-
1
-
-
19944429772
-
A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis
-
Andries, K., Verhasselt, P., Guillemont, J., Gohlmann, H. W., Neefs, J. M., Winkler, H., van Gestel, J., Timmerman, P., Zhu, M., Lee, E., et al. (2005). A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis. Science 307, 223-227.
-
(2005)
Science
, vol.307
, pp. 223-227
-
-
Andries, K.1
Verhasselt, P.2
Guillemont, J.3
Gohlmann, H.W.4
Neefs, J.M.5
Winkler, H.6
van Gestel, J.7
Timmerman, P.8
Zhu, M.9
Lee, E.10
-
2
-
-
34250198660
-
The Mycobacterium tuberculosis FAS-II condensing enzymes: their role in mycolic acid biosynthesis, acid-fastness, pathogenesis and in future drug development
-
Bhatt, A., Molle, V., Besra, G. S., Jacobs, W. R., Jr., and Kremer, L. (2007). The Mycobacterium tuberculosis FAS-II condensing enzymes: their role in mycolic acid biosynthesis, acid-fastness, pathogenesis and in future drug development. Mol Microbiol 64, 1442-1454.
-
(2007)
Mol Microbiol
, vol.64
, pp. 1442-1454
-
-
Bhatt, A.1
Molle, V.2
Besra, G.S.3
Jacobs Jr., W.R.4
Kremer, L.5
-
3
-
-
0034493825
-
Mycobacterium tuberculosis and HIV co-infection in the lung: synergic immune dysregulation leading to disease progression
-
Bocchino, M., Sanduzzi, A., and Bariffi, F. (2000). Mycobacterium tuberculosis and HIV co-infection in the lung: synergic immune dysregulation leading to disease progression. Monaldi Arch Chest Dis 55, 381-388.
-
(2000)
Monaldi Arch Chest Dis
, vol.55
, pp. 381-388
-
-
Bocchino, M.1
Sanduzzi, A.2
Bariffi, F.3
-
4
-
-
3543012707
-
Crystallography & NMR system: A new software suite for macromolecular structure determination
-
Brunger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., et al. (1998). Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr D Biol Crystallogr 54, 905-921.
-
(1998)
Acta Crystallogr D Biol Crystallogr
, vol.54
, pp. 905-921
-
-
Brunger, A.T.1
Adams, P.D.2
Clore, G.M.3
Delano, W.L.4
Gros, P.5
Grosse-Kunstleve, R.W.6
Jiang, J.S.7
Kuszewski, J.8
Nilges, M.9
Pannu, N.S.10
-
5
-
-
47249147003
-
Functional analysis of GlnE, an essential adenylyl transferase in Mycobacterium tuberculosis
-
Carroll, P., Pashley, C. A., and Parish, T. (2008). Functional analysis of GlnE, an essential adenylyl transferase in Mycobacterium tuberculosis. J Bacteriol 190, 4894-4902.
-
(2008)
J Bacteriol
, vol.190
, pp. 4894-4902
-
-
Carroll, P.1
Pashley, C.A.2
Parish, T.3
-
6
-
-
0031315805
-
The mycobacterial cell wall: structure, biosynthesis and sites of drug action
-
Chatterjee, D. (1997). The mycobacterial cell wall: structure, biosynthesis and sites of drug action. Curr Opin Chem Biol 1, 579-588.
-
(1997)
Curr Opin Chem Biol
, vol.1
, pp. 579-588
-
-
Chatterjee, D.1
-
7
-
-
0038154018
-
The crystal structure of the first enzyme in the pantothenate biosynthetic pathway, ketopantoate hydroxymethyltransferase, from M tuberculosis
-
Chaudhuri, B. N., Sawaya, M. R., Kim, C. Y., Waldo, G. S., Park, M. S., Terwilliger, T. C., and Yeates, T. O. (2003). The crystal structure of the first enzyme in the pantothenate biosynthetic pathway, ketopantoate hydroxymethyltransferase, from M tuberculosis. Structure 11, 753-764.
-
(2003)
Structure
, vol.11
, pp. 753-764
-
-
Chaudhuri, B.N.1
Sawaya, M.R.2
Kim, C.Y.3
Waldo, G.S.4
Park, M.S.5
Terwilliger, T.C.6
Yeates, T.O.7
-
8
-
-
63149141487
-
Mycobacterium tuberculosis pantothenate kinase: possible changes in location of ligands during enzyme action
-
Chetnani, B., Das, S., Kumar, P., Surolia, A., and Vijayan, M. (2009). Mycobacterium tuberculosis pantothenate kinase: possible changes in location of ligands during enzyme action. Acta Crystallogr D Biol Crystallogr 65, 312-325.
-
(2009)
Acta Crystallogr D Biol Crystallogr
, vol.65
, pp. 312-325
-
-
Chetnani, B.1
Das, S.2
Kumar, P.3
Surolia, A.4
Vijayan, M.5
-
9
-
-
0036299101
-
Crystal structure of MabA from Mycobacterium tuberculosis, a reductase involved in long-chain fatty acid biosynthesis
-
Cohen-Gonsaud, M., Ducasse, S., Hoh, F., Zerbib, D., Labesse, G., and Quemard, A. (2002). Crystal structure of MabA from Mycobacterium tuberculosis, a reductase involved in long-chain fatty acid biosynthesis. J Mol Biol 320, 249-261.
-
(2002)
J Mol Biol
, vol.320
, pp. 249-261
-
-
Cohen-Gonsaud, M.1
Ducasse, S.2
Hoh, F.3
Zerbib, D.4
Labesse, G.5
Quemard, A.6
-
10
-
-
0035931926
-
Massive gene decay in the leprosy bacillus
-
Cole, S. T., Eiglmeier, K., Parkhill, J., James, K. D., Thomson, N. R., Wheeler, P. R., Honore, N., Garnier, T., Churcher, C., Harris, D., et al. (2001). Massive gene decay in the leprosy bacillus. Nature 409, 1007-1011.
