Distribution of kainate receptor subunit mRNAs in human hippocampus, neocortex and cerebellum, and bilateral reduction of hippocampal GluR6 and KA2 transcripts in schizophrenia

Brain Research

Volumn 751, Issue 2, 1997, Pages 217-231

  Porter, Richard H P ^a,b   Eastwood, Sharon L ^b   Harrison, Paul J ^b  

^a Cerebrus Limited   (United Kingdom)

^b WARNEFORD HOSPITAL   (United Kingdom)

Author keywords

gene expression; glutamate receptor; human brain; hybridization, in situ; kainic acid receptor; messenger RNA; schizophrenia

Indexed keywords

GLUTAMATE RECEPTOR; KAINIC ACID RECEPTOR; MESSENGER RNA; RECEPTOR SUBUNIT;

ADULT; AGED; ANIMAL TISSUE; ARTICLE; CEREBELLUM; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; MALE; NEOCORTEX; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; SCHIZOPHRENIA;

AGED; ANIMALS; BRAIN; CEREBELLUM; CEREBRAL CORTEX; FEMALE; HIPPOCAMPUS; HUMANS; HYDROGEN-ION CONCENTRATION; KAINIC ACID; MALE; MIDDLE AGED; RATS; RECEPTORS, GLUTAMATE; RECEPTORS, KAINIC ACID; REFERENCE VALUES; RNA, MESSENGER; SCHIZOPHRENIA; TISSUE DISTRIBUTION;

EID: 0030933984     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(96)01404-7     Document Type: Article

References (59)

