Resolution, absolute stereochemistry, and enantiopharmacology of the GluR1-4 and GluR5 antagonist 2-amino-3-[5-tert-butyl-3(phosphonomethoxy)-4- isoxazolyllpropionic acid

Chirality

Volumn 11, Issue 10, 1999, Pages 752-759

  Møller, Eva H ^a   Egebjerg, Jan ^b   Brehm, Lotte ^a   Stensbøl, Tine B ^a   Johansen, Tommy N ^a   Madsen, Ulf ^a   Krogsgaard Larsen, Povl ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Department of Medicinal Chemistry Royal Danish School of Pharmacy ^*

Author keywords

(S) and (R) ATPO; Chiral HPLC; Cloned ionotropic glutamate receptors; GluR1 4; GluR5 antagonist; X ray crystallography

Indexed keywords

2 AMINO 3 [5 TERT BUTYL 3 (PHOSPHONOMETHOXY) 4 ISOXAZOLYL]PROPIONIC ACID; GLUTAMATE RECEPTOR ANTAGONIST; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PHOSPHONOAMINO ACID; PROPIONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHEMICAL BOND; CHIRALITY; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; STEREOCHEMISTRY; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

EID: 0032731808     PISSN: 08990042     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-636X(1999)11:10<752::AID-CHIR3>3.0.CO;2-T     Document Type: Article

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