-
(2001)
Nature
, vol.409
, pp. 1007-1011
-
-
Cole, S.T.1
Eiglmeier, K.2
Parkhill, J.3
James, K.D.4
Thomson, N.R.5
Wheeler, P.R.6
Honore, N.7
Garnier, T.8
Churcher, C.9
Harris, D.10
-
11
-
-
0029658688
-
The F0F1-type ATP synthases of bacteria: structure and function of the F0 complex
-
Deckers-Hebestreit, G., and Altendorf, K. (1996). The F0F1-type ATP synthases of bacteria: structure and function of the F0 complex. Annu Rev Microbiol 50, 791-824.
-
(1996)
Annu Rev Microbiol
, vol.50
, pp. 791-824
-
-
Deckers-Hebestreit, G.1
Altendorf, K.2
-
12
-
-
0028988237
-
Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis
-
Dessen, A., Quemard, A., Blanchard, J. S., Jacobs, W. R., Jr., and Sacchettini, J. C. (1995). Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis. Science 267, 1638-1641.
-
(1995)
Science
, vol.267
, pp. 1638-1641
-
-
Dessen, A.1
Quemard, A.2
Blanchard, J.S.3
Jacobs Jr., W.R.4
Sacchettini, J.C.5
-
13
-
-
33745503978
-
Structure of chorismate synthase from Mycobacterium tuberculosis
-
Dias, M. V., Borges, J. C., Ely, F., Pereira, J. H., Canduri, F., Ramos, C. H., Frazzon, J., Palma, M. S., Basso, L. A., Santos, D. S., et al. (2006). Structure of chorismate synthase from Mycobacterium tuberculosis. J Struct Biol 154, 130-143.
-
(2006)
J Struct Biol
, vol.154
, pp. 130-143
-
-
Dias, M.V.1
Borges, J.C.2
Ely, F.3
Pereira, J.H.4
Canduri, F.5
Ramos, C.H.6
Frazzon, J.7
Palma, M.S.8
Basso, L.A.9
Santos, D.S.10
-
14
-
-
0347361707
-
In vitro inhibition of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein reductase MabA by isoniazid
-
Ducasse-Cabanot, S., Cohen-Gonsaud, M., Marrakchi, H., Nguyen, M., Zerbib, D., Bernadou, J., Daffe, M., Labesse, G., and Quemard, A. (2004). In vitro inhibition of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein reductase MabA by isoniazid. Antimicrob Agents Chemother 48, 242-249.
-
(2004)
Antimicrob Agents Chemother
, vol.48
, pp. 242-249
-
-
Ducasse-Cabanot, S.1
Cohen-Gonsaud, M.2
Marrakchi, H.3
Nguyen, M.4
Zerbib, D.5
Bernadou, J.6
Daffe, M.7
Labesse, G.8
Quemard, A.9
-
15
-
-
0037228454
-
Roles of Mycobacterium smegmatis D-alanine:D-alanine ligase and D-alanine racemase in the mechanisms of action of and resistance to the peptidoglycan inhibitor D-cycloserine
-
Feng, Z., and Barletta, R. G. (2003). Roles of Mycobacterium smegmatis D-alanine: D-alanine ligase and D-alanine racemase in the mechanisms of action of and resistance to the peptidoglycan inhibitor D-cycloserine. Antimicrob Agents Chemother 47, 283-291.
-
(2003)
Antimicrob Agents Chemother
, vol.47
, pp. 283-291
-
-
Feng, Z.1
Barletta, R.G.2
-
16
-
-
11844271947
-
The crystal structure of Mycobacterium tuberculosis thymidylate kinase in complex with 3′-azidodeoxythymidine monophosphate suggests a mechanism for competitive inhibition
-
Fioravanti, E., Adam, V., Munier-Lehmann, H., and Bourgeois, D. (2005). The crystal structure of Mycobacterium tuberculosis thymidylate kinase in complex with 3′-azidodeoxythymidine monophosphate suggests a mechanism for competitive inhibition. Biochemistry 44, 130-137.
-
(2005)
Biochemistry
, vol.44
, pp. 130-137
-
-
Fioravanti, E.1
Adam, V.2
Munier-Lehmann, H.3
Bourgeois, D.4
-
17
-
-
0344837328
-
Mycobacterium tuberculosis thymidylate kinase: structural studies of intermediates along the reaction pathway
-
Fioravanti, E., Haouz, A., Ursby, T., Munier-Lehmann, H., Delarue, M., and Bourgeois, D. (2003). Mycobacterium tuberculosis thymidylate kinase: structural studies of intermediates along the reaction pathway. J Mol Biol 327, 1077-1092.
-
(2003)
J Mol Biol
, vol.327
, pp. 1077-1092
-
-
Fioravanti, E.1
Haouz, A.2
Ursby, T.3
Munier-Lehmann, H.4
Delarue, M.5
Bourgeois, D.6
-
18
-
-
0026482281
-
The redox centers of ribonucleotide reductase of Escherichia coli
-
Fontecave, M., Nordlund, P., Eklund, H., and Reichard, P. (1992). The redox centers of ribonucleotide reductase of Escherichia coli. Adv Enzymol Relat Areas Mol Biol 65, 147-183.
-
(1992)
Adv Enzymol Relat Areas Mol Biol
, vol.65
, pp. 147-183
-
-
Fontecave, M.1
Nordlund, P.2
Eklund, H.3
Reichard, P.4
-
19
-
-
48649109470
-
Secondary structure conversions of Mycobacterium tuberculosis ribonucleotide reductase protein R2 under varying pH and temperature conditions
-
Georgieva, E. R., Narvaez, A. J., Hedin, N., and Graslund, A. (2008). Secondary structure conversions of Mycobacterium tuberculosis ribonucleotide reductase protein R2 under varying pH and temperature conditions. Biophys Chem 137, 43-48.
