-
1
-
-
0022276121
-
The earliest medical texts
-
Frey EF. The earliest medical texts. Clio. Med. 20(1-4), 79-90 (1985).
-
(1985)
Clio. Med.
, vol.20
, Issue.1-4
, pp. 79-90
-
-
Frey, E.F.1
-
2
-
-
0023524855
-
Accelerator mass spectrometry for measurement of long-lived radioisotopes
-
Elmore D, Phillips FM. Accelerator mass spectrometry for measurement of long-lived radioisotopes. Science 236(4801), 543-550 (1987). (Pubitemid 17604482)
-
(1987)
Science
, vol.236
, Issue.4801
, pp. 543-550
-
-
Elmore David1
Phillips Fred, M.2
-
3
-
-
0025062962
-
Accelerator mass spectrometry in biomedical dosimetry: Relationship between low-level exposure and covalent binding of heterocyclic amine carcinogens to DNA
-
DOI 10.1073/pnas.87.14.5288
-
Turteltaub KW, Felton JS, Gledhill BL et al. Accelerator mass spectrometry in biomedical dosimetry. relationship between low-level exposure and covalent binding of heterocyclic amine carcinogens to DNA. Proc. Natl Acad. Sci. USA 87(14), 5288-5292 (1990). (Pubitemid 20260164)
-
(1990)
Proceedings of the National Academy of Sciences of the United States of America
, vol.87
, Issue.14
, pp. 5288-5292
-
-
Turteltaub, K.W.1
Felton, J.S.2
Gledhill, B.L.3
Vogel, J.S.4
Southon, J.R.5
Caffee, M.W.6
Finkel, R.C.7
Nelson, D.E.8
Proctor, I.D.9
Davis, J.C.10
-
4
-
-
0032529441
-
Analytical performance of accelerator mass spectrometry and liquid scintillation counting for detection of 14C-labeled atrazine metabolites in human urine
-
Gilman SD, Gee SJ, Hammock BD et al. Analytical performance of accelerator mass spectrometry and liquid scintillation counting for detection of 14C-labeled atrazine metabolites in human urine. Anal. Chem. 70(16), 3463-3469 (1998).
-
(1998)
Anal. Chem.
, vol.70
, Issue.16
, pp. 3463-3469
-
-
Gilman, S.D.1
Gee, S.J.2
Hammock, B.D.3
-
5
-
-
0034672461
-
A validation study comparing accelerator MS and liquid scintillation counting for analysis of 14C-labelled drugs in plasma, urine and faecal extracts
-
Garner RC, Barker J, Flavell C et al. A validation study comparing accelerator MS and liquid scintillation counting for analysis of 14C-labelled drugs in plasma, urine and faecal extracts. J. Pharm. Biomed. Anal. 24(2), 197-209 (2000).
-
(2000)
J. Pharm. Biomed. Anal.
, vol.24
, Issue.2
, pp. 197-209
-
-
Garner, R.C.1
Barker, J.2
Flavell, C.3
-
6
-
-
2942595807
-
Comparison of accelerator mass spectrometry with gas chromatography for the determination of pesticide residues in individual items in the diets of wild birds and mammals
-
Brown P, Garner C, Glass R, Ridgway C, Hart A. Comparison of accelerator mass spectrometry with gas chromatography for the determination of pesticide residues in individual items in the diets of wild birds and mammals. J. Agric. Food Chem. 52(12), 3693-3701 (2004).
-
(2004)
J. Agric. Food Chem.
, vol.52
, Issue.12
, pp. 3693-3701
-
-
Brown, P.1
Garner, C.2
Glass, R.3
Ridgway, C.4
Hart, A.5
-
7
-
-
0346497617
-
14C in Nonvolatile Samples by Accelerator Mass Spectrometry
-
DOI 10.1021/ac030181y
-
Liberman RG, Tannenbaum SR, Hughey BJ et al. An interface for direct analysis of 14C in nonvolatile samples by accelerator mass spectrometry. Anal. Chem. 76(2), 328-334 (2004). (Pubitemid 38090768)
-
(2004)
Analytical Chemistry
, vol.76
, Issue.2
, pp. 328-334
-
-
Liberman, R.G.1
Tannenbaum, S.R.2
Hughey, B.J.3
Shefer, R.E.4
Klinkowstein, R.E.5
Prakash, C.6
Harriman, S.P.7
Skipper, P.L.8
-
8
-
-
46849106697
-
Integration of continuous-flow accelerator mass spectrometry with chromatography and mass-selective detection
-
DOI 10.1021/ac800286g
-
Flarakos J, Liberman RG, Tannenbaum SR, Skipper PL. Integration of continuous-flow accelerator mass spectrometry with chromatography and mass-selective detection. Anal. Chem. 80(13), 5079-5085 (2008). (Pubitemid 351956318)
-
(2008)
Analytical Chemistry
, vol.80
, Issue.13
, pp. 5079-5085
-
-
Flarakos, J.1
Liberman, R.G.2
Tannenbaum, S.R.3
Skipper, P.L.4
-
9
-
-
68049111488
-
Gas chromatograph-combustion system for (14) C-accelerator mass spectrometry
-
Mcintyre CP, Sylva SP, Roberts ML. Gas chromatograph-combustion system for (14) C-accelerator mass spectrometry. Anal. Chem. 81(15), 6 (2009).
-
(2009)
Anal. Chem.
, vol.81
, Issue.15
, pp. 6
-
-
McIntyre, C.P.1
Sylva, S.P.2
Roberts, M.L.3
-
10
-
-
48249097413
-
Performance evaluation of the new AMS system at Accium BioSciences
-
Zoppi U, Crye J, Song Q, Arjomand A. Performance evaluation of the new AMS system at Accium BioSciences. Radiocarbon 49(1), 10 (2007).
-
(2007)
Radiocarbon
, vol.49
, Issue.1
, pp. 10
-
-
Zoppi, U.1
Crye, J.2
Song, Q.3
Arjomand, A.4
-
11
-
-
60149111433
-
Comparison of a 250 KV single-stage accelerator mass spectrometer with a 5 MV tandem accelerator mass spectrometer - Fitness for purpose in bioanalysis
-
Young GC, Corless S, Felgate CC, Colthup PV. Comparison of a 250 KV single-stage accelerator mass spectrometer with a 5 MV tandem accelerator mass spectrometer - fitness for purpose in bioanalysis. Rapid Commun. Mass Spectrom. 22(24), 4035-4042 (2008).
-
(2008)
Rapid Commun. Mass Spectrom.
, vol.22
, Issue.24
, pp. 4035-4042
-
-
Young, G.C.1
Corless, S.2
Felgate, C.C.3
Colthup, P.V.4
-
12
-
-
43949136451
-
Subattomole sensitivity in biological accelerator mass spectrometry
-
DOI 10.1021/ac800174j
-
Salehpour M, Possnert G, Bryhni H. Subattomole sensitivity in biological accelerator mass spectrometry. Anal. Chem. 80(10), 3515-3521 (2008). (Pubitemid 351705849)
-
(2008)
Analytical Chemistry
, vol.80
, Issue.10
, pp. 3515-3521
-
-
Salehpour, M.1
Possnert, G.2
Bryhni, H.3
-
13
-
-
58749104933
-
Biological accelerator mass spectrometry at Uppsala University
-
Salehpour M, Possnert G, Bryhni H, Palminger-Hallen I, Stahle L. Biological accelerator mass spectrometry at Uppsala University. Appl. Radiat. Isot. 67(3), 495-499 (2009).
-
(2009)
Appl. Radiat. Isot.
, vol.67
, Issue.3
, pp. 495-499
-
-
Salehpour, M.1
Possnert, G.2
Bryhni, H.3
Palminger-Hallen, I.4
Stahle, L.5
-
15
-
-
0029311007
-
Accelerator mass spectrometry
-
Vogel JS, Turteltaub KW, Finkel R, Nelson DE. Accelerator mass spectrometry. Anal. Chem. 67(11), 353A-359A (1995).
-
(1995)
Anal. Chem.
, vol.67
, Issue.11
-
-
Vogel, J.S.1
Turteltaub, K.W.2
Finkel, R.3
Nelson, D.E.4
-
16
-
-
30144437351
-
Accelerator mass spectrometry for biomedical research
-
DOI 10.1016/S0076-6879(05)02014-8, PII S0076687905020148, 14, Biological Mass Spectrometry
-
Brown K, Dingley KH, Turteltaub KW. Accelerator mass spectrometry for biomedical research. Methods Enzymol. 402, 423-443 (2005). (Pubitemid 43053135)
-
(2005)
Methods in Enzymology
, vol.402
, pp. 423-443
-
-
Brown, K.1
Dingley, K.H.2
Turteltaub, K.W.3
-
17
-
-
50149101320
-
Accelerator mass spectrometry
-
Hellborg R, Skog G. Accelerator mass spectrometry. Mass Spectrom. Rev. 27(5), 398-427 (2008).
-
(2008)
Mass Spectrom. Rev.
, vol.27
, Issue.5
, pp. 398-427
-
-
Hellborg, R.1
Skog, G.2
-
18
-
-
0000677819
-
Rapid production of graphite without contamination for biomedical AMS
-
Vogel JS. Rapid production of graphite without contamination for biomedical AMS. Radiocarbon 34, 344-350 (1992).
-
(1992)
Radiocarbon
, vol.34
, pp. 344-350
-
-
Vogel, J.S.1
-
19
-
-
0038709670
-
14C via accelerator mass spectrometry
-
DOI 10.1021/ac026334j
-
Ognibene TJ, Bench G, Vogel JS, Peaslee GF, Murov S. A high-throughput method for the conversion of CO2 obtained from biochemical samples to graphite in septa-sealed vials for quantification of 14C via accelerator mass spectrometry. Anal. Chem. 75(9), 2192-2196 (2003). (Pubitemid 36542364)
-
(2003)
Analytical Chemistry
, vol.75
, Issue.9
, pp. 2192-2196
-
-
Ognibene, T.J.1
Bench, G.2
Vogel, J.S.3
Peaslee, G.F.4
Murov, S.5
-
20
-
-
54349091286
-
Biological/ biomedical accelerator mass spectrometry targets. 2. Physical, morphological, and structural characteristics
-
Kim SH, Kelly PB, Clifford AJ. Biological/ biomedical accelerator mass spectrometry targets. 2. Physical, morphological, and structural characteristics. Anal. Chem. 80(20), 7661-7669 (2008).
-
(2008)
Anal. Chem.
, vol.80
, Issue.20
, pp. 7661-7669
-
-
Kim, S.H.1
Kelly, P.B.2
Clifford, A.J.3
-
21
-
-
54349090949
-
Biological/ biomedical accelerator mass spectrometry targets. 1. Optimizing the CO2 reduction step using zinc dust
-
Kim SH, Kelly PB, Clifford AJ. Biological/ biomedical accelerator mass spectrometry targets. 1. Optimizing the CO2 reduction step using zinc dust. Anal. Chem. 80(20), 7651-7660 (2008).
-
(2008)
Anal. Chem.
, vol.80
, Issue.20
, pp. 7651-7660
-
-
Kim, S.H.1
Kelly, P.B.2
Clifford, A.J.3
-
22
-
-
67650770348
-
Accelerator mass spectrometry targets of submilligram carbonaceous samples using the high-throughput Zn reduction method
-
Kim SH, Kelly PB, Clifford AJ. Accelerator mass spectrometry targets of submilligram carbonaceous samples using the high-throughput Zn reduction method. Anal. Chem. 81(14), 5949-5954 (2009).
-
(2009)
Anal. Chem.
