Synthesis of tricyclic 1,3-oxazin-4-ones and kinetic analysis of cholesterol esterase and acetylcholinesterase inhibition

Journal of Medicinal Chemistry

Volumn 48, Issue 26, 2005, Pages 8270-8288

  Pietsch, Markus ^a   Gütschow, Michael ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

6,7 DIHYDRO 2 (DIMETHYLAMINO) 4H,5H CYCLOPENTA[4,5]THIENO[2,3 D][1,3]OXAZIN 4 ONE; 6,7 DIHYDRO 2 (DIMETHYLAMINO) 4H,5H CYCLOPENTA[4,5]THIENO[2,3 D][1,3]OXAZIN 4 ONE DERIVATIVE; 7 BENZYL 5,6,7,8 TETRAHYDRO 2 (N 3,4 DIMETHOXYBENZYL N METHYLAMINO) 4H PYRIDO[4',3':4,5]THIENO[2,3 D][1,3]OXAZIN 4 ONE; CHOLESTEROL ESTERASE; CHOLINESTERASE INHIBITOR; NITROGEN; THIENO[1,3]OXAZIN 4 ONE; THIENO[1,3]THIAZIN 4 ONE; TRICYCLIC 1,3 OXAZIN 4 ONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYMATIC DEGRADATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; IC 50; STRUCTURE ACTIVITY RELATION;

ACETYLCHOLINESTERASE; ANIMALS; CATTLE; CHOLESTEROL ESTERASE; CHOLINESTERASE INHIBITORS; ELECTROPHORUS; ENZYME INHIBITORS; HETEROCYCLIC COMPOUNDS, 3-RING; KINETICS; OXAZINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 29844436355     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0508639     Document Type: Article

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