-
(2008)
Biophys Chem
, vol.137
, pp. 43-48
-
-
Georgieva, E.R.1
Narvaez, A.J.2
Hedin, N.3
Graslund, A.4
-
20
-
-
33845926247
-
Genetic diversity and population structure of Mycobacterium tuberculosis in HIV-1-infected compared with uninfected individuals in Burkina Faso
-
Godreuil, S., Renaud, F., van de Perre, P., Carriere, C., Torrea, G., and Banuls, A. L. (2007). Genetic diversity and population structure of Mycobacterium tuberculosis in HIV-1-infected compared with uninfected individuals in Burkina Faso. Aids 21, 248-250.
-
(2007)
Aids
, vol.21
, pp. 248-250
-
-
Godreuil, S.1
Renaud, F.2
van de Perre, P.3
Carriere, C.4
Torrea, G.5
Banuls, A.L.6
-
21
-
-
2442717521
-
Biochemical and genetic analysis of the four DNA ligases of mycobacteria
-
Gong, C., Martins, A., Bongiorno, P., Glickman, M., and Shuman, S. (2004). Biochemical and genetic analysis of the four DNA ligases of mycobacteria. J Biol Chem 279, 20594-20606.
-
(2004)
J Biol Chem
, vol.279
, pp. 20594-20606
-
-
Gong, C.1
Martins, A.2
Bongiorno, P.3
Glickman, M.4
Shuman, S.5
-
22
-
-
33746528061
-
Dual role of isocitrate lyase 1 in the glyoxylate and methylcitrate cycles in Mycobacterium tuberculosis
-
Gould, T. A., van de Langemheen, H., Munoz-Elias, E. J., McKinney, J. D., and Sacchettini, J. C. (2006). Dual role of isocitrate lyase 1 in the glyoxylate and methylcitrate cycles in Mycobacterium tuberculosis. Mol Microbiol 61, 940-947.
-
(2006)
Mol Microbiol
, vol.61
, pp. 940-947
-
-
Gould, T.A.1
van de Langemheen, H.2
Munoz-Elias, E.J.3
McKinney, J.D.4
Sacchettini, J.C.5
-
23
-
-
0032979147
-
The two types of 3-dehydroquinase have distinct structures but catalyze the same overall reaction
-
Gourley, D. G., Shrive, A. K., Polikarpov, I., Krell, T., Coggins, J. R., Hawkins, A. R., Isaacs, N. W., and Sawyer, L. (1999). The two types of 3-dehydroquinase have distinct structures but catalyze the same overall reaction. Nat Struct Biol 6, 521-525.
-
(1999)
Nat Struct Biol
, vol.6
, pp. 521-525
-
-
Gourley, D.G.1
Shrive, A.K.2
Polikarpov, I.3
Krell, T.4
Coggins, J.R.5
Hawkins, A.R.6
Isaacs, N.W.7
Sawyer, L.8
-
24
-
-
0038136960
-
Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism
-
Haouz, A., Vanheusden, V., Munier-Lehmann, H., Froeyen, M., Herdewijn, P., van Calenbergh, S., and Delarue, M. (2003). Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism. J Biol Chem 278, 4963-4971.
-
(2003)
J Biol Chem
, vol.278
, pp. 4963-4971
-
-
Haouz, A.1
Vanheusden, V.2
Munier-Lehmann, H.3
Froeyen, M.4
Herdewijn, P.5
van Calenbergh, S.6
Delarue, M.7
-
25
-
-
33745607880
-
Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis
-
Hasan, S., Daugelat, S., Rao, P. S., and Schreiber, M. (2006). Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis. PLoS Comput Biol 2, e61.
-
(2006)
PLoS Comput Biol
, vol.2
-
-
Hasan, S.1
Daugelat, S.2
Rao, P.S.3
Schreiber, M.4
-
26
-
-
0036232990
-
Purification, characterization, and identification of novel inhibitors of the beta-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus
-
He, X., and Reynolds, K. A. (2002). Purification, characterization, and identification of novel inhibitors of the beta-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus. Antimicrob Agents Chemother 46, 1310-1318.
-
(2002)
Antimicrob Agents Chemother
, vol.46
, pp. 1310-1318
-
-
He, X.1
Reynolds, K.A.2
-
27
-
-
21644453614
-
Identification and active expression of the Mycobacterium tuberculosis gene encoding 5-phospho-"alpha"-d-ribose-1-diphosphate: decaprenyl-phosphate 5-phosphoribosyltransferase, the first enzyme committed to decaprenylphosphoryl-d-arabinose synthesis
-
Huang, H., Scherman, M. S., D'Haeze, W., Vereecke, D., Holsters, M., Crick, D. C., and McNeil, M. R. (2005). Identification and active expression of the Mycobacterium tuberculosis gene encoding 5-phospho-"alpha"-d-ribose-1-diphosphate: decaprenyl-phosphate 5-phosphoribosyltransferase, the first enzyme committed to decaprenylphosphoryl-d-arabinose synthesis. J Biol Chem 280, 24539-24543.
-
(2005)
J Biol Chem
, vol.280
, pp. 24539-24543
-
-
Huang, H.1
Scherman, M.S.2
D'Haeze, W.3
Vereecke, D.4
Holsters, M.5
Crick, D.C.6
McNeil, M.R.7
-
28
-
-
0030009737
-
The ribonucleotide reductase system of Lactococcus lactis. Characterization of an NrdEF enzyme and a new electron transport protein
-
Jordan, A., Pontis, E., Aslund, F., Hellman, U., Gibert, I., and Reichard, P. (1996). The ribonucleotide reductase system of Lactococcus lactis. Characterization of an NrdEF enzyme and a new electron transport protein. J Biol Chem 271, 8779-8785.
-
(1996)
J Biol Chem
, vol.271
, pp. 8779-8785
-
-
Jordan, A.1
Pontis, E.2
Aslund, F.3
Hellman, U.4
Gibert, I.5
Reichard, P.6
-
29
-
-
0035854786
-
Galactan biosynthesis in Mycobacterium tuberculosis. Identification of a bifunctional UDP-galactofuranosyltransferase
-
Kremer, L., Dover, L. G., Morehouse, C., Hitchin, P., Everett, M., Morris, H. R., Dell, A., Brennan, P. J., McNeil, M. R., Flaherty, C., et al. (2001). Galactan biosynthesis in Mycobacterium tuberculosis. Identification of a bifunctional UDP-galactofuranosyltransferase. J Biol Chem 276, 26430-26440.