, vol.81
, Issue.14
, pp. 5949-5954
-
-
Kim, S.H.1
Kelly, P.B.2
Clifford, A.J.3
-
24
-
-
79953270349
-
Methods and applications of HPLC-AMS
-
Buchholz BA, Dueker SR, Lin Y, Clifford AJ, Vogel J. Methods and applications of HPLC-AMS. Nucl. Instrum. Methods Phys. Res. B (192), 5 (2000).
-
(2000)
Nucl. Instrum. Methods Phys. Res. B
, vol.192
, pp. 5
-
-
Buchholz, B.A.1
Dueker, S.R.2
Lin, Y.3
Clifford, A.J.4
Vogel, J.5
-
25
-
-
43849103059
-
High-performance liquid chromatography accelerator mass spectrometry. Correcting for losses during analysis by internal standardization
-
Lappin G, Simpson M, Shishikura Y, Garner C. High-performance liquid chromatography accelerator mass spectrometry. Correcting for losses during analysis by internal standardization. Anal. Biochem. 378(1), 93-95 (2008).
-
(2008)
Anal. Biochem.
, vol.378
, Issue.1
, pp. 93-95
-
-
Lappin, G.1
Simpson, M.2
Shishikura, Y.3
Garner, C.4
-
26
-
-
16644393883
-
DNA isolation and sample preparation for quantification of adduct levels by accelerator mass spectrometry
-
Dingley KH, Ubick EA, Vogel JS, Haack KW. DNA isolation and sample preparation for quantification of adduct levels by accelerator mass spectrometry. Methods Mol. Biol. 291, 21-27 (2005).
-
(2005)
Methods Mol. Biol.
, vol.291
, pp. 21-27
-
-
Dingley, K.H.1
Ubick, E.A.2
Vogel, J.S.3
Haack, K.W.4
-
27
-
-
30144435074
-
Quantitating isotopic molecular labels with accelerator mass spectrometry
-
DOI 10.1016/S0076-6879(05)02013-6, PII S0076687905020136, 13, Biological Mass Spectrometry
-
Vogel JS, Love AH. Quantitating isotopic molecular labels with accelerator mass spectrometry. Methods Enzymol. 402, 402-422 (2005). (Pubitemid 43053134)
-
(2005)
Methods in Enzymology
, vol.402
, pp. 402-422
-
-
Vogel, J.S.1
Love, A.H.2
-
28
-
-
0034646463
-
Isotope-labeled immunoassays without radiation waste
-
DOI 10.1073/pnas.040575997
-
Shan G, Huang W, Gee SJ, Buchholz BA, Vogel JS, Hammock BD. Isotope-labeled immunoassays without radiation waste. Proc. Natl Acad. Sci. USA 97(6), 2445-2449 (2000). (Pubitemid 30159190)
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, Issue.6
, pp. 2445-2449
-
-
Shan, G.1
Huang, W.2
Gee, S.J.3
Buchholz, B.A.4
Vogel, J.S.5
Hammock, B.D.6
-
29
-
-
34547441808
-
Measurement of 7,8-dihydro-8-oxo-2′-deoxyguanosine metabolism in MCF-7 cells at low concentrations using accelerator mass spectrometry
-
DOI 10.1073/pnas.0701733104
-
Hah SS, Mundt JM, Kim HM, Sumbad RA, Turteltaub KW, Henderson PT. Measurement of 7,8-dihydro-8-oxo-2′-deoxyguanosine metabolism in MCF-7 cells at low concentrations using accelerator mass spectrometry. Proc. Natl Acad. Sci. USA 104(27), 11203-11208 (2007). (Pubitemid 47175119)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.27
, pp. 11203-11208
-
-
Sang, S.H.1
Mundt, J.M.2
Kim, H.M.3
Sumbad, R.A.4
Turteltaub, K.W.5
Henderson, P.T.6
-
30
-
-
0031031304
-
Kinetic modeling of folate metabolism through use of chronic administration of deuterium-labeled folic acid in men
-
Stites TE, Bailey LB, Scott KC, Toth JP, Fisher WP, Gregory JF 3rd. Kinetic modeling of folate metabolism through use of chronic administration of deuterium-labeled folic acid in men. Am. J. Clin. Nutr. 65(1), 53-60 (1997). (Pubitemid 27020459)
-
(1997)
American Journal of Clinical Nutrition
, vol.65
, Issue.1
, pp. 53-60
-
-
Stites, T.E.1
Bailey, L.B.2
Scott, K.C.3
Toth, J.P.4
Fisher, W.P.5
Gregory III, J.F.6
-
31
-
-
0030130818
-
Application of accelerator mass spectrometry (AMS) for high-sensitivity measurements of 14CO2 in long-term studies of fat metabolism
-
Stenstrom K, Leide-Svegborn S, Erlandsson B et al. Application of accelerator mass spectrometry (AMS) for high-sensitivity measurements of 14CO2 in long-term studies of fat metabolism. Appl. Radiat. Isot. 47(4), 417-422 (1996).
-
(1996)
Appl. Radiat. Isot.
, vol.47
, Issue.4
, pp. 417-422
-
-
Stenstrom, K.1
Leide-Svegborn, S.2
Erlandsson, B.3
-
32
-
-
0031848359
-
The dynamics of folic acid metabolism in an adult given a small tracer dose of 14C-folic acid
-
Clifford AJ, Arjomand A, Dueker SR, Schneider PD, Buchholz BA, Vogel JS. The dynamics of folic acid metabolism in an adult given a small tracer dose of 14C-folic acid. Adv. Exp. Med. Biol. 445, 239-251 (1998).
-
(1998)
Adv. Exp. Med. Biol.
, vol.445
, pp. 239-251
-
-
Clifford, A.J.1
Arjomand, A.2
Dueker, S.R.3
Schneider, P.D.4
Buchholz, B.A.5
Vogel, J.S.6
-
33
-
-
0344171985
-
14C-labeled folic acid with accelerator mass spectrometry
-
DOI 10.1006/abio.1999.4041
-
Buchholz BA, Arjomand A, Dueker SR, Schneider PD, Clifford AJ, Vogel JS. Intrinsic erythrocyte labeling and attomole pharmacokinetic tracing of 14C-labeled folic acid with accelerator mass spectrometry. Anal. Biochem. 269(2), 348-352 (1999). (Pubitemid 29201035)
-
(1999)
Analytical Biochemistry
, vol.269
, Issue.2
, pp. 348-352
-
-
Buchholz, B.A.1
Arjomand, A.2
Dueker, S.R.3
Schneider, P.D.4
Clifford, A.J.5
Vogel, J.S.6
-
34
-
-
4544374215
-
Quantitation of in vivo human folate metabolism
-
Lin Y, Dueker SR, Follett JR et al. Quantitation of in vivo human folate metabolism. Am. J. Clin. Nutr. 80(3), 680-691 (2004). (Pubitemid 41115534)
-
(2004)
American Journal of Clinical Nutrition
, vol.80
, Issue.3
, pp. 680-691
-
-
Lin, Y.1
Dueker, S.R.2
Follett, J.R.3
Fadel, J.G.4
Arjomand, A.5
Schneider, P.D.6
Miller, J.W.7
Green, R.8
Buchholz, B.A.9
Vogel, J.S.10
Phair, R.D.11
Clifford, A.J.12
-
35
-
-
0033730058
-
Long-term kinetic study of b-carotene, using accelerator mass spectrometry in an adult volunteer
-
Dueker SR, Lin Y, Buchholz BA et al. Long-term kinetic study of b-carotene, using accelerator mass spectrometry in an adult volunteer. J. Lipid Res. 41(11), 1790-1800 (2000).
-
(2000)
J. Lipid Res.
, vol.41
, Issue.11
, pp. 1790-1800
-
-
Dueker, S.R.1
Lin, Y.2
Buchholz, B.A.3
-
36
-
-
0036933508
-
Dual isotope test for assessing b-carotene cleavage to vitamin A in humans
-
DOI 10.1007/s00394-002-0368-0
-
Hickenbottom SJ, Lemke SL, Dueker SR et al. Dual isotope test for assessing b-carotene cleavage to vitamin A in humans. Eur. J. Nutr. 41(4), 141-147 (2002). (Pubitemid 36056322)
-
(2002)
European Journal of Nutrition
, vol.41
, Issue.4
, pp. 141-147
-
-
Hickenbottom, S.J.1
Lemke, S.L.2
Dueker, S.R.3
Lin, Y.4
Follett, J.R.5
Carkeet, C.6
Buchholz, B.A.7
Vogel, J.S.8
Clifford, A.J.9
-
37
-
-
0142042392
-
Absorption and retinol equivalence of b-carotene in humans is influenced by dietary vitamin A intake
-
DOI 10.1194/jlr.M300116-JLR200
-
Lemke SL, Dueker SR, Follett JR et al. Absorption and retinol equivalence of b-carotene in humans is influenced by dietary vitamin A intake. J. Lipid Res. 44(8), 1591-1600 (2003). (Pubitemid 37279605)
-
(2003)
Journal of Lipid Research
, vol.44
, Issue.8
, pp. 1591-1600
-
-
Lemke, S.L.1
Dueker, S.R.2
Follett, J.R.3
Lin, Y.4
Carkeet, C.5
Buchholz, B.A.6
Vogel, J.S.7
Clifford, A.J.8
-
38
-
-
33847774261
-
Excentral cleavage of b-carotene in vivo in a healthy man
-
Ho CC, DE Moura FF, Kim SH, Clifford AJ. Excentral cleavage of b-carotene in vivo in a healthy man. Am. J. Clin. Nutr. 85(3), 770-777 (2007). (Pubitemid 46393509)
-
(2007)
American Journal of Clinical Nutrition
, vol.85
, Issue.3
, pp. 770-777
-
-
Ho, C.C.1
De Moura, F.F.2
Kim, S.-H.3
Clifford, A.J.4
-
39
-
-
67749113261
-
A minute dose of 14C-b-carotene is absorbed and converted to retinoids in humans
-
Ho CC, De Moura FF, Kim SH, Burri BJ, Clifford AJ. A minute dose of 14C-b-carotene is absorbed and converted to retinoids in humans. J. Nutr. 139(8), 1480-1486 (2009).
-
(2009)
J. Nutr.
, vol.139
, Issue.8
, pp. 1480-1486
-
-
Ho, C.C.1
De Moura, F.F.2
Kim, S.H.3
Burri, B.J.4
Clifford, A.J.5
-
40
-
-
33644875399
-
Kinetics of 14C distribution after tracer dose of 14C-lutein in an adult woman
-
De Moura FF, Ho CC, Getachew G, Hickenbottom S, Clifford AJ. Kinetics of 14C distribution after tracer dose of 14C-lutein in an adult woman. Lipids 40(10), 1069-1073 (2005).
