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Bioorganic and Medicinal Chemistry

Volumn 19, Issue 4, 2011, Pages 1528-1534

Lipophilic derivatives of leu-enkephalinamide: In vitro permeability, stability and in vivo nasal delivery

(3) Cros, Cécile D a Toth, Istvan a Blanchfield, Joanne T a

a UNIVERSITY OF QUEENSLAND (Australia)

Author keywords

Leu enkephalinamide; Nasal delivery; Opioid peptides; Pain mediating drugs

Indexed keywords

ENKEPHALINAMIDE DERIVATIVE; LEUCINE ENKEPHALINAMIDE;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL FREE SYSTEM; CELL MEMBRANE PERMEABILITY; CELL STRAIN CACO 2; CONTROLLED STUDY; DIASTEREOISOMER; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DEGRADATION; DRUG PENETRATION; DRUG SOLUBILITY; DRUG STABILITY; DRUG SYNTHESIS; DRUG TISSUE LEVEL; HUMAN; IN VIVO STUDY; LIPOPHILICITY; MALE; NONHUMAN; OLFACTORY BULB; RAT;

ANIMALS; CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; ENKEPHALIN, LEUCINE; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LIPIDS; MALE; MOLECULAR STRUCTURE; NASAL MUCOSA; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 79951557217 PISSN: 09680896 EISSN: None Source Type: Journal
DOI: 10.1016/j.bmc.2010.12.042 Document Type: Article

Times cited : (20)

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