Species and strain comparisons in the macromolecular binding of extremely low doses of [14C]benzene in rodents, using accelerator mass spectrometry

Toxicology and Applied Pharmacology

Volumn 159, Issue 2, 1999, Pages 83-90

  Mani, Chitra ^a   Freeman, Stewart ^b   Nelson, David O ^b   Vogel, John S ^b   Turteltaub, Kenneth W ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b LAWRENCE LIVERMORE NATIONAL LABORATORY   (United States)

Author keywords

Accelerator mass spectrometry; Benzene; DNA adduct; Mice; Protein adduct; Radiocarbon; Rat

Indexed keywords

BENZENE; DNA; PROTEIN;

ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; CARCINOGENICITY; DNA ADDUCT; GENOTOXICITY; MALE; MASS SPECTROMETRY; METABOLIC CAPACITY; MOUSE; NONHUMAN; RAT; SPECIES; STRAIN DIFFERENCE;

EID: 0033200379     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1999.8707     Document Type: Article

References (53)

1. Threshold limit values for chemical substances and physical agents and biological exposure indices. 1994;37.
2. Aksoy M. Hematotoxicity and carcinogenicity of benzene. Environ. Health Perspect. 82:1989;193-197.
3. Arfellini G., Grilli S., Colacci A., Mazzullo M., Prodi G. In vivo and in vitro binding of benzene to nucleic acids and proteins of various rat and mouse organs. Cancer Lett. 15:1985;159-168.
4. Bauer H., Dimitriadis E. A., Snyder R. An in vivo study of benzene metabolite DNA adduct formation in liver of male new zealand rabbits. Arch. Toxicol. 63:1989;209-213.
5. Bodell W. J., Pathak D. N., Levay G., Ye Q., Pongracz K. Investigation of the DNA adducts formed in B6C3F1 mice treated with benzene: Implications for molecular dosimetry. Environ. Health Persp. 104:1996;1189-1193.
6. Chambers J. M., Hastie T. J. Statistical Models. 1992;S. Wadsworth and Brooks, Pacific Grove.
7. 14C]-benzene in B6C3F1 mice. Carcinogenesis. 18:1997;2421-2427.
8. Eastmond D. A., Smith M. T., Irons R. D. An interaction of benzene metabolites reproduces the myelotoxicity observed with benzene exposure. Toxicol. Appl. Pharmacol. 1:1987;85-95.
9. Frantz C. E., Bangerter C., Fultz E., Mayer K. M., Vogel J. S., Turteltaub K. W. Dose-response studies of MeIQx in rat liver and liver DNA at low doses. Carcinogenesis. 16:1995;367-374.
10. Greenlee W. F., Sun J. D., Bus J. S. A proposed mechanism of benzene toxicity: Formation of reactive intermediates from polyphenol metabolites. Toxicol. Appl. Pharmacol. 59:1981;187-195.
11. Hochberg Y., Tamhane A. C. Multiple Comparison Procedures. 1987;Wiley, New York.
12. Hoffmann D., Brunnemann K. D., Hoffmann I. Significance of benzene in tobacco carcinogenesis. Mhlman M. A. Advances in Modern Environmental Toxicology, Benzene: Occupational and Environmental Hazards-Scientific Update. 1989;99-112 Princeton Scientific, Princeton.
13. Huff J. E., Eastin W., Roycroft J., Eustis S. L., Haseman J. K. Carcinogenesis studies of benzene, methyl benzene, and dimethyl benzenes. Ann. NY Acad. Sci. 534:1988;427-440.
14. Huff J. National Toxicology Program. Toxicology and Carcinogenesis Studies of Benzene (CAS No. 71-43-2) in F344/N Rats and B5C3F1 Mice (gavage studies). 1983.
15. Huff J. E., Haseman J. K., De Marini D. M., Eustis S., Maronpot R. R., Peters A. C., Persing R. L., Chrisp C. E., Jacobs A. C. Multiple site carcinogenicity of benzene in Fischer 344 rats and B6C3F1 mice. Environ. Health Perspect. 82:1989;125-163.