-
(2005)
Lipids
, vol.40
, Issue.10
, pp. 1069-1073
-
-
De Moura, F.F.1
Ho, C.C.2
Getachew, G.3
Hickenbottom, S.4
Clifford, A.J.5
-
41
-
-
33645838380
-
Human vitamin B12 absorption measurement by accelerator mass spectrometry using specifically labeled (14)C-cobalamin
-
Carkeet C, Dueker SR, Lango J et al. Human vitamin B12 absorption measurement by accelerator mass spectrometry using specifically labeled (14)C-cobalamin. Proc. Natl Acad. Sci. USA 103(15), 5694-5699 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, Issue.15
, pp. 5694-5699
-
-
Carkeet, C.1
Dueker, S.R.2
Lango, J.3
-
42
-
-
33845488327
-
A feasibility study quantifying in vivo human a-tocopherol metabolism
-
Clifford AJ, De Moura FF, Ho CC et al. A feasibility study quantifying in vivo human a-tocopherol metabolism. Am. J. Clin. Nutr. 84(6), 1430-1441 (2006). (Pubitemid 44912828)
-
(2006)
American Journal of Clinical Nutrition
, vol.84
, Issue.6
, pp. 1430-1441
-
-
Clifford, A.J.1
De Moura, F.F.2
Ho, C.C.3
Chuang, J.C.4
Follett, J.5
Fadel, J.G.6
Novotny, J.A.7
-
43
-
-
0032806626
-
Comparative biotransformation studies of MeIQx and PhIP in animal models and humans
-
DOI 10.1016/S0304-3835(99)00118-4, PII S0304383599001184
-
Garner RC, Lightfoot TJ, Cupid BC et al. Comparative biotransformation studies of MeIQx and PhIP in animal models and humans. Cancer Lett. 143(2), 161-165 (1999). (Pubitemid 29392950)
-
(1999)
Cancer Letters
, vol.143
, Issue.2
, pp. 161-165
-
-
Garner, R.C.1
Lightfoot, T.J.2
Cupid, B.C.3
Russell, D.4
Coxhead, J.M.5
Kutschera, W.6
Priller, A.7
Rom, W.8
Steier, P.9
Alexander, D.J.10
Leveson, S.H.11
Dingley, K.H.12
Mauthe, R.J.13
Turteltaub, K.W.14
-
44
-
-
0032970624
-
DNA and protein adduct formation in the colon and blood of humans after exposure to a dietary-relevant dose of 2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine
-
Dingley KH, Curtis KD, Nowell S, Felton JS, Lang NP, Turteltaub KW. DNA and protein adduct formation in the colon and blood of humans after exposure to a dietary-relevant dose of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Cancer Epidemiol. Biomarkers Prev. 8(6), 507-512 (1999). (Pubitemid 29270334)
-
(1999)
Cancer Epidemiology Biomarkers and Prevention
, vol.8
, Issue.6
, pp. 507-512
-
-
Dingley, K.H.1
Curtis, K.D.2
Nowell, S.3
Felton, J.S.4
Lang, N.P.5
Turteltaub, K.W.6
-
45
-
-
0032782320
-
Macromolecular adduct formation and metabolism of heterocyclic amines in humans and rodents at low doses
-
DOI 10.1016/S0304-3835(99)00116-0, PII S0304383599001160
-
Turteltaub KW, Dingley KH, Curtis KD et al. Macromolecular adduct formation and metabolism of heterocyclic amines in humans and rodents at low doses. Cancer Lett. 143(2), 149-155 (1999). (Pubitemid 29392948)
-
(1999)
Cancer Letters
, vol.143
, Issue.2
, pp. 149-155
-
-
Turteltaub, K.W.1
Dingley, K.H.2
Curtis, K.D.3
Malfatti, M.A.4
Turesky, R.J.5
Colin Garner, R.6
Felton, J.S.7
Lang, N.P.8
-
46
-
-
33751357589
-
The urinary metabolite profile of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine is predictive of colon DNA adducts after a low-dose exposure in humans
-
DOI 10.1158/0008-5472.CAN-06-1573
-
Malfatti MA, Dingley KH, Nowell-Kadlubar S et al. The urinary metabolite profile of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine is predictive of colon DNA adducts after a low-dose exposure in humans. Cancer Res. 66(21), 10541-10547 (2006). (Pubitemid 44810823)
-
(2006)
Cancer Research
, vol.66
, Issue.21
, pp. 10541-10547
-
-
Malfatti, M.A.1
Dingley, K.H.2
Nowell-Kadlubar, S.3
Ubick, E.A.4
Mulakken, N.5
Nelson, D.6
Lang, N.P.7
Felton, J.S.8
Turteltaub, K.W.9
-
47
-
-
12144291342
-
1-macromolecular adducts in rats and humans at dietary levels of exposure
-
DOI 10.1016/j.fct.2003.10.015, PII S0278691503003259
-
Cupid BC, Lightfoot TJ, Russell D et al. The formation of AFB(1)-macromolecular adducts in rats and humans at dietary levels of exposure. Food Chem. Toxicol. 42(4), 559-569 (2004). (Pubitemid 38314826)
-
(2004)
Food and Chemical Toxicology
, vol.42
, Issue.4
, pp. 559-569
-
-
Cupid, B.C.1
Lightfoot, T.J.2
Russell, D.3
Gant, S.J.4
Turner, P.C.5
Dingley, K.H.6
Curtis, K.D.7
Leveson, S.H.8
Turteltaub, K.W.9
Garner, R.C.10
-
48
-
-
0033521847
-
Comparison of DNA-adduct and tissue-available dose levels of MeIQx in human and rodent colon following administration of a very low dose
-
DOI 10.1002/(SICI)1097-0215(19990209)80:4<539::AID-IJC10>3.0.CO;2-C
-
Mauthe RJ, Dingley KH, Leveson SH et al. Comparison of DNA-adduct and tissue-available dose levels of MeIQx in human and rodent colon following administration of a very low dose. Int. J. Cancer 80(4), 539-545 (1999). (Pubitemid 29047518)
-
(1999)
International Journal of Cancer
, vol.80
, Issue.4
, pp. 539-545
-
-
Mauthe, R.J.1
Dingley, K.H.2
Leveson, S.H.3
Freeman, S.P.H.T.4
Turesky, R.J.5
Garner, R.C.6
Turteltaub, K.W.7
-
49
-
-
0031844149
-
Covalent binding of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline to albumin and hemoglobin at environmentally relevant doses: Comparison of human subjects and f344 rats
-
Dingley KH, Freeman SP, Nelson DO, Garner RC, Turteltaub KW. Covalent binding of 2-amino-3,8-dimethylimidazo[4,5-f] quinoxaline to albumin and hemoglobin at environmentally relevant doses. Comparison of human subjects and F344 rats. Drug Metab. Dispos. 26(8), 825-828 (1998). (Pubitemid 28376445)
-
(1998)
Drug Metabolism and Disposition
, vol.26
, Issue.8
, pp. 825-828
-
-
Dingley, K.H.1
Freeman, S.P.H.T.2
Nelson, D.O.3
Garner, R.C.4
Turteltaub, K.W.5
-
50
-
-
0031009598
-
MeIQx-DNA adduct formation in rodent and human tissues at low doses
-
DOI 10.1016/S0027-5107(97)00049-3, PII S0027510797000493
-
Turteltaub KW, Mauthe RJ, Dingley KH et al. MeIQx-DNA adduct formation in rodent and human tissues at low doses. Mutat. Res. 376(1-2), 243-252 (1997). (Pubitemid 27248608)
-
(1997)
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
, vol.376
, Issue.1-2
, pp. 243-252
-
-
Turteltaub, K.W.1
Mauthe, R.J.2
Dingley, K.H.3
Vogel, J.S.4
Frantz, C.E.5
Garner, R.C.6
Shen, N.7
-
51
-
-
0031868439
-
Distribution and metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP) in female rats and their pups at dietary doses
-
DOI 10.1093/carcin/19.5.919
-
Mauthe RJ, Snyderwine EG, Ghoshal A, Freeman SP, Turteltaub KW. Distribution and metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PHiP) in female rats and their pups at dietary doses. Carcinogenesis 19(5), 919-924 (1998). (Pubitemid 28376787)
-
(1998)
Carcinogenesis
, vol.19
, Issue.5
, pp. 919-924
-
-
Mauthe, R.J.1
Snyderwine, E.G.2
Ghoshal, A.3
Freeman, S.P.H.T.4
Turteltaub, K.W.5
-
52
-
-
0038544339
-
Inhibition of nicotine-DNA adduct formation in mice by six dietary constituents
-
DOI 10.1016/S0278-6915(03)00032-2
-
Cheng Y, Li HL, Wang HF et al. Inhibition of nicotine-DNA adduct formation in mice by six dietary constituents. Food Chem. Toxicol. 41(7), 1045-1050 (2003). (Pubitemid 36694513)
-
(2003)
Food and Chemical Toxicology
, vol.41
, Issue.7
, pp. 1045-1050
-
-
Cheng, Y.1
Li, H.L.2
Wang, H.F.3
Sun, H.F.4
Liu, Y.F.5
Peng, S.X.6
Liu, K.X.7
Guo, Z.Y.8
-
53
-
-
0037368390
-
Inhibition of nitrobenzene-induced DNA and hemoglobin adductions by dietary constituents
-
DOI 10.1016/S0969-8043(02)00315-9
-
Li H, Cheng Y, Wang H et al. Inhibition of nitrobenzene-induced DNA and hemoglobin adductions by dietary constituents. Appl. Radiat. Isot. 58(3), 291-298 (2003). (Pubitemid 36204026)
-
(2003)
Applied Radiation and Isotopes
, vol.58
, Issue.3
, pp. 291-298
-
-
Li, H.1
Cheng, Y.2
Wang, H.3
Sun, H.4
Liu, Y.5
Liu, K.6
Peng, S.7
-
54
-
-
20644458109
-
14C-Moli1901 in beagle dogs after intratracheal instillation
-
DOI 10.1016/j.cbi.2005.04.002, PII S0009279705001134
-
Rickert DE, Dingley K, Ubick E, Dix KJ, Molina L. Determination of the tissue distribution and excretion by accelerator mass spectrometry of the nonadecapeptide 14C-Moli1901 in beagle dogs after intratracheal instillation. Chem. Biol. Interact. 155(1-2), 55-61 (2005). (Pubitemid 40835989)
-
(2005)
Chemico-Biological Interactions
, vol.155
, Issue.1-2
, pp. 55-61
-
-
Rickert, D.E.1
Dingley, K.2
Ubick, E.3
Dix, K.J.4
Molina, L.5
-
55
-
-
33644840258
-
Accelerator mass spectrometry allows for cellular quantification of doxorubicin at femtomolar concentrations
-
DeGregorio MW, Dingley KH, Wurz GT, Ubick E, Turteltaub KW. Accelerator mass spectrometry allows for cellular quantification of doxorubicin at femtomolar concentrations. Cancer Chemother. Pharmacol. 57(3), 335-342 (2006).
-
(2006)
Cancer Chemother. Pharmacol.
, vol.57
, Issue.3
, pp. 335-342
-
-
Degregorio, M.W.1
Dingley, K.H.2
Wurz, G.T.3
Ubick, E.4
Turteltaub, K.W.5
-
56
-
-
0033053821
-
Biokinetics and radiation doses for carbon-14 urea in adults and children undergoing the Helicobacter pylori breath test
-
DOI 10.1007/s002590050424
-
Leide-Svegborn S, Stenstrom K, Olofsson M et al. Biokinetics and radiation doses for carbon-14 urea in adults and children undergoing the Helicobacter pylori breath test. Eur. J. Nucl. Med. 26(6), 573-580 (1999). (Pubitemid 29263627)
-
(1999)
European Journal of Nuclear Medicine
, vol.26
, Issue.6
, pp. 573-580
-
-
Leide-Svegborn, S.1
Stenstrom, K.2
Olofsson, M.3
Mattsson, S.4
Nilsson, L.-E.5
Nosslin, B.6
Pau, K.7
Johansson, L.8
Erlandsson, B.9
Hellborg, R.10
Skog, G.11
-
57
-
-
0036967159
-
14C urea breath tests in children
-
Gunnarsson M, Leide-Svegborn S, Stenstrom K et al. No radiation protection reasons for restrictions on 14C urea breath tests in children. Br. J. Radiol. 75(900), 982-986 (2002). (Pubitemid 36149763)
-
(2002)
British Journal of Radiology
, vol.75
, Issue.900
, pp. 982-986
-
-
Gunnarsson, M.1
Leide-Svegborn, S.2
Stenstrom, K.3
Skog, G.4
Nilsson, L.-E.5
Hellborg, R.6
Mattsson, S.7
-
58
-
-
0037406978
-
Early microdose drug studies in human volunteers can minimise animal testing: Proceedings of a workshop organised by Volunteers in Research and Testing
-
DOI 10.1016/S0928-0987(03)00040-X
-
Combes RD, Berridge T, Connelly J et al. Early microdose drug studies in human volunteers can minimise animal testing. Proceedings of a workshop organised by volunteers in research and testing. Eur. J. Pharm. Sci. 19(1), 1-11 (2003). (Pubitemid 36506932)
-
(2003)
European Journal of Pharmaceutical Sciences
, vol.19
, Issue.1
, pp. 1-11
-
-
Combes, R.D.1
Berridge, T.2
Connelly, J.3
Eve, M.D.4
Garner, R.C.5
Toon, S.6
Wilcox, P.7
-
59
-
-
0037365932
-
Big physics, small doses: The use of AMS and PET in human microdosing of development drugs
-
DOI 10.1038/nrd1037
-
Lappin G, Garner RC. Big physics, small doses. The use of AMS and PET in human microdosing of development drugs. Nat. Rev. Drug Discov. 2(3), 233-240 (2003). (Pubitemid 37361669)
-
(2003)
Nature Reviews Drug Discovery
, vol.2
, Issue.3
, pp. 233-240
-
-
Lappin, G.1
Garner, R.C.2
-
60
-
-
37349047419
-
Smarter candidate selection - Utilizing microdosing in exploratory clinical studies
-
Buchan P. Smarter candidate selection - utilizing microdosing in exploratory clinical studies. Ernst Schering Res. Found Workshop 59, 7-27 (2007).
