZYME KINETICS; ENZYME SUBSTRATE COMPLEX; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANIMALS; BINDING SITES; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; ISOENZYMES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN STRUCTURE, SECONDARY; PROTEIN-TYROSINE-PHOSPHATASE;

EID: 0035846571 PISSN: 00062960 EISSN: None Source Type: Journal
DOI: 10.1021/bi011389l Document Type: Article

Times cited : (87)

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