-
(2001)
J Biol Chem
, vol.276
, pp. 26430-26440
-
-
Kremer, L.1
Dover, L.G.2
Morehouse, C.3
Hitchin, P.4
Everett, M.5
Morris, H.R.6
Dell, A.7
Brennan, P.J.8
McNeil, M.R.9
Flaherty, C.10
-
30
-
-
69949130235
-
ACCase 6 is the essential acetyl-CoA carboxylase involved in fatty acid and mycolic acid biosynthesis in mycobacteria
-
Kurth, D. G., Gago, G. M., de la Iglesia, A., Bazet Lyonnet, B., Lin, T. W., Morbidoni, H. R., Tsai, S. C., and Gramajo, H. (2009). ACCase 6 is the essential acetyl-CoA carboxylase involved in fatty acid and mycolic acid biosynthesis in mycobacteria. Microbiology 155, 2664-2675.
-
(2009)
Microbiology
, vol.155
, pp. 2664-2675
-
-
Kurth, D.G.1
Gago, G.M.2
de la Iglesia, A.3
Bazet Lyonnet, B.4
Lin, T.W.5
Morbidoni, H.R.6
Tsai, S.C.7
Gramajo, H.8
-
31
-
-
0016864934
-
Cell walls of Mycobacteria and related organisms; chemistry and immunostimulant properties
-
Lederer, E., Adam, A., Ciorbaru, R., Petit, J. F., and Wietzerbin, J. (1975). Cell walls of Mycobacteria and related organisms; chemistry and immunostimulant properties. Mol Cell Biochem 7, 87-104.
-
(1975)
Mol Cell Biochem
, vol.7
, pp. 87-104
-
-
Lederer, E.1
Adam, A.2
Ciorbaru, R.3
Petit, J.F.4
Wietzerbin, J.5
-
32
-
-
65749086527
-
The dual function of the Mycobacterium tuberculosis FadD32 required for mycolic acid biosynthesis
-
Leger, M., Gavalda, S., Guillet, V., van der Rest, B., Slama, N., Montrozier, H., Mourey, L., Quemard, A., Daffe, M., and Marrakchi, H. (2009). The dual function of the Mycobacterium tuberculosis FadD32 required for mycolic acid biosynthesis. Chem Biol 16, 510-519.
-
(2009)
Chem Biol
, vol.16
, pp. 510-519
-
-
Leger, M.1
Gavalda, S.2
Guillet, V.3
van der Rest, B.4
Slama, N.5
Montrozier, H.6
Mourey, L.7
Quemard, A.8
Daffe, M.9
Marrakchi, H.10
-
33
-
-
13444274582
-
The 1.9 Å crystal structure of alanine racemase from Mycobacterium tuberculosis contains a conserved entryway into the active site
-
LeMagueres, P., Im, H., Ebalunode, J., Strych, U., Benedik, M. J., Briggs, J. M., Kohn, H., and Krause, K. L. (2005). The 1. 9 Å crystal structure of alanine racemase from Mycobacterium tuberculosis contains a conserved entryway into the active site. Biochemistry 44, 1471-1481.
-
(2005)
Biochemistry
, vol.44
, pp. 1471-1481
-
-
Lemagueres, P.1
Im, H.2
Ebalunode, J.3
Strych, U.4
Benedik, M.J.5
Briggs, J.M.6
Kohn, H.7
Krause, K.L.8
-
34
-
-
0035800652
-
X-ray structure of TMP kinase from Mycobacterium tuberculosis complexed with TMP at 1.95 Å resolution
-
Li de la Sierra, I., Munier-Lehmann, H., Gilles, A. M., Barzu, O., and Delarue, M. (2001). X-ray structure of TMP kinase from Mycobacterium tuberculosis complexed with TMP at 1. 95 Å resolution. J Mol Biol 311, 87-100.
-
(2001)
J Mol Biol
, vol.311
, pp. 87-100
-
-
Li de la Sierra, I.1
Munier-Lehmann, H.2
Gilles, A.M.3
Barzu, O.4
Delarue, M.5
-
35
-
-
32644490022
-
rmlB and rmlC genes are essential for growth of mycobacteria
-
Li, W., Xin, Y., McNeil, M. R., and Ma, Y. (2006). rmlB and rmlC genes are essential for growth of mycobacteria. Biochem Biophys Res Commun 342, 170-178.
-
(2006)
Biochem Biophys Res Commun
, vol.342
, pp. 170-178
-
-
Li, W.1
Xin, Y.2
McNeil, M.R.3
Ma, Y.4
-
36
-
-
0035038011
-
Drug targeting Mycobacterium tuberculosis cell wall synthesis: genetics of dTDP-rhamnose synthetic enzymes and development of a microtiter plate-based screen for inhibitors of conversion of dTDP-glucose to dTDP-rhamnose
-
Ma, Y., Stern, R. J., Scherman, M. S., Vissa, V. D., Yan, W., Jones, V. C., Zhang, F., Franzblau, S. G., Lewis, W. H., and McNeil, M. R. (2001). Drug targeting Mycobacterium tuberculosis cell wall synthesis: genetics of dTDP-rhamnose synthetic enzymes and development of a microtiter plate-based screen for inhibitors of conversion of dTDP-glucose to dTDP-rhamnose. Antimicrob Agents Chemother 45, 1407-1416.
-
(2001)
Antimicrob Agents Chemother
, vol.45
, pp. 1407-1416
-
-
Ma, Y.1
Stern, R.J.2
Scherman, M.S.3
Vissa, V.D.4
Yan, W.5
Jones, V.C.6
Zhang, F.7
Franzblau, S.G.8
Lewis, W.H.9
McNeil, M.R.10
-
37
-
-
33644697200
-
Architecture of mammalian fatty acid synthase at 4.5 Å resolution
-
Maier, T., Jenni, S., and Ban, N. (2006). Architecture of mammalian fatty acid synthase at 4. 5 Å resolution. Science 311, 1258-1262.
