Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium

Human Molecular Genetics

Volumn 8, Issue 4, 1999, Pages 575-583

  Chang, Jinghua T ^a   Esumi, Noriko ^a   Moore, Kathryn ^c   Li, Yuanyuan ^a   Zhang, Suiyuan ^a   Chew, Christina ^a   Goodman, Barbara ^b   Rattner, Amir ^b   Moody, Sally ^c   Stetten, Gail ^b   Campochiaro, Peter A ^a,b   Zack, Donald J ^a,b  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; SECRETORY PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHROMOSOME 10Q; CHROMOSOME 4Q; CONTROLLED STUDY; EMBRYO; EMBRYO AXIS; EXON; GENE MAPPING; MOLECULAR CLONING; NONHUMAN; PANCREAS; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TISSUE SPECIFICITY; XENOPUS;

ANIMALIA; INSECTA; VERTEBRATA;

EID: 0032998688     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/8.4.575     Document Type: Article

References (58)

1. Cadigan, K.M. and Nusse, R. (1997) Wnt signaling: a common theme in animal development. Genes Dev., 11, 3286-3305.
2. Dale, T.C. (1998) Signal transduction by the Wnt family of ligands. Biochem. J., 329, 209-223.
3. Moon, R.T., Brown, J.D. and Torres, M. (1997) WNTs modulate cell fate and behavior during vertebrate development. Trends Genet., 13, 157-162.
4. Bhanot, P., Brink, M., Samos, C.H., Hsieh, J.C., Wang, Y., Macke, J.P., Andrew, D., Nathans, J. and Nusse, R. (1996) A new member of the frizzled family from Drosophila functions as a Wingless receptor. Nature, 382, 225-230.
5. Yang-Snyder, J., Miller, J.R., Brown, J.D., Lai, C.J. and Moon, R.T. (1996) A frizzled homolog functions in a vertebrate Wnt signaling pathway. Curr. Biol., 6, 1302-1306.
6. He, X., Saint-Jeannet, J.P., Wang, Y., Nathans, J., Dawid, I. and Varmus, H. (1997) A member of the Frizzled protein family mediating axis induction by Wnt-5A. Science, 275, 1652-1654.
7. Gubb, D. and Garcia-Bellido, A. (1982) A genetic analysis of the determination of cuticular polarity during development in Drosophila melanogaster. J. Embryol. Exp. Morphol., 68, 37-57.
8. Vinson, C.R. and Adler, P.N. (1987) Directional non-cell autonomy and the transmission of polarity information by the frizzled gene of Drosophila. Nature, 329, 549-551.
9. Chan, S.D., Karpf, D.B., Fowlkes, M.E., Hooks, M., Bradley, M.S., Vuong, V., Bambino, T, Liu, M.Y., Arnaud, C.D., Strewler, G.J. et al. (1992) Two homologs of the Drosophila polarity gene frizzled (fz) are widely expressed in mammalian tissues. J. Biol. Chem., 267, 25202-25207.
10. Wang, Y., Macke, J.P., Abella, B.S., Andreasson, K., Worley, P., Gilbert, D.J., Copeland, N.G., Jenkins, N.A. and Nathans, J. (1996) A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. J. Biol. Chem., 271, 4468-4476.
11. Sawa, H., Lobel, L. and Horvitz, H.R. (1996) The Caenorhabditis elegans gene lin-17, which is required for certain asymmetric cell divisions, encodes a putative seven-transmembrane protein similar to the Drosophila frizzled protein. Genes Dev., 10, 2189-2197.
12. Nusse, R. and Varmus, H.E. (1992) Wnt genes. Cell, 69, 1073-1087.
13. Du, S.J., Purcell, S.M., Christian, J.L., McGrew, L.L. and Moon, R.T. (1995) Identification of distinct classes and functional domains of Wnts through expression of wild-type and chimeric proteins in Xenopus embryos. Mol. Cell. Biol., 15, 2625-2634.
14. Torres, M.A., Yang-Snyder, J.A., Purcell, S.M., DeMarais, A.A., McGrew, L.L. and Moon, R.T. (1996) Activities of the Wnt-1 class of secreted signaling factors are antagonized by the Wnt-5A class and by a dominant negative cadherin in early Xenopus development. J. Cell Biol., 133, 1123-1137.
15. Rattner, A., Hsieh, J.C., Smallwood, P.M., Gilbert, D.J., Copeland, N.G., Jenkins, N.A. and Nathans, J. (1997) A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors. Proc. Natl Acad. Sci. USA, 94, 2859-2863.
16. Leyns, L., Bouwmeester, T., Kim, S.H., Piccolo, S. and De Robertis, E.M. (1997) Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer. Cell, 88, 747-756.
