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Volumn 1, Issue 5, 2005, Pages 0349-0358

Flux Balance Analysis of Mycolic Acid Pathway: Targets for Anti-Tubercular Drugs

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIOSYNTHESIS; HYDRAZINE; METABOLISM; TUBES (COMPONENTS);

EID: 33847654799     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.0010046.eor     Document Type: Article
Times cited : (97)

References (59)
  • 1
    • 0038784717 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis: Pathogenesis and molecular determinants of virulence
    • Smith I (2003) Mycobacterium tuberculosis: Pathogenesis and molecular determinants of virulence. Clin Microbiol Rev 16: 463-496.
    • (2003) Clin Microbiol Rev , vol.16 , pp. 463-496
    • Smith, I.1
  • 3
    • 0034073375 scopus 로고    scopus 로고
    • Oxygenated mycolic acids are necessary for virulence of Mycobacterium tuberculosis in mice
    • Dubnau E, Chan J, Raynaud C, Mohan V, Lane elle M, et al. (2000) Oxygenated mycolic acids are necessary for virulence of Mycobacterium tuberculosis in mice. Mol Microbiol 36: 630-637.
    • (2000) Mol Microbiol , vol.36 , pp. 630-637
    • Dubnau, E.1    Chan, J.2    Raynaud, C.3    Mohan, V.4    Lane Elle, M.5
  • 4
    • 0033634971 scopus 로고    scopus 로고
    • A novel mycolic acid cyclopropane synthetase is required for cording, persistence, and virulence of Mycobacterium tuberculosis
    • Glickman M, Cox J, Jacobs W (2000) A novel mycolic acid cyclopropane synthetase is required for cording, persistence, and virulence of Mycobacterium tuberculosis. Mol Cell 5: 717-727.
    • (2000) Mol Cell , vol.5 , pp. 717-727
    • Glickman, M.1    Cox, J.2    Jacobs, W.3
  • 5
    • 0034770036 scopus 로고    scopus 로고
    • Biosynthesis of the arabinogalactanpeptidoglycan complex of Mycobacterium tuberculosis
    • Crick DC, Mahapatra S, Brennan PJ (2001) Biosynthesis of the arabinogalactanpeptidoglycan complex of Mycobacterium tuberculosis. Glycobiology 11: 107R-118R.
    • (2001) Glycobiology , vol.11
    • Crick, D.C.1    Mahapatra, S.2    Brennan, P.J.3
  • 6
    • 12844278679 scopus 로고    scopus 로고
    • Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis
    • Takayama K, Wang C, Besra GS (2005) Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis. Clin Microbiol Rev 18: 81-101.
    • (2005) Clin Microbiol Rev , vol.18 , pp. 81-101
    • Takayama, K.1    Wang, C.2    Besra, G.S.3
  • 8
    • 3142581371 scopus 로고    scopus 로고
    • Rational design of new antituberculosis agents: Receptor-independent four-dimensional quantitative structure-activity relationship analysis of a set of isoniazid derivatives
    • Pasqualoto KFM, Ferreira EI, Santos-Filho OA, Hopfinger AJ (2004) Rational design of new antituberculosis agents: Receptor-independent four-dimensional quantitative structure-activity relationship analysis of a set of isoniazid derivatives. J Med Chem 47: 3755-3764.
    • (2004) J Med Chem , vol.47 , pp. 3755-3764
    • Pasqualoto, K.F.M.1    Ferreira, E.I.2    Santos-Filho, O.A.3    Hopfinger, A.J.4
  • 10
    • 0028156861 scopus 로고
    • A, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis
    • Banerjee A, Dubnau E, Quemard A, Balasubramanian V, Um K, et al. (1994) inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis. Science 263: 227-230.
    • (1994) Science , vol.263 , pp. 227-230
    • Banerjee, A.1    Dubnau, E.2    Quemard, A.3    Balasubramanian, V.4    Um, K.5
  • 11
    • 0037316239 scopus 로고    scopus 로고
    • Reconstruction of metabolic networks from genome data and analysis of their global structure for various organisms
    • Ma H, Zeng AP (2003) Reconstruction of metabolic networks from genome data and analysis of their global structure for various organisms. Bioinformatics 19: 270-277.
