Quantitation of in vivo human folate metabolism

American Journal of Clinical Nutrition

Volumn 80, Issue 3, 2004, Pages 680-691

  Lin, Yumei ^a   Dueker, Stephen R ^a   Follett, Jennifer R ^a   Fadel, James G ^a   Arjomand, Ali ^a   Schneider, Philip D ^b   Miller, Joshua W ^b   Green, Ralph ^b   Buchholz, Bruce A ^c   Vogel, John S ^c   Phair, Robert D ^d   Clifford, Andrew J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c LAWRENCE LIVERMORE NATIONAL LABORATORY   (United States)

^d Integrative Biolnformatics Inc   (United States)

Author keywords

14C; Accelerator mass spectrometry; Folate; Kinetic model; Metabolism

Indexed keywords

CARBON 14; FOLIC ACID; GLUTAMIC ACID; (4 AMINOBENZOYL)GLUTAMIC ACID; 4-AMINOBENZOYLGLUTAMIC ACID; CARBON; GLUTAMIC ACID DERIVATIVE;

ADULT; ARTICLE; BONE MARROW; CATABOLISM; DATA ANALYSIS; DIETARY INTAKE; DIGESTION; DOSIMETRY; FOLATE METABOLISM; FOLIC ACID BLOOD LEVEL; GASTROINTESTINAL ABSORPTION; HUMAN; IN VIVO STUDY; POPULATION RESEARCH; QUANTITATIVE ANALYSIS; RECYCLING; TISSUE LEVEL; BIOLOGICAL MODEL; BLOOD; CHEMISTRY; ERYTHROCYTE; FECES; FEMALE; INTESTINE ABSORPTION; MALE; METABOLIC CLEARANCE RATE; METABOLISM; MIDDLE AGED; URINE;

ADULT; CARBON RADIOISOTOPES; ERYTHROCYTES; FECES; FEMALE; FOLIC ACID; GLUTAMATES; HUMANS; INTESTINAL ABSORPTION; MALE; METABOLIC CLEARANCE RATE; MIDDLE AGED; MODELS, BIOLOGICAL;

EID: 4544374215     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/80.3.680     Document Type: Article

References (60)

