C17,20-lyase inhibitors. Part 2: Design, synthesis and structure-activity relationships of (2-naphthylmethyl)-1H-imidazoles as novel C17,20-lyase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 16, 2004, Pages 4313-4336

  Matsunaga, Nobuyuki ^a   Kaku, Tomohiro ^a   Ojida, Akio ^a   Tanaka, Toshimasa ^a   Hara, Takahito ^b   Yamaoka, Masuo ^b   Kusaka, Masami ^b   Tasaka, Akihiro ^a  

^a Med Chemistry Research Laboratories   (Japan)

^b Pharmacol Research Laboratories   (Japan)

Author keywords

11 Hydroxylase; Androgen; C17,20 lyase; Testosterone

Indexed keywords

ANTINEOPLASTIC AGENT; HYDROXYL GROUP; IMIDAZOLE DERIVATIVE; NAPHTHYL GROUP; PROPANE; STEROID 11BETA MONOOXYGENASE; STEROID 17,20 LYASE; STEROID 17,20 LYASE INHIBITOR; UNCLASSIFIED DRUG; ENZYME INHIBITOR; LYASE; TESTOSTERONE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; INFORMED CONSENT; ISOMERISM; LIVER WEIGHT; NONHUMAN; PROSTATE; RAT; SEMINAL VESICLE; TESTOSTERONE SYNTHESIS; ANIMAL; BIOSYNTHESIS; CHEMICAL MODEL; CHEMISTRY; DRUG ANTAGONISM; LIVER; MALE; PROSTATE TUMOR; PROTEIN BINDING; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; ENZYME INHIBITORS; HUMANS; IMIDAZOLES; LIVER; LYASES; MALE; MODELS, CHEMICAL; PROSTATE; PROSTATIC NEOPLASMS; PROTEIN BINDING; RATS; SEMINAL VESICLES; STRUCTURE-ACTIVITY RELATIONSHIP; TESTOSTERONE;

EID: 3242754330     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.06.016     Document Type: Article

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