17. Wang, S., Krinks, M., Lin, K., Luyten, P.P. and Moos, M. Jr (1997) Frzb, a secreted protein expressed in the Spemann organizer, binds and inhibits Wnt-8. Cell, 88, 757-766.
18. Moon, R.T., Brown, J.D., Yang-Snyder, J.A. and Miller, J.R. (1997) Structurally related receptors and antagonists compete for secreted Wnt ligands. Cell, 88, 725-728.
19. Mayr, T., Deutsch, U., Kuhl, M., Drexler, H.C., Lottspeich, F., Deutzmann, R., Wedlich, D. and Risau, W. (1997) Fritz: a secreted frizzled-related protein that inhibits Wnt activity. Mech. Dev., 63, 109-125.
20. Wolf, V., Ke, G., Dharmarajan, A.M., Bielke, W., Artuso, L., Saurer, S. and Friis, R. (1997) DDC-4, an apoptosis-associated gene, is a secreted frizzled relative. FEBS Lett., 417, 385-389.
21. Melkonyan, H.S., Chang, W.C., Shapiro, J.P., Mahadevappa, M., Fitzpatrick, P.A., Kiefer, M.C., Tomei, L.D. and Umansky, S.R. (1997) SARPs: a family of secreted apoptosis-related proteins. Proc. Natl Acad. Sci. USA, 94, 13636-13641.
22. Salic, A.N., Kroll, K.L., Evans, L.M. and Kirschner, M.W. (1997) Sizzled: a secreted Xwnt8 antagonist expressed in the ventral marginal zone of Xenopus embryos. Development, 124, 4739-4748.
23. Hu, E., Zhu, Y., Fredrickson, T., Barnes, M., Kelsell, D., Beeley, L. and Brooks, D. (1998) Tissue restricted expression of two human frzbs in preadipocytes and pancreas. Biochem. Biophys. Res. Commun., 247, 287-293.
24. Lin, K., Wang, S., Julius, M.A., Kitajewski, J., Moos, M. Jr and Luyten, F.P. (1997) The cysteine-rich frizzled domain of Frzb-1 is required and sufficient for modulation of Wnt signaling. Proc. Natl Acad. Sci. USA, 94, 11196-11200.
25. Chang, J.T., Milligan, S., Li. Y., Chew, C.E., Wiggs, J., Capeland, N.G., Jenkins, N.A., Campochiaro, P.A., Hyde, D.R. and Zack, D.J. (1997) Mammalian homolog of Drosophila retinal degeneration B rescues the mutant fly phenotype. J. Neurosci., 17, 5881-5890.
26. Mount, S.M. (1982) A catalogue of splice junction sequences. Nucleic Acids Res., 10, 459-472.
27. Sokol, S., Christian, J.L., Moon, R.T. and Melton, D.A. (1991) Injected Wnt RNA induces a complete body axis in Xenopus embryos. Cell, 67, 741-752.
28. Hu, X. and Zuckerman, K.S. (1998) Cloning and sequencing of an alternative splicing-derived cDNA variantof the GM-CSF receptor alpha subunit, which encodes a truncated protein. Am. J. Hematol., 58, 145-147.
29. Dastot, F., Duquesnoy, P., Sobrier, M.L., Goossens, M. and Amselem, S. (1998) Evolutionary divergence of the truncated growth hormone receptor isoform in its ability to generate a soluble growth hormone binding protein. Mol. Cell. Endocrinol., 137, 79-84.
30. Hanneken, A. and Baird, A. (1995) Soluble forms of the high-affinity fibroblast growth factor receptor in human vitreous fluid. Invest. Ophthalmol. Vis. Sci., 36, 1192-1196.
31. Hardiman, G., Albright, S., Tsunoda, J., McClanahan, T. and Lee, F. (1996) The mouse Wnt-10B gene isolated from helper T cells is widely expressed and a possible oncogene in BR6 mouse mammary tumorigenesis. Gene, 172, 199-205.
32. Hardiman, G., Kastelein, R.A. and Bazan, J.F. (1997) Isolation, characterization and chromosomal localization of human WNT10B. Cytogenet. Cell Genet., 77, 278-282.
33. Young, R.W. (1984) Cell death during differentiation of the retina in the mouse. J. Comp. Neurol., 229, 362-373.
34. Penfold, P.L. and Provis, J.M. (1986) Cell death in the development of the human retina: phagocytosis of pyknotic and apoptotic bodies by retinal cells. Graefes Arch. Clin. Exp. Ophthalmol., 224, 549-553.
35. Chang, G.Q., Hao, Y. and Wong, F. (1993) Apoptosis: final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice. Neuron, 11, 595-605.
36. Portera-Cailliau, C., Sung, C.H., Nathans, J. and Adler, R. (1994) Apoptotic photoreceptor cell death in mouse models of retinitis pigmentosa. Proc. Natl Acad. Sci. USA, 91, 974-978.