-
(2006)
Science
, vol.311
, pp. 1258-1262
-
-
Maier, T.1
Jenni, S.2
Ban, N.3
-
38
-
-
48249091632
-
Deciphering the proteomic profile of Mycobacterium leprae cell envelope
-
Marques, M. A., Neves-Ferreira, A. G., da Silveira, E. K., Valente, R. H., Chapeaurouge, A., Perales, J., da Silva Bernardes, R., Dobos, K. M., Spencer, J. S., Brennan, P. J., et al. (2008). Deciphering the proteomic profile of Mycobacterium leprae cell envelope. Proteomics 8, 2477-2491.
-
(2008)
Proteomics
, vol.8
, pp. 2477-2491
-
-
Marques, M.A.1
Neves-Ferreira, A.G.2
da Silveira, E.K.3
Valente, R.H.4
Chapeaurouge, A.5
Perales, J.6
da Silva Bernardes, R.7
Dobos, K.M.8
Spencer, J.S.9
Brennan, P.J.10
-
39
-
-
34447508216
-
Phaser crystallographic software
-
McCoy, A. J., Grosse-Kunstleve, R. W., Adams, P. D., Winn, M. D., Storoni, L. C., and Read, R. J. (2007). Phaser crystallographic software. J Appl Crystallogr 40, 658-674.
-
(2007)
J Appl Crystallogr
, vol.40
, pp. 658-674
-
-
McCoy, A.J.1
Grosse-Kunstleve, R.W.2
Adams, P.D.3
Winn, M.D.4
Storoni, L.C.5
Read, R.J.6
-
40
-
-
33748419613
-
Novel targets for tuberculosis drug discovery
-
Mdluli, K., and Spigelman, M. (2006). Novel targets for tuberculosis drug discovery. Curr Opin Pharmacol 6, 459-467.
-
(2006)
Curr Opin Pharmacol
, vol.6
, pp. 459-467
-
-
Mdluli, K.1
Spigelman, M.2
-
41
-
-
0035219809
-
Biosynthesis of menaquinone (vitamin K2) and ubiquinone (coenzyme Q): a perspective on enzymatic mechanisms
-
Meganathan, R. (2001). Biosynthesis of menaquinone (vitamin K2) and ubiquinone (coenzyme Q): a perspective on enzymatic mechanisms. Vitam Horm 61, 173-218.
-
(2001)
Vitam Horm
, vol.61
, pp. 173-218
-
-
Meganathan, R.1
-
42
-
-
63449142502
-
Function and regulation of class I ribonucleotide reductase-encoding genes in mycobacteria
-
Mowa, M. B., Warner, D. F., Kaplan, G., Kana, B. D., and Mizrahi, V. (2009). Function and regulation of class I ribonucleotide reductase-encoding genes in mycobacteria. J Bacteriol 191, 985-995.
-
(2009)
J Bacteriol
, vol.191
, pp. 985-995
-
-
Mowa, M.B.1
Warner, D.F.2
Kaplan, G.3
Kana, B.D.4
Mizrahi, V.5
-
43
-
-
20944450448
-
Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence
-
Munoz-Elias, E. J., and McKinney, J. D. (2005). Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence. Nat Med 11, 638-644.
-
(2005)
Nat Med
, vol.11
, pp. 638-644
-
-
Munoz-Elias, E.J.1
McKinney, J.D.2
-
44
-
-
33745235266
-
Role of the methylcitrate cycle in Mycobacterium tuberculosis metabolism, intracellular growth, and virulence
-
Munoz-Elias, E. J., Upton, A. M., Cherian, J., and McKinney, J. D. (2006). Role of the methylcitrate cycle in Mycobacterium tuberculosis metabolism, intracellular growth, and virulence. Mol Microbiol 60, 1109-1122.
-
(2006)
Mol Microbiol
, vol.60
, pp. 1109-1122
-
-
Munoz-Elias, E.J.1
Upton, A.M.2
Cherian, J.3
McKinney, J.D.4
-
45
-
-
13844296950
-
Crystal structure of a substrate complex of Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III (FabH) with lauroyl-coenzyme A
-
Musayev, F., Sachdeva, S., Scarsdale, J. N., Reynolds, K. A., and Wright, H. T. (2005). Crystal structure of a substrate complex of Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III (FabH) with lauroyl-coenzyme A. J Mol Biol 346, 1313-1321.
-
(2005)
J Mol Biol
, vol.346
, pp. 1313-1321
-
-
Musayev, F.1
Sachdeva, S.2
Scarsdale, J.N.3
Reynolds, K.A.4
Wright, H.T.5
-
46
-
-
0034629289
-
Thymidine diphosphate-6-deoxy-L-lyxo-4-hexulose reductase synthesizing dTDP-6-deoxy-L-talose from Actinobacillus actinomycetemcomitans
-
Nakano, Y., Suzuki, N., Yoshida, Y., Nezu, T., Yamashita, Y., and Koga, T. (2000). Thymidine diphosphate-6-deoxy-L-lyxo-4-hexulose reductase synthesizing dTDP-6-deoxy-L-talose from Actinobacillus actinomycetemcomitans. J Biol Chem 275, 6806-6812.
-
(2000)
J Biol Chem
, vol.275
, pp. 6806-6812
-
-
Nakano, Y.1
Suzuki, N.2
Yoshida, Y.3
Nezu, T.4
Yamashita, Y.5
Koga, T.6
-
47
-
-
0037205463
-
The crystal structure of Mycobacterium tuberculosis alkylhydroperoxidase AhpD, a potential target for antitubercular drug design
-
Nunn, C. M., Djordjevic, S., Hillas, P. J., Nishida, C. R., and Ortiz de Montellano, P. R. (2002). The crystal structure of Mycobacterium tuberculosis alkylhydroperoxidase AhpD, a potential target for antitubercular drug design. J Biol Chem 277, 20033-20040.
