Steady-state kinetics and inhibitory action of antitubercular phenothiazines on Mycobacterium tuberculosis Type-II NADH-menaquinone oxidoreductase (NDH-2)

Journal of Biological Chemistry

Volumn 281, Issue 17, 2006, Pages 11456-11463

  Yano, Takahiro ^a,b   Lin Sheng, Li ^a   Weinstein, Edward ^a   Teh, Jiah Shin ^a   Rubin, Harvey ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; BACTERIA; BIOCHEMISTRY; GROWTH KINETICS; MOLECULAR BIOLOGY; PULMONARY DISEASES; REACTION KINETICS;

ANTITUBERCULAR PHENOTHIAZINES; MYCOBACTERIUM SMEGMATIS EXPRESSION SYSTEM; MYCOBACTERIUM TUBERCULOSIS; STEADY-STATE KINETICS;

ENZYME INHIBITION;

1,4 NAPHTHOQUINONE; DECYLUBIQUINONE; MENADIONE; MENAQUINONE; MENATETRENONE; OXIDOREDUCTASE; PHENOTHIAZINE DERIVATIVE; QUINONE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; TRIFLUOPERAZINE; UBIQUINONE; UNCLASSIFIED DRUG;

ARTICLE; DRUG INHIBITION; DRUG MECHANISM; DRUG STRUCTURE; ELECTRON TRANSPORT; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; STEADY STATE;

ANTITUBERCULAR AGENTS; BINDING, COMPETITIVE; ENZYME INHIBITORS; FLAVIN-ADENINE DINUCLEOTIDE; KINETICS; MYCOBACTERIUM TUBERCULOSIS; NAD; PHENOTHIAZINES; QUINONE REDUCTASES; QUINONES; UBIQUINONE;

BACTERIA (MICROORGANISMS); MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS;

EID: 33744957049     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M508844200     Document Type: Article

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