Genetic and pharmacological inhibition of PDK1 in cancer cells: Characterization of a selective allosteric kinase inhibitor

Journal of Biological Chemistry

Volumn 286, Issue 8, 2011, Pages 6433-6448

  Nagashima, Kumiko ^a   Shumway, Stuart D ^a   Sathyanarayanan, Sriram ^a   Chen, Albert H ^a   Dolinski, Brian ^a   Xu, Youyuan ^a   Keilhack, Heike ^a   Nguyen, Thi ^a   Wiznerowicz, Maciej ^a   Li, Lixia ^a   Lutterbach, Bart A ^a   Chi, An ^a   Paweletz, Cloud ^a   Allison, Timothy ^a   Yan, Youwei ^a   Munshi, Sanjeev K ^a   Klippel, Anke ^a   Kraus, Manfred ^a   Bobkova, Ekaterina V ^a   Deshmukh, Sujal ^a   Xu, Zangwei ^a   Mueller, Uwe ^a   Szewczak, Alexander A ^a   Pan, Bo Sheng ^a   Richon, Victoria ^a   Pollock, Roy ^a   Blume Jensen, Peter ^a   Northrup, Alan ^a   Andersen, Jannik N ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIPROLIFERATIVE EFFECT; BINDING MODES; CANCER CELL LINES; CANCER CELLS; COLONY FORMATION; CRYSTALLOGRAPHIC STUDIES; CULTURE CONDITIONS; DRUG RESPONSE; DRUG TARGETS; IN-CELL; IN-VITRO; KINASE INHIBITORS; MONOLAYER CULTURE; ONCOGENIC PROTEINS; PHARMACOLOGICAL INHIBITION; PHOSPHOINOSITIDE-DEPENDENT KINASE 1; THERAPEUTIC TARGETS; TUMORIGENESIS;

BINDING ENERGY; CELLS; DISEASES; ENZYME INHIBITION; ENZYMES; MONOLAYERS; PHOSPHORYLATION; TISSUE CULTURE; X RAY CRYSTALLOGRAPHY;

CELL CULTURE;

PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1 INHIBITOR; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANCHORAGE INDEPENDENT GROWTH; ANIMAL CELL; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER INHIBITION; CANCER INVASION; CELL MIGRATION; CELL PROLIFERATION; COLONY FORMATION; CONTROLLED STUDY; DRUG EFFECT; DRUG IDENTIFICATION; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG RESPONSE; DRUG SELECTIVITY; DRUG SENSITIVITY; DRUG STRUCTURE; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MONOLAYER CULTURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; TUMOR XENOGRAFT;

ALLOSTERIC REGULATION; ANIMALS; CATALYTIC DOMAIN; CELL LINE, TUMOR; CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; DOGS; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; NEOPLASM PROTEINS; NEOPLASMS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES;

EID: 79953181999     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.156463     Document Type: Article

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