1. Akbarian, S., Smith, M.A. and Jones, E.G., Editing for an AMPA receptor subunit mRNA in prefrontal cortex and striatum in Alzheimer's disease, Huntington's disease and schizophrenia, Brain Res., 699 (1995) 297-304.
2. Bahn, S., Volk, B. and Wisden, W., Kainate receptor gene expression in the developing rat brain, J. Neurosci., 14 (1994) 5525-5547.
3. Barton, A.J.L., Pearson, R.C.A., Najlerahim, A. and Harrison, P.J., Pre- and post mortem influences on brain RNA, J. Neurochem., 61 (1993) 1-11.
4. Bettler, B. and Mulle, C., Neurotransmitter Receptors II. AMPA and kainate receptors, Neuropharmacology, 34 (1994) 123-139.
5. Bettler B., Boulter, J., Hermans-Borgmeyer, I., O'Shea-Greenfield, A., Deneris, E.S., Moll, C., Borgmeyer, U., Hollmann, M. and Heinemann, S., Cloning of a novel glutamate receptor subunit, GluR5: expression in the nervous system during development, Neuron, (1990) 583-595.
6. 2A receptor mRNA in human brain, Brain Res., 676 (1995) 157-168.
7. 2A receptor mRNAs and binding site densities in schizophrenia, Neuropsychopharmacology, 15 (1996) 442-455.
8. Chittajallu, R., Vignes, M., Dev, K.K., Barnes, J.M., Collingridge, G.L. and Henley, J.M., Regulation of glutamate release by presynaptic kainate receptors in the hippocampus, Nature, 379 (1996) 78-81.
9. Deakin, J.F.W., Simpson, M.D.C., Gilchrist, A.C., Skan, W.C., Royston, M.C., Reynolds, G.P. and Cross, A.J., Frontal cortical and left temporal glutamatergic dysfunction in schizophrenia, J. Neurochem., 52 (1989) 1781-1786.
10. Eastwood, S.L., Burnet, P.W.J., Beckwith, J., Kerwin, R.W. and Harrison, P.J., AMPA glutamate receptors and their flip and flop mRNAs in human hippocampus, NeuroReport, 5 (1994) 1325-1328.
11. Eastwood, S.L., McDonald, B., Burnet, P.W.J., Beckwith, J.P., Kerwin, R.W. and Harrison, P.J., Decreased expression of mRNAs encoding non-NMDA glutamate receptors GluR1 and GluR2 in medial temporal lobe neurons in schizophrenia, Mol. Brain Res., 29 (1995) 211-223.
12. Eastwood, S.L., Kerwin, R.W. and Harrison, P.J., Immunoautoradiographic evidence for a loss of α-amino-3-hydroxy-5-methyl-4-isoxazole propionate-preferring non-Af-methyl-D-aspartate glutamate receptors within the medial temporal lobe in schizophrenia, Biol. Psychiatry, (in press).
13. Eastwood, S.L., Porter, R.H.P. and Harrison, P.J., The effect of chronic haloperidol treatment on glutamate receptor subunit (GluR1, GluR2, KA1, KA2, NR1) mRNAs and glutamate binding protein mRNA in rat forebrain, Neurosci. Lett., 212 (1996) 163-166.
14. Eastwood, S.L., Burnet, P.W.J. and Harrison, P.J., GluR2 glutamate receptor subunit flip and flop isoforms are decreased in the hippocampal formation in schizophrenia: a reverse transcriptase-polymerase chain reaction (RT-PCR) study, Mol. Brain Res. (in press).
15. Egebjerg, J., Bettler, B., Hermans-Borgmeyer, I. and Heinemann, S., Cloning of a cDNA for a glutamate receptor subunit activated by kainate but not AMPA, Nature, 351 (1991) 745-748.
16. Garcia-Ladona, F.J., Palacios, J.M., Probst, A., Wieser, H.G. and Mengod, G., Excitatory amino acid AMPA receptor mRNA localization in several regions of normal and neurological disease affected human brain. An in situ hybridization histochemistry study, Mol. Brain Res., 21 (1994) 75-84.
17. Good, P.F., Huntley, G.W., Rogers, S.W., Heinemann, S.F. and Morrison, J.H., Organization and quantitative analysis of kainate receptor subunit GluR5-7 immunoreactivity in monkey hippocampus, Brain Res., 624 (1993) 347-353.
18. Gregor, P., O'Hara, B.F., Yang, X. and Uhl, G.R., Expression and novel subunit isoforms of glutamate receptor genes GluR5 and GluR6, NeuroReport, 4 (1993) 1343-1346.
19. Harrison, P.J., Advances in post mortem molecular neurochemistry and neuropathology: examples from schizophrenia research, Br. Med. Bull., 52 (1996) 527-538.
20. Harrison, P.J., Barton, A.J.L., Najlerahim, A. and Pearson, R.C.A., Distribution of a kainate/AMPA receptor mRNA in normal and Alzheimer brain, NeuroReport, 1 (1990) 149-152.
