NAD+-dependent DNA ligase (Rv3014c) from Mycobacterium tuberculosis: Crystal structure of the adenylation domain and identification of novel inhibitors

Journal of Biological Chemistry

Volumn 280, Issue 34, 2005, Pages 30273-30281

  Srivastava, Sandeep Kumar ^a   Tripathi, Rama Pati ^a   Ramachandran, Ravishankar ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; CHEMICAL BONDS; CRYSTAL STRUCTURE; DISEASES; ENZYME INHIBITION; ENZYMES; ESCHERICHIA COLI; ESTERS; MUTAGENESIS; PHOSPHORUS;

ADENYLATION; DNA LIGASES; LIGASE MUTANTS; PHOSPHODIESTER BONDS;

DNA;

ADENOSINE NUCLEOSIDE; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; ANTIINFECTIVE AGENT; BACTERIAL DNA; BACTERIAL ENZYME; ENZYME INHIBITOR; GLYCOSYLUREIDE DERIVATIVE; LIGASE; MUTANT PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE; NUCLEOSIDE DERIVATIVE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE 1; POLYDEOXYRIBONUCLEOTIDE SYNTHASE INHIBITOR; T4 LIGASE; UNCLASSIFIED DRUG;

ADENYLATION; ARTICLE; BACTERIAL STRAIN; BACTERICIDAL ACTIVITY; BACTERIUM CULTURE; BINDING AFFINITY; BINDING ASSAY; BINDING SITE; CALCULATION; CATALYST; CHEMICAL BOND; COMPUTER MODEL; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA REPAIR; DNA REPLICATION; DRUG DESIGN; DRUG SPECIFICITY; DRUG TARGETING; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME SUBSTRATE; ESCHERICHIA COLI; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR CLONING; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SALMONELLA TYPHIMURIUM; STRUCTURE ANALYSIS; TEMPERATURE SENSITIVITY;

ANTI-INFECTIVE AGENTS; BINDING SITES; BINDING, COMPETITIVE; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; DNA; DNA LIGASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRONS; ENZYME INHIBITORS; ESCHERICHIA COLI; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; MODELS, CHEMICAL; MODELS, MOLECULAR; MUTATION; MYCOBACTERIUM TUBERCULOSIS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; TEMPERATURE; TIME FACTORS;

ESCHERICHIA COLI; MYCOBACTERIUM TUBERCULOSIS; SALMONELLA TYPHIMURIUM;

EID: 24044548989     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M503780200     Document Type: Article

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