NAD+-dependent DNA ligase (Rv3014c) from Mycobacterium tuberculosis: Novel structure-function relationship and identification of a specific inhibitor

Proteins: Structure, Function and Genetics

Volumn 69, Issue 1, 2007, Pages 97-111

  Srivastava, Sandeep Kumar ^a   Dube, Divya ^a   Kukshal, Vandana ^a   Jha, Ashok Kumar ^a   Hajela, Kanchan ^a   Ramachandran, Ravishankar ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

BRCT domain; Mutants; Mycobacterium tuberculosis; N substituted indole; NAD+ dependent DNA ligase; Virtualscreening

Indexed keywords

INDOLE; METAL; MUTANT PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; SODIUM CHLORIDE; WATER;

ADENYLATION; ARTICLE; BACTERIAL SURVIVAL; BINDING AFFINITY; COMPUTER MODEL; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME STRUCTURE; ESCHERICHIA COLI; GENE DELETION; GENETIC COMPLEMENTATION; IC 50; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR CLONING; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PH MEASUREMENT; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PURIFICATION; SCREENING TEST; STEADY STATE; THERMUS; WATER ANALYSIS;

BINDING SITES; CLONING, MOLECULAR; DNA BREAKS, SINGLE-STRANDED; DNA LIGASES; ENZYME INHIBITORS; INDOLES; KINETICS; MUTATION; MYCOBACTERIUM TUBERCULOSIS; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); LIGA; MYCOBACTERIUM TUBERCULOSIS;

EID: 34548331696     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.21457     Document Type: Article

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