Localization and differential activity of P-glycoprotein in the bovine olfactory and nasal respiratory mucosae

Pharmaceutical Research

Volumn 22, Issue 7, 2005, Pages 1121-1128

  Kandimalla, Karunya K ^a,b   Donovan, Maureen D ^a  

^a UNIVERSITY OF IOWA   (United States)

^b FLORIDA A AND M UNIVERSITY   (United States)

Author keywords

CNS; Efflux; Etoposide; Membrane transport proteins; Nasal respiratory mucosa; Nose brain transport; Olfactory mucosa; P glycoprotein

Indexed keywords

2,4 DINITROPHENOL; ETOPOSIDE; GLYCOPROTEIN P; METHOTREXATE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY C 219; MULTIDRUG RESISTANCE PROTEIN 1; QUINIDINE; UNCLASSIFIED DRUG; VERLUKAST;

ANIMAL TISSUE; APICAL MEMBRANE; ARTICLE; CILIATED EPITHELIUM; CONCENTRATION RESPONSE; CONTROLLED STUDY; IMMUNOLOCALIZATION; NONHUMAN; NOSE MUCOSA; OLFACTORY EPITHELIUM; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; RESPIRATORY TRACT MUCOSA; SECRETORY CELL; SUBMUCOSA;

2,4-DINITROPHENOL; ANIMALS; CATTLE; ETOPOSIDE; IMMUNOHISTOCHEMISTRY; METHOTREXATE; NASAL MUCOSA; OLFACTORY MUCOSA; P-GLYCOPROTEIN; PERMEABILITY; PROPIONATES; QUINIDINE; QUINOLINES;

EID: 23744505489     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-005-5420-3     Document Type: Article

References (46)

