Accelerator mass spectrometry (AMS): Recent experience of its use in a clinical study and the potential future of the technique

Xenobiotica

Volumn 31, Issue 8-9, 2001, Pages 619-632

  Young, G ^a   Ellis, W ^a   Ayrton, J ^a   Hussey, E ^a   Adamkiewicz, B ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON 14; DRUG METABOLITE; GI 181771; NEW DRUG; UNCLASSIFIED DRUG;

ACCELERATOR MASS SPECTROMETRY; ADULT; ARTICLE; CLINICAL STUDY; CLINICAL TRIAL; DILUTION; DRUG DETERMINATION; HUMAN; HUMAN EXPERIMENT; INTERMETHOD COMPARISON; IONIZING RADIATION; ISOTOPE LABELING; LIQUID SCINTILLATION COUNTING; MALE; MASS; MASS SPECTROMETRY; NORMAL HUMAN; SAMPLING; TECHNIQUE; VALIDATION PROCESS;

ADMINISTRATION, ORAL; ADULT; ANIMALS; CARBON RADIOISOTOPES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; MALE; MASS SPECTROMETRY;

EID: 0034830621     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.1080/00498250110052724     Document Type: Article

References (9)

1. Radiocarbon dating using electrostatic accelerators: Negative ions provide the key
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4. 14C]-labelled drugs in plasma, urine and faecal extracts
5. ICH guideline 1996
6. A preliminary evaluation of accelerator mass spectrometry in the biomedical field
7. Carbon-14: Direct detection at natural concentrations
8. Rapid production of graphite without contamination for biomedical AMS