-
1
-
-
0026555576
-
The effect of adjuvant tamoxifen - The latest results from the cancer-research-campaign adjuvant breast trial
-
Riley, D., Baum, M., Macintyre, J. et al. (1992) The effect of adjuvant tamoxifen - the latest results from the cancer-research-campaign adjuvant breast trial. Eur. J. Cancer, 28A, 904-907.
-
(1992)
Eur. J. Cancer
, vol.28 A
, pp. 904-907
-
-
Riley, D.1
Baum, M.2
Macintyre, J.3
-
2
-
-
0026445256
-
The case for clinical trials of tamoxifen for prevention of breast cancer
-
Powles, T.J. (1992) The case for clinical trials of tamoxifen for prevention of breast cancer. Lancet, 340, 1145-1147.
-
(1992)
Lancet
, vol.340
, pp. 1145-1147
-
-
Powles, T.J.1
-
3
-
-
0028899660
-
Tamoxifen induces short-term cumulative DNA damage and liver tumors in rats: Promotion by phenobarbital
-
Carthew, R. Martin, E.A., White, I.N.H., De Matteis, R. Edwards, R.E., Dorman, B.M., Heydon, R.T. and Smith, L.L. (1995) Tamoxifen induces short-term cumulative DNA damage and liver tumors in rats: Promotion by phenobarbital. Cancer Res., 55, 544-547.
-
(1995)
Cancer Res.
, vol.55
, pp. 544-547
-
-
Carthew, P.1
Martin, E.A.2
White, I.N.H.3
De Matteis, F.4
Edwards, R.E.5
Dorman, B.M.6
Heydon, R.T.7
Smith, L.L.8
-
4
-
-
0027308685
-
The triphenylethylene drug tamoxifen is a strong liver carcinogen in the rat
-
Williams, G.M. Iatropoulos, M.J., Djordjevic, M.V. and Kaltenberg, O.P. (1993) The triphenylethylene drug tamoxifen is a strong liver carcinogen in the rat. Carcinogenesis, 14, 315-317.
-
(1993)
Carcinogenesis
, vol.14
, pp. 315-317
-
-
Williams, G.M.1
Iatropoulos, M.J.2
Djordjevic, M.V.3
Kaltenberg, O.P.4
-
5
-
-
0027201501
-
Two-year carcinogenicity study of tamoxifen in Alderly Park Wistar-derived rats
-
Greaves, P., Goonetilleke, R., Nunn, G., Topham, J. and Orton, T (1993) Two-year carcinogenicity study of tamoxifen in Alderly Park Wistar-derived rats. Cancer Res., 53, 3919-3924.
-
(1993)
Cancer Res.
, vol.53
, pp. 3919-3924
-
-
Greaves, P.1
Goonetilleke, R.2
Nunn, G.3
Topham, J.4
Orton, T.5
-
6
-
-
0027397629
-
Tamoxifen induces hepatocellular carcinoma in rat liver - A 1-year study with 2 antiestrogens
-
Hirsimaki, P., Hirsimaki, Y., Nieminen, L. and Payne, B.J. (1993) Tamoxifen induces hepatocellular carcinoma in rat liver - a 1-year study with 2 antiestrogens. Arch. Toxicol., 67, 49-54.
-
(1993)
Arch. Toxicol.
, vol.67
, pp. 49-54
-
-
Hirsimaki, P.1
Hirsimaki, Y.2
Nieminen, L.3
Payne, B.J.4
-
7
-
-
0029052183
-
32P-post-labelling in three rat stains exposed to dietary tamoxifen: The relationship between cell proliferation and liver tumour formation
-
32P-post-labelling in three rat stains exposed to dietary tamoxifen: the relationship between cell proliferation and liver tumour formation. Carcinogenesis, 16, 1299-1304.
-
(1995)
Carcinogenesis
, vol.16
, pp. 1299-1304
-
-
Carthew, P.1
Rich, K.J.2
Martin, E.A.3
De Matteis, F.4
Lim, C.K.5
Manson, M.M.6
Festing, M.7
White, I.N.H.8
Smith, L.L.9
-
8
-
-
0030578894
-
The role of cell death and cell proliferation in the promotion of rat liver tumours by tamoxifen
-
Carthew, P., Nolan, B.M., Edwards, R.E. and Smith, L.L. (1996) The role of cell death and cell proliferation in the promotion of rat liver tumours by tamoxifen. Cancer Lett., 106, 163-169.
-
(1996)
Cancer Lett.