-
(2007)
Ernst Schering Res. Found Workshop
, vol.59
, pp. 7-27
-
-
Buchan, P.1
-
61
-
-
37849003251
-
Innovative strategies for early clinical R & D
-
Butz RF, Morelli G. Innovative strategies for early clinical R & D. IDrugs 11(1), 36-41 (2008).
-
(2008)
IDrugs
, vol.11
, Issue.1
, pp. 36-41
-
-
Butz, R.F.1
Morelli, G.2
-
62
-
-
74949109430
-
The use of the exploratory IND in the evaluation and development of 18F-PET radiopharmaceuticals for amyloid imaging in the brain. A review of one company's experience. Q
-
Carpenter AP, Pontecorvo MJ, Hefti FF, Skovronsky DM. The use of the exploratory IND in the evaluation and development of 18F-PET radiopharmaceuticals for amyloid imaging in the brain. A review of one company's experience. Q. J. Nucl. Med. Mol. Imaging 53(4), 387-393 (2009).
-
(2009)
J. Nucl. Med. Mol. Imaging
, vol.53
, Issue.4
, pp. 387-393
-
-
Carpenter, A.P.1
Pontecorvo, M.J.2
Hefti, F.F.3
Skovronsky, D.M.4
-
63
-
-
52449105234
-
Leveraging exploratory investigational new drug studies to accelerate drug development
-
Jacobson-Kram D, Mills G. Leveraging exploratory investigational new drug studies to accelerate drug development. Clin. Cancer Res. 14(12), 3670-3674 (2008).
-
(2008)
Clin. Cancer Res.
, vol.14
, Issue.12
, pp. 3670-3674
-
-
Jacobson-Kram, D.1
Mills, G.2
-
64
-
-
52649181124
-
Phase 0 clinical trials. Conceptions and misconceptions
-
Kummar S, Rubinstein L, Kinders R et al. Phase 0 clinical trials. Conceptions and misconceptions. Cancer J. 14(3), 133-137 (2008).
-
(2008)
Cancer J.
, vol.14
, Issue.3
, pp. 133-137
-
-
Kummar, S.1
Rubinstein, L.2
Kinders, R.3
-
65
-
-
39049185884
-
A new regulatory strategy for early clinical drug development in the United States
-
Exploratory IND
-
Sarapa N. Exploratory IND. A new regulatory strategy for early clinical drug development in the United States. Ernst Schering Res. Found. Workshop (59), 151-163 (2007).
-
(2007)
Ernst Schering Res. Found. Workshop
, vol.59
, pp. 151-163
-
-
Sarapa, N.1
-
66
-
-
33344461870
-
Evaluation of microdosing to assess pharmacokinetic linearity in rats using liquid chromatography-tandem mass spectrometry
-
DOI 10.1124/dmd.105.007195
-
Balani SK, Nagaraja NV, Qian MG et al. Evaluation of microdosing to assess pharmacokinetic linearity in rats using liquid chromatography-tandem mass spectrometry. Drug Metab. Dispos. 34(3), 384-388 (2006). (Pubitemid 43290896)
-
(2006)
Drug Metabolism and Disposition
, vol.34
, Issue.3
, pp. 384-388
-
-
Balani, S.K.1
Nagaraja, N.V.2
Qian, M.G.3
Costa, A.O.4
Daniels, J.S.5
Yang, H.6
Shimoga, P.R.7
Wu, J.-T.8
Gan, L.-S.9
Lee, F.W.10
Miwa, G.T.11
-
67
-
-
33748157070
-
A positron emission tomography microdosing study with a potential antiamyloid drug in healthy volunteers and patients with Alzheimer's disease
-
DOI 10.1016/j.clpt.2006.05.007, PII S0009923606001998
-
Bauer M, Langer O, Dal-Bianco P et al. A positron emission tomography microdosing study with a potential antiamyloid drug in healthy volunteers and patients with Alzheimer's disease. Clin. Pharmacol. Ther. 80(3), 216-227 (2006). (Pubitemid 44313902)
-
(2006)
Clinical Pharmacology and Therapeutics
, vol.80
, Issue.3
, pp. 216-227
-
-
Bauer, M.1
Langer, O.2
Dal-Bianco, P.3
Karch, R.4
Brunner, M.5
Abrahim, A.6
Lanzenberger, R.7
Hofmann, A.8
Joukhadar, C.9
Carminati, P.10
Ghirardi, O.11
Piovesan, P.12
Forloni, G.13
Corrado, M.E.14
Lods, N.15
Dudczak, R.16
Auff, E.17
Kletter, K.18
Muller, M.19
-
68
-
-
39749165005
-
Microdosing studies in humans: The role of positron emission tomography
-
DOI 10.2165/00126839-200809020-00002
-
Bauer M, Wagner CC, Langer O. Microdosing studies in humans. The role of positron emission tomography. Drugs RD 9(2), 73-81 (2008). (Pubitemid 351311221)
-
(2008)
Drugs in R and D
, vol.9
, Issue.2
, pp. 73-81
-
-
Bauer, M.1
Wagner, C.C.2
Langer, O.3
-
69
-
-
6944241355
-
Evaluation of microdosing strategies for studies in preclinical drug development: Demonstration of linear pharmacokinetics in dogs of a nucleoside analog over a 50-fold dose range
-
DOI 10.1124/dmd.104.000422
-
Sandhu P, Vogel JS, Rose MJ et al. Evaluation of microdosing strategies for studies in preclinical drug development. Demonstration of linear pharmacokinetics in dogs of a nucleoside analog over a 50-fold dose range. Drug Metab. Dispos. 32(11), 1254-1259 (2004). (Pubitemid 39410909)
-
(2004)
Drug Metabolism and Disposition
, vol.32
, Issue.11
, pp. 1254-1259
-
-
Sandhu, P.1
Vogel, J.S.2
Rose, M.J.3
Ubick, E.A.4
Brunner, J.E.5
Wallace, M.A.6
Adelsberger, J.K.7
Baker, M.P.8
Henderson, P.T.9
Pearson, P.G.10
Baillie, T.A.11
-
70
-
-
33748167008
-
Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs
-
DOI 10.1016/j.clpt.2006.05.008, PII S0009923606002001
-
Lappin G, Kuhnz W, Jochemsen R et al. Use of microdosing to predict pharmacokinetics at the therapeutic dose. Experience with 5 drugs. Clin. Pharmacol. Ther. 80(3), 203-215 (2006). (Pubitemid 44313903)
-
(2006)
Clinical Pharmacology and Therapeutics
, vol.80
, Issue.3
, pp. 203-215
-
-
Lappin, G.1
Kuhnz, W.2
Jochemsen, R.3
Kneer, J.4
Chaudhary, A.5
Oosterhuis, B.6
Drijfhout, W.J.7
Rowland, M.8
Garner, R.C.9
-
71
-
-
49449110661
-
Use of accelerator mass spectrometry to measure the pharmacokinetics and peripheral blood mononuclear cell concentrations of zidovudine
-
Vuong L, Ruckle JL, Blood AB et al. Use of accelerator mass spectrometry to measure the pharmacokinetics and peripheral blood mononuclear cell concentrations of zidovudine. J Pharm Sci 97(7), 2833-2843 (2008).
-
(2008)
J Pharm Sci
, vol.97
, Issue.7
, pp. 2833-2843
-
-
Vuong, L.1
Ruckle, J.L.2
Blood, A.B.3
-
72
-
-
79953274516
-
New paradigm of early clinical research - EUMAPP
-
Garner C. New paradigm of early clinical research - EUMAPP. Parliament Magazine 238, 1 (2007).
-
(2007)
Parliament Magazine
, vol.238
, pp. 1
-
-
Garner, C.1
-
73
-
-
71449119505
-
Microdose pharmacokinetics of IDX899 and IDX989, candidate HIV-1 non-nucleoside reverse transcriptase inhibitors, following oral and intravenous administration in healthy male subjects
-
Zhou XJ, Garner RC, Nicholson S, Kissling CJ, Mayers D. Microdose pharmacokinetics of IDX899 and IDX989, candidate HIV-1 non-nucleoside reverse transcriptase inhibitors, following oral and intravenous administration in healthy male subjects. J. Clin. Pharmacol. (2009).
-
(2009)