    • (2003) Bioinformatics , vol.19 , pp. 270-277
    • Ma, H.1    Zeng, A.P.2
  • 12
    • 0030804853 scopus 로고    scopus 로고
    • Flux analysis of underdetermined metabolic networks: The quest for the missing constraints
    • Bonarius HPJ, Schmid G, Tramper J (1997) Flux analysis of underdetermined metabolic networks: The quest for the missing constraints. Trends Biotech 15: 308-314.
    • (1997) Trends Biotech , vol.15 , pp. 308-314
    • Bonarius, H.P.J.1    Schmid, G.2    Tramper, J.3
  • 13
    • 0033080396 scopus 로고    scopus 로고
    • Detection of elementary flux modes in biochemical networks: A promising tool for pathway analysis and metabolic engineering
    • Schuster S, Dandekar T, Fell DA (1999) Detection of elementary flux modes in biochemical networks: A promising tool for pathway analysis and metabolic engineering. Trends Biotech 17: 53-60.
    • (1999) Trends Biotech , vol.17 , pp. 53-60
    • Schuster, S.1    Dandekar, T.2    Fell, D.A.3
  • 14
    • 55449118495 scopus 로고    scopus 로고
    • Computational analysis of biochemical systems: A practical guide for biochemists and molecular biologists
    • Voit EO (2000) Computational analysis of biochemical systems: A practical guide for biochemists and molecular biologists. Cambridge: Cambridge University Press. 531 p.
    • (2000) Cambridge: Cambridge University Press. , vol.531
    • Voit, E.O.1
  • 15
    • 0037079050 scopus 로고    scopus 로고
    • Metabolic network structure determines key aspects of functionality and regulation
    • Stelling J, Klamt S, Bettenbrock K, Schuster S, Gilles ED (2002) Metabolic network structure determines key aspects of functionality and regulation. Nature 420: 190-193.
    • (2002) Nature , vol.420 , pp. 190-193
    • Stelling, J.1    Klamt, S.2    Bettenbrock, K.3    Schuster, S.4    Gilles, E.D.5
  • 16
    • 0036304317 scopus 로고    scopus 로고
    • The role of stoichiometric analysis in studies of metabolism: An example
    • Cornish-Bowden A, Hofmeyr JHS (2002) The role of stoichiometric analysis in studies of metabolism: An example. J Theor Biol 216: 179-191.
    • (2002) J Theor Biol , vol.216 , pp. 179-191
    • Cornish-Bowden, A.1    Hofmeyr, J.H.S.2
  • 17
    • 0037385718 scopus 로고    scopus 로고
    • Genome-scale microbial in silico models: The constraints-based approach
    • Price ND, Papin JA, Schilling CH, Palsson BO (2003) Genome-scale microbial in silico models: The constraints-based approach. Trends Biotech 21: 162-169.
    • (2003) Trends Biotech , vol.21 , pp. 162-169
    • Price, N.D.1    Papin, J.A.2    Schilling, Ch.3    Palsson, B.O.4
  • 18
    • 12444346818 scopus 로고    scopus 로고
    • From annotated genomes to metabolic flux models and kinetic parameter fitting
    • Segre D, Zucker J, Katz J, Lin X, D'haeseleer P, et al. (2003) From annotated genomes to metabolic flux models and kinetic parameter fitting. OMICS 7: 301-316.
    • (2003) OMICS , vol.7 , pp. 301-316
    • Segre, D.1    Zucker, J.2    Katz, J.3    Lin, X.4    D'Haeseleer, P.5
  • 19
    • 0033580813 scopus 로고    scopus 로고
    • Systems properties of the Haemophilus influenzae Rd metabolic genotype
    • Edwards JS, Palsson BO (1999) Systems properties of the Haemophilus influenzae Rd metabolic genotype. J Biol Chem 274: 17410-17416.
    • (1999) J Biol Chem , vol.274 , pp. 17410-17416
    • Edwards, J.S.1    Palsson, B.O.2
  • 20
    • 0037313750 scopus 로고    scopus 로고
    • Genome-scale reconstruction of the Saccharomyces cerevisiae metabolic network
    • Forster J, Famili I, Fu P, Palsson BO, Nielsen J (2003) Genome-scale reconstruction of the Saccharomyces cerevisiae metabolic network. Genome Res 13: 244-253.