-
(2002)
J Biol Chem
, vol.277
, pp. 20033-20040
-
-
Nunn, C.M.1
Djordjevic, S.2
Hillas, P.J.3
Nishida, C.R.4
Ortiz de Montellano, P.R.5
-
48
-
-
33646893263
-
Crystallographic and pre-steady-state kinetics studies on binding of NADH to wild-type and isoniazid-resistant enoyl-ACP (CoA) reductase enzymes from Mycobacterium tuberculosis
-
Oliveira, J. S., Pereira, J. H., Canduri, F., Rodrigues, N. C., de Souza, O. N., de Azevedo, W. F., Jr., Basso, L. A., and Santos, D. S. (2006). Crystallographic and pre-steady-state kinetics studies on binding of NADH to wild-type and isoniazid-resistant enoyl-ACP (CoA) reductase enzymes from Mycobacterium tuberculosis. J Mol Biol 359, 646-666.
-
(2006)
J Mol Biol
, vol.359
, pp. 646-666
-
-
Oliveira, J.S.1
Pereira, J.H.2
Canduri, F.3
Rodrigues, N.C.4
de Souza, O.N.5
de Azevedo Jr., W.F.6
Basso, L.A.7
Santos, D.S.8
-
49
-
-
15744389881
-
The acyl-AMP ligase FadD32 and AccD4-containing acyl-CoA carboxylase are required for the synthesis of mycolic acids and essential for mycobacterial growth: identification of the carboxylation product and determination of the acyl-CoA carboxylase components
-
Portevin, D., de Sousa-D'Auria, C., Montrozier, H., Houssin, C., Stella, A., Laneelle, M. A., Bardou, F., Guilhot, C., and Daffe, M. (2005). The acyl-AMP ligase FadD32 and AccD4-containing acyl-CoA carboxylase are required for the synthesis of mycolic acids and essential for mycobacterial growth: identification of the carboxylation product and determination of the acyl-CoA carboxylase components. J Biol Chem 280, 8862-8874.
-
(2005)
J Biol Chem
, vol.280
, pp. 8862-8874
-
-
Portevin, D.1
de Sousa-D'Auria, C.2
Montrozier, H.3
Houssin, C.4
Stella, A.5
Laneelle, M.A.6
Bardou, F.7
Guilhot, C.8
Daffe, M.9
-
50
-
-
74849116693
-
Integration of informal medical practitioners in DOTS implementation to improve case detection rate
-
Qureshi, H., Arif, A., Alam, E., and Qadir, N. (2010). Integration of informal medical practitioners in DOTS implementation to improve case detection rate. J Pak Med Assoc 60, 33-37.
-
(2010)
J Pak Med Assoc
, vol.60
, pp. 33-37
-
-
Qureshi, H.1
Arif, A.2
Alam, E.3
Qadir, N.4
-
51
-
-
33847654799
-
Flux balance analysis of mycolic acid pathway: targets for anti-tubercular drugs
-
Raman, K., Rajagopalan, P., and Chandra, N. (2005). Flux balance analysis of mycolic acid pathway: targets for anti-tubercular drugs. PLoS Comput Biol 1, e46.
-
(2005)
PLoS Comput Biol
, vol.1
-
-
Raman, K.1
Rajagopalan, P.2
Chandra, N.3
-
52
-
-
55849142244
-
New anti-tuberculosis drugs in clinical trials with novel mechanisms of action
-
Rivers, E. C., and Mancera, R. L. (2008a). New anti-tuberculosis drugs in clinical trials with novel mechanisms of action. Drug Discov Today 13, 1090-1098.
-
(2008)
Drug Discov Today
, vol.13
, pp. 1090-1098
-
-
Rivers, E.C.1
Mancera, R.L.2
-
53
-
-
53249084552
-
New anti-tuberculosis drugs with novel mechanisms of action
-
Rivers, E. C., and Mancera, R. L. (2008b). New anti-tuberculosis drugs with novel mechanisms of action. Curr Med Chem 15, 1956-1967.
-
(2008)
Curr Med Chem
, vol.15
, pp. 1956-1967
-
-
Rivers, E.C.1
Mancera, R.L.2
-
54
-
-
3042782938
-
The MEP pathway: a new target for the development of herbicides, antibiotics and antimalarial drugs
-
Rodriguez-Concepcion, M. (2004). The MEP pathway: a new target for the development of herbicides, antibiotics and antimalarial drugs. Curr Pharm Des 10, 2391-2400.
-
(2004)
Curr Pharm Des
, vol.10
, pp. 2391-2400
-
-
Rodriguez-Concepcion, M.1
-
55
-
-
0036796061
-
A pantothenate auxotroph of Mycobacterium tuberculosis is highly attenuated and protects mice against tuberculosis
-
Sambandamurthy, V. K., Wang, X., Chen, B., Russell, R. G., Derrick, S., Collins, F. M., Morris, S. L., and Jacobs, W. R., Jr. (2002). A pantothenate auxotroph of Mycobacterium tuberculosis is highly attenuated and protects mice against tuberculosis. Nat Med 8, 1171-1174.
-
(2002)
Nat Med
, vol.8
, pp. 1171-1174
-
-
Sambandamurthy, V.K.1
Wang, X.2
Chen, B.3
Russell, R.G.4
Derrick, S.5
Collins, F.M.6
Morris, S.L.7
Jacobs Jr., W.R.8
-
56
-
-
0035827542
-
Crystal structure of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III
-
Scarsdale, J. N., Kazanina, G., He, X., Reynolds, K. A., and Wright, H. T. (2001). Crystal structure of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III. J Biol Chem 276, 20516-20522.