, vol.106
, pp. 163-169
-
-
Carthew, P.1
Nolan, B.M.2
Edwards, R.E.3
Smith, L.L.4
-
9
-
-
0000151348
-
Tamoxifen
-
Laurence, D.R., McLean, A.E.M. and Weatherall, M (eds) Academic Press, New York
-
Tucker, M.J., Adams, H.K. and Patterson, J.S. (1984) Tamoxifen. In Laurence, D.R., McLean, A.E.M. and Weatherall, M (eds) Safety Testing of New Drugs. Academic Press, New York, pp. 125-161.
-
(1984)
Safety Testing of New Drugs
, pp. 125-161
-
-
Tucker, M.J.1
Adams, H.K.2
Patterson, J.S.3
-
10
-
-
0027054733
-
Genotoxic potential of tamoxifen and analogues in female Fischer F344/N rats, DBA/2 and C57BL/6 mice and in human MCL-5 cells
-
White, I.N.H., De Matteis, F., Davies, A., Smith, L.L., Crofton Sleigh, C., Venitt, S., Hewer, A. and Phillips, D.H. (1992) Genotoxic potential of tamoxifen and analogues in female Fischer F344/N rats, DBA/2 and C57BL/6 mice and in human MCL-5 cells. Carcinogenesis, 13, 2197-2203.
-
(1992)
Carcinogenesis
, vol.13
, pp. 2197-2203
-
-
White, I.N.H.1
De Matteis, F.2
Davies, A.3
Smith, L.L.4
Crofton Sleigh, C.5
Venitt, S.6
Hewer, A.7
Phillips, D.H.8
-
11
-
-
0028226088
-
Strong intensification of mouse hepatic tamoxifen DNA adduct formation by pretreatment with the sulfotransferase inhibitor and ubiquitous environmental pollutant pentachlorophenol
-
Randerath, K., Bi, J., Mabon, N., Sriram, P. and Moorthy, B. (1994) Strong intensification of mouse hepatic tamoxifen DNA adduct formation by pretreatment with the sulfotransferase inhibitor and ubiquitous environmental pollutant pentachlorophenol. Carcinogenesis, 15, 797-800.
-
(1994)
Carcinogenesis
, vol.15
, pp. 797-800
-
-
Randerath, K.1
Bi, J.2
Mabon, N.3
Sriram, P.4
Moorthy, B.5
-
12
-
-
0028172454
-
32P-postlabeling and use of metabolic inhibitors for two distinct pathways leading to mouse hepatic DNa adduct formation and identification of 4-hydroxytamoxifen as a proximate metabolite
-
32P-postlabeling and use of metabolic inhibitors for two distinct pathways leading to mouse hepatic DNA adduct formation and identification of 4-hydroxytamoxifen as a proximate metabolite. Carcinogenesis, 15, 2089-2094.
-
(1994)
Carcinogenesis
, vol.15
, pp. 2089-2094
-
-
Randerath, K.1
Moorthy, B.2
Mabon, N.3
Sriram, P.4
-
13
-
-
0027742939
-
High performance liquid chromatography of tamoxifen and metabolites in plasma and tissues
-
Lim, C.K., Chow, L.C.L., Yuan, Z.X. and Smith, L.L. (1993) High performance liquid chromatography of tamoxifen and metabolites in plasma and tissues. Biomed. Chromatog., 7, 311-314.
-
(1993)
Biomed. Chromatog.
, vol.7
, pp. 311-314
-
-
Lim, C.K.1
Chow, L.C.L.2
Yuan, Z.X.3
Smith, L.L.4
-
14
-
-
0000530035
-
Non-random binding of the carcinogen N-hydroxy-2-acetylaminofluorene to repetitive sequences of rat liver DNA in vivo
-
Gupta, R.C. (1984) Non-random binding of the carcinogen N-hydroxy-2-acetylaminofluorene to repetitive sequences of rat liver DNA in vivo. Proc. Natl Acad. Sci. USA, 81, 6943-6947.
-
(1984)
Proc. Natl Acad. Sci. USA
, vol.81
, pp. 6943-6947
-
-
Gupta, R.C.1
-
15
-
-
0027347175
-
Studies on DNa adduction with heterocyclic amines by accelerator mass spectrometry: A new technique for tracing isotope-labelled DNa adduction
-
Phillips, D.H., Castegnaro, M. and Bartsch, H. (eds) IARC, Lyon, France
-
Turteltaub, K.W., Vogel, J.S., Frantz, C.E. and Fultz, F. (1993) Studies on DNA adduction with heterocyclic amines by accelerator mass spectrometry: a new technique for tracing isotope-labelled DNA adduction. In Phillips, D.H., Castegnaro, M. and Bartsch, H. (eds) Postlabeling Methods for Detection of DNA Adducts. IARC, Lyon, France, pp. 293-301.
