Medicinal chemistry of competitive kainate receptor antagonists

ACS Chemical Neuroscience

Volumn 2, Issue 2, 2011, Pages 60-74

  Larsen, Ann M ^a   Bunch, Lennart ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

competitive antagonists; Glutamate receptors; kainic acid receptors; medicinal chemistry; structureactivity relationship studies

Indexed keywords

2 [5 (4 DIMETHYLSULFAMOYLPHENYL) 6,7,8,9 TETRAHYDRO 8 METHYL 2 OXO 1H PYRROLO[3,2 H]ISOQUINOLIN 3 YLIMINOXY] 4 HYDROXYBUTYRIC ACID; 2,3 QUINOXALINEDIONE DERIVATIVE; 6 (4 CARBOXYBENZYL) 1,2,3,4,4A,5,6,7,8,8A DECAHYDRO 3 ISOQUINOLINECARBOXYLIC ACID; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; 6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; 6,7 DINITRO 2,3 QUINOXALINEDIONE; 6,7,8,9 TETRAHYDRO 5 NITROBENZ[G]INDOLE 2,3 DIONE 3 OXIME; BSF 84077; BSF 91594; GLUTAMATE RECEPTOR; IONOTROPIC RECEPTOR; ISOQUINOLINE DERIVATIVE; KAINIC ACID RECEPTOR; KAINIC ACID RECEPTOR ANTAGONIST; LU 115455; LU 136541; LU 97175; LY 2935558; LY 377770; LY 457691; LY 458545; LY 466195; NS 257; PHOSPHONIC ACID DERIVATIVE; TEZAMPANEL; UBP 282; UBP 296; UBP 302; UBP 304; UBP 310; UNCLASSIFIED DRUG; UNINDEXED DRUG;

DRUG ACTIVITY; DRUG STRUCTURE; EPILEPSY; HUMAN; LONG TERM POTENTIATION; MAJOR DEPRESSION; MOSSY FIBER; NERVE CELL PLASTICITY; NEUROPATHIC PAIN; NEUROPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; SCHIZOPHRENIA; STRUCTURE ACTIVITY RELATION;

COMPETITIVE ANTAGONISTS; GLUTAMATE RECEPTORS; KAINIC ACID RECEPTORS; MEDICINAL CHEMISTRY; STRUCTURE-ACTIVITY RELATIONSHIP STUDIES;

ANIMALS; BINDING, COMPETITIVE; CHEMISTRY, PHARMACEUTICAL; CRYSTALLOGRAPHY, X-RAY; HUMANS; QUINOXALINES; RECEPTORS, KAINIC ACID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79951828235     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn1001039     Document Type: Review

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