Characterizing the expression of CYP3A4 and efflux transporters (P-gp, MRP1, and MRP2) in CYP3A4-transfected Caco-2 cells after induction with sodium butyrate and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate

Pharmaceutical Research

Volumn 18, Issue 8, 2001, Pages 1102-1109

  Cummins, C L ^a   Mangravite, L M ^a   Benet, L Z ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Caco 2 cells; Confocal; CYP3A4; MRP1; MRP2; P glycoprotein

Indexed keywords

BUTYRIC ACID; CYTOCHROME P450 3A4; DIGOXIN; GLYCOPROTEIN P; MIDAZOLAM; MULTIDRUG RESISTANCE PROTEIN; PHORBOL 13 ACETATE 12 MYRISTATE;

APICAL MEMBRANE; ARTICLE; CELL LINE; CONTROLLED STUDY; DRUG TRANSPORT; ENDOPLASMIC RETICULUM; ENZYME INDUCTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MONOLAYER CULTURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT;

BLOTTING, WESTERN; BUTYRATES; CACO-2 CELLS; CYTOCHROME P-450 ENZYME SYSTEM; DENSITOMETRY; DNA-BINDING PROTEINS; ENZYME INDUCTION; GABA MODULATORS; HUMANS; INTESTINAL ABSORPTION; MICROSCOPY, CONFOCAL; MIDAZOLAM; MITOCHONDRIAL PROTEINS; MIXED FUNCTION OXYGENASES; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; P-GLYCOPROTEIN; RIBOSOMAL PROTEINS; SACCHAROMYCES CEREVISIAE PROTEINS; TETRADECANOYLPHORBOL ACETATE; TRANSFECTION;

EID: 0034807802     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1010914624111     Document Type: Article

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