-
(2001)
J Biol Chem
, vol.276
, pp. 20516-20522
-
-
Scarsdale, J.N.1
Kazanina, G.2
He, X.3
Reynolds, K.A.4
Wright, H.T.5
-
57
-
-
0032534756
-
Crystal structure of quinolinic acid phosphoribosyltransferase from Mmycobacterium tuberculosis: a potential TB drug target
-
Sharma, V., Grubmeyer, C., and Sacchettini, J. C. (1998). Crystal structure of quinolinic acid phosphoribosyltransferase from Mmycobacterium tuberculosis: a potential TB drug target. Structure 6, 1587-1599.
-
(1998)
Structure
, vol.6
, pp. 1587-1599
-
-
Sharma, V.1
Grubmeyer, C.2
Sacchettini, J.C.3
-
58
-
-
0033871202
-
Structure of isocitrate lyase, a persistence factor of Mycobacterium tuberculosis
-
Sharma, V., Sharma, S., Hoener zu Bentrup, K., McKinney, J. D., Russell, D. G., Jacobs, W. R., Jr., and Sacchettini, J. C. (2000). Structure of isocitrate lyase, a persistence factor of Mycobacterium tuberculosis. Nat Struct Biol 7, 663-668.
-
(2000)
Nat Struct Biol
, vol.7
, pp. 663-668
-
-
Sharma, V.1
Sharma, S.2
Hoener Zu Bentrup, K.3
McKinney, J.D.4
Russell, D.G.5
Jacobs Jr., W.R.6
Sacchettini, J.C.7
-
59
-
-
0018135309
-
The tyrosine free radical in ribonucleotide reductase from Escherichia coli
-
Sjoberg, B. M., Reichard, P., Graslund, A., and Ehrenberg, A. (1978). The tyrosine free radical in ribonucleotide reductase from Escherichia coli. J Biol Chem 253, 6863-6865.
-
(1978)
J Biol Chem
, vol.253
, pp. 6863-6865
-
-
Sjoberg, B.M.1
Reichard, P.2
Graslund, A.3
Ehrenberg, A.4
-
60
-
-
34548331696
-
NAD+-dependent DNA ligase (Rv3014c) from Mycobacterium tuberculosis: novel structurefunction relationship and identification of a specific inhibitor
-
Srivastava, S. K., Dube, D., Kukshal, V., Jha, A. K., Hajela, K., and Ramachandran, R. (2007). NAD+-dependent DNA ligase (Rv3014c) from Mycobacterium tuberculosis: novel structurefunction relationship and identification of a specific inhibitor. Proteins 69, 97-111.
-
(2007)
Proteins
, vol.69
, pp. 97-111
-
-
Srivastava, S.K.1
Dube, D.2
Kukshal, V.3
Jha, A.K.4
Hajela, K.5
Ramachandran, R.6
-
61
-
-
24044548989
-
NAD+-dependent DNA Ligase (Rv3014c) from Mycobacterium tuberculosis. Crystal structure of the adenylation domain and identification of novel inhibitors
-
Srivastava, S. K., Tripathi, R. P., and Ramachandran, R. (2005). NAD+-dependent DNA Ligase (Rv3014c) from Mycobacterium tuberculosis. Crystal structure of the adenylation domain and identification of novel inhibitors. J Biol Chem 280, 30273-30281.
-
(2005)
J Biol Chem
, vol.280
, pp. 30273-30281
-
-
Srivastava, S.K.1
Tripathi, R.P.2
Ramachandran, R.3
-
62
-
-
12844278679
-
Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis
-
Takayama, K., Wang, C., and Besra, G. S. (2005). Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis. Clin Microbiol Rev 18, 81-101.
-
(2005)
Clin Microbiol Rev
, vol.18
, pp. 81-101
-
-
Takayama, K.1
Wang, C.2
Besra, G.S.3
-
63
-
-
33746776204
-
The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase
-
Tang, Y., Kim, C. Y., Mathews, II, Cane, D. E., and Khosla, C. (2006). The 2. 7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase. Proc Natl Acad Sci U S A 103, 11124-11129.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 11124-11129
-
-
Tang, Y.1
Kim, C.Y.2
Mathews, I.I.3
Cane, D.E.4
Khosla, C.5
-
64
-
-
34547127139
-
Type II NADH: menaquinone oxidoreductase of Mycobacterium tuberculosis
-
Teh, J. S., Yano, T., and Rubin, H. (2007). Type II NADH: menaquinone oxidoreductase of Mycobacterium tuberculosis. Infect Disord Drug Targets 7, 169-181.
-
(2007)
Infect Disord Drug Targets
, vol.7
, pp. 169-181
-
-
Teh, J.S.1
Yano, T.2
Rubin, H.3
-
65
-
-
1842577641
-
Enzymic activation and transfer of fatty acids as acyl-adenylates in mycobacteria
-
Trivedi, O. A., Arora, P., Sridharan, V., Tickoo, R., Mohanty, D., and Gokhale, R. S. (2004). Enzymic activation and transfer of fatty acids as acyl-adenylates in mycobacteria. Nature 428, 441-445.
-
(2004)
Nature
, vol.428
, pp. 441-445
-
-
Trivedi, O.A.1
Arora, P.2
Sridharan, V.3
Tickoo, R.4
Mohanty, D.5
Gokhale, R.S.6
-
66
-
-
3042589730
-
Crystal structure of the biologically active form of class Ib ribonucleotide reductase small subunit from Mycobacterium tuberculosis
-
Uppsten, M., Davis, J., Rubin, H., and Uhlin, U. (2004). Crystal structure of the biologically active form of class Ib ribonucleotide reductase small subunit from Mycobacterium tuberculosis. FEBS Lett 569, 117-122.
-
(2004)
FEBS Lett
, vol.569
, pp. 117-122
-
-
Uppsten, M.1
Davis, J.2
Rubin, H.3
Uhlin, U.4
-
67
-
-
9744241646
-
Discovery of bicyclic thymidine analogues as selective and high-affinity inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase
-
Vanheusden, V., Munier-Lehmann, H., Froeyen, M., Busson, R., Rozenski, J., Herdewijn, P., and van Calenbergh, S. (2004). Discovery of bicyclic thymidine analogues as selective and high-affinity inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase. J Med Chem 47, 6187-6194.
