Investigation of the route of absorption of lipid and sugar modified Leu-enkephalin analogues and their enzymatic stability using the Caco-2 cell monolayer system

Medicinal Chemistry

Volumn 2, Issue 2, 2006, Pages 203-211

  Wu, Sherry ^a   Campbell, Christopher ^a   Koda, Yasuko ^a   Blanchfield, Joanne T ^a   Toth, Istvan ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Caco 2 cells; Drug delivery liposaccharides; Glucose transporter; Leu enkephalin; Lipoamino acids; p glycoprotein hPepT1

Indexed keywords

CARRIER PROTEIN; GLUCOSE; GLUCOSE TRANSPORTER; GLYCOPROTEIN P; GLYCYLSARCOSINE; LEUCINE ENKEPHALIN DERIVATIVE; VINBLASTINE;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CULTURE; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG ABSORPTION; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG PENETRATION; DRUG STABILITY; DRUG SYNTHESIS; DRUG TRANSPORT; ENZYME DEGRADATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MONOLAYER CULTURE; PEPTIDE ANALYSIS; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION;

ABSORPTION; CACO-2 CELLS; CARBOHYDRATES; CARRIER PROTEINS; CELLS, CULTURED; DRUG RESISTANCE, MULTIPLE; ENKEPHALIN, LEUCINE; ENZYME STABILITY; GLUCOSE TRANSPORT PROTEINS, FACILITATIVE; GLYCOPROTEINS; HUMANS; LIPIDS; LIPOPOLYSACCHARIDES; LIPOPROTEINS; OLIGOPEPTIDES; P-GLYCOPROTEIN; SYMPORTERS;

EID: 33746137342     PISSN: 15734064     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340606776056205     Document Type: Article

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