J. Clin. Pharmacol.
-
-
Zhou, X.J.1
Garner, R.C.2
Nicholson, S.3
Kissling, C.J.4
Mayers, D.5
-
74
-
-
0034830621
-
Accelerator mass spectrometry (AMS): Recent experience of its use in a clinical study and the potential future of the technique
-
DOI 10.1080/00498250110052724
-
Young G, Ellis W, Ayrton J, Hussey E, Adamkiewicz B. Accelerator mass spectrometry (AMS). Recent experience of its use in a clinical study and the potential future of the technique. Xenobiotica 31(8-9), 619-632 (2001). (Pubitemid 32826395)
-
(2001)
Xenobiotica
, vol.31
, Issue.8-9
, pp. 619-632
-
-
Young, G.1
Ellis, W.2
Ayrton, J.3
Hussey, E.4
Adamkiewicz, B.5
-
75
-
-
0036141803
-
14C-diosmin tablets after oral administration to healthy volunteers by accelerator mass spectrometry and liquid scintillation counting
-
DOI 10.1002/jps.1168
-
Garner RC, Garner JV, Gregory S, Whattam M, Calam A, Leong D. Comparison of the absorption of micronized (Daflon 500 mg) and nonmicronized 14C-diosmin tablets after oral administration to healthy volunteers by accelerator mass spectrometry and liquid scintillation counting. J. Pharm. Sci. 91(1), 32-40 (2002). (Pubitemid 34074465)
-
(2002)
Journal of Pharmaceutical Sciences
, vol.91
, Issue.1
, pp. 32-40
-
-
Garner, R.C.1
Garner, J.V.2
Gregory, S.3
Whattam, M.4
Calam, A.5
Leong, D.6
-
76
-
-
34547113063
-
Pharmacokinetic investigation of imatinib using accelerator mass spectrometry in patients with chronic myeloid leukemia
-
DOI 10.1158/1078-0432.CCR-06-2179
-
Boddy AV, Sludden J, Griffin MJ et al. Pharmacokinetic investigation of imatinib using accelerator mass spectrometry in patients with chronic myeloid leukemia. Clin. Cancer Res. 13(14), 4164-4169 (2007). (Pubitemid 47105979)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.14
, pp. 4164-4169
-
-
Boddy, A.V.1
Sludden, J.2
Griffin, M.J.3
Garner, C.4
Kendrick, J.5
Mistry, P.6
Dutreix, C.7
Newell, D.R.8
O'Brien, S.G.9
-
77
-
-
0035987901
-
14C-labeled (R)-6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4 -(3-chlorophenyl)-1-methyl-2(1H)-quinolinone (R115777), a farnesyl transferase inhibitor
-
DOI 10.1124/dmd.30.7.823
-
Garner RC, Goris I, Laenen AA et al. Evaluation of accelerator mass spectrometry in a human mass balance and pharmacokinetic study-experience with 14C-labeled (r)-6-[amino(4-chlorophenyl) (1-methyl-1h-imidazol-5-yl)methyl]-4- (3-chlorophenyl)-1-methyl-2(1h)-quinolinone (r115777), a farnesyl transferase inhibitor. Drug Metab. Dispos. 30(7), 823-830 (2002). (Pubitemid 34671095)
-
(2002)
Drug Metabolism and Disposition
, vol.30
, Issue.7
, pp. 823-830
-
-
Garner, R.C.1
Goris, I.2
Laenen, A.A.E.3
Vanhoutte, E.4
Meuldermans, W.5
Gregory, S.6
Garner, J.V.7
Leong, D.8
Whattam, M.9
Calam, A.10
Snel, C.A.W.11
-
78
-
-
25444451050
-
14C-nelfinavir mesylate solution and oral nelfinavir to healthy volunteers
-
DOI 10.1177/0091270005280051
-
Sarapa N, Hsyu PH, Lappin G, Garner RC. The application of accelerator mass spectrometry to absolute bioavailability studies in humans. Simultaneous administration of an intravenous microdose of 14C-nelfinavir mesylate solution and oral nelfinavir to healthy volunteers. J. Clin. Pharmacol. 45(10), 1198-1205 (2005). (Pubitemid 41361920)
-
(2005)
Journal of Clinical Pharmacology
, vol.45
, Issue.10
, pp. 1198-1205
-
-
Sarapa, N.1
Hsyu, P.-H.2
Lappin, G.3
Garner, R.C.4
-
79
-
-
67649306825
-
Use of an intravenous microdose of 14C-labeled drug and accelerator mass spectrometry to measure absolute oral bioavailability in dogs; Cross-comparison of assay methods by accelerator mass spectrometry and liquid chromatography-tandem mass spectrometry
-
Miyaji Y, Ishizuka T, Kawai K et al. Use of an intravenous microdose of 14C-labeled drug and accelerator mass spectrometry to measure absolute oral bioavailability in dogs; cross-comparison of assay methods by accelerator mass spectrometry and liquid chromatography-tandem mass spectrometry. Drug Metab. Pharmacokinet. 24(2), 130-138 (2009).
-
(2009)
Drug Metab. Pharmacokinet.
, vol.24
, Issue.2
, pp. 130-138
-
-
Miyaji, Y.1
Ishizuka, T.2
Kawai, K.3
-
80
-
-
33644973286
-
Determination of the bioavailability of [14C]-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers
-
Klem B, Lappin G, Nicholson S et al. Determination of the bioavailability of [14C]-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. J. Clin. Pharmacol. 46(4), 456-460 (2006).
-
(2006)
J. Clin. Pharmacol.
, vol.46
, Issue.4
, pp. 456-460
-
-
Klem, B.1
Lappin, G.2
Nicholson, S.3
-
81
-
-
34250614320
-
Human mass balance study of the novel anticancer agent ixabepilone using accelerator mass spectrometry
-
DOI 10.1007/s10637-007-9041-z
-
Beumer JH, Garner RC, Cohen MB et al. Human mass balance study of the novel anticancer agent ixabepilone using accelerator mass spectrometry. Invest. New Drugs 25(4), 327-334 (2007). (Pubitemid 46944849)
-
(2007)
Investigational New Drugs
, vol.25
, Issue.4
, pp. 327-334
-
-
Beumer, J.H.1
Garner, R.C.2
Cohen, M.B.3
Galbraith, S.4
Duncan, G.F.5
Griffin, T.6
Beijnen, J.H.7
Schellens, J.H.M.8
-
82
-
-
65249152385
-
Application of liquid chromatography-accelerator mass spectrometry (LC-AMS) to evaluate the metabolic profiles of a drug candidate in human urine and plasma
-
Prakash C, Shaffer CL, Tremaine LM et al. Application of liquid chromatography-accelerator mass spectrometry (LC-AMS) to evaluate the metabolic profiles of a drug candidate in human urine and plasma. Drug Metab. Lett. 1(3), 226-231 (2007).
-
(2007)
Drug Metab. Lett.
, vol.1
, Issue.3
, pp. 226-231
-
-
Prakash, C.1
Shaffer, C.L.2
Tremaine, L.M.3
-
83
-
-
33646823282
-
Novel use of accelerator mass spectrometry for the quantification of low levels of systemic therapeutic recombinant protein
-
DOI 10.1016/j.jpba.2006.02.019, PII S0731708506001932
-
Lappin G, Garner RC, Meyers T, Powell J, Varley P. Novel use of accelerator mass spectrometry for the quantification of low levels of systemic therapeutic recombinant protein. J. Pharm. Biomed. Anal. 41(4), 1299-1302 (2006). (Pubitemid 43775886)
-
(2006)
Journal of Pharmaceutical and Biomedical Analysis
, vol.41
, Issue.4
, pp. 1299-1302
-
-
Lappin, G.1
Garner, R.C.2
Meyers, T.3
Powell, J.4
Varley, P.5
-
84
-
-
0028488067
-
Applications of low-abundance-radioisotope measurements with accelerator mass spectrometry to the biomedical sciences
-
Nakamura T. [Applications of low-abundance-radioisotope measurements with accelerator mass spectrometry to the biomedical sciences]. Tanpakushitsu Kakusan Koso 39(11), 2011-2020 (1994).
-
(1994)
Tanpakushitsu Kakusan Koso
, vol.39
, Issue.11
, pp. 2011-2020
-
-
Nakamura, T.1
-
85
-
-
0030733223
-
A preliminary evaluation of accelerator mass spectrometry in the biomedical field
-
DOI 10.1016/S0731-7085(97)00104-0, PII S0731708597001040
-
Kaye B, Garner RC, Mauthe RJ, Freeman SP, Turteltaub KW. A preliminary evaluation of accelerator mass spectrometry in the biomedical field. J. Pharm. Biomed. Anal. 16(3), 541-543 (1997). (Pubitemid 27514399)
-
(1997)
Journal of Pharmaceutical and Biomedical Analysis
, vol.16
, Issue.3
, pp. 541-543
-
-
Kaye, B.1
Garner, R.C.2
Mauthe, R.J.3
Freeman, S.P.H.T.4
Turteltaub, K.W.5
-
86
-
-
0033059135
-
Biomedical applications of accelerator mass spectrometry-isotope measurements at the level of the atom
-
DOI 10.1002/(SICI)1097-0231(19990228)13:4<285::AID-RCM469>3.0.CO;2- R
-
Barker J, Garner RC. Biomedical applications of accelerator mass spectrometry-isotope measurements at the level of the atom. Rapid Commun. Mass Spectrom. 13(4), 285-293 (1999). (Pubitemid 29101097)
-
(1999)
Rapid Communications in Mass Spectrometry
, vol.13
, Issue.4
, pp. 285-293
-
-
Barker, J.1
Garner, R.C.2
-
88
-
-
0033625265
-
Bioanalytical application of accelerator mass spectrometry for pharmaceutical research
-
Turteltaub KW, Vogel JS. Bioanalytical applications of accelerator mass spectrometry for pharmaceutical research. Curr. Pharm. Des. 6(10), 991-1007 (2000). (Pubitemid 30439022)
-
(2000)
Current Pharmaceutical Design
, vol.6
, Issue.10
, pp. 991-1007
-
-
Turteltaub, K.W.1
Vogel, J.S.2
-
89
-
-
0034954468
-
Mass spectrometry innovations in drug discovery and development
-
DOI 10.1023/A:1011049231231
-
Papac DI, Shahrokh Z. Mass spectrometry innovations in drug discovery and development. Pharm Res 18(2), 131-145 (2001). (Pubitemid 32592591)
-
(2001)
Pharmaceutical Research
, vol.18
, Issue.2
, pp. 131-145
-
-
Papac, D.I.1
Shahrokh, Z.2
-
90
-
-
6944233468
-
14C-isotope measurement in biomedical accelerator mass spectrometry
-
DOI 10.1007/s00216-003-2348-5
-
Lappin G, Garner RC. Current perspectives of 14C-isotope measurement in biomedical accelerator mass spectrometry. Anal. Bioanal. Chem. 378(2), 356-364 (2004). (Pubitemid 40890243)
-
(2004)
Analytical and Bioanalytical Chemistry
, vol.378
, Issue.2
, pp. 356-364
-
-
Lappin, G.1
Garner, R.C.2
-
91
-
-
3242776195
-
Techniques: The application of accelerator mass spectrometry to pharmacology and toxicology
-
DOI 10.1016/j.tips.2004.06.009, PII S0165614704001786
-
White IN, Brown K. Techniques. The application of accelerator mass spectrometry to pharmacology and toxicology. Trends Pharmacol. Sci. 25(8), 442-447 (2004). (Pubitemid 38981561)
-
(2004)
Trends in Pharmacological Sciences
, vol.25
, Issue.8
, pp. 442-447
-
-
White, I.N.H.1
Brown, K.2
-
92
-
-
33748361948
-
The use of accelerator mass spectrometry to obtain early human ADME/PK data
-
Lappin G, Garner RC. The use of accelerator mass spectrometry to obtain early human ADME/PK data. Expert Opin. Drug Metab. Toxicol. 1(1), 23-31 (2005).
-
(2005)
Expert Opin. Drug Metab. Toxicol.
, vol.1
, Issue.1
, pp. 23-31
-
-
Lappin, G.1
Garner, R.C.2
-
93
-
-
14744276329
-
Neuroscience and accelerator mass spectrometry
-
DOI 10.1002/jms.734
-
Palmblad M, Buchholz BA, Hillegonds DJ, Vogel JS. Neuroscience and accelerator mass spectrometry. J. Mass Spectrom. 40(2), 154-159 (2005). (Pubitemid 40327255)
-
(2005)
Journal of Mass Spectrometry
, vol.40
, Issue.2
, pp. 154-159
-
-
Palmblad, M.1
Buchholz, B.A.2
Hillegonds, D.J.3
Vogel, J.S.4
-
94
-
-
33645499508
-
Accelerator mass spectrometry for quantitative in vivo tracing
-
Vogel JS. Accelerator mass spectrometry for quantitative in vivo tracing. Biotechniques (Suppl.) 25-29 (2005).
-
(2005)
Biotechniques
, Issue.SUPPL.
, pp. 25-29
-
-
Vogel, J.S.1
-
95
-
-
33644650632
-
Applications of accelerator mass spectrometry for pharmacological and toxicological research
-
Brown K, Tompkins EM, White IN. Applications of accelerator mass spectrometry for pharmacological and toxicological research. Mass Spectrom. Rev. 25(1), 127-145 (2006).
-
(2006)
Mass Spectrom. Rev.
