Synthesis of thieno[2,3-b]pyridinones acting as cytoprotectants and as inhibitors of [3H]glycine binding to the N-methyl-D-aspartate (NMDA) receptor

Journal of Medicinal Chemistry

Volumn 49, Issue 3, 2006, Pages 864-871

  Buchstaller, Hans Peter ^a,c   Siebert, Carsten D ^a   Steinmetz, Ralf ^a   Frank, Ina ^a   Berger, Michael L ^a,b,d   Gottschlich, Rudolf ^a,c   Leibrock, Joachim ^a,c   Krug, Michael ^a,c   Steinhilber, Dieter ^a   Noe, Christian R ^a,b  

^a GOETHE UNIVERSITY   (Germany)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c MERCK KGAA   (Germany)

^d Medical University of Vienna   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

3 PHENYL 4 HYDROXYQUINOLIN 2(1H) ONE; 4 HYDROXY 5 PHENYLTHIENO[2,3 B]PYRIDIN 6(7H) ONE; 7 CHLORO 4 HYDROXY 3 (3 PHENOXYPHENYL) 2 QUINOLONE; AMINOTHIOPHENE CARBOXYLIC ACID METHYL ESTER DERIVATIVE; BENZENE DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; GLYCINE RECEPTOR; GLYCINE RECEPTOR ANTAGONIST; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; QUINOLINONE DERIVATIVE; THIENO[2,3 B]PYRIDINONE DERIVATIVE; THIENOPYRIDINONE DERIVATIVE; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; CYCLIZATION; DRUG ACETYLATION; DRUG POTENCY; DRUG RECEPTOR BINDING; FIBROBLAST; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PHENYLACETYLATION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SEIZURE; SUBSTITUTION REACTION;

ANIMALS; BINDING, COMPETITIVE; BLOOD-BRAIN BARRIER; CELL LINE; CYTOPROTECTION; ELECTROSHOCK; GLYCINE; HUMANS; MALE; MICE; PROTEIN SUBUNITS; PYRIDONES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE; RECOMBINANT PROTEINS; SEIZURES; THIOPHENES; TRANSFECTION;

EID: 32344438181     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0503493     Document Type: Article

References (29)

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