In Vitro Inhibition of the Mycobacterium tuberculosis β-Ketoacyl-Acyl Carrier Protein Reductase MabA by Isoniazid

Antimicrobial Agents and Chemotherapy

Volumn 48, Issue 1, 2004, Pages 242-249

  Ducasse Cabanot, Stéphanie ^a   Cohen Gonsaud, Martin ^b,c   Marrakchi, Hedia ^a   Nguyen, Michel ^b   Zerbib, Didier ^a   Bernadou, Jean ^b   Daffé, Mamadou ^a   Labesse, Gilles ^b   Quémard, Annaïk ^a  

^a INSTITUT DE PHARMACOLOGIE ET DE BIOLOGIE STRUCTURALE   (France)

^b CNRS   (France)

^c BioXTal   (France)

Author keywords

[No Author keywords available]

Indexed keywords

3 OXOACYL ACYL CARRIER PROTEIN REDUCTASE; ISONIAZID; MANGANESE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; NICOTINE DERIVATIVE; OXIDOREDUCTASE; PROTEIN MABA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TYROSINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTIBACTERIAL ACTIVITY; ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; COVALENT BOND; CRYSTAL STRUCTURE; DRUG MECHANISM; DRUG PROTEIN BINDING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; FATTY ACID SYNTHESIS; IC 50; IN VITRO STUDY; KINETICS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOLECULAR MODEL; MYCOBACTERIUM TUBERCULOSIS; PRIORITY JOURNAL; PURIFICATION; REDUCTION; SPECTROFLUOROMETRY; WILD TYPE;

ACYL CARRIER PROTEIN; ANTITUBERCULAR AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; CRYSTALLOGRAPHY, X-RAY; FATTY ACIDS; ISONIAZID; MODELS, MOLECULAR; MYCOBACTERIUM TUBERCULOSIS; NADP; PROTEIN CONFORMATION; SPECTROMETRY, FLUORESCENCE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 0347361707     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.48.1.242-249.2004     Document Type: Article

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