1. M. Dahlin U. Bergman B. Jansson E. Bjork E. Brittebo 2000 Transfer of dopamine in the olfactory pathway following nasal administration in mice Pharm. Res. 17 737 742
2. T. Sakane M. Akizuki M. Yoshida S. Yamashita T. Nadai M. Hashida H. Sezaki 1991 Transport of cephalexin to the cerebrospinal fluid directly from the nasal cavity J. Pharm. Pharmacol. 43 449 451
3. T. C. A. Kumar G. F. X. David A. Sankaranarayanan V. Puri K. R. Sundram 1982 Pharmacokinetics of progesterone after its administration to ovariectomized rhesus monkeys by injection, infusion, or nasal spraying Proc. Natl. Acad. Sci. USA 79 4185 4189
4. R. J. Henry N. Ruano D. Casto R. H. Wolf 1998 A pharmacokinetic study of midazolam in dogs: nasal drop vs. atomizer administration Pediatr. Dent. 20 321 326
5. 125I-NGF to the brain via the olfactory route Drug Deliv. 4 87 92
6. S. S. Erlich J. G. McComb S. Hyman M. H. Weiss 1986 Ultrastructural morphology of the olfactory pathway for cerebrospinal fluid drainage in the rabbit J. Neurosurg. 64 466 473
7. S. Kida A. Pantazis R. O. Weller 1993 CSF drains directly from the subarachnoid space into nasal lymphatics in the rat. Anatomy, histology and immunological significance Neuropathol. Appl. Neurobiol. 19 480 488
8. R. G. Thorne C. R. Emory T. A. Ala W. H. Frey II 1995 Quantitative analysis of the olfactory pathway for drug delivery to the brain Brain Res. 692 278 282
9. H. Tjalve J. Henriksson J. Tallkvist B. S. Larsson N. G. Lindquist 1996 Uptake of manganese and cadmium from the nasal mucosa into the central nervous system via olfactory pathways in rats Pharmacol. Toxicol. 79 347 356
10. K. Kristensson Y. Olsson 1971 Retrograde axonal transport of protein Brain Res. 29 363 365
11. K. J. Chou M. D. Donovan 1997 Distribution of antihistamines into the CSF following intranasal delivery Biopharm. Drug Dispos. 18 335 346
12. H. S. Chow Z. Chen G. T. Matsuura 1999 Direct transport of cocaine from the nasal cavity to the brain following intranasal cocaine administration in rats J. Pharm. Sci. 88 754 758
13. X.-Q. Chen J. R. Fawcett Y.-E. Rahman T. A. Ala W. H. Frey II 1998 Delivery of nerve growth factor to the brain via the olfactory pathway J. Alzheimer's Dis. 1 35 44
14. F. Thiebaut T. Tsuruo H. Hamada M. M. Gottesman I. Pastan M. C. Willingham 1987 Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues Proc. Natl. Acad. Sci. USA 84 7735 7738
15. H. Sun H. Dai N. Shaik W. F. Elmquist 2003 Drug efflux transporters in the CNS Adv. Drug Deliv. Rev. 55 83 105
16. A. H. Dantzig R. L. Shepard J. Cao K. L. Law W. J. Ehlhardt T. M. Baughman T. F. Bumol J. J. Starling 1996 Reversal of P-glycoprotein-mediated multidrug resistance by a potent cyclopropyldibenzosuberane modulator, LY335979 Cancer Res. 56 4171 4179
17. A. H. Schinkel J. W. Jonker 2003 Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview Adv. Drug Deliv. Rev. 55 3 29
18. C. F. Higgins M. M. Gottesman 1992 Is the multidrug transporter a flippase? Trends Biochem. Sci. 17 18 21
19. M. A. Wioland J. Fleury-Feith P. Corlieu F. Commo G. Monceaux J. Lacau-St-Guily J. F. Bernaudin 2000 CFTR, MDR1, and MRP1 immunolocalization in normal human nasal respiratory mucosa J. Histochem. Cytochem. 48 1215 1222
20. C. L. Graff G. M. Pollack 2003 P-glycoprotein attenuates brain uptake of substrates after nasal instillation Pharm. Res. 20 1225 1230
21. C. L. Graff G. M. Pollack 2005 Functional evidence for P-glycoprotein at the nose-brain barrier Pharm. Res. 22 86 93
22. K. K. Kandimalla M. D. Donovan 2005 Carrier mediated transport of chlorpheniramine and chlorcyclizine across bovine olfactory mucosa: implications on nose-to-brain transport J. Pharm. Sci. 94 613 624
23. L. Campbell A.-N. G. Abulrob L. E. Kandalaft S. Plummer A. J. Hollins A. Gibbs M. Gumbleton 2003 Constitutive expression of P-glycoprotein in normal lung alveolar epithelium and functionality in primary alveolar epithelial cultures J. Pharmacol. Exp. Ther. 304 441 452
24. V. D. Makhey A. Guo D. A. Norris P. Hu J. Yan P. J. Sinko 1998 Characterization of the regional intestinal kinetics of drug efflux in rat and human intestine and in Caco-2 cells Pharm. Res. 15 1160 1167
25. Y. Emi D. Tsunashima K. Ogawara K. Higaki T. Kimura 1998 Role of P-glycoprotein as a secretory mechanism in quinidine absorption from rat small intestine J. Pharm. Sci. 87 295 299
26. K. O. Hamilton E. Topp I. Makagiansar T. Siahaan M. Yazdanian K. L. Audus 2001 Multidrug resistance-associated protein-1 functional activity in Calu-3 cells J. Pharmacol. Exp. Ther. 298 1199 1205
27. R. H. Stephens C. A. O'Neill A. Warhurst G. L. Carlson M. Rowland G. Warhurst 2001 Kinetic profiling of P-glycoprotein-mediated drug efflux in rat and human intestinal epithelia J.Pharmacol. Exp. Ther. 296 584 591
28. N. Zelcer T. Saeki G. Reid J. H. Beijnen P. Borst 2001 Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3) J. Biol. Chem. 276 46400 46407
29. F. Thiebaut T. Tsuruo H. Hamada M. M. Gottesman I. Pastan M. C. Willingham 1989 Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein J. Histochem. Cytochem. 37 159 164
30. Z. S. Chen K. Lee S. Walther R. B. Raftogianis M. Kuwano H. Zeng G. D. Kruh 2002 Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system Cancer Res. 62 3144 3150
31. J. H. Hooijberg H. J. Broxterman M. Kool Y. G. Assaraf G. J. Peters P. Noordhuis R. J. Scheper P. Borst H. M. Pinedo G. Jansen 1999 Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2 Cancer Res. 59 2532 2535
32. P. Breedveld N. Zelcer D. Pluim O. Sonmezer M. M. Tibben J. H. Beijnen A. H. Schinkel O. van Tellingen P. Borst J.H. Schellens 