Dual isotope test for assessing β-carotene cleavage to vitamin A in humans

European Journal of Nutrition

Volumn 41, Issue 4, 2002, Pages 141-147

  Hickenbottom, Sabrina J ^a   Lemke, Shawna L ^a   Dueker, Stephen R ^a   Lin, Yumei ^a   Follett, Jennifer R ^a   Carkeet, Colleen ^a   Buchholz, Bruce A ^b   Vogel, John S ^b   Clifford, Andrew J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b LAWRENCE LIVERMORE NATIONAL LABORATORY   (United States)

Author keywords

carotene; AMS; Carbon 14; Human; Stable isotope; Vitamin A

Indexed keywords

BETA CAROTENE; RETINOL ACETATE; STABLE ISOTOPE;

ABSORPTION; ADULT; ARTICLE; BIOACCUMULATION; BIOAVAILABILITY; CASE REPORT; DEGRADATION; DOSE RESPONSE; FECES ANALYSIS; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALE; MASS SPECTROMETRY; MOLECULAR STABILITY; URINALYSIS; URINARY EXCRETION; VITAMIN BLOOD LEVEL;

ADULT; BETA CAROTENE; BIOLOGICAL AVAILABILITY; CARBON RADIOISOTOPES; DEUTERIUM; FECES; HUMANS; KINETICS; MALE; VITAMIN A;

EID: 0036933508     PISSN: 14366207     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00394-002-0368-0     Document Type: Article

References (37)