-
(2004)
J Med Chem
, vol.47
, pp. 6187-6194
-
-
Vanheusden, V.1
Munier-Lehmann, H.2
Froeyen, M.3
Busson, R.4
Rozenski, J.5
Herdewijn, P.6
van Calenbergh, S.7
-
68
-
-
0042284453
-
3′-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase
-
Vanheusden, V., Munier-Lehmann, H., Froeyen, M., Dugue, L., Heyerick, A., De Keukeleire, D., Pochet, S., Busson, R., Herdewijn, P., and van Calenbergh, S. (2003). 3′-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase. J Med Chem 46, 3811-3821.
-
(2003)
J Med Chem
, vol.46
, pp. 3811-3821
-
-
Vanheusden, V.1
Munier-Lehmann, H.2
Froeyen, M.3
Dugue, L.4
Heyerick, A.5
de Keukeleire, D.6
Pochet, S.7
Busson, R.8
Herdewijn, P.9
van Calenbergh, S.10
-
69
-
-
18744410941
-
Nitric oxide and Mycobacterium leprae pathogenicity
-
Visca, P., Fabozzi, G., Milani, M., Bolognesi, M., and Ascenzi, P. (2002). Nitric oxide and Mycobacterium leprae pathogenicity. IUBMB Life 54, 95-99.
-
(2002)
IUBMB Life
, vol.54
, pp. 95-99
-
-
Visca, P.1
Fabozzi, G.2
Milani, M.3
Bolognesi, M.4
Ascenzi, P.5
-
70
-
-
0034282416
-
DNA repair patch-mediated double strand DNA break formation in human cells
-
Vispe, S., and Satoh, M. S. (2000). DNA repair patch-mediated double strand DNA break formation in human cells. J Biol Chem 275, 27386-27392.
-
(2000)
J Biol Chem
, vol.275
, pp. 27386-27392
-
-
Vispe, S.1
Satoh, M.S.2
-
71
-
-
0037407932
-
Crystal structures of a pantothenate synthetase from M. tuberculosis and its complexes with substrates and a reaction intermediate
-
Wang, S., and Eisenberg, D. (2003). Crystal structures of a pantothenate synthetase from M. tuberculosis and its complexes with substrates and a reaction intermediate. Protein Sci 12, 1097-1108.
-
(2003)
Protein Sci
, vol.12
, pp. 1097-1108
-
-
Wang, S.1
Eisenberg, D.2
-
72
-
-
32344437061
-
Crystal structure of the pantothenate synthetase from Mycobacterium tuberculosis, snapshots of the enzyme in action
-
Wang, S., and Eisenberg, D. (2006). Crystal structure of the pantothenate synthetase from Mycobacterium tuberculosis, snapshots of the enzyme in action. Biochemistry 45, 1554-1561.
-
(2006)
Biochemistry
, vol.45
, pp. 1554-1561
-
-
Wang, S.1
Eisenberg, D.2
-
73
-
-
20144385739
-
Inhibitors of type II NADH:menaquinone oxidoreductase represent a class of antitubercular drugs
-
Weinstein, E. A., Yano, T., Li, L. S., Avarbock, D., Avarbock, A., Helm, D., McColm, A. A., Duncan, K., Lonsdale, J. T., and Rubin, H. (2005). Inhibitors of type II NADH: menaquinone oxidoreductase represent a class of antitubercular drugs. Proc Natl Acad Sci U S A 102, 4548-4553.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 4548-4553
-
-
Weinstein, E.A.1
Yano, T.2
Li, L.S.3
Avarbock, D.4
Avarbock, A.5
Helm, D.6
McColm, A.A.7
Duncan, K.8
Lonsdale, J.T.9
Rubin, H.10
-
74
-
-
33744957049
-
Steady-state kinetics and inhibitory action of antitubercular phenothiazines on mycobacterium tuberculosis type-II NADH-menaquinone oxidoreductase (NDH-2)
-
Yano, T., Li, L. S., Weinstein, E., Teh, J. S., and Rubin, H. (2006). Steady-state kinetics and inhibitory action of antitubercular phenothiazines on mycobacterium tuberculosis type-II NADH-menaquinone oxidoreductase (NDH-2). J Biol Chem 281, 11456-11463.
-
(2006)
J Biol Chem
, vol.281
, pp. 11456-11463
-
-
Yano, T.1
Li, L.S.2
Weinstein, E.3
Teh, J.S.4
Rubin, H.5
-
75
-
-
0031001270
-
MMAS-1, the branch point between cis- and transcyclopropane-containing oxygenated mycolates in Mycobacterium tuberculosis
-
Yuan, Y., Crane, D. C., Musser, J. M., Sreevatsan, S., and Barry, C. E., 3rd (1997). MMAS-1, the branch point between cis- and transcyclopropane-containing oxygenated mycolates in Mycobacterium tuberculosis. J Biol Chem 272, 10041-10049.
-
(1997)
J Biol Chem
, vol.272
, pp. 10041-10049
-
-
Yuan, Y.1
Crane, D.C.2
Musser, J.M.3
Sreevatsan, S.4
Barry 3rd, C.E.5
-
76
-
-
77649270286
-
Crystal structure of ArgP from Mycobacterium tuberculosis confirms two distinct conformations of full-length LysR transcriptional regulators and reveals its function in DNA binding and transcriptional regulation
-
Zhou, X., Lou, Z., Fu, S., Yang, A., Shen, H., Li, Z., Feng, Y., Bartlam, M., Wang, H., and Rao, Z. Crystal structure of ArgP from Mycobacterium tuberculosis confirms two distinct conformations of full-length LysR transcriptional regulators and reveals its function in DNA binding and transcriptional regulation. J Mol Biol 396, 1012-1024.
-
J Mol Biol
, vol.396
, pp. 1012-1024
-
-
Zhou, X.1
Lou, Z.2
Fu, S.3
Yang, A.4
Shen, H.5
Li, Z.6
Feng, Y.7
Bartlam, M.8
Wang, H.9
Rao, Z.10
|