Synthesis and evaluation of azole-substituted tetrahydronaphthalenes as inhibitors of P450 arom, P450 17, and P450 TxA2

Archiv der Pharmazie

Volumn 329, Issue 5, 1996, Pages 251-261

  Hartmann, Rolf W ^a   Frotscher, Martin ^a   Ledergerber, Dorothea ^a   Wächter, Gerald A ^a   Grün, Gertrud L ^a   Sergejew, Tom F ^a,b  

^a SAARLAND UNIVERSITY   (Germany)

^b CIBA GEIGY LTD   (Switzerland)

Author keywords

17 hydroxylase C17,20 lyase (P450 17) inhibitors; antimetastatics; antitumor drugs; aromatase (P450 arom) inhibitors; azole substituted; tetrahydronaphthalenes; thromboxane A2 synthase (P450 TxA2) inhibitors

Indexed keywords

ALDOSTERONE; AMINOGLUTETHIMIDE; ANDROSTENEDIONE; ANTINEOPLASTIC AGENT; AROMATASE; CORTICOSTERONE; CYTOCHROME P450; DAZOXIBEN; ENZYME INHIBITOR; ESTRADIOL; FADROZOLE; IMIDAZOLE DERIVATIVE; KETOCONAZOLE; TESTOSTERONE PROPIONATE; TETRALIN DERIVATIVE; THROMBOXANE SYNTHASE;

ADRENAL GLAND; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BLOOD; CATTLE; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN TISSUE; NONHUMAN; ORAL DRUG ADMINISTRATION; PLACENTA; PRIORITY JOURNAL; RAT; REACTION ANALYSIS; STEROIDOGENESIS; STRUCTURE ACTIVITY RELATION; SUBCUTANEOUS DRUG ADMINISTRATION; TESTIS; UTERUS WEIGHT;

ANIMALS; AZOLES; CATTLE; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; HUMANS; MALE; RATS; RATS, SPRAGUE-DAWLEY; TETRAHYDRONAPHTHALENES; TUMOR CELLS, CULTURED;

EID: 0030006607     PISSN: 03656233     EISSN: None     Source Type: Journal    
DOI: 10.1002/ardp.19963290506     Document Type: Article

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