, vol.25
, Issue.1
, pp. 127-145
-
-
Brown, K.1
Tompkins, E.M.2
White, I.N.3
-
96
-
-
51049120013
-
Biomedical accelerator mass spectrometry. Recent applications in metabolism and pharmacokinetics
-
Lappin G, Stevens L. Biomedical accelerator mass spectrometry. Recent applications in metabolism and pharmacokinetics. Expert Opin. Drug Metab. Toxicol. 4(8), 1021-1033 (2008).
-
(2008)
Expert Opin. Drug Metab. Toxicol.
, vol.4
, Issue.8
, pp. 1021-1033
-
-
Lappin, G.1
Stevens, L.2
-
97
-
-
50149107949
-
Editorial. Accelerator mass spectrometry
-
Larsson M. Editorial. Accelerator mass spectrometry. Mass Spectrom. Rev. 27(5), 397 (2008).
-
(2008)
Mass Spectrom. Rev.
, vol.27
, Issue.5
, pp. 397
-
-
Larsson, M.1
-
98
-
-
68149139355
-
Recent advances in biomedical applications of accelerator mass spectrometry
-
Hah SS. Recent advances in biomedical applications of accelerator mass spectrometry. J. Biomed. Sci. 16, 54 (2009).
-
(2009)
J. Biomed. Sci.
, vol.16
, pp. 54
-
-
Hah, S.S.1
-
99
-
-
0037381098
-
14C]oleate fat malabsorption breath test
-
DOI 10.1016/S0969-8043(03)00051-4
-
Gunnarsson M, Stenstrom K, Leide-Svegborn S et al. Biokinetics and radiation dosimetry for patients undergoing a glycerol tri[1-14C] oleate fat malabsorption breath test. Appl. Radiat. Isot. 58(4), 517-526 (2003). (Pubitemid 36369439)
-
(2003)
Applied Radiation and Isotopes
, vol.58
, Issue.4
, pp. 517-526
-
-
Gunnarsson, M.1
Stenstrom, K.2
Leide-Svegborn, S.3
Faarinen, M.4
Magnusson, C.-E.5
Aberg, M.6
Skog, G.7
Hellborg, R.8
Mattsson, S.9
-
100
-
-
37549061379
-
Long-term biokinetics and radiation exposure of patients undergoing 14C-glycocholic acid and 14C-xylose breath tests
-
Gunnarsson M, Leide-Svegborn S, Stenstrom K et al. Long-term biokinetics and radiation exposure of patients undergoing 14C-glycocholic acid and 14C-xylose breath tests. Cancer Biother. Radiopharm. 22(6), 762-771 (2007).
-
(2007)
Cancer Biother. Radiopharm.
, vol.22
, Issue.6
, pp. 762-771
-
-
Gunnarsson, M.1
Leide-Svegborn, S.2
Stenstrom, K.3
-
101
-
-
0025780051
-
Marked longevity of human lung parenchymal elastic fibers deduced from prevalence of D-aspartate and nuclear weapons-related radiocarbon
-
Shapiro SD, Endicott SK, Province MA, Pierce JA, Campbell EJ. Marked longevity of human lung parenchymal elastic fibers deduced from prevalence of D-aspartate and nuclear weapons-related radiocarbon. J. Clin. Invest. 87(5), 1828-1834 (1991).
-
(1991)
J. Clin. Invest.
, vol.87
, Issue.5
, pp. 1828-1834
-
-
Shapiro, S.D.1
Endicott, S.K.2
Province, M.A.3
Pierce, J.A.4
Campbell, E.J.5
-
102
-
-
64249107059
-
Evidence for cardiomyocyte renewal in humans
-
Bergmann O, Bhardwaj RD, Bernard S et al. Evidence for cardiomyocyte renewal in humans. Science 324(5923), 98-102 (2009).
-
(2009)
Science
, vol.324
, Issue.5923
, pp. 98-102
-
-
Bergmann, O.1
Bhardwaj, R.D.2
Bernard, S.3
-
103
-
-
33747605325
-
Neocortical neurogenesis in humans is restricted to development
-
DOI 10.1073/pnas.0605177103
-
Bhardwaj RD, Curtis MA, Spalding KL et al. Neocortical neurogenesis in humans is restricted to development. Proc. Natl Acad. Sci. USA 103(33), 12564-12568 (2006). (Pubitemid 44267298)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.33
, pp. 12564-12568
-
-
Bhardwaj, R.D.1
Curtis, M.A.2
Spalding, K.L.3
Buchholz, B.A.4
Fink, D.5
Bjork-Eriksson, T.6
Nordborg, C.7
Gage, F.H.8
Druid, H.9
Eriksson, P.S.10
Frisen, J.11
-
104
-
-
44849132591
-
Dynamics of fat cell turnover in humans
-
DOI 10.1038/nature06902, PII NATURE06902
-
Spalding KL, Arner E, Westermark PO et al. Dynamics of fat cell turnover in humans. Nature 453(7196), 783-787 (2008). (Pubitemid 351793777)
-
(2008)
Nature
, vol.453
, Issue.7196
, pp. 783-787
-
-
Spalding, K.L.1
Arner, E.2
Westermark, P.O.3
Bernard, S.4
Buchholz, B.A.5
Bergmann, O.6
Blomqvist, L.7
Hoffstedt, J.8
Naslund, E.9
Britton, T.10
Concha, H.11
Hassan, M.12
Ryden, M.13
Frisen, J.14
Arner, P.15
-
105
-
-
25144490184
-
Age written in teeth by nuclear tests
-
DOI 10.1038/437333a, PII 437333
-
Spalding KL, Buchholz BA, Bergman LE, Druid H, Frisen J. Forensics. Age written in teeth by nuclear tests. Nature 437(7057), 333-334 (2005). (Pubitemid 41613486)
-
(2005)
Nature
, vol.437
, Issue.7057
, pp. 333-334
-
-
Spalding, K.L.1
Buchholz, B.A.2
Bergman, L.-E.3
Druid, H.4
Frisen, J.5
-
106
-
-
0034742598
-
14C-labeled small intestinal submucosa (SIS) when used for urinary bladder repair
-
DOI 10.1016/S0142-9612(01)00007-2, PII S0142961201000072
-
Record RD, Hillegonds D, Simmons C et al. In vivo degradation of 14C-labeled small intestinal submucosa (sis) when used for urinary bladder repair. Biomaterials 22(19), 2653-2659 (2001). (Pubitemid 32727840)
-
(2001)
Biomaterials
, vol.22
, Issue.19
, pp. 2653-2659
-
-
Record, R.D.1
Hillegonds, D.2
Simmons, C.3
Tullius, R.4
Rickey, F.A.5
Elmore, D.6
Badylak, S.F.7
-
107
-
-
33749561409
-
A quantitative method for evaluating the degradation of biologic scaffold materials
-
DOI 10.1016/j.biomaterials.2006.08.022, PII S0142961206007253
-
Gilbert TW, Stewart-Akers AM, Badylak SF. A quantitative method for evaluating the degradation of biologic scaffold materials. Biomaterials 28(2), 147-150 (2007). (Pubitemid 44537385)
-
(2007)
Biomaterials
, vol.28
, Issue.2
, pp. 147-150
-
-
Gilbert, T.W.1
Stewart-Akers, A.M.2
Badylak, S.F.3
-
108
-
-
8544229900
-
In vivo release from a drug delivery MEMS device
-
DOI 10.1016/j.jconrel.2004.08.018, PII S0168365904003827
-
Li Y, Shawgo RS, Tyler B et al. In vivo release from a drug delivery MEMS device. J. Control Release 100(2), 211-219 (2004). (Pubitemid 39491273)
-
(2004)
Journal of Controlled Release
, vol.100
, Issue.2
, pp. 211-219
-
-
Li, Y.1
Shawgo, R.S.2
Tyler, B.3
Henderson, P.T.4
Vogel, J.S.5
Rosenberg, A.6
Storm, P.B.7
Langer, R.8
Brem, H.9
Cima, M.J.10
-
109
-
-
0034291343
-
Tips and traps in the 14C Bio-AMS preparation laboratory
-
Buchholz BA, Freeman S, Haack K, Vogel J. Tips and traps in the 14C Bio-AMS preparation laboratory. Nucl. Instrum. Methods Phys. Res. B 172, 5 (2000).
-
(2000)
Nucl. Instrum. Methods Phys. Res. B
, vol.172
, pp. 5
-
-
Buchholz, B.A.1
Freeman, S.2
Haack, K.3
Vogel, J.4
-
110
-
-
67649267420
-
Determination of protein-ligand interactions using accelerator mass spectrometry. Modified crosslinking assay
-
Hah SS. Determination of protein-ligand interactions using accelerator mass spectrometry. Modified crosslinking assay. Anal. Sci. 25(5), 731-733 (2009).
-
(2009)
Anal. Sci.
, vol.25
, Issue.5
, pp. 731-733
-
-
Hah, S.S.1
-
111
-
-
58249120534
-
Accelerator mass spectrometry analysis of background 14C-concentrations in human blood. Aiming at reference data for further microdosing studies
-
Minamimoto R, Hamabe Y, Miyaoka T et al. Accelerator mass spectrometry analysis of background 14C-concentrations in human blood. Aiming at reference data for further microdosing studies. Ann. Nucl. Med. 22(10), 883-889 (2008).
-
(2008)
Ann. Nucl. Med.
, vol.22
, Issue.10
, pp. 883-889
-
-
Minamimoto, R.1
Hamabe, Y.2
Miyaoka, T.3
-
112
-
-
0026110073
-
A new method for carbon isotopic analysis of protein
-
Nelson DE. A new method for carbon isotopic analysis of protein. Science 251(4993), 552-554 (1991). (Pubitemid 21926155)
-
(1991)
Science
, vol.251
, Issue.4993
, pp. 552-554
-
-
Nelson, D.E.1
-
113
-
-
17844363740
-
Mass by energy loss quantitation as a practical submicrogram balance
-
Palmblad M, Bench G, Vogel JS. Mass by energy loss quantitation as a practical submicrogram balance. Anal. Chem. 77(3), 952-953 (2005).
-
(2005)
Anal. Chem.
, vol.77
, Issue.3
, pp. 952-953
-
-
Palmblad, M.1
Bench, G.2
Vogel, J.S.3
-
115
-
-
0025144610
-
Radiochromatography in pharmaceutical and biomedical analysis
-
DOI 10.1016/S0378-4347(00)82282-3
-
Veltkamp AC. Radiochromatography in pharmaceutical and biomedical analysis. J. Chromatogr. 531, 101-129 (1990). (Pubitemid 20324568)
-
(1990)
Journal of Chromatography - Biomedical Applications
, vol.531
, pp. 101-129
-
-
Veltkamp, A.C.1
-
116
-
-
0031806078
-
Initial uptake kinetics in human skin exposed to dilute aqueous trichloroethylene in vitro
-
Bogen KT, Keating GA, Meissner S, Vogel JS. Initial uptake kinetics in human skin exposed to dilute aqueous trichloroethylene in vitro. J. Expo. Anal. Environ. Epidemiol. 8(2), 253-271 (1998). (Pubitemid 28236477)
-
(1998)
Journal of Exposure Analysis and Environmental Epidemiology
, vol.8
, Issue.2
, pp. 253-271
-
-
Bogen, K.T.1
Keating, G.2
Meissner, S.3
Vogel, J.S.4
-
117
-
-
0026664881
-
Fate and distribution of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in mice at a human dietary equivalent dose
-
Turteltaub KW, Vogel JS, Frantz CE, Shen N. Fate and distribution of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in mice at a human dietary equivalent dose. Cancer Res. 52(17), 4682-4687 (1992).
-
(1992)
Cancer Res.