    • (2003) Genome Res , vol.13 , pp. 244-253
    • Forster, J.1    Famili, I.2    Fu, P.3    Palsson, B.O.4    Nielsen, J.5
  • 21
    • 0034625143 scopus 로고    scopus 로고
    • The Escherichia coli MG1655 in silico metabolic genotype: Its definition, characteristics, and capabilities
    • Edwards JS, Palsson BO (2000) The Escherichia coli MG1655 in silico metabolic genotype: Its definition, characteristics, and capabilities. Proc Natl Acad Sci U S A 97: 5528-5533.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 5528-5533
    • Edwards, J.S.1    Palsson, B.O.2
  • 22
    • 17844405878 scopus 로고    scopus 로고
    • Genome-scale reconstruction of the metabolic network in Staphylococcus aureus N315: An initial draft to the two-dimensional annotation
    • Becker SA, Palsson BO (2005) Genome-scale reconstruction of the metabolic network in Staphylococcus aureus N315: An initial draft to the two-dimensional annotation. BMC Microbiology 5: 8.
    • (2005) BMC Microbiology , vol.5 , pp. 8
    • Becker, S.A.1    Palsson, B.O.2
  • 23
    • 4544275674 scopus 로고    scopus 로고
    • Microbial type i fatty acid synthases (FAS): Major players in a network of cellular FAS systems
    • Schweizer E, Hofmann J (2004) Microbial type I fatty acid synthases (FAS): Major players in a network of cellular FAS systems. Microbiol Mol Biol Rev 68: 501-517.
    • (2004) Microbiol Mol Biol Rev , vol.68 , pp. 501-517
    • Schweizer, E.1    Hofmann, J.2
  • 24
    • 0026659794 scopus 로고
    • Purification and characterization of an unusually large fatty acid synthase from Mycobacterium tuberculosis var. bovis BCG
    • Kikuchi S, Rainwater DL, Kolattukudy P (1992) Purification and characterization of an unusually large fatty acid synthase from Mycobacterium tuberculosis var. bovis BCG. Arch Biochem and Biophys 295: 318-326.
    • (1992) Arch Biochem and Biophys , vol.295 , pp. 318-326
    • Kikuchi, S.1    Rainwater, D.L.2    Kolattukudy, P.3
  • 25
    • 0034623067 scopus 로고    scopus 로고
    • Identification and substrate specificity of b-ketoacyl (acyl carrier protein) synthase III (mtFabH) from Mycobacterium tuberculosis
    • Choi KH, Kremer L, Besra GS, Rock CO (2000) Identification and substrate specificity of b-ketoacyl (acyl carrier protein) synthase III (mtFabH) from Mycobacterium tuberculosis. J Biol Chem 275: 28201-28207.
    • (2000) J Biol Chem , vol.275 , pp. 28201-28207
    • Choi, K.H.1    Kremer, L.2    Besra, G.S.3    Rock, C.O.4
  • 26
    • 0035827542 scopus 로고    scopus 로고
    • Crystal structure of the Mycobacterium tuberculosis b-ketoacyl-acyl carrier protein synthase III
    • Scarsdale JN, Kazanina G, He X, Reynolds KA, Wright HT (2001) Crystal structure of the Mycobacterium tuberculosis b-ketoacyl-acyl carrier protein synthase III. J Biol Chem 276: 20516-20522.
    • (2001) J Biol Chem , vol.276 , pp. 20516-20522
    • Scarsdale, J.N.1    Kazanina, G.2    He, X.3    Reynolds, K.A.4    Wright, H.T.5
  • 27
    • 0032508046 scopus 로고    scopus 로고
    • Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
    • Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, et al. (1998) Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393: 537-544.
