Improvement of intestinal absorption of leucine enkephalin by sugar coupling and peptidase inhibitors

Journal of Pharmaceutical Sciences

Volumn 85, Issue 8, 1996, Pages 854-857

  Mizuma, Takashi ^a   Ohta, Kunihiro ^a   Koyanagi, Akihiro ^a   Awazu, Shoji ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELLOBIOSE; GENTIOBIOSE; LEUCINE ENKEPHALIN; MEMBRANE METALLOENDOPEPTIDASE; SUGAR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG CLEARANCE; DRUG DEGRADATION; DRUG STABILITY; ENZYME ACTIVITY; ENZYME INHIBITION; INTESTINE ABSORPTION; INTESTINE MUCOSA; MALE; NONHUMAN; RAT;

EID: 0029781483     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1021/js950507l     Document Type: Article

References (10)

1. Geary, L. E.; Wiley, K. S.; Scott, W. L.; Cohen, M. L. J. Pharmacol. Exp. Ther. 1982, 221, 104-111.
2. Cohen, M. L.; Geary, L. E.; Wiley, K. S.; Scott, W. L. J. Pharmacol. Exp. Ther. 1983, 224, 379-385.
3. Mizuma, T.; Sakai, N.; Awazu, S. Biochem. Biophys. Res. Commun. 1994, 203, 1412-1416.
4. Gray, G. R. Arch. Biochem. Biophys. 1974, 163, 426-428.
5. Mizuma, T.; Ohta, K.,; Hayashi, M.; Awazu, S. Biochem. Pharmacol. 1992, 43, 2037-2039.
6. (a) Gibaldi, M.; Perrier, D. Pharmacokinetics; Marcel Dekker, Inc.: New York, 1982; pp 319-353.
7. (b) Gibaldi, M.; Perrier, D. Pharmacokinetics; Marcel Dekker, Inc., New York, 1982; pp 1-43.
8. Yamaoka, K.; Tanigawara, Y.; Nakagawa, T.; Uno, T. J. Pharmacobio-Dyn. 1981, 4, 879-885.
9. Aungst, B. J.; Blake, J. A.; Hussain, M. A. J. Pharmacol. Exp. Ther. 1991, 259, 139-145.
10. Yamamoto, A.; Nakamura, J.; Takada, S.; Kimura, T.; Sezaki, H. J. Pharm. Sci. 1984, 73, 48-52.