Purification, characterization, and identification of novel inhibitors of the β-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus

Antimicrobial Agents and Chemotherapy

Volumn 46, Issue 5, 2002, Pages 1310-1318

  He, Xin ^a   Reynolds, Kevin A ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 OXOACYL ACYL CARRIER PROTEIN SYNTHASE; 4 PHENYL 5 PHENYLIMINO[1,2,4]DITHIAZOLIDIN 3 ONE; 5 CHLORO 4 PHENYL[1,2]DITHIOL 3 ONE; ACYL CARRIER PROTEIN; ACYL COENZYME A; ANTIBIOTIC AGENT; CERULENIN; DIMER; ENZYME INHIBITOR; FATTY ACID; HR 12; HR 19; ISOBUTYRYL COENZYME A; MALONYL ACYL CARRIER PROTEIN; POLYHISTIDINE; THIOLACTOMYCIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BACILLUS SUBTILIS; BACTERIAL GENOME; CELL VIABILITY; CHELATION; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG PURIFICATION; DRUG SCREENING; DRUG STRUCTURE; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME PURIFICATION; ENZYME SPECIFICITY; ESCHERICHIA COLI; FATTY ACID SYNTHESIS; GEL FILTRATION CHROMATOGRAPHY; GEL PERMEATION CHROMATOGRAPHY; GENE MUTATION; IC 50; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MICHAELIS CONSTANT; MOLECULAR WEIGHT; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEQUENCE HOMOLOGY; STAPHYLOCOCCUS AUREUS; VANCOMYCIN RESISTANT STAPHYLOCOCCUS AUREUS;

3-OXOACYL-(ACYL-CARRIER-PROTEIN) SYNTHASE; AMINO ACID SEQUENCE; ENZYME INHIBITORS; HUMANS; KINETICS; METHICILLIN RESISTANCE; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; SUBSTRATE SPECIFICITY; SULFHYDRYL COMPOUNDS; THIOPHENES;

EID: 0036232990     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.46.5.1310-1318.2002     Document Type: Article

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