    • (1998) Nature , vol.393 , pp. 537-544
    • Cole, S.T.1    Brosch, R.2    Parkhill, J.3    Garnier, T.4    Churcher, C.5
  • 28
    • 0036606073 scopus 로고    scopus 로고
    • Mycolic acid biosynthesis and enzymic characterization of the betaketoacylACP synthase A-condensing enzyme from Mycobacterium tuberculosis
    • Kremer L, Dover L, Carre re S, Nampoothiri K, Lesjean S, et al. (2002) Mycolic acid biosynthesis and enzymic characterization of the betaketoacylACP synthase A-condensing enzyme from Mycobacterium tuberculosis. Biochem J 364: 423-430.
    • (2002) Biochem J , vol.364 , pp. 423-430
    • Kremer, L.1    Dover, L.2    Carre Re, S.3    Nampoothiri, K.4    Lesjean, S.5
  • 29
    • 0036228187 scopus 로고    scopus 로고
    • MabA (FabG1), a Mycobacterium tuberculosis protein involved in the longchain fatty acid elongation system FAS-II
    • Marrakchi H, Ducasse S, Labesse G, Montrozier H, Margeat E, et al. (2002) MabA (FabG1), a Mycobacterium tuberculosis protein involved in the longchain fatty acid elongation system FAS-II. Microbiology 148: 951-960.
    • (2002) Microbiology , vol.148 , pp. 951-960
    • Marrakchi, H.1    Ducasse, S.2    Labesse, G.3    Montrozier, H.4    Margeat, E.5
  • 30
    • 0029000868 scopus 로고
    • Enzymatic characterization of the target for isoniazid in Mycobacterium tuberculosis
    • Quemard A, Sacchettini JC, Dessen A, Vilcheze C, Bittman R, et al. (1995) Enzymatic characterization of the target for isoniazid in Mycobacterium tuberculosis. Biochemistry 34: 8235-8241.
    • (1995) Biochemistry , vol.34 , pp. 8235-8241
    • Quemard, A.1    Sacchettini, J.C.2    Dessen, A.3    Vilcheze, C.4    Bittman, R.5
  • 31
    • 0035861550 scopus 로고    scopus 로고
    • Purification and biochemical characterization of the Mycobacterium tuberculosis b-ketoacyl-acyl carrier protein synthases KasA and KasB
    • Schaeffer ML, Agnihotri G, Volker C, Kallender H, Brennan PJ, et al. (2001) Purification and biochemical characterization of the Mycobacterium tuberculosis b-ketoacyl-acyl carrier protein synthases KasA and KasB. J Biol Chem 276: 47029-47037.
    • (2001) J Biol Chem , vol.276 , pp. 47029-47037
    • Schaeffer, M.L.1    Agnihotri, G.2    Volker, C.3    Kallender, H.4    Brennan, P.J.5
  • 32
    • 9144238713 scopus 로고    scopus 로고
    • Unique mechanism of action of the thiourea drug isoxyl on Mycobacterium tuberculosis
    • Phetsuksiri B, Jackson M, Scherman H, McNeil M, Besra GS, et al. (2003) Unique mechanism of action of the thiourea drug isoxyl on Mycobacterium tuberculosis. J Biol Chem 278: 53123-53130.
    • (2003) J Biol Chem , vol.278 , pp. 53123-53130
    • Phetsuksiri, B.1    Jackson, M.2    Scherman, H.3    McNeil, M.4    Besra, G.S.5
  • 33
    • 0035910583 scopus 로고    scopus 로고
    • The Mycobacterium tuberculosis cmaA2 gene encodes a mycolic acid trans-cyclopropane synthetase
    • Glickman M, Cahill S, Jacobs W (2001) The Mycobacterium tuberculosis cmaA2 gene encodes a mycolic acid trans-cyclopropane synthetase. J Biol Chem 276: 2228-2233.
    • (2001) J Biol Chem , vol.276 , pp. 2228-2233
    • Glickman, M.1    Cahill, S.2    Jacobs, W.3
  • 34
    • 0037470224 scopus 로고    scopus 로고
    • Tracking the putative biosynthetic precursors of oxygenated mycolates of Mycobacterium tuberculosis
    • Dinadayala P, Laval F, Raynaud C, Lemassu A, Laneelle M, et al. (2003) Tracking the putative biosynthetic precursors of oxygenated mycolates of Mycobacterium tuberculosis. J Biol Chem 278: 7310-7319.