16. Kautiainen A., Vogel J. S., Turteltaub K. W. Trichloroethylene covalently binds macromolecules dose dependently in mice. Chemico-Biol. Interact. 106:1997;109-121.
17. Krewet E., Verkoyen C., Muller G., Schell C., Popp W., Norpoth K. Studies on guanine adducts excreted in rat urine after benzene exposure. Carcinogenesis. 14:1993;245-250.
18. Levay G., Pathak D. N., Bodell W. J. Detection of DNA adducts in the white blood cells of B5C3F1 mice treated with benzene. Carcinogenesis. 17:1996;151-153.
19. Longacre S. L., Kocsis J. J., Snyder R. Influence of strain differences in mice on the metabolism and toxicity of benzene. Toxicol. Appl. Pharmacol. 60:1981;398-409.
20. Lutz W. K. In vivo covalent binding or organic chemicals to DNA as a quantitative indicator in the process of chemical carcinogenesis. Mutat. Res. 65:1979;289-356.
21. Maltoni C., Ciliberti A., Cotti G., Conti B., Belpoggi F. Benzene: An experimental multipotential carcinogen. Results of the long term bioassays performed at the Bologna Institute of Oncology. Environ. Health Perspect. 82:1989;102-124.
22. Maltoni C., Scarnato C. First experimental demonstration of the carcinogenic effects of benzene. Med. Lav. 5:1982;352-357.
23. Mathews J. M., Etheridge A. S., Mathews H. B. Dose dependent metabolism of benzene in hamsters, rats and mice. Toxicol. Sci. 44:1998;14-21.
24. Mauthe R. J., Dingley K. H., Levenson S., Garner C. R., Turesky R. J., Turteltaub K. W. MeIQx-DNA adduct formation in rodent and human colon at low dose. Int. J. Cancer. 4:1999;539-545.
25. Mazzullo M., Bartoli S., Bonora B., Colacci A., Grilli S., Lattanzi G., Niero A., Turina M. P., Parodi S. Benzene adducts with rat and nucleic acids and proteins: Dose-response relationship after treatment in vivo. Environ. Health Perspect. 82:1989;259-266.
26. 13C benzene. Cancer Res. 54:1994;4907-4914.
27. Medinsky M. A., Sabourin P. J., Lucier G., Birnbaum L. S., Henderson R. F. A physiological model for simulation of benzene metabolism by rats and mice. Toxicol. Appl. Pharmacol. 99:1989;193-206.
28. Pathak D. N., Levay G., Bodell W. J. DNA adduct formation in the bone marrow of B6C3F1 mice treated with benzene. Carcinogenesis. 16:1995;1803-1808.
29. Paustenbach D. J., Bass R. D., Price P. Benzene toxicity and risk assessment, 1972-1992: Implications for future regulation. Environ. Health Perspect. 101:1993;177-200.
30. Poirier M. C., Beland F. A. DNA adduct measurements and tumor incidence during chronic carcinogen exposure in animal models: Implications for DNA adduct-based human cancer risk assessment. Toxicology. 5:1992;749-755.
31. 32P-postlabeling with the DNA adduct formed in HL-60 cells treated with hydroquinone. Chem. Res. Toxicol. 3:1996;593-598.
32. Rappaport S. M., McDonald T. A., Yeowell-O'Connell K. The use of protein adducts to investigate the disposition of reactive metabolites of benzene. Environ. Health Perspect. 104:1996;1235-1237.
33. 32P analysis of DNA adducts in tissues of benzene-treated rats. Environ. Health Perspect. 82:1989;253-257.
34. Reddy M. V., Schultz S. C., Blackburn G. R., Mackerer C. R. Lack of DNA adduct formation in mice treated with benzene. Mutat. Res. 325:1994;149-155.
