Potent dual thymidylate synthase and dihydrofolate reductase inhibitors: Classical and nonclassical 2-amino-4-oxo-5-arylthio-substituted-6- methylthieno[2,3-d]pyrimidine antifolates

Journal of Medicinal Chemistry

Volumn 51, Issue 18, 2008, Pages 5789-5797

  Gangjee, Aleem ^a   Qiu, Yibin ^a   Li, Wei ^a   Kisliuk, Roy L ^b  

^a DUQUESNE UNIVERSITY   (United States)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 4 OXO 6 METHYLPHENYLSULFANYLTHIENO[2,3 D]PYRIMIDINE; 2 AMINO 5 [(2,5 DIMETHOXYPHENYL)SULFANYL] 6 METHYLTHIENO[2,3 D]PYRIMIDIN 4(3H) ONE; 2 AMINO 5 [(3,4 DICHLOROPHENYL)SULFANYL] 6 METHYLTHIENO[2,3 D]PYRIMIDIN 4(3H) ONE; 2 AMINO 5 [(3,5 DICHLOROPHENYL)SULFANYL] 6 METHYLTHIENO[2,3 D]PYRIMIDIN 4(3H) ONE; 2 AMINO 5 [(4 CHLOROPHENYL)SULFANYL] 6 METHYLTHIENO[2,3 D]PYRIMIDIN 4(3H)ONE; 2 AMINO 5 [(4 FLUOROPHENYL)SULFANYL] 6 METHYLTHIENO[2,3 D]PYRIMIDIN 4(3H) ONE; 2 AMINO 6 METHYL 5 (2 NAPHTHYLSULFANYL)THIENO[2,3 D]PYRIMIDIN 4(3H) ONE; 2 AMINO 6 METHYL 5 (PYRIDIN 4 YLSULFANYL)THIENO[2,3 D]PYRIMIDIN 4(3H) ONE; 2 AMINO 6 METHYL 5 [(4 NITROPHENYL)SULFANYL]THIENO[2,3 D]PYRIMIDIN 4(3H) ONE; 2 AMINO 6 METHYLTHIENO[2,3 D]PYRIMIDIN 4(3H) ONE; 4 OXO 6 METHYLTHIENO[2,3 D]PYRIMIDINE DERIVATIVE; BENZOIC ACID DERIVATIVE; DIHYDROFOLATE REDUCTASE; DIHYDROFOLATE REDUCTASE INHIBITOR; FOLIC ACID ANTAGONIST; GLUTAMIC ACID DIETHYL ESTER; N [4 [(2 AMINO 6 METHYL 4 OXO 3,4 DIHYDROTHIENO[2,3 D]PYRIMIDIN 5 YL)SULFANYL]BENZOYL]GLUTAMIC ACID; PYRIMIDINE DERIVATIVE; THYMIDYLATE SYNTHASE; THYMIDYLATE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; IC 50; NONHUMAN; REACTION ANALYSIS; SAPONIFICATION; STRUCTURE ANALYSIS; ULLMANN REACTION;

ENZYME INHIBITORS; FOLIC ACID ANTAGONISTS; HUMANS; MODELS, MOLECULAR; PYRIMIDINES; TETRAHYDROFOLATE DEHYDROGENASE; THYMIDYLATE SYNTHASE;

EID: 52449089998     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm8006933     Document Type: Article

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