, vol.52
, Issue.17
, pp. 4682-4687
-
-
Turteltaub, K.W.1
Vogel, J.S.2
Frantz, C.E.3
Shen, N.4
-
118
-
-
0028860187
-
Dose-response studies of MeIQx in rat liver and liver DNA at low doses
-
Frantz CE, Bangerter C, Fultz E, Mayer KM, Vogel JS, Turteltaub KW. Dose-response studies of MeIQx in rat liver and liver DNA at low doses. Carcinogenesis 16(2), 367-373 (1995).
-
(1995)
Carcinogenesis
, vol.16
, Issue.2
, pp. 367-373
-
-
Frantz, C.E.1
Bangerter, C.2
Fultz, E.3
Mayer, K.M.4
Vogel, J.S.5
Turteltaub, K.W.6
-
119
-
-
0029421815
-
Assessment of the DNA adduction and pharmacokinetics of PHiP and MeIQx in rodents at doses approximating human exposure using the technique of accelerator mass spectrometry (AMS) and 32P-postlabeling
-
Turteltaub KW, Vogel JS, Frantz C, Felton JS, Mcmanus M. Assessment of the DNA adduction and pharmacokinetics of PHiP and MeIQx in rodents at doses approximating human exposure using the technique of accelerator mass spectrometry (AMS) and 32P-postlabeling. Princess Takamatsu Symp. 23, 93-102 (1995).
-
(1995)
Princess Takamatsu Symp.
, vol.23
, pp. 93-102
-
-
Turteltaub, K.W.1
Vogel, J.S.2
Frantz, C.3
Felton, J.S.4
McManus, M.5
-
120
-
-
0031428098
-
1 mice
-
DOI 10.1093/carcin/18.12.2421
-
Creek MR, Mani C, Vogel JS, Turteltaub KW. Tissue distribution and macromolecular binding of extremely low doses of [14C]-benzene in B6C3F1 mice. Carcinogenesis 18(12), 2421-2427 (1997). (Pubitemid 28134658)
-
(1997)
Carcinogenesis
, vol.18
, Issue.12
, pp. 2421-2427
-
-
Creek, M.R.1
Mani, C.2
Vogel, J.S.3
Turteltaub, K.W.4
-
121
-
-
0031418207
-
Investigation of the formation and accumulation of liver DNA adducts in mice chronically exposed to tamoxifen
-
DOI 10.1093/carcin/18.11.2209
-
Martin EA, Carthew P, White IN et al. Investigation of the formation and accumulation of liver DNA adducts in mice chronically exposed to tamoxifen. Carcinogenesis 18(11), 2209-2215 (1997). (Pubitemid 28134750)
-
(1997)
Carcinogenesis
, vol.18
, Issue.11
, pp. 2209-2215
-
-
Martin, E.A.1
Carthew, P.2
White, I.N.H.3
Heydon, R.T.4
Gaskell, M.5
Mauthe, R.J.6
Turteltaub, K.W.7
Smith, L.L.8
-
122
-
-
0030613674
-
14C]radiolabelled tamoxifen or toremifene to rat DNA using accelerator mass spectrometry
-
DOI 10.1016/S0009-2797(97)00063-X, PII S000927979700063X
-
White IN, Martin EA, Mauthe RJ, Vogel JS, Turteltaub KW, Smith LI. Comparisons of the binding of [14C]radiolabelled tamoxifen or toremifene to rat DNA using accelerator mass spectrometry. Chem. Biol. Interact. 106(2), 149-160 (1997). (Pubitemid 27463416)
-
(1997)
Chemico-Biological Interactions
, vol.106
, Issue.2
, pp. 149-160
-
-
White, I.N.H.1
Martin, E.A.2
Mauthe, R.J.3
Vogel, J.S.4
Turteltaub, K.W.5
Smith, L.L.6
-
124
-
-
0033566776
-
HPLC-accelerator MS measurement of atrazine metabolites in human urine after dermal exposure
-
Buchholz BA, Fultz E, Haack KW et al. HPLC-accelerator MS measurement of atrazine metabolites in human urine after dermal exposure. Anal. Chem. 71(16), 3519-3525 (1999).
-
(1999)
Anal. Chem.
, vol.71
, Issue.16
, pp. 3519-3525
-
-
Buchholz, B.A.1
Fultz, E.2
Haack, K.W.3
-
125
-
-
0033567104
-
Dose-dependent binding of ortho-phenylphenol to protein but not DNA in the urinary bladder of male F344 rats
-
DOI 10.1006/taap.1999.8722
-
Kwok ES, Buchholz BA, Vogel JS, Turteltaub KW, Eastmond DA. Dose-dependent binding of ortho-phenylphenol to protein but not DNA in the urinary bladder of male F344 rats. Toxicol. Appl. Pharmacol. 159(1), 18-24 (1999). (Pubitemid 29404757)
-
(1999)
Toxicology and Applied Pharmacology
, vol.159
, Issue.1
, pp. 18-24
-
-
Kwok, E.S.C.1
Buchholz, B.A.2
Vogel, J.S.3
Turteltaub, K.W.4
Eastmond, D.A.5
-
126
-
-
0032775522
-
14C]2-amino-1-methyl-6- phenylimidazo[4,5-b]pyridine (PhIP)
-
DOI 10.1016/S0304-3835(99)00142-1, PII S0304383599001421
-
Lang NP, Nowell S, Malfatti MA et al. In vivo human metabolism of [2-14C]2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PHiP). Cancer Lett. 143(2), 135-138 (1999). (Pubitemid 29392945)
-
(1999)
Cancer Letters
, vol.143
, Issue.2
, pp. 135-138
-
-
Lang, N.P.1
Nowell, S.2
Malfatti, M.A.3
Kulp, K.S.4
Knize, M.G.5
Davis, C.6
Massengill, J.7
Williams, S.8
MacLeod, S.9
Dingley, K.H.10
Felton, J.S.11
Turteltaub, K.W.12
-
127
-
-
0033200379
-
14C]benzene in rodents, using accelerator mass spectrometry
-
DOI 10.1006/taap.1999.8707
-
Mani C, Freeman S, Nelson DO, Vogel JS, Turteltaub KW. Species and strain comparisons in the macromolecular binding of extremely low doses of [14C]benzene in rodents, using accelerator mass spectrometry. Toxicol. Appl. Pharmacol. 159(2), 83-90 (1999). (Pubitemid 29426579)
-
(1999)
Toxicology and Applied Pharmacology
, vol.159
, Issue.2
, pp. 83-90
-
-
Mani, C.1
Freeman, S.2
Nelson, D.O.3
Vogel, J.S.4
Turteltaub, K.W.5
-
128
-
-
0034195193
-
14C-acetic anhydride and accelerator mass spectrometry
-
DOI 10.1016/S0009-2797(00)00160-5, PII S0009279700001605
-
Goldman R, Day BW, Carver TA, Mauthe RJ, Turteltaub KW, Shields PG. Quantitation of benzo[a]pyrene-DNA adducts by postlabeling with 14C-acetic anhydride and accelerator mass spectrometry. Chem. Biol. Interact. 126(3), 171-183 (2000). (Pubitemid 30336354)
-
(2000)
Chemico-Biological Interactions
, vol.126
, Issue.3
, pp. 171-183
-
-
Goldman, R.1
Day, B.W.2
Carver, T.A.3
Mauthe, R.J.4
Turteltaub, K.W.5
Shields, P.G.6
-
129
-
-
0036850662
-
Identification of human CYP forms involved in the activation of tamoxifen and irreversible binding to DNA
-
Boocock DJ, Brown K, Gibbs AH, Sanchez E, Turteltaub KW, White IN. Identification of human CYP forms involved in the activation of tamoxifen and irreversible binding to DNA. Carcinogenesis 23(11), 1897-1901 (2002). (Pubitemid 35355938)
-
(2002)
Carcinogenesis
, vol.23
, Issue.11
, pp. 1897-1901
-
-
Boocock, D.J.1
Brown, K.2
Gibbs, A.H.3
Sanchez, E.4
Turteltaub, K.W.5
White, I.N.H.6
-
130
-
-
0036989924
-
Protein binding of isofluorophate in vivo after coexposure to multiple chemicals
-
Vogel JS, Keating GA 2nd, Buchholz BA. Protein binding of isofluorophate in vivo after coexposure to multiple chemicals. Environ. Health Perspect. 110(Suppl. 6), 1031-1036 (2002). (Pubitemid 36204297)
-
(2002)
Environmental Health Perspectives
, vol.110
, Issue.SUPPL. 6
, pp. 1031-1036
-
-
Vogel, J.S.1
Keating II, G.A.2
Buchholz, B.A.3
-
131
-
-
2342629468
-
Attomole detection of in vivo protein targets of benzene in mice. Evidence for a highly reactive metabolite
-
Williams KE, Carver TA, Miranda JJ et al. Attomole detection of in vivo protein targets of benzene in mice. Evidence for a highly reactive metabolite. Mol. Cell. Proteomics 1(11), 885-895 (2002).
-
(2002)
Mol. Cell. Proteomics
, vol.1
, Issue.11
, pp. 885-895
-
-
Williams, K.E.1
Carver, T.A.2
Miranda, J.J.3
-
132
-
-
0037457275
-
Binding of nitrobenzene to hepatic DNA and hemoglobin at low doses in mice
-
DOI 10.1016/S0378-4274(02)00438-1, PII S0378427402004381
-
Li H, Wang H, Sun H, Liu Y, Liu K, Peng S. Binding of nitrobenzene to hepatic DNA and hemoglobin at low doses in mice. Toxicol. Lett. 139(1), 25-32 (2003). (Pubitemid 36197844)
-
(2003)
Toxicology Letters
, vol.139
, Issue.1
, pp. 25-32
-
-
Li, H.1
Wang, H.2
Sun, H.3
Liu, Y.4
Liu, K.5
Peng, S.6
-
133
-
-
10744221981
-
Tamoxifen DNA damage detected in human endometrium using accelerator mass spectrometry
-
Martin EA, Brown K, Gaskell M et al. Tamoxifen DNA damage detected in human endometrium using accelerator mass spectrometry. Cancer Res. 63(23), 8461-8465 (2003). (Pubitemid 37549502)
-
(2003)
Cancer Research
, vol.63
, Issue.23
, pp. 8461-8465
-
-
Martin, E.A.1
Brown, K.2
Gaskell, M.3
Al-Azzawi, F.4
Garner, R.C.5
Boocock, D.J.6
Mattock, E.7
Pring, D.W.8
Dingley, K.9
Turteltaub, K.W.10
Smith, L.L.11
White, I.N.H.12
-
134
-
-
0038005343
-
Benzene metabolism in rodents at doses relevant to human exposure from urban air
-
discussion 27-35
-
Turteltaub KW, Mani C. Benzene metabolism in rodents at doses relevant to human exposure from urban air. Res. Rep. Health Eff. Inst. (113), 1-26; discussion 27-35 (2003).
-
(2003)
Res. Rep. Health Eff. Inst.