21. Harrison, P.J., McLaughlin, D. and Kerwin, R.W. Decreased hippocampal expression of a glutamate receptor gene in schizophrenia, Lancet, 337 (1991) 450-452.
22. Harrison, P.J., Heath, P.R., Eastwood, S.L., Burnet, P.W.J., McDonald, B. and Pearson, R.C.A., The relative importance of premortem acidosis and postmortem interval for human brain gene expression studies: selective mRNA vulnerability and comparison with their encoded proteins, Neurosci. Lett., 200 (1995) 151-154.
23. Henley, J.M., Kainate-binding proteins: phylogeny, structures and possible functions, Trends Pharmacol. Sci., 15 (1994) 182-190.
24. Herb, A., Burnashev, N., Werner, P., Sakmann, B., Wisden, W. and Seeburg, P.H., The KA-2 subunit of excitatory amino acid receptors shows a widespread expression in brain and forms ion channels with distantly related subunits, Neuron, 8 (1992) 775-785.
25. Hollmann, M. and Heinemann, S., Cloned glutamate receptors, Annu. Rev. Neurosci., 17 (1994) 31-108.
26. Hoo, K.H., Nutt, S.L., Fletcher, E.J., Elliott, C.E., Korczak, B., Deverill, R., Rampersad, V., Fantaske, R. and Kamboj, R.K., Functional expression and characterization of the human EAA4 (GluR6) glutamate receptor: a kainate selective ion channel subunit, Receptor Channels, 2 (1994) 327-337.
27. Huntley, G.W., Rogers, S.W., Moran, T., Janssen, W., Archin, N., Vickers, J.C., Cauley, K., Heinemann, S.F. and Morrison, J.H., Selective distribution of kainate receptor subunit immunoreactivity in monkey neocortex revealed by a monoclonal antibody that recog-nizes glutamate receptor subunits GluR5/6/7, J. Neurosci., 13 (1993) 2965-2981.
28. 3H]kainic acid binding sites, Neuroscience, 32 (1989) 587-607.
29. Kamboj, R.K., Schoepp, D.D., Nutt, S., Shekter, L., Korczak, B., True, R.A., Zimmerman, D.M. and Wosnick, M.A., Molecular structure and pharmacological characterization of humEAA2, a novel human kainate receptor subunit, Mol. Pharmacol., 42 (1992) 10-15.
30. Kamboj, R.K., Schoepp, D.D., Nutt, S., Shekter, L., Korczak, B., True, R.A., Rampersad, V., Zimmerman, D.M. and Wosnick, M.A., Molecular cloning, expression, and pharmacological characterization of humEAAl, a human kainate receptor subunit, J. Neurochem., 62 (1994) 1-9.
31. Kerwin, R.W. and Murray, R.M., A developmental perspective on the pathology and neurochemistry of the temporal lobe in schizophrenia, Schizophrenia Res., 1 (1992) 1-12.
32. Kerwin, R.W., Patel, S., Meldrum, B.S., Czudek, C. and Reynolds, G.P., Asymmetrical loss of glutamate receptor subtype in left hippocampus in schizophrenia, Lancet, 1 (1988) 583-584.
33. Kerwin, R., Patel, S. and Meldrum, B., Quantitative autoradiographic analysis of glutamate binding sites in the hippocampal formation in normal and schizophrenic brain post mortem, Neuroscience, 39 (1990) 25-32.
34. Kim, J.S., Kornhuber, H.H., Schmid-Burgk, W. and Holzmuller, B., Low cerebrospinal fluid glutamate in schizophrenic patients and a new hypothesis on schizophrenia, Neurosci. Lett., 20 (1980) 379-383.
35. Kingsbury, A.E., Foster, O.J.F., Nisbet, A.P., Cairns, N., Bray, L., Eve, D.J., Lees, A.J. and Marsden, C.D., Tissue pH as an indicator of mRNA preservation in human post-mortem brain, Mol. Brain Res., 28 (1995) 311-318.
36. Kornhuber, J., Mack-Burckhardt, F., Riederer, P., Hebenstreit, G.F., Reynolds, G.P., Andrews, H.B. and Beckmann, H., [3H]MK-801 binding sites in postmortem brain regions of schizophrenic patients, J. Neural Transm., 77 (1989) 231-236.
37. 3H]Amino-3-hydroxy-5-methylisoxazole-4-propionic acid binding to human cerebral cortical membranes: minimal changes in postmortem brains of chronic schizophrenics, J. Neurochem., 59 (1992) 829-837.
38. Lomeli, H., Wisden, W., Kohler, M., Keinanen, K., Sommer, B. and Seeburg, P.H., High-affinity kainate and domoate receptors in rat brain, FEBS Lett., 307 (1992) 139-143.