-
(1993)
Postlabeling Methods for Detection of DNA Adducts
, pp. 293-301
-
-
Turteltaub, K.W.1
Vogel, J.S.2
Frantz, C.E.3
Fultz, F.4
-
16
-
-
0026064491
-
Metabolites, pharmacodynamics and pharmacokinetics of tamoxifen in rats and mice compared to the breast cancer patient
-
Robinson, S.P. Langan-Fahey, L., Johnson, D.A. and Jordan, V.C. (1991) Metabolites, pharmacodynamics and pharmacokinetics of tamoxifen in rats and mice compared to the breast cancer patient. Drug Metab. Dispos., 19, 36-43.
-
(1991)
Drug Metab. Dispos.
, vol.19
, pp. 36-43
-
-
Robinson, S.P.1
Langan-Fahey, L.2
Johnson, D.A.3
Jordan, V.C.4
-
17
-
-
0028177045
-
A comparative study of tamoxifen metabolism in female rat, mouse and human liver microsomes
-
Lim, C.K., Yuan, Z., Lamb, J.H., White, I.N.H., De Matteis, F. and Smith, L.L. (1994) A comparative study of tamoxifen metabolism in female rat, mouse and human liver microsomes. Carcinogenesis, 15, 589-593.
-
(1994)
Carcinogenesis
, vol.15
, pp. 589-593
-
-
Lim, C.K.1
Yuan, Z.2
Lamb, J.H.3
White, I.N.H.4
De Matteis, F.5
Smith, L.L.6
-
18
-
-
0015763703
-
The metabolism of Tamoxifen *(ICI 46,476) Part I: In laboratory animals
-
Fromson, J.M., Pearson, S. and Bramah, S. (1973) The metabolism of Tamoxifen *(ICI 46,476) Part I: in laboratory animals. Xenobiotica, 3, 693-703.
-
(1973)
Xenobiotica
, vol.3
, pp. 693-703
-
-
Fromson, J.M.1
Pearson, S.2
Bramah, S.3
-
19
-
-
0025363917
-
Metabolism of tamoxifen by isolated rat hepatocytes. Identification of the glucuronide of 4-hydroxytamoxifen
-
McCague, R., Parr, I.B., Leclercq, G., Leung, O.T. and Jarman, M. (1990) Metabolism of tamoxifen by isolated rat hepatocytes. Identification of the glucuronide of 4-hydroxytamoxifen. Biochem. Pharmacol., 39, 1459-1465.
-
(1990)
Biochem. Pharmacol.
, vol.39
, pp. 1459-1465
-
-
McCague, R.1
Parr, I.B.2
Leclercq, G.3
Leung, O.T.4
Jarman, M.5
-
20
-
-
74049104736
-
Toremifene, unlike tamoxifen, is not genotoxic in rat liver
-
Martin, E.A., Turteltaub, K.W., Mauthe, R., White, I.N.H., Styles, JA. and Smith, L.L. (1996) Toremifene, unlike tamoxifen, is not genotoxic in rat liver. Toxicologist, 30, 233.
-
(1996)
Toxicologist
, vol.30
, pp. 233
-
-
Martin, E.A.1
Turteltaub, K.W.2
Mauthe, R.3
White, I.N.H.4
Styles, J.A.5
Smith, L.L.6
-
21
-
-
21544449310
-
Increased clearance of tamoxifen and its metabolites in rat liver correlates with an increased expression of P-glycoprotein
-
Smith, L.L., White, I.N.H. and Gant, T.W. (1994) Increased clearance of tamoxifen and its metabolites in rat liver correlates with an increased expression of P-glycoprotein. Toxicologist, 14, 403.
-
(1994)
Toxicologist
, vol.14
, pp. 403
-
-
Smith, L.L.1
White, I.N.H.2
Gant, T.W.3
-
22
-
-
0029985407
-
Activation of tamoxifen and its metabolite α-hydroxytamoxifen to DNA binding products: Comparisons between human, rat and mouse hepatocytes
-
Phillips, D.H., Carmichael, P.L., Hewer, A., Cole, K.J., Hardcastle, I.R., Poon, G.K., Keogh, A. and Strain, A.J. (1996) Activation of tamoxifen and its metabolite α-hydroxytamoxifen to DNA binding products: comparisons between human, rat and mouse hepatocytes. Carcinogenesis, 17, 89-94.