37. Quigley, H.A., Nickells, R.W., Kerrigan, L.A., Pease, M.E., Thibault, D.J. and Zack, D.J. (1995) Retinal ganglion cell death in experimental glaucoma and after axotomy occurs by apoptosis. Invest. Ophthalmol. Vis. Sci., 36, 774-786.
38. Ahmed, Y., Hayashi, S., Levine, A. and Wieschaus, E. (1998) Regulation of armadillo by a Drosophila APC inhibits neuronal apoptosis during retinal development. Cell, 93, 1171-1182.
39. Traboulsi, E.I., Apostolides, J., Giardiello, F.M., Krush, A.J., Booker, S.V., Hamilton, S.R. and Hussels, I.E. (1996) Pigmented ocular fundus lesions and APC mutations in familial adenomatous polyposis. Ophthalmic Genet., 17, 167-174.
40. Reck, A.C., Bunyan, D., Eccles, D. and Humphry, R. (1997) The presence of congenital hypertrophy of the retinal pigment epithelium in a subgroup of patients with adenomatous polyposis coli mutations. Eye, 11, 298-300.
41. Marcus, D.M., Rustgi, A.K., Defoe, D., Brooks, S.E., McCormick, R.S., Thompson, T.P., Edelmann, W., Kucherlapati, R. and Smith, S. (1997) Retinal pigment epithelium abnormalities in mice with adenomatous polyposis coli gene disruption. Arch. Ophthalmol., 115, 645-650.
42. Lee, C.H.J., Delia, N.G., Chew, C.E. and Zack, D.J. (1996) Rin, a neuron-specific and calmodulin-binding small G-protein, and Rit define a novel subfamily of ras proteins. J. Neurosci., 16, 6784-6794.
43. Wehrli, M. and Tomlinson, A. (1998) Independent regulation of anterior/posterior and equatorial/polar polarity in the Drosophila eye; evidence for the involvement of Wnt signaling in the equatorial/polar axis. Development, 125, 1421-1432.
44. Heberlein, U., Borod, E.R. and Chanut, F.A. (1998) Dorsoventral patterning in the Drosophila retina by wingless. Development, 125, 567-577.
45. Sambrook, J., Fritsch, E.F. and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
46. Della, N.G., Campochiaro, P.A. and Zack, D.J. (1996) Localization of TIMP-3 mRNA expression to the retinal pigment epithelium. Invest. Ophthalmol. Vis. Sci., 37, 1921-1924.
47. Chomczynski, P. and Sacchi, N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162, 156-159.
48. Dunn, K.C., Aotaki-Keen, A.E., Putkey, F.R. and Hjelmeland, L.M. (1996) ARPE-19, a human retinal pigment epithelial cell line with differentiated properties. Exp. Eye Res., 62, 155-169.
49. Kigasawa, K., Soushi, S., Tanaka, Y. and Obazawa, H. (1994) Morphologic and chromosomal study of a human retinal pigment epithelial cell line. Jpn. J. Ophthalmol., 38, 10-15.
50. Pinkel, D., Straume, T. and Gray, J.W. (1986) Cytogenetic analysis using quantitative, high-sensitivity, fluorescence hybridization. Proc. Natl Acad. Sci. USA, 83, 2934-2938.
51. Yunis, J.J. (1976) High resolution of human chromosomes. Science, 191, 1268-1270.
52. Moody, S.A. (1987) Fates of the blastomeres of the 16-cell stage Xenopus embryo. Dev. Biol., 119, 560-578.
53. Jacobson, M. and Hirose, G. (1981) Clonal organization of the central nervous system of the frog. II. Clones stemming from individual blastomeres of the 32- and 64-cell stages. J. Neurosci., 1, 271-284.
54. Moody, S.A. (1987) Fates of the blastomeres of the 32-cell-stage Xenopus embryo. Dev. Biol., 122, 300-319.
55. Nieuwkoop, P.D. and Faber, J. (1994) Normal Table of Xenopus (Daudin). Garland Publishing, New York, NY.
56. Finch, P.W., He, X., Kelley, M.J., Uren, A., Schaudies, R.P., Popescu, N.C., Rudikoff, S., Aaronson, S.A., Varmus, H.E. and Rubin, J.S. (1997) Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. Proc. Natl Acad. Sci. USA, 94, 6770-6775.
57. Shirozu, M., Tada, H., Tashiro, K., Nakamura, T., Lopez, N.D., Nazarea, M., Hamada, T., Sato, T., Nakano, T. and Honjo, T. (1996) Characterization of novel secreted and membrane proteins isolated by the signal sequence trap method. Genomics, 37, 273-280.
58. Hoang, B., Moos, M. Jr, Vukicevic, S. and Luyten, F.P. (1996) Primary structure and tissue distribution of FRZB, a novel protein related to Drosophila frizzled, suggest a role in skeletal morphogenesis. J. Biol. Chem., 271, 26131-26137.