39. Meador-Woodruff, J.H., King, S.P., Damask, S.P. and Bovenkerk, K.A., Differential regulation of hippocampal AMPA and kainate receptor subunit expression by haloperidol and clozapine, Mol. Psychiatry, 1 (1996) 41-53.
40. Miller, M., Urban, J. and Dorsa, D., Quantification of mRNA in discrete cell groups of brain by in situ hybridization histochemistry. In P.M. Conn (Ed.), Methods in Neuroscience, Vol. 1, Academic Press, San Diego, pp. 164-181.
41. 3H]kainate binding sites in rat hippocampus, Neurochem. Res., 11 (1986) 1073-1082.
42. Monaghan, D.T., Bridges, R.J. and Cotman, C.W., The excitatory amino acid receptors: their classes, pharmacology, and distinct prop-erties in the function of the central nervous system, Annu. Rev. Pharmacol. Toxicol., 29 (1989) 365-402.
43. Nunez, D.J., Davenport, A.P., Emson, P.C. and Brown, M.J., A quantitative 'in situ' hybridization method using computer-assisted image analysis, Biochem. J., 263 (1989) 121-127.
44. Nutt, S.L., Hoo, K.H., Rampersad, V., Deverill, R.M., Elliott, C.E., Fletcher, E.J., Adams, S.L., Korczak, B., Foldes, R.L. and Kamboj, R. K., Molecular characterization of the human EAA5 (GluR7) receptor: a high-affinity kainate receptor with novel potential RNA editing sites, Receptor Channels, 2 (1994) 315-326.
45. Nutt, S.L. and Kamboj, R.K., RNA editing of human kainate receptor subunits, NeuroReport, 5 (1994) 2625-2629.
46. Olney, J.W. and Farber, N.B., Glutamate receptor dysfunction and schizophrenia, Arch. Gen. Psychiatry, 52 (1995) 998-1007.
47. Owen, F. and Simpson, M.D.C., The neurochemistry of schizophrenia. In S.R. Hirsch and D.R. Weinberger (Eds.), Schizophrenia, Blackwells, Oxford, 1995, pp. 358-378.
48. Petralia, R.S., Wiang, Y.-X. and Wenthold, R.J., Histological and ultrastructural localization of the kainate receptor subunits, KA2 and GluR6/7, in the rat nervous system using selective antipeptide antibodies, J. Comp. Neurol., 349 (1994) 85-110.
49. Porter, R.H.P., Burnet, P.W.J., Eastwood, S.L. and Harrison, P.J., Contrasting effects of electroconvulsive shock on mRNAs encoding the high affinity kainate receptor subunits (KA1 and KA2) and cyclophilin in the rat, Brain Res., 710 (1996) 97-102.
50. Represa, A., Tremblay, E. and Ben-Ari, Y., Kainate binding sites in the hippocampal mossy fibres: localization and plasticity, Neuroscience 20 (1987) 739-748.
51. Seeburg, P.H., The molecular biology of mammalian glutamate receptor channels, Trends Neurosci., 16 (1993) 359-365.
52. Tremblay, E., Represa, A. and Ben-Ari, Y., Autoradiographic localization of kainic acid binding sites in the human hippocampus, Brain Res., 343 (1985) 378-382.
53. Tsai, G., Passani, L.A., Slusher, B.S., Carter, R., Baer, L., Kleinman, J.E. and Coyle, J.T., Abnormal excitatory neurotransmitter metabolism in schizophrenic brains, Arch. Gen. Psychiatry, 52 (1995) 829-836.
54. Ulas, J. and Cotman, C.W., Excitatory amino acid receptors in schizophrenia, Schizophrenia Bull., 19 (1993) 105-117.
55. Vickers, J.C., Huntley, G.W., Hof, P.R., Bederson, J., DeFelipe, J. and Morrison, J.H., Immunocytochemical localization of non-NMDA inotropic excitatory amino acid receptor subunits in human neocortex, Brain Res., 671 (1995) 175-180.
56. Werner, P., Voigt, M., Keinanen, K., Wisden, W. and Seeburg, P.H., Cloning of a putative high-affinity kainate receptor expressed predominantly in hippocampal CA3 cells, Nature, 351 (1991) 742-744.
57. Wisden, W. and Seeburg, P.H., A complex mosaic of high-affinity kainate receptors in rat brain, J. Neurosci., 13 (1993) 3582-3598.
58. Young, A.B. and Fagg, G.E., Excitatory amino acid receptors in the brain: membrane binding and receptor autoradiographic approaches, Trends Pharmacol. Sci., 11 (1990) 126-133.
59. Zaidel, D.W., Esiri, M.M. and Harrison, P.J., The hippocampus in schizophrenia: lateralized increase in neuronal density and altered cytoarchitectural asymmetry, Psychol. Med., (in press).