NS-257, a novel competitive AMPA receptor antagonist, interacts with kainate and NMDA receptors

Brain Research

Volumn 821, Issue 2, 1999, Pages 374-382

  Nijholt, Ingrid ^a   Blank, Thomas ^a   Grafelmann, Birgit ^a   Cepok, Sabine ^a   Kügler, Heidemarie ^a   Spiess, Joachim ^a  

^a MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

Author keywords

Concanavalin A; Cyclothiazide; Electrophysiology; Glutamate; Pharmacology; Xenopus oocyte

Indexed keywords

6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; AMPA RECEPTOR ANTAGONIST; CONCANAVALIN A; CYCLOTHIAZIDE; GLUTAMATE RECEPTOR; KAINIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NS 257; RECEPTOR SUBTYPE; SULFONAMIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; DRUG EFFECT; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SOLUBILITY; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BLOCKING;

ANIMALS; ANTIHYPERTENSIVE AGENTS; BENZOTHIADIAZINES; CONCANAVALIN A; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; INDOLES; KAINIC ACID; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; MICROINJECTIONS; N-METHYLASPARTATE; OOCYTES; PATCH-CLAMP TECHNIQUES; RECEPTORS, AMPA; RECEPTORS, KAINIC ACID; RECEPTORS, N-METHYL-D-ASPARTATE; RNA, COMPLEMENTARY; RNA, MESSENGER; SULFONAMIDES; XENOPUS;

EID: 0033550946     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(99)01102-6     Document Type: Article

References (30)

1. Castillo P.E., Malenka R.C., Nicoll R.A. Kainate receptors mediate a slow postsynaptic current in hippocampal CA3 neurons. Nature. 388:1997;182-186.
2. Cathala G., Savouret J.F., Mendez B., West B.L., Karin M., Martial J.A., Baxter J.D. A method for isolation of intact, translationally active ribonucleic acid. DNA. 2:1983;329-335.
3. Collingridge G.L., Lester R.A.J. Excitatory amino acid receptors in vertebrate central nervous system. Pharmacol. Rev. 40:1989;143-210.
4. Gill R. The pharmacology of α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)/kainate antagonists and their role in cerebral ischaemia. Cerebrovasc. Brain Metab. Rev. 6:1994;225-256.
5. Hollmann M., Heinemann S. Cloned glutamate receptors. Annu. Rev. Neurosci. 17:1994;31-108.
6. 3H]kainate binding sites with different molecular target sizes Neurosci. Lett. 65:1986;47-52.
7. Huettner J.E. Glutamate receptor channels in rat DRG neurons: activation by kainate and quisqualate and blockade of desensitization by Con A. Neuron. 5:1990;255-266.
8. Kushner L., Lerma J., Zukin R.S., Bennett M.V.L. Coexpression of N-methyl-D-aspartate and phencyclidine receptors in Xenopus oocytes injected with rat brain mRNA. Proc. Natl. Acad. Sci. USA. 85:1988;3250-3254.
9. Lerma J., Paternain A.V., Naranjo J.R., Mellström B. Functional kainate-selective glutamate receptors in cultured hippocampal neurons. Proc. Natl. Acad. Sci. USA. 90:1993;11688-11692.
10. Lerma J. Kainate reveals its targets. Neuron. 19:1997;1155-1158.
11. Lerma J., Morales M., Vicente M.A., Herreras O. Glutamate receptors of the kainate type and synaptic transmission. Trends Neurosci. 20:1997;9-12.
12. Lipton S.A., Rosenberg P.A. Excitatory amino acids as a final common pathway for neurologic disorders. New Engl. J. Med. 330:1994;613-622.
13. 3H]kainic acid to receptor sites in rat brain Molec. Pharmacol. 15:1979;492-505.
14. Meldrum B., Garthwaite J. Excitatory amino acid neurotoxicity and neurodegenerative disease. Trends Pharmacol. Sci. 11:1990;379-387.
15. 3H]NS-257 , a novel competitive AMPA receptor antagonist, to rat brain membranes and brain sections J. Neurochem. 65:1995;1264-1273.
16. Okada M., Kohara A., Yamaguchi T. Characterization of YM90K, a selective and potent antagonist of AMPA receptors, in rat cortical mRNA-injected Xenopus oocytes. Eur. J. Pharmacol. 309:1996;299-306.
17. Partin K.M., Patneau D.K., Mayer M.L. Cyclothiazide differentially modulates desensitization of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor splice variants. Molec. Pharmacol. 46:1994;129-138.
18. Partin K.M., Patneau D.K., Winters C.A., Mayer M.L., Buonanno A. Selective modulation of desensitization at AMPA versus kainate receptors by cyclothiazide and concanavalin A. Neuron. 11:1993;1069-1082.
19. Paternain A.V., Morales M., Lerma J. Selective antagonism of AMPA receptors unmasks the kainate receptor-mediated responses in hippocampal neurons. Neuron. 14:1995;185-189.
20. Patneau D.K., Vyklicky L. Jr., Mayer M.L. Hippocampal neurons exhibit cyclothiazide-sensitive rapidly desensitizing responses to kainate. J. Neurosci. 13:1993;3496-3509.
21. Patneau D.K., Wright P.W., Winters C., Mayer M.L., Gallo V. Glial cells of the oligodendrocyte lineage express both kainate- and AMPA-preferring subtypes of glutamate receptor. Neuron. 12:1994;357-371.
22. Porter R.H.P., Greenamyre J.T. Regional variations in the pharmacology of AMPA receptors as revealed by receptor autoradiography. Brain Res. 644:1994;202-206.
23. Rodriquez-Moreno A., Herreras O., Lerma J. Kainate receptors presynaptically downregulate GABAergic inhibition in the rat hippocampus. Neuron. 19:1997;893-901.
24. Rodriquez-Moreno A., Lerma J. Kainate receptor modulation of GABA release involves a metabotropic function. Neuron. 20:1998;1211-1218.
25. Stühmer W. Electrophysiological recording from Xenopus oocytes. Methods Enzymol. 207:1992;319-339.
26. Vignes M., Collingridge G.L. The synaptic activation of kainate receptors. Nature. 388:1997;179-182.
27. Wätjen F., Bigge C.F., Jensen L.H., Boxer P.A., Lescosky L.J., Nielsen E.O., Malone T.C., Campbell G.W., Coughenour L.L., Rock D.M., Drejer J., Marcoux F.W. NS-257 (1,2,3,6,7,8-hexahydro-3(hydroxyimino-N,N,7-trimethyl-2-oxobenzo(2,1-b:3,4- c′)dipyrrole-5-sulfonamide) is a potent, systemically active AMPA receptor antagonist. Bioorg. Med. Chem. Lett. 4:1994;371-376.
28. Wisden W., Seeburg P. A complex mosaic of high-affinity kainate receptors exists in rat brain. J. Neurosci. 13:1993;3582-3598.
29. Wong L.A., Mayer M.L. Differential modulation by cyclothiazide and concanavalin A of desensitization at native α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid- and kainate-preferring glutamate receptors. Molec. Pharmacol. 44:1993;504-510.
30. Xue D., Haung Z.-G., Barnes K., Lesiuk H.J., Smith K.E., Buchan A.M. Delayed treatment with AMPA, but not NMDA, antagonists reduces neocortical infarction. J. Cereb. Blood Flow Metab. 14:1994;251-261.