Evaluation of accelerator mass spectrometry in a human mass balance and pharmacokinetic study-experience with 14C-labeled (R)-6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4 -(3-chlorophenyl)-1-methyl-2(1H)-quinolinone (R115777), a farnesyl transferase inhibitor

Drug Metabolism and Disposition

Volumn 30, Issue 7, 2002, Pages 823-830

  Garner, R C ^a   Goris, I ^b   Laenen, A A E ^c   Vanhoutte, E ^a   Meuldermans, W ^b   Gregory, S ^a   Garner, J V ^c   Leong, D ^a   Whattam, M ^a   Calam, A ^b   Snel, C A W ^b  

^a Department of Pharmacokinetics ^*  (United Kingdom)

^b JANSSEN RESEARCH FOUNDATION   (Belgium)

^c CBAMS Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETONITRILE; CARBON 14; DRUG METABOLITE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; TIPIFARNIB; ENZYME INHIBITOR; FARNESYL TRANS TRANSFERASE; QUINOLONE DERIVATIVE; TRANSFERASE;

ACCELERATOR MASS SPECTROMETRY; ARTICLE; CELL FRACTIONATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG FECES LEVEL; DRUG LABELING; DRUG URINE LEVEL; EVALUATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALE; MASS SPECTROMETRY; NORMAL HUMAN; PLASMA; PRIORITY JOURNAL; RADIOACTIVITY; TANDEM MASS SPECTROMETRY; ADULT; CHEMISTRY; DRUG ANTAGONISM; INSTRUMENTATION; MAGNETIC AND ELECTROMAGNETIC EQUIPMENT; METHODOLOGY;

ADULT; ALKYL AND ARYL TRANSFERASES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME INHIBITORS; HUMAN; MALE; PARTICLE ACCELERATORS; QUINOLONES; SPECTRUM ANALYSIS, MASS; SUPPORT, NON-U.S. GOV'T; FARNESYLTRANSTRANSFERASE; HUMANS; MASS SPECTROMETRY;

EID: 0035987901     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.30.7.823     Document Type: Article

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