1. Steinberg SE. Mechanisms of folate homeostasis. Am J Physiol 1984;246:G319-24.
2. Shane B. Folate metabolism. In: Piciano MF, Stokstad ELR, Gregory JF, eds. Folic acid metabolism in health and disease. Contemporary issues in clinical nutrition. New York: Wiley-Liss, 1990:65-78.
3. Stokstad ELR. Historical perspectives on key advances in the biochemistry and physiology of folates. In: Piciano MF, Stokstad ELR, Gregory JFI, eds. Folic acid metabolism in health and disease. Contemporary issues in clinical nutrition. New York: Wiley-Liss, 1990:1-21.
4. Shane B. Folate chemistry and metabolism. In: Bailey LB, ed. Folate in health and disease. New York: Marcel Dekker, Inc, 1995:1-22.
5. Wagner C. Biochemical role of folate in cellular metabolism. In: Bailey LB, ed. Folate in health and disease. New York: Marcel Dekker, Inc, 1995:23-42.
6. 3H-folic Acid. Br J Haematol 1960;6:439-55.
7. Sheehy TW, Santini R Jr, Guerra R, Angel R, Plough IC. Tritiated folic acid as a diagnostic aid in folic acid deficiency. J Lab Clin Med 1963;61:650-9.
8. Johns DG, Sperti S, Burgen ASV. The metabolism of tritiated folic acid in man. Montreal: McGill University Clinic, 1961:1684-95.
9. Baker SJ, Kumar S, Swaminathan SP. Excretion of folic acid in bile. Lancet 1965;1:685.
10. Herbert V. Excretion of folic acid in bile. Lancet 1965;1:913.
11. McLean A, Chanarin I. Urinary excretion of 5-methyltetrahydrofolate in man. Blood 1966;27:386-8.
12. Saleh AM, Pheasant AE, Blair JA, Allan RN, Walters J. Folate metabolism in man: the effect of malignant disease. Br J Cancer 1982;46:346-53.
13. Butterworth CE Jr, Baugh CM, Krumdieck C. A study of folate absorption and metabolism in man utilizing carbon-14-labeled polyglutamates synthesized by the solid phase method. J Clin Invest 1969;48:1131-42.
14. Perry J, Chanarin I. Intestinal absorption of reduced folate compounds in man. Br J Haematol 1970;18:329-39.
15. Whitehead VM, Cooper BA, Pratt RF. Absorption of folic acid. Lancet 1972;1:326.
16. 14C folic acid, with observations on the effect of diphenylhydantoin administration. Am J Clin Nutr 1978;31:88-93.
17. Vogel JS, Turteltaub KW, Finkel R, Nelson DE. Accelerator mass spectrometry: isotope quantification at attomole sensitivity. Anal Chem 1995;67:A353-9.
18. Phair RD. Development of kinetic models in the nonlinear world of molecular cell biology. Metabolism 1997;46:1489-95.
19. Phair RD, Misteli T. Kinetic modelling approaches to in vivo imaging. Nat Rev Mol Cell Biol 2001;2:898-907.
20. Vicini P, Cobelli C. The iterative two-stage population approach to IVGTT minimal modeling: improved precision with reduced sampling. Intravenous glucose tolerance test. Am J Physiol Endocrinol Metab 2001;280:E179-86.
21. DiCenzo R, Forrest A, Slish JC, Cole C, Guillet R. A gentamicin pharmacokinetic population model and once-daily dosing algorithm for neonates. Pharmacotherapy 2003;23:585-91.
22. Plante LT, Williamson KL, Pastore EJ. Preparation of folic acid specifically labeled with carbon-13 in the benzoyl carbonyl. Methods Enzymol 1980;66:533-5.
23. Block G, Hartman AM, Dresser CM, Carroll MD, Gannon J, Gardner L. A data-based approach to diet questionnaire design and testing. Am J Epidemiol 1986;124:452-69.
24. Lin Y, Dueker SR, Jones AD, Clifford AJ. A parallel processing solid phase extraction protocol for the determination of whole blood folate. Anal Biochem 2002;301:14-20.
25. Dueker SR, Lin Y, Jones AD, et al. Determination of blood folate using acid extraction and internally standardized gas chromatography-mass spectrometry detection. Anal Biochem 2000;283:266-75.
26. Gilfix BM, Blank DW, Rosenblatt DS. Novel reductant for determination of total plasma homocysteine. Clin Chem 1997;43:687-8.
27. Vogel JS. Rapid production of graphite without contamination for biomedical AMS. Radiocarbon 1992;34:344-50.
28. Pella E. Elemental organic analysis. Am Lab 1990;22:116-25.
29. Suh JR, Herbig AK, Stover PJ. New perspectives on folate catabolism. Annu Rev Nutr 2001;21:255-82.
30. Koury MJ. Red blood cell production and kinetics. In: Simon TL, Dzik WH, Snyder EL, Stowell CP, Strauss RG, eds. Rossi's principles of transfusion medicine. 3rd ed. New York: Lippincott Williams & Wilkins, 2002:93-100.
31. Barrett PH, Bell BM, Cobelli C, et al. SAAMII: simulation, analysis, and modeling software for tracer and pharmacokinetic studies. Metabolism 1998;47:484-92.
32. Cobelli C, Foster DM. Compartmental models: theory and practice using the SAAMII software system. Adv Exp Med Biol 1998;445:79-101.
33. Jacquez JA. Compartmental analysis in biology and medicine. In: Arbor A, ed. Compartmental analysis in biology and medicine. 3rd ed. Ann Arbor, MI: BioMedware, 1996.