    • (2003) J Biol Chem , vol.278 , pp. 7310-7319
    • Dinadayala, P.1    Laval, F.2    Raynaud, C.3    Lemassu, A.4    Laneelle, M.5
  • 36
    • 0037424531 scopus 로고    scopus 로고
    • The mmaA2 gene of Mycobacterium tuberculosis encodes the distal cyclopropane synthase of the a-mycolic acid
    • Glickman MS (2003) The mmaA2 gene of Mycobacterium tuberculosis encodes the distal cyclopropane synthase of the a-mycolic acid. J Biol Chem 278: 7844-7849.
    • (2003) J Biol Chem , vol.278 , pp. 7844-7849
    • Glickman, M.S.1
  • 37
    • 0029803546 scopus 로고    scopus 로고
    • A common mechanism for the biosynthesis of methoxy and cyclopropyl mycolic acids in Mycobacterium tuberculosis
    • Yuan Y, Barry CE III (1996) A common mechanism for the biosynthesis of methoxy and cyclopropyl mycolic acids in Mycobacterium tuberculosis. Proc Natl Acad Sci U S A 93: 12828-12833.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 12828-12833
    • Yuan, Y.1    Iii, B.C.E.2
  • 38
    • 0029048109 scopus 로고
    • Identification of a gene involved in the biosynthesis of cyclopropanated mycolic acids in Mycobacterium tuberculosis
    • Yuan Y, Lee R, Besra G, Belisle J, Barry C (1995) Identification of a gene involved in the biosynthesis of cyclopropanated mycolic acids in Mycobacterium tuberculosis. Proc Natl Acad Sci U S A 92: 6630-6634.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 6630-6634
    • Yuan, Y.1    Lee, R.2    Besra, G.3    Belisle, J.4    Barry, C.5
  • 39
    • 0031001270 scopus 로고    scopus 로고
    • MMAS-1, the branch point between cis- And trans-cyclopropane-containing oxygenated mycolates in Mycobacterium tuberculosis
    • Yuan Y, Crane D, Musser J, Sreevatsan S, Barry C (1997) MMAS-1, the branch point between cis- and trans-cyclopropane-containing oxygenated mycolates in Mycobacterium tuberculosis. J Biol Chem 272: 10041-10049.
    • (1997) J Biol Chem , vol.272 , pp. 10041-10049
    • Yuan, Y.1    Crane, D.2    Musser, J.3    Sreevatsan, S.4    Barry, C.5
  • 40
    • 15744389881 scopus 로고    scopus 로고
    • The acyl-AMP ligase FadD32 and AccD4-containing acyl-CoA carboxylase are required for the synthesis of mycolic acids and essential for mycobacterial growth
    • Portevin D, de Sousa-D'Auria C, Montrozier H, Houssin C, Stella A, et al. (2005) The acyl-AMP ligase FadD32 and AccD4-containing acyl-CoA carboxylase are required for the synthesis of mycolic acids and essential for mycobacterial growth. J Biol Chem 280: 8862-8874.
    • (2005) J Biol Chem , vol.280 , pp. 8862-8874
    • Portevin, D.1    De Sousa-D'Auria, C.2    Montrozier, H.3    Houssin, C.4    Stella, A.5
  • 41
    • 0034924433 scopus 로고    scopus 로고
    • Separation and characterization of individual mycolic acids in representative mycobacteria
    • Watanabe M, Aoyagi Y, Ridell M, Minnikin D (2001) Separation and characterization of individual mycolic acids in representative mycobacteria. Microbiology 147: 1825-1837.
    • (2001) Microbiology , vol.147 , pp. 1825-1837
    • Watanabe, M.1    Aoyagi, Y.2    Ridell, M.3    Minnikin, D.4
  • 42
    • 0015373050 scopus 로고
    • Effect of isoniazid on the in vivo mycolic acid synthesis, cell growth, and viability of Mycobacterium tuberculosis
    • Takayama K, Wang L, David HL (1972) Effect of isoniazid on the in vivo mycolic acid synthesis, cell growth, and viability of Mycobacterium tuberculosis. Antimicrob Agents Chemother 2: 29-35.
