In vitro evaluation of the potential of thiomers for the nasal administration of Leu-enkephalin

Amino Acids

Volumn 30, Issue 4, 2006, Pages 417-423

  Bernkop Schnurch A ^a   Obermair, K ^a   Greimel, A ^a   Palmberger, T F ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Enzyme inhibition; Leu enkephalin; Nasal permeation; Thiolated polycarbophil; Thiomers

Indexed keywords

EXCIPIENT; GLUTATHIONE; LEUCINE ENKEPHALIN; POLYCARBOPHIL; TYROSINE;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHROMATOGRAPHY; DIFFUSION; DRUG DEGRADATION; DRUG UPTAKE; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; NOSE MUCOSA; PERMEABILITY; PRIORITY JOURNAL;

ACRYLIC RESINS; ADMINISTRATION, INTRANASAL; ANIMALS; BIOTRANSFORMATION; CATTLE; DRUG EVALUATION, PRECLINICAL; ENKEPHALIN, LEUCINE; EXCIPIENTS; NASAL MUCOSA; SULFHYDRYL COMPOUNDS; TIME FACTORS;

BOS TAURUS;

EID: 33745105965     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00726-006-0266-5     Document Type: Article

References (20)

1. RU Agu VH Dang M Jorissen R Kinget N Verbeke 2004 Metabolism and absorption enhancement of methionine enkephalin in human nasal epithelium Peptides 25 563 569
2. Albrecht K, Zirm EJ, Bernkop-Schnürch A (2005) In vitro evaluation of parameters influencing the mucoadhesive properties of thiomer particles. 32nd Annual Meeting of the Controlled Release Society, Miami
3. A Bernkop-Schnürch H Zarti GF Walker 2001a Thiolation of polycarbophil enhances its inhibition of soluble and intestinal brush border membrane bound aminopeptidase N J Pharm Sci 90 1907 1914
4. A Bernkop-Schnürch CE Kast MF Richter 2001b Improvement in the mucoadhesive properties of alginate by the covalent attachment of cysteine J Control Release 71 277 285
5. A Bernkop-Schnürch C Paikl C Valenta 1997 Novel bioadhesive chitosan-EDTA conjugate protects leucine enkephalin from degradation by aminopeptidase N Pharm Res 14 917 922
6. A Bernkop-Schnürch V Schwarz S Steininger 1999 Polymers with thiol groups: a new generation of mucoadhesive polymers? Pharm Res 16 876 881
7. AE Clausen A Bernkop-Schnürch 2000 In vitro evaluation of the permeation-enhancing effect of thiolated polycarbophil J Pharm Sci 89 1253 1261
8. Greimel A, Del Curto MD, D'Antonio M, Palmberger T, Bernkop-Schnürch A (2006) In vitro evaluation of thiomer microparticles for nasal drug delivery. J Drug Del Sci Tech (in press)
9. AF Habeeb 1973 A sensitive method for localization of disulfide containing peptides in column effluents Anal Biochem 56 60 65
10. ME Imam M Hornof C Valenta A Bernkop-Schnürch 2003 Evidence for the interpenetration of mucoadhesive polymers into the mucus gel layer STP Pharm Sci 13 171 176
11. AH Krauland A Bernkop-Schnürch 2004 Thiomers: development and in vitro evaluation of a peroral microparticulate peptide delivery system Eur J Pharm Biopharm 57 181 187
12. Langoth N, Bernkop-Schnürch A, Kurka P (2006a) The inhibitory effect of glutathione towards buccal enzymatic degradation of therapeutic peptides. J Drug Del Sci Tech (in press)
13. Langoth N, Guggi D, Bernkop-Schnürch A (2006b) Investigation on the cytotoxicity of (thiolated) polyacrylates. Toxicol in vitro (in press)
14. VM Leitner D Guggi A Bernkop-Schnürch 2004a Thiomers in noninvasive polypeptide delivery: in vitro and in vivo characterization of a polycarbophil-cysteine/glutathione gel formulation for human growth hormone J Pharm Sci 93 1682 1691
15. VM Leitner D Guggi AH Krauland A Bernkop-Schnürch 2004b Nasal delivery of human growth hormone: in vitro and in vivo evaluation of a thiomer/glutathione microparticulate delivery system J Control Release 100 87 95
16. MK Marschütz A Bernkop-Schnürch 2002 Thiolated polymers: self-crosslinking properties of thiolated 450∈kDa poly(acrylic acid) and their influence on mucoadhesion Eur J Pharm Sci 15 387 394
17. UA Remigius M Jorissen T Willems R Kinget N Verbeke 2003 Mechanistic appraisal of the effects of some protease inhibitors on ciliary beat frequency in a sequential cell culture system of human nasal epithelium Eur J Pharm Biopharm 55 283 289
18. RG Riley KL Green JD Smart J Tsibouklis JA Davis F Hampson PW Dettmar WR Wilber 2001 The gastrointestinal transit profile of 14C-labelled poly(acrylic acids): an in vivo study Biomaterials 22 1861 1867
19. M Tafaghodi S Abolghasem Sajadi Tabassi MR Jaafari SR Zakavi M Momen-Nejad 2004 Evaluation of the clearance characteristics of various microspheres in the human nose by gamma-scintigraphy Int J Pharm 280 125 135
20. C Wadell E Bjork O Camber 2003 Permeability of porcine nasal mucosa correlated with human nasal absorption Eur J Pharm Sci 18 47 53