A structure-based design approach to the development of novel, reversible AChE inhibitors

Journal of Medicinal Chemistry

Volumn 44, Issue 20, 2001, Pages 3203-3215

  Doucet Personeni, C ^a   Bentley, P D ^a   Fletcher, R J ^a   Kinkaid, A ^a   Kryger, G ^b   Pirard, B ^a   Taylor, A ^a   Taylor, R ^c   Taylor, J ^a   Viner, R ^a   Silman, I ^b   Sussman, J L ^b   Greenblatt, H M ^b   Lewis, T ^a  

^a JEALOTT S HILL INTERNATIONAL RESEARCH CENTRE   (United Kingdom)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^c CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 (N,N,N TRIMETHYLAMMONIO)TRIFLUOROACETOPHENONE; 4 AMINO 5 FLUORO 2 METHYL 3 (3 TRIFLUOROACETYLBENZYLTHIOMETHYL)QUINOLINE; ACETOPHENONE DERIVATIVE; CHOLINESTERASE INHIBITOR; QUINOLINE DERIVATIVE; TACRINE; UNCLASSIFIED DRUG;

ARTICLE; CHIMERA; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG STRUCTURE; ENZYME INHIBITION; STRUCTURE ACTIVITY RELATION;

ACETOPHENONES; ACETYLCHOLINESTERASE; AMINOQUINOLINES; ANIMALS; BINDING SITES; CHOLINESTERASE INHIBITORS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP; TACRINE; TORPEDO;

EID: 0035959984     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010826r     Document Type: Article

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