Analysis of DNA adducts formed in vivo in rats and mice from 1,2-dibromoethane, 1,2-dichloroethane, dibromomethane, and dichloromethane using HPLC/accelerator mass spectrometry and relevance to risk estimates

Chemical Research in Toxicology

Volumn 20, Issue 11, 2007, Pages 1594-1600

  Watanabe, Kengo ^a,c   Liberman, Rosa G ^b   Skipper, Paul L ^b   Tannenbaum, Steven R ^b   Guengerich, F Peter ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c DAIICHI SANKYO CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DICHLOROETHANE; 1,2,DIBROMOETHANE; CARBON 14; DIBROMOMETHANE; DICHLOROMETHANE; DIHALOMETHANE; GLUTATHIONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATTRIBUTABLE RISK; BODY WEIGHT; CONTROLLED STUDY; DNA BINDING; DNA DETERMINATION; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; ISOLATED LIVER; KIDNEY; MALE; MASS SPECTROMETRY; MOUSE; NONHUMAN; RAT; RISK ASSESSMENT;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA ADDUCTS; ETHYLENE DIBROMIDE; ETHYLENE DICHLORIDES; FEMALE; HYDROCARBONS, BROMINATED; KIDNEY; LIVER; MALE; MASS SPECTROMETRY; METHYLENE CHLORIDE; MICE; RATS; RESEARCH DESIGN; RISK ASSESSMENT;

MUS; RATTUS; RODENTIA;

EID: 37249092679     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx700125p     Document Type: Article

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