    • (1972) Antimicrob Agents Chemother , vol.2 , pp. 29-35
    • Takayama, K.1    Wang, L.2    David, H.L.3
  • 43
    • 0038410325 scopus 로고    scopus 로고
    • Inactivation of the inhA-encoded fatty acid synthase II (FASII) enoyl-acyl carrier protein reductase induces accumulation of the FASI end products and cell lysis of Mycobacterium smegmatis
    • Vilche ze C, Morbidoni HR, Weisbrod TR, Iwamoto H, Kuo M, et al. (2000) Inactivation of the inhA-encoded fatty acid synthase II (FASII) enoyl-acyl carrier protein reductase induces accumulation of the FASI end products and cell lysis of Mycobacterium smegmatis. J Bacteriol 182: 4059-4067.
    • (2000) J Bacteriol , vol.182 , pp. 4059-4067
    • Vilcheze, C.1    Morbidoni, H.R.2    Weisbrod, T.R.3    Iwamoto, H.4    Kuo, M.5
  • 44
    • 0031694056 scopus 로고    scopus 로고
    • The effect of oxygenated mycolic acid composition on cell wall function and macrophage growth in Mycobacterium tuberculosis
    • Yuan Y, Zhu Y, Crane DD, Barry CE III (1998) The effect of oxygenated mycolic acid composition on cell wall function and macrophage growth in Mycobacterium tuberculosis. Mol Microbiol 29: 1449-1458.
    • (1998) Mol Microbiol , vol.29 , pp. 1449-1458
    • Yuan, Y.1    Zhu, Y.2    Crane, D.D.3    Iii, B.C.E.4
  • 45
    • 0035987344 scopus 로고    scopus 로고
    • Location of functional groups in mycobacterial meromycolate chains; the recognition of new structural principles in mycolic acids
    • Watanabe M, Aoyagi Y, Mitome H, Fujita T, Naoki H, et al. (2002) Location of functional groups in mycobacterial meromycolate chains; the recognition of new structural principles in mycolic acids. Microbiology 148: 1881-1902.
    • (2002) Microbiology , vol.148 , pp. 1881-1902
    • Watanabe, M.1    Aoyagi, Y.2    Mitome, H.3    Fujita, T.4    Naoki, H.5
  • 46
    • 0345701347 scopus 로고    scopus 로고
    • Genes required for mycobacterial growth defined by high density mutagenesis
    • Sassetti CM, Boyd DH, Rubin EJ (2003) Genes required for mycobacterial growth defined by high density mutagenesis. Mol Microbiol 48: 77-84.
    • (2003) Mol Microbiol , vol.48 , pp. 77-84
    • Sassetti, C.M.1    Boyd, D.H.2    Rubin, E.J.3
  • 47
    • 0037069467 scopus 로고    scopus 로고
    • Analysis of optimality in natural and perturbed metabolic networks
    • Segre D, Vitkup D, Church GM (2002) Analysis of optimality in natural and perturbed metabolic networks. Proc Natl Acad Sci U S A 99: 15112-15117.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 15112-15117
    • Segre, D.1    Vitkup, D.2    Church, G.M.3
  • 48
    • 0035133932 scopus 로고    scopus 로고
    • Differential expression of mycobacterial proteins following phagocytosis by macrophages
    • Monahan IM, Betts J, Banerjee DK, Butcher PD (2001) Differential expression of mycobacterial proteins following phagocytosis by macrophages. Microbiology 147: 459-471.
    • (2001) Microbiology , vol.147 , pp. 459-471
    • Monahan, I.M.1    Betts, J.2    Banerjee, D.K.3    Butcher, P.D.4
  • 49
    • 0032486197 scopus 로고    scopus 로고
    • Inhibition of a Mycobacterium tuberculosis b-ketoacyl ACP synthase by isoniazid
    • Mdluli K, Slayden RA, Zhu Y, Ramaswamy S, Pan X, et al. (1998) Inhibition of a Mycobacterium tuberculosis b-ketoacyl ACP synthase by isoniazid. Science 280: 1607-1610.
