Reversible lipidization for the oral delivery of leu-enkephalin

Journal of Drug Targeting

Volumn 14, Issue 3, 2006, Pages 127-136

  Wang, Jeffrey ^a,b   Hogenkamp, Derk J ^b   Tran, Minhtam ^b   Li, Wen Yen ^b   Yoshimura, Ryan F ^b   Johnstone, Timothy B C ^b   Shen, Wei Chiang ^c   Gee, Kelvin W ^b  

^a WESTERN UNIVERSITY OF HEALTH SCIENCES   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Antinociception; Biodistribution; Leu enkephalin; Oral delivery; Pharmacokinetics; Reversible lipidization

Indexed keywords

ACETONITRILE; BUFFER; DISULFIDE; LEUCINE ENKEPHALIN; MALEIC ANHYDRIDE; OPIATE RECEPTOR; PHOSPHATE;

ACIDITY; ANIMAL TISSUE; ANTINOCICEPTION; AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG ABSORPTION; DRUG ACTIVITY; DRUG ADMINISTRATION ROUTE; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG HYDROLYSIS; DRUG METABOLISM; DRUG STABILITY; DRUG STRUCTURE; ENZYME DEGRADATION; LIPOPHILICITY; LIVER HOMOGENATE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; SMALL INTESTINE MUCOSA; TIME; TISSUE PREPARATION;

ADMINISTRATION, ORAL; ANIMALS; CACO-2 CELLS; ENKEPHALIN, LEUCINE; HALF-LIFE; HUMANS; INTESTINAL MUCOSA; INTESTINE, SMALL; LIPIDS; LIVER; MICE; RADIOIMMUNOASSAY; TISSUE DISTRIBUTION;

EID: 33745083089     PISSN: 1061186X     EISSN: 10292330     Source Type: Journal    
DOI: 10.1080/10611860600648221     Document Type: Article

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