34. Vicini P, Barrett PH, Cobelli C, Foster DM, Schumitzky A. Approaches to population kinetic analysis with application to metabolic studies. Adv Exp Med Biol 1998;445:103-13.
35. Steimer JL, Mallet A, Golmard JL, Boisvieux JF. Alternative approaches to estimation of population pharmacokinetic parameters: comparison with the nonlinear mixed-effect model. Drug Metab Rev 1984;15:265-92.
36. Drusano GL, Liu W, Perkins R, et al. Determination of robust ocular pharmacokinetic parameters in serum and vitreous humor of albino rabbits following systemic administration of ciprofloxacin from sparse data sets by using IT2S, a population pharmacokinetic modeling program. Antimicrob Agents Chemother 1995;39:1683-7.
37. Beal SL, Sheiner LB. Estimating population kinetics. Crit Rev Biomed Eng 1982;8:195-22.
38. Cooperman JM, Pesci-Bourel A, Luhby AL. Urinary excretion of folic acid activity in man. Clin Chem 1970;16:375-81.
39. Bills ND, Koury MJ, Clifford AJ, Dessypris EN. Ineffective hematopoiesis in folate-deficient mice. Blood 1992;79:2273-80.
40. London IM, Shemin D, West R, Rittenberg D. Heme synthesis and red blood cell dynamics in normal humans and in subjects with polycythemia vera, sickle-cell anemia, and pernicious anemia. J Biol Chem 1949;179:463-84.
41. Institute of Medicine, National Academy of Sciences. Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin and choline. Washington, DC: National Academy of Sciences, 1998.
42. Herbert V, Drivas G, Manusselis C, Mackler B, Eng J, Schwartz E. Are colon bacteria a major source of cobalamin analogues in human tissues? Trans Assoc Am Physicians 1984;97:161-71.
43. Hoppner K, Lampi B, Smith DC. Data on folacin activity in foods: availability, applications, and limitations. In. Folic acid: biochemistry and physiology in relation to the human nutrition requirements. Washington, DC: National Academy of Sciences, 1977:69-81.
44. Stokstad ELR, Shin YS, Tamura T. Distribution of folate forms in food and folate bioavailability. In: Folic acid: biochemistry and physiology in relation to the human nutrition requirements. Washington, DC: National Academy of Sciences, 1977:56-68.
45. Konings EJ, Troost FJ, Castenmiller JJ, Roomans HH, Van Den Brandt PA, Saris WH. Intestinal absorption of different types of folate in healthy subjects with an ileostomy. Br J Nutr 2002;88:235-42.
46. Muller HG, Facer MR, Bills ND, Clifford AJ. Exchangeability of food folates in a depletion-repletion rat growth bioassay. J Nutr 1996;126:2585-92.
47. Steinberg SE, Campbell CL, Hillman RS. Kinetics of the normal folate enterohepatic cycle. J Clin Invest 1979;64:83-8.
48. Halsted CH, Robles EA, Mezey E. Intestinal malabsorption in folate-deficient alcoholics. Gastroenterology 1973;64:526-32.
49. Leonard JP, Desager JP, Beckers C, Harvengt C. In vitro binding of various biological substances by two hypocholesterolaemic resins. Cholestyramine and colestipol. Arzneimittelforschung 1979;29:979-81.
50. Nikkila EA, Miettinen TA, Lanner A. Treatment of hypercholesterolemia with Secholex. A long-term clinical trial and comparison with cholestyramine. Atherosclerosis 1976;24:407-19.
51. Hernendez-Diaz S, Werler MM, Walker AM, Mitchell AA. Folic acid antagonists during pregnancy and the risk of birth defects. N Engl J Med 2000;343:1608-14.
52. Kemppainen TA, Kosma VM, Janatuinen EK, Julkunen RJ, Pikkarainen PH, Uusitupa MI. Nutritional status of newly diagnosed celiac disease patients before and after the institution of a celiac disease diet-association with the grade of mucosal villous atrophy. Am J Clin Nutr 1998;67:482-7.
53. Lim ML. A perspective on tropical sprue. Curr Gastroenterol 2001;3:322-7.
54. Doyle TJ, Bryan RT. Infectious disease morbidity in the US region bordering Mexico, 1990-1998. J Infect Dis 2000;182:1503-10.
55. Hendricks KA, Simpson JS, Larsen RD. Neural tube defects along the Texas-Mexico border, 1993-1995. Am J Epidemiol 1999;149:1119-27.
56. Lavoie A, Cooper BA. Rapid transfer of folic acid from blood to bile in man, and its conversion into folate coenzymes and into a pteroylglutamate with little biological activity. Clin Sci Mol Med 1974;46:729-41.
57. Herbert V. Experimental nutritional folate deficiency in man. Trans Assoc Am Physicians 1962;75:307-20.
58. Sauberlich HE, Kretsch MJ, Skala JH, Johnson HL, Taylor PC. Folate requirement and metabolism in nonpregnant women. Am J Clin Nutr 1987;46:1016-28.
59. Suh JR, Oppenheim EW, Girgis S, Stover PJ. Purification and properties of a folate-catabolizing enzyme. J Biol Chem 2000;275:35646-55.
60. Kownacki-Brown PA, Wang C, Bailey LB, Toth JP, Gregory JF III. Urinary excretion of deuterium-labeled folate and the metabolite p-aminobenzoylglutamate in humans. J Nutr 1993;123:1101-8.