    • (1998) Science , vol.280 , pp. 1607-1610
    • Mdluli, K.1    Slayden, R.A.2    Zhu, Y.3    Ramaswamy, S.4    Pan, X.5
  • 52
    • 10644250404 scopus 로고    scopus 로고
    • Evolving a lingua franca and associated software infrastructure for computational systems biology: The Systems Biology Markup Language (SBML) project
    • Hucka M, Finney A, Bornstein B, Keating S, Shapiro B, et al. (2004) Evolving a lingua franca and associated software infrastructure for computational systems biology: The Systems Biology Markup Language (SBML) project. Syst Biol 1: 41-53.
    • (2004) Syst Biol , vol.1 , pp. 41-53
    • Hucka, M.1    Finney, A.2    Bornstein, B.3    Keating, S.4    Shapiro, B.5
  • 53
    • 0036001069 scopus 로고    scopus 로고
    • Metabolic modelling of microbes: The flux-balance approach
    • Edwards JS, Covert M, Palsson BO (2002) Metabolic modelling of microbes: The flux-balance approach. Environ Microbiol 4: 133-133.
    • (2002) Environ Microbiol , vol.4 , pp. 133-133
    • Edwards, J.S.1    Covert, M.2    Palsson, B.O.3
  • 55
    • 13444283465 scopus 로고    scopus 로고
    • Simulation and validation of modelled sphingolipid metabolism in Saccharomyces cerevisiae
    • Alvarez-Vasquez F, Sims K, Cowart L, Okamoto Y, Voit E, et al. (2005) Simulation and validation of modelled sphingolipid metabolism in Saccharomyces cerevisiae. Nature 433: 425-430.
    • (2005) Nature , vol.433 , pp. 425-430
    • Alvarez-Vasquez, F.1    Sims, K.2    Cowart, L.3    Okamoto, Y.4    Voit, E.5
  • 56
    • 0035125986 scopus 로고    scopus 로고
    • In silico predictions of Escherichia coli metabolic capabilities are consistent with experimental data
    • Edwards JS, Ibarra RU, Palsson BO (2001) In silico predictions of Escherichia coli metabolic capabilities are consistent with experimental data. Nat Biotechnol 19: 125-130.
    • (2001) Nat Biotechnol , vol.19 , pp. 125-130
    • Edwards, J.S.1    Ibarra, R.U.2    Palsson, B.O.3
  • 57
    • 0030801002 scopus 로고    scopus 로고
    • Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
    • Altschul SF, Madden TL, Scha ffer AA, Zhang J, Zhang Z, et al. (1997) Gapped BLAST and PSI-BLAST: A new generation of protein database search programs. Nucleic Acids Res 25: 3389-3402.
    • (1997) Nucleic Acids Res , vol.25 , pp. 3389-3402
    • Altschul, S.F.1    Madden, T.L.2    Scha Ffer, A.A.3    Zhang, J.4    Zhang, Z.5
  • 58
    • 0035958944 scopus 로고    scopus 로고
    • Biochemical characterization of acyl carrier protein (AcpM) and malonylCoA:AcpM transacylase (mtFabD), two major components of Mycobacterium tuberculosis fatty acid synthase II
    • Kremer L, Nampoothiri KM, Lesjean S, Dover LG, Grahami S, et al. (2001) Biochemical characterization of acyl carrier protein (AcpM) and malonylCoA:AcpM transacylase (mtFabD), two major components of Mycobacterium tuberculosis fatty acid synthase II. J Biol Chem 276: 27967-27974.
    • (2001) J Biol Chem , vol.276 , pp. 27967-27974
    • Kremer, L.1    Nampoothiri, K.M.2    Lesjean, S.3    Dover, L.G.4    Grahami, S.5
  • 59
    • 0347719360 scopus 로고    scopus 로고
    • A polyketide synthase catalyzes the last condensation step of mycolic acid biosynthesis in mycobacteria and related organisms
    • Portevin D, De Sousa-D'Auria C, Houssin C, Grimaldi C, Chami M, et al. (2004) A polyketide synthase catalyzes the last condensation step of mycolic acid biosynthesis in mycobacteria and related organisms. Proc Natl Acad Sci U S A 101: 314-319.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 314-319
    • Portevin, D.1    De Sousa-D'Auria, C.2    Houssin, C.3    Grimaldi, C.4    Chami, M.5


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