1. Edwards A, Nguyen C, You C, et al. (2002) Alpha- and beta-carotene from a commercial puree are more bioavailable to humans than from boiled-mashed carrots, as determined using an extrinsic stable isotope reference method. J Nutr 132:159-167
2. De Pee S, West CE, Permaesih D, et al. (1998) Orange fruit is more effective than are dark-green, leafy vegetables in increasing serum concentrations of retinol and beta-carotene in school-children in Indonesia. Am J Clin Nutr 68:1058-1067
3. Borel P, Tyssandier V, Mekki N, et al. (1998) Chylomicron beta-carotene and retinyl palmitate responses are dramatically diminished when men ingest beta-carotene with medium-chain rather than long-chain triglycerides. J Nutr 128:1361-1367
4. Hu X, Jandacek RJ, White WS (2000) Intestinal absorption of beta-carotene ingested with a meal rich in sunflower oil or beef tallow: postprandial appearance in triacylglycerol-rich lipoproteins in women. Am J Clin Nutr 71:1170-1180
5. Sommer A, West KP (1996) Vitamin A deficiency: Health, Survival, and Vision, Oxford University Press, New York, pp xiii, 438, [8] of plates
6. Ribaya-Mercado JD, Solon FS, Solon MA, et al. (2000) Bioconversion of plant carotenoids to vitamin A in Filipino school-aged children varies inversely with vitamin A status. Am J Clin Nutr 72:455-465
7. White WS, Stacewicz-Sapuntzakis M, Erdman JW Jr, et al. (1994) Pharmacokinetics of beta-carotene and canthaxanthin after ingestion of individual and combined doses by human subjects. J Am Coll Nutr 13:665-671
8. Kostic D, White WS, Olson JA (1995) Intestinal absorption, serum clearance, and interaction between lutein and beta-carotene when administered to human adults in separate or combined oral doses. Am J Clin Nutr 62:604-610
9. Tyssandier V, Cardinault N, Caris-Veyrat C, et al. (2002) Vegetable-borne lutein, lycopene, and β-carotene compete for incorporation into chylomicrons, with no adverse effect on the medium-term (3-wk) plasma status of carotenoids in humans. Am J Clin Nutr 75:526-534
10. von Lintig J, Vogt K (2000) Filling the gap in vitamin A research: molecular identification of an enzyme cleaving β-carotene to retinal. J Bio Chem 275:11915-11920
11. Wyss A, Wirtz G, Woggon WD, et al. (2000) Cloning and expression of b,β-carotene 15,15′-dioxygenase. Biochem Biophys Res Commun 271:334-336
12. Ahmed F (1999) Vitamin A deficiency in Bangladesh: a review and recommendations for improvement. Public Health Nutr 2:1-14
13. De Pee S, West CE (1996) Dietary carotenoids and their role in combating vitamin A deficiency: a review of the literature. Eur J Clin Nutr 50:S38-S53
14. Blomstrand R, Werner B (1967) Studies on the intestinal absorption of radioactive beta-carotene and vitamin A in man. Conversion of beta-carotene into vitamin A. Scand J Clin Lab Invest 19:339-345
15. Goodman DS, Blomstrand R, Werner B, et al. (1966) The intestinal absorption and metabolism of vitamin A and beta-carotene in man. J Clin Invest 45:1615-1623
16. Sauberlich HE, Hodges RE, Wallace DL, et al. (1974) Vitamin A metabolism and requirements in the human studied with the use of labeled retinol. Vitam Horm 32:251-275
17. 13C] carotene using high-precision isotope ratio mass spectrometry. Methods Enzymol 282:130-140
18. van Lieshout M, West CE, Muhilal, et al. (2001) Bioefficacy of β-carotene dissolved in oil studied in children in Indonesia. Am J Clin Nutr 73:949-958
19. Dueker SR, Lin Y, Buchholz BA, et al. (2000) Long-term kinetic study of beta-carotene, using accelerator mass spectrometry in an adult volunteer. J Lipid Res 41:1790-1800
20. Tang G, Qin J, Dolnikowski GG, et al. (2000) Vitamin A equivalence of beta-carotene in a woman as determined by a stable isotope reference method. Eur J Nutr 39:7-11
21. Lin Y, Dueker SR, Burri BJ, et al. (2000) Variability of the conversion of beta-carotene to vitamin A in women measured by using a double-tracer study design. Am J Clin Nutr 71:1545-1554
22. Hickenbottom SJ, Lin Y, et al. (2002) Variability of the conversion of β-carotene to vitamin A in men measured by using a double-tracer study design. Am J Clin Nutr 75:900-907
23. Novotny JA, Britz S, Pawlosky RJ, et al. (2001) Absorption of beta-carotene from carbon-13 labeled kale. FASEB J 15:A954
24. Handelman GJ, Haskell MJ, Jones AD, et al. (1993) An improved protocol for determining ratios of retinol-d4 to retinol isolated from human plasma. Anal Chem 65:2024-2028
25. 4)retinyl acetate in human subjects with estimated low or high total body stores of vitamin A. Am J Clin Nutr 68:90-95
26. Vogel JS, Turteltaub KW, Finkel R, et al. (1995) Accelerator mass spectrometry: isotope quantification at attomole sensitivity. Anal Chem 67:353A-359A
27. Vogel JS, Turteltaub KW (1998) Accelerator mass spectrometry as a bioanalytical tool in nutrition research. In: Clifford AJ, Muller H-G (eds) Mathematical Modeling in Experimental Nutrition. Plenum Press, New York, pp 397-410
28. Dueker SR, Jones AD, Clifford AJ (1998) Protocol development for biological tracer studies. In: Clifford AJ, Muller H-G (eds) Mathematical Modeling in Experimental Nutrition. Plenum Press, New York, pp 363-378
29. nd edn, Academic Press, London; New York, p 2
30. 14C-folic acid. In: Clifford AJ, Müller H-G (eds) Mathematical Modeling in Experimental Nutrition. Plenum Press, New York, pp 239-252
31. Olson JA (1986) Physiological and metabolic basis of major signs of vitamin A deficiency. In: Bauernfeind JC (ed) Vitamin A Deficiency and its Control. Academic Press, Orlando, FL, pp 19-67
32. Furr HC, Clark RM (1997) Intestinal absorption and tissue distribution of carotenoids. J Nutr Biochem 8:364-377
33. van Vliet T, Schreurs W, van den Berg H (1995) Intestinal beta-carotene absorption and cleavage in men: response of beta-carotene and retinyl esters in the triglyceride-rich lipoprotein fraction after a single oral dose of beta-carotene. Am J Clin Nutr 62:110-116
34. During A, Nagao A, Hoshino C, et al. (1996) Assay of beta-carotene 15,15′-dioxygenase activity by reverse-phase high-pressure liquid chromatography. Anal Biochem 241:199-205
35. Novotny JA, Zech LA, Furr HC, et al. (1996) Mathematical modeling in nutrition: constructing a physiologic compartmental model of the dynamics of β-carotene metabolism. In: Coburn S, Townsend D (eds) Advances in Food and Nutrition Research, Vol. 40. Academic Press, Inc., San Diego, CA
36. Borel P, Grolier P, Mekki N, et al. (1998) Low and high responses to pharmacological doses of beta-carotene: proportion in the population, mechanisms involved and consequences on beta-carotene metabolism. J Lipid Res 39:2250-2260
37. van Vliet T, Schreurs W, van den Berg H (1995) Intestinal beta-carotene absorption and cleavage in men: response of beta-carotene and retinyl esters in the triglyceride-rich lipoprotein fraction after a single oral dose of beta-carotene. Am J Clin Nutr 62:110-116