, vol.113
, pp. 1-26
-
-
Turteltaub, K.W.1
Mani, C.2
-
135
-
-
1342310580
-
Ochratoxin A: Lack of formation of covalent DNA adducts
-
DOI 10.1021/tx034188m
-
Mally A, Zepnik H, Wanek P et al. Ochratoxin A. Lack of formation of covalent DNA adducts. Chem. Res. Toxicol. 17(2), 234-242 (2004). (Pubitemid 38252503)
-
(2004)
Chemical Research in Toxicology
, vol.17
, Issue.2
, pp. 234-242
-
-
Mally, A.1
Zepnik, H.2
Wanek, P.3
Eder, E.4
Dingley, K.5
Ihmels, H.6
Volkel, W.7
Dekant, W.8
-
136
-
-
23844518964
-
Formation of MTBE-DNA adducts in mice measured with accelerator mass spectrometry
-
DOI 10.1002/tox.20124
-
Du HF, Xu LH, Wang HF et al. Formation of MTBE-DNA adducts in mice measured with accelerator mass spectrometry. Environ. Toxicol. 20(4), 397-401 (2005). (Pubitemid 41176676)
-
(2005)
Environmental Toxicology
, vol.20
, Issue.4
, pp. 397-401
-
-
Du, H.F.1
Xu, L.H.2
Wang, H.F.3
Liu, Y.F.4
Tang, X.Y.5
Liu, K.X.6
Peng, S.X.7
-
137
-
-
27744567967
-
The impact of glucuronidation on the bioactivation and DNA adduction of the cooked-food carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in vivo
-
DOI 10.1093/carcin/bgi151
-
Malfatti MA, Ubick EA, Felton JS. The impact of glucuronidation on the bioactivation and DNA adduction of the cooked-food carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in vivo. Carcinogenesis 26(11), 2019-2028 (2005). (Pubitemid 41631276)
-
(2005)
Carcinogenesis
, vol.26
, Issue.11
, pp. 2019-2028
-
-
Malfatti, M.A.1
Ubick, E.A.2
Felton, J.S.3
-
138
-
-
33645469269
-
DNA adduct formation by ochratoxin A: Review of the available evidence
-
DOI 10.1080/02652030500317544, PII Q72W6558L2205W42, ILSI Supplement on Ochratoxin A in Food
-
Mally A, Dekant W. DNA adduct formation by ochratoxin a. Review of the available evidence. Food Addit. Contam. 22(Suppl. 1), 65-74 (2005). (Pubitemid 44574576)
-
(2005)
Food Additives and Contaminants
, vol.22
, Issue.SUPPL. 1
, pp. 65-74
-
-
Mally, A.1
Dekant, W.2
-
139
-
-
33646574280
-
DNA adducts formed by a novel antitumor agent 11b-dichloro in vitro and in vivo
-
DOI 10.1158/1535-7163.MCT-05-0464
-
Hillier SM, Marquis JC, Zayas B et al. DNA adducts formed by a novel antitumor agent 11b-dichloro in vitro and in vivo. Mol. Cancer Ther. 5(4), 977-984 (2006). (Pubitemid 43724598)
-
(2006)
Molecular Cancer Therapeutics
, vol.5
, Issue.4
, pp. 977-984
-
-
Hillier, S.M.1
Marquis, J.C.2
Zayas, B.3
Wishnok, J.S.4
Liberman, R.G.5
Skipper, P.L.6
Tannenbaum, S.R.7
Essigmann, J.M.8
Croy, R.G.9
-
140
-
-
33748648174
-
DNA adduct formation by 2,6-dimethyl-, 3,5-dimethyl-, and 3-ethylaniline in vivo in mice
-
DOI 10.1021/tx060082q
-
Skipper PL, Trudel LJ, Kensler TW et al. DNA adduct formation by 2,6-dimethyl-, 3,5-dimethyl-, and 3-ethylaniline in vivo in mice. Chem. Res. Toxicol. 19(8), 1086-1090 (2006). (Pubitemid 44384839)
-
(2006)
Chemical Research in Toxicology
, vol.19
, Issue.8
, pp. 1086-1090
-
-
Skipper, P.L.1
Trudel, L.J.2
Kensler, T.W.3
Groopman, J.D.4
Egner, P.A.5
Liberman, R.G.6
Wogan, G.N.7
Tannenbaum, S.R.8
-
141
-
-
33644959847
-
Adduction of biomacromolecules with acrylamide (AA) in mice at environmental dose levels studied by accelerator mass spectrometry
-
Xie Q, Sun H, Liu Y, Ding X, Fu D, Liu K. Adduction of biomacromolecules with acrylamide (AA) in mice at environmental dose levels studied by accelerator mass spectrometry. Toxicol. Lett. 163(2), 101-108 (2006).
-
(2006)
Toxicol. Lett.
, vol.163
, Issue.2
, pp. 101-108
-
-
Xie, Q.1
Sun, H.2
Liu, Y.3
Ding, X.4
Fu, D.5
Liu, K.6
-
142
-
-
34547105315
-
14C]-labeled therapeutic dose
-
DOI 10.1158/0008-5472.CAN-07-0913
-
Brown K, Tompkins EM, Boocock DJ et al. Tamoxifen forms DNA adducts in human colon after administration of a single [14C]-labeled therapeutic dose. Cancer Res. 67(14), 6995-7002 (2007). (Pubitemid 47105548)
-
(2007)
Cancer Research
, vol.67
, Issue.14
, pp. 6995-7002
-
-
Brown, K.1
Tompkins, E.M.2
Boocock, D.J.3
Martin, E.A.4
Farmer, P.B.5
Turteltaub, K.W.6
Ubick, E.7
Hemingway, D.8
Horner-Glister, E.9
White, I.N.H.10
-
143
-
-
38149050735
-
Characterization of oxaliplatin-DNA adduct formation in DNA and differentiation of cancer cell drug sensitivity at microdose concentrations
-
Hah SS, Sumbad RA, De Vere White RW, Turteltaub KW, Henderson PT. Characterization of oxaliplatin-DNA adduct formation in DNA and differentiation of cancer cell drug sensitivity at microdose concentrations. Chem. Res. Toxicol. 20(12), 1745-1751 (2007).
-
(2007)
Chem. Res. Toxicol.
, vol.20
, Issue.12
, pp. 1745-1751
-
-
Hah, S.S.1
Sumbad, R.A.2
De Vere White, R.W.3
Turteltaub, K.W.4
Henderson, P.T.5
-
144
-
-
37249092679
-
Analysis of DNA adducts formed in vivo in rats and mice from 1,2-dibromoethane, 1,2-dichloroethane, dibromomethane, and dichloromethane using HPLC/accelerator mass spectrometry and relevance to risk estimates
-
DOI 10.1021/tx700125p
-
Watanabe K, Liberman RG, Skipper PL, Tannenbaum SR, Guengerich FP. Analysis of DNA adducts formed in vivo in rats and mice from 1,2-dibromoethane, 1,2-dichloroethane, dibromomethane, and dichloromethane using HPLC/accelerator mass spectrometry and relevance to risk estimates. Chem. Res. Toxicol. 20(11), 1594-1600 (2007). (Pubitemid 350275604)
-
(2007)
Chemical Research in Toxicology
, vol.20
, Issue.11
, pp. 1594-1600
-
-
Watanabe, K.1
Liberman, R.G.2
Skipper, P.L.3
Tannenbaum, S.R.4
Guengerich, F.P.5
-
145
-
-
36148968408
-
Adduction of DNA with MTBE and TBA in mice studied by accelerator mass spectrometry
-
DOI 10.1002/tox.20295
-
Yuan Y, Wang HF, Sun HF et al. Adduction of DNA with MTBE and TBA in mice studied by accelerator mass spectrometry. Environ. Toxicol. 22(6), 630-635 (2007). (Pubitemid 350105975)
-
(2007)
Environmental Toxicology
, vol.22
, Issue.6
, pp. 630-635
-
-
Yuan, Y.1
Wang, H.F.2
Sun, H.F.3
Du, H.F.4
Xu, L.H.5
Liu, Y.F.6
Ding, X.F.7
Fu, D.P.8
Liu, K.X.9
-
146
-
-
52649163984
-
Detection of adriamycin-DNA adducts by accelerator mass spectrometry at clinically relevant adriamycin concentrations
-
Coldwell KE, Cutts SM, Ognibene TJ, Henderson PT, Phillips DR. Detection of adriamycin-DNA adducts by accelerator mass spectrometry at clinically relevant adriamycin concentrations. Nucleic Acids Res. 36(16), e100 (2008).
-
(2008)
Nucleic Acids Res.
, vol.36
, Issue.16
-
-
Coldwell, K.E.1
Cutts, S.M.2
Ognibene, T.J.3
Henderson, P.T.4
Phillips, D.R.5
-
147
-
-
47049085037
-
1dG {3-(2-Deoxy-b-D-erythropentofuranosyl)pyrimido[1,2- a]purin-10(3H)-one}, by accelerator mass spectrometry
-
DOI 10.1021/tx800049v
-
Knutson CG, Skipper PL, Liberman RG, Tannenbaum SR, Marnett LJ. Monitoring in vivo metabolism and elimination of the endogenous DNA adduct, M1DG
-
(2008)
Chemical Research in Toxicology
, vol.21
, Issue.6
, pp. 1290-1294
-
-
Knutson, C.G.1
Skipper, P.L.2
Liberman, R.G.3
Tannenbaum, S.R.4
Marnett, L.J.5
-
148
-
-
50449089942
-
Inhibition of acrylamide toxicity in mice by three dietary constituents
-
Xie Q, Liu Y, Sun H et al. Inhibition of acrylamide toxicity in mice by three dietary constituents. J. Agric. Food Chem. 56(15), 6054-6060 (2008).
-
(2008)
J. Agric. Food Chem.
, vol.56
, Issue.15
, pp. 6054-6060
-
-
Xie, Q.1
Liu, Y.2
Sun, H.3
-
149
-
-
66149087753
-
Dose-response relationships for n7-(2-hydroxyethyl)guanine induced by low-dose [14C]ethylene oxide. Evidence for a novel mechanism of endogenous adduct formation
-
Marsden DA, Jones DJ, Britton RG et al. Dose-response relationships for n7-(2-hydroxyethyl)guanine induced by low-dose [14C]ethylene oxide. Evidence for a novel mechanism of endogenous adduct formation. Cancer Res. 69(7), 3052-3059 (2009).
-
(2009)
Cancer Res.
, vol.69
, Issue.7
, pp. 3052-3059
-
-
Marsden, D.A.1
Jones, D.J.2
Britton, R.G.3
-
150
-
-
3042676313
-
Oral administration of a low dose of midazolam (75) as an in vivo probe for CYP3A activity
-
Eap CB, Buclin T, Cucchia G et al. Oral administration of a low dose of midazolam (75 microg) as an in vivo probe for CYP3A activity. Eur. J. Clin. Pharmacol. 60(4), 237-246 (2004). (Pubitemid 38916442)
-
(2004)
European Journal of Clinical Pharmacology
, vol.60
, Issue.4
, pp. 237-246
-
-
Eap, C.B.1
Buclin, T.2
Cucchia, G.3
Zullino, D.4
Hustert, E.5
Bleiber, G.6
Golay, K.P.7
Aubert, A.-C.8
Baumann, P.9
Telenti, A.10
Kerb, R.11
-
151
-
-
31344470714
-
Mass balance studies, with a focus on anticancer drugs
-
DOI 10.2165/00003088-200645010-00003
-
Beumer JH, Beijnen JH, Schellens JH. Mass balance studies, with a focus on anticancer drugs. Clin. Pharmacokinet. 45(1), 33-58 (2006). (Pubitemid 43145014)
-
(2006)
Clinical Pharmacokinetics
, vol.45
, Issue.1
, pp. 33-58
-
-
Beumer, J.H.1
Beijnen, J.H.2
Schellens, J.H.M.3
-
152
-
-
33846444020
-
The use of isotopes in the determination of absolute bioavailability of drugs in humans
-
DOI 10.1517/17425255.2.3.419
-
Lappin G, Rowland M, Garner RC. The use of isotopes in the determination of absolute bioavailability of drugs in humans. Expert Opin. Drug Metab. Toxicol. 2(3), 419-427 (2006). (Pubitemid 46141407)
-
(2006)
Expert Opinion on Drug Metabolism and Toxicology
, vol.2
, Issue.3
, pp. 419-427
-
-
Lappin, G.1
Rowland, M.2
Garner, R.C.3
|