35. Rinskey R. A., Smith A. B., Hornung R., Filloon T. G., Young R. J., Okun A. K., Ladrigan P. J. Benzene and leukemia, an epidemiological risk assessment. N. Engl. J. Med. 316:1987;1044.
36. Ritschel W. A. Hand Book of Basic Pharmacokinetics. 1980;Drug Intelligence Publications, Inc.
37. 14C]benzene administered orally or by inhalation in rats and mice. Toxicol. Appl. Pharmacol. 87:1987;325-336.
38. 3H]benzene by F344/N rats and B6C3F1 mice. Toxicol. Appl. Pharmacol. 94:1988;1288-1140.
39. Sabourin P. J., Bechtold W. E., Griffith W. C., Birnbaum L. S., Lucier G., Henderson R. F. Effect of exposure concentration, exposure rate and route of administration on metabolism of benzene by F344 rats and B6C3F1 mice. Toxicol. Appl. Pharmacol. 99:1989;421-444.
40. 14C]benzene by cynomolgus monkeys and chimpanzees. Toxicol. Appl. Pharmacol. 114:1992;277-284.
41. Seaton M. J., Schlosser P. M., Bond J. A., Medinsky M. A. Benzene metabolism by human liver microsomes in relation to cytochrome P450 2E1 activity. Carcinogenesis. 15:1994;1799-1806.
42. Sun J. D., Medinsky M. A., Birnbaum L. S., Lucier G., Henderson R. F. Benzene hemoglobin adducts in mice and rats: Characterization of formation and physiological modeling. Fundam. Appl. Toxicol. 15:1990;468-475.
43. Smith M. T., Robertson M. L., Yager J. W., Eastmond D. A. Role of metabolism in benzene-induced myelotoxicity and leukemogenesis. Prog. Clin. Biol. Res. 340B:1990;125-136.
44. Snyder R., Kalf A. Perspective on benzene leukemogenesis. Crit. Rev. Toxicol. 24:1994;177-209.
45. Snyder R., Kocsis J. J. Current concepts of chronic benzene toxicity. CRC Crit. Rev. Toxicol. 3:1975;265-288.
46. Snyder R., Witz G., Goldstein B. D. The toxicology of benzene. Environ. Health Perspect. 100:1993;293-306.
47. Turteltaub K. W., Vogel J. S. Application of accelerator mass spectrometry in toxicology: A highly sensitive tool for low-level isotope measurements. Burlingame A. L., Carr S. A. Mass Spectrometry in the Biological Sciences. 1995;477-495 Humana Press, Totawa.
48. Turteltaub K. W., Vogel J. S., Frantz C. E., Fultz E. Studies on DNA adduction with heterocyclic amines by accelerator mass spectrometry: A new technique for tracing isotope-labeled DNA adduction. Phillips D. H., Castegnaro M., Bartsch H. Postlabeling Methods for Detection of DNA Adducts. 1993;293-230 International Agency for Research on Cancer, Lyon.
49. Vogel J. S. Rapid production of graphite without contamination for biological. Radiocarbon. 34:1992;344-350.
50. Vogel J. S., Turteltaub K. W., Finkel R., Nelson D. E. Accelerator mass spectrometry: Isotope identification at attomole sensitivity. Anal. Chem. 67:1995;353A-359A.
51. Wallace L. A. The exposure of the general population to benzene. Mehlman M. A. Benzene: Occupational and Environmental Hazards - Scientific Update. 1989;113-130 Princeton Scientific Publishing Co., Inc. Princeton.
52. Witz G., Maniara W., Mylavarapu V., Goldstein B. D. Comparative metabolism of benzene and trans,trans-muconaldehyde to trans, trans-muconic acid in DBA/2N and C57BL/6 mice. Biochem. Pharmacol. 40:1990;1275-1280.
53. Yeowell-O'Connell K., Rothman N., Smith M. T., Hayes R. B., Li G., Waidyanatha S., Dosemeci M., Zang L., Yin S., Titenko-Holland N., Rappaport S. M. Hemoglobin and albumin adducts of benzene oxide among workers exposed to high levels of benzene. Carcinogenesis. 19:1998;1567-1571.