Formation of MTBE-DNA adducts in mice measured with accelerator mass spectrometry

Environmental Toxicology

Volumn 20, Issue 4, 2005, Pages 397-401

  Du, H F ^a   Xu, L H ^a   Wang, H F ^b   Liu, Y F ^b   Tang, X Y ^c   Liu, K X ^c   Peng, S X ^c  

^a FUDAN UNIVERSITY   (China)

^b PEKING UNIVERSITY   (China)

^c PEKING UNIVERSITY   (China)

Author keywords

Accelerator mass spectroscopy (AMS); DNA adduct; Genotoxicity; Methyl fert butyl ether (MTBE)

Indexed keywords

BINDING ENERGY; BIOLOGICAL ORGANS; DNA; ETHERS; GASOLINE; MASS SPECTROMETRY;

ACCELERATOR MASS SPECTROMETRY (AMS); DNA ADDUCTS; GENOTOXICITY; METHYL FERT-BUTYL ETHER (MTBE);

TOXICITY;

DNA; GASOLINE; TERT BUTYL METHYL ETHER;

DNA; GENOTOXICITY; MASS SPECTROMETRY; MTBE;

ACCELERATOR MASS SPECTROMETRY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DNA ADDUCT; DNA BINDING; GENOTOXICITY; ISOTOPE LABELING; KIDNEY SIZE; KINETICS; LIVER; LUNG; MALE; MASS SPECTROMETRY; MEASUREMENT; METABOLISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; TISSUE DISTRIBUTION;

ANIMALS; DNA; DNA ADDUCTS; DNA REPAIR; DOSE-RESPONSE RELATIONSHIP, DRUG; KIDNEY; LIVER; LUNG; MALE; MASS SPECTROMETRY; METHYL ETHERS; MICE;

RODENTIA;

EID: 23844518964     PISSN: 15204081     EISSN: None     Source Type: Journal    
DOI: 10.1002/tox.20124     Document Type: Article

References (28)

1. Ahmed FE. 2001. Toxicology and human health effects following exposure to oxygenated or reformulated gasoline. Toxicol Lett 123:89-113.
2. [AGFA] Asian Clean Fuels Association; [EFOA] European Fuel Oxygenates Association. 2002. The MTBE resource guide. Brussels, Belgium.
3. Belpoggi F, Soffritti M, Maltoni C. 1995. Methyl tertiary-butyl ether (MTBE)-a gasoline additive-causes testicular and lymphohaematopoietic cancers in rats. Toxicol Ind Health 11: 119-149.
4. Bird MG, Burleigh-Flayer HD, Chun JS, Douglas JF, Kneiss JJ, Andrews LS. 1997. Oncogenicity studies of inhaled methyl tertiary-butyl ether (MTBE) in CD-1 mice and F-344 rats. J Appl Toxicol 17:S45-S55.
5. Boeniger MF. 1987. Formate in urine as a biological indicator of formaldehyde exposure: a review. Am Ind Hyg Assoc J 48:900-908.
6. Brown SL. 1997. Atmospheric and potable water exposures to methyl tert-butyl ether (MTBE). Reg Toxicol Pharmacol 25:256-276.
7. Caprino L, Togna GI. 1999. Potential health effects of gasoline and its constituents: a review of current literature (1990-1997) on lexicological data. Environ Health Perspect 106:115-125.
8. Chen CE, Guo ZY, Van SQ, Zhang ZF, Gong LH, Li RX, Yu JK. 1990. Status of tandem accelerator mass spectrometry facility at Peking University. Nucl Instr Meth Phys Res 852:306-309.
9. Chen Y. 2004. Study of the incorporation and adduction for formic acid and DNA [PhD dissertation]. Peking University, Beijing, China.
10. Davis SW, Powers SE. 2000. Alternative sorbents for removing MTBE from gasoline-contaminated ground water. J Environ Eng 126:354-360.
11. Dekant W, Bernauer U, Rosner E, Amberg A. 2001. Toxicokinetics of ethers used as fuel oxygenates. Toxicol Lett 124:37-45.
12. Garner RC. 1998. The role of DNA adducts in chemical carcinogenesis. Mutat Res 402:67-75.
13. Garner RC. 2000. Accelerator mass spectrometry in pharmaceutical research and development - a new ultrasensitive analytical method of isotope measurement. Curr Drug Metab 1:205-213.
14. Hong JY, Yang CS, Lee M, Wang YY, Huang WQ, Tan Y, Patten CJ, Bondoc FY. 1997. Role of cytochromes P450 in the metabolism of methyl tert-butyl ether in human livers. Arch Toxicol 71:266-269.
15. Kado NY, Kuzmicky PA, Loarca-Piña GL, Mumtaz MM. 1998. Genotoxicity testing of methyl tertiary-butyl ether (MTBE) in the Salmonella microsuspension assay and mouse bone marrow micronucleus test. Mutat Res 412:131-38.
16. Kryukov VI, Antonov KV, Miroshnikov AI. 1997. Formylation of nucleosides with formic acid. Bioorg Chem (Russ) 23: 903-905.
17. Mormile MR, Liu S, Suflita JM. 1994. Anaerobic biodegradation of gasoline oxygenates: extrapolation of information to multiple sites and redox conditions. Environ Sci Tech 28:1727-1732.
18. Lee LS, Quintana PJE, de Peyster A. 1998. Comet assay evaluation of the effect of methyl-butyl ether (MTBE) on rat lymphocytes (Abstract 923, 1998). The Toxicologist 42(1-S):187.
19. Otteneder M, Lutz WK. 1999. Correlation of DNA adduct levels with tumor incidence: carcinogenic potency of DNA adducts. Mutat Res 424:237-247.
20. Phillips DH, Farmer PB, Beland FA, Nath RG, Poinier MC, Reddy MW, Turteltaub KW. 2000. Methods of DNA adduct determination and their application to testing compounds for genotoxicity. Environ Mol Mutagen 35:222-233.
21. Squillace PJ, Pankow JF, Korte NE, Zogorski JS. 1997. Review of the environmental behavior and fate of methyl tert-bulyl ether. Environ Toxicol Chem 16:1836-1844.
22. Suflita JM, Mormile MR. 1993. Anerobic biodegradation of known and potential gasoline oxygenates in the terrestrial sub-surface. Environ Sci Tech 27:976-978.
23. Turini A, Amato G, Longo V, Gervasi PG. 1998. Oxidation of methyl- and ethyl-tertiary-butyl ethers in rat liver microsomes: role of the cytochrome P450 isoforms. Arch Toxicol 72:207-214.
24. 14C-AMS). Chin Sei Bull 46:537-543.
25. Wang HF, Xu LH, Sun HF, Xue B, Liu YF, Liu KX, Peng SX, Guo ZY. 2004. High binding of formic acid to biomacromolecules in mice. Nucl Instr Meth Phys Res 8223-224:745-749.
26. Vogel JS. 1992. Rapid production of graphite without contamination for biomedical AMS. Radiocarbon 34:344-350.
27. Zhou W, Yuan D, Huang G, Zhang H, Ye SH. 2000. Mutagenicity of methyl tertiary butyl ether. J Environ Pathol Toxicol Oncol 19:35-39.
28. Zou J. 2004. Status and prospect of MTBE supply/demand. Petrol Petrochem Today (Chinese) 11:23-27.