-
(1996)
Carcinogenesis
, vol.17
, pp. 89-94
-
-
Phillips, D.H.1
Carmichael, P.L.2
Hewer, A.3
Cole, K.J.4
Hardcastle, I.R.5
Poon, G.K.6
Keogh, A.7
Strain, A.J.8
-
23
-
-
0031054835
-
Identification of tamoxifen-DNA adducts formed by α-sulfate tamoxifen and α-acetoxytamoxifen
-
Dasardhi, L. and Shibutani, S. (1997) Identification of tamoxifen-DNA adducts formed by α-sulfate tamoxifen and α-acetoxytamoxifen. Chem. Res. Toxicol., 10, 189-196.
-
(1997)
Chem. Res. Toxicol.
, vol.10
, pp. 189-196
-
-
Dasardhi, L.1
Shibutani, S.2
-
24
-
-
0031427032
-
Minor products of reaction of DNA with α-acetoxytamoxifen
-
Osborne, M.R., Hardcastle, I.R. and Phillips, D.H. (1997) Minor products of reaction of DNA with α-acetoxytamoxifen. Carcinogenesis, 18, 539-543.
-
(1997)
Carcinogenesis
, vol.18
, pp. 539-543
-
-
Osborne, M.R.1
Hardcastle, I.R.2
Phillips, D.H.3
-
25
-
-
0030069966
-
Tamoxifen metabolic activation: Comparison of DNA adducts formed by microsomal and chemical activation of tamoxifen and 4-hydroxytamoxifen with DNA adducts formed in vivo
-
Moorthy, B., Sriram, P., Pathak, D.N., Bodell, W.J. and Randerath, K. (1996) Tamoxifen metabolic activation: Comparison of DNA adducts formed by microsomal and chemical activation of tamoxifen and 4-hydroxytamoxifen with DNA adducts formed in vivo. Cancer Res., 56, 53-57.
-
(1996)
Cancer Res.
, vol.56
, pp. 53-57
-
-
Moorthy, B.1
Sriram, P.2
Pathak, D.N.3
Bodell, W.J.4
Randerath, K.5
-
26
-
-
0026788021
-
Molecular dosimetry of ethylene oxide: Formation and persistence of 7-(2-hydroxyethyl)guanine in DNA following repeated exposures of rats and mice
-
Walker, V.E., Fennell, T.R., Upton, P.B., Skopek, T.R., Prevost, V., Shuker, D.E.G. and Swenberg, J.A. (1992) Molecular dosimetry of ethylene oxide: formation and persistence of 7-(2-hydroxyethyl)guanine in DNA following repeated exposures of rats and mice. Cancer Res., 52, 4328-1334.
-
(1992)
Cancer Res.
, vol.52
, pp. 4328-11334
-
-
Walker, V.E.1
Fennell, T.R.2
Upton, P.B.3
Skopek, T.R.4
Prevost, V.5
Shuker, D.E.G.6
Swenberg, J.A.7
-
28
-
-
0028979270
-
32P-postlabelled DNA-adducts in liver obtained from women treated with tamoxifen
-
32P-postlabelled DNA-adducts in liver obtained from women treated with tamoxifen. Carcinogenesis, 16, 1651-1654.
-
(1995)
Carcinogenesis
, vol.16
, pp. 1651-1654
-
-
Martin, E.A.1
Rich, K.J.2
White, I.N.H.3
Woods, K.L.4
Powles, T.J.5
Smith, L.L.6
-
29
-
-
0029978834
-
Lack of genotoxicity of tamoxifen in human endometrium
-
Carmichael, P.L., Ugwumadu, A.H.N., Neven, P., Hewer, A. J., Poon, G.K. and Phillips, D.H. (1996) Lack of genotoxicity of tamoxifen in human endometrium. Cancer Res., 56, 1475-1479.
-
(1996)
Cancer Res.
, vol.56
, pp. 1475-1479
-
-
Carmichael, P.L.1
Ugwumadu, A.H.N.2
Neven, P.3
Hewer, A.J.4
Poon, G.K.5
Phillips, D.H.6
-
30
-
-
0029745072
-
Tamoxifen-induced DNA adducts in endometrial samples from breast cancer patients
-
Hemminki, K., Rajaniemi, H., Lindahl, B. and Moberger, B. (1996) Tamoxifen-induced DNA adducts in endometrial samples from breast cancer patients. Cancer Res., 56, 4374-4377.
-
(1996)
Cancer Res.
, vol.56
, pp. 4374-4377
-
-
Hemminki, K.1
Rajaniemi, H.2
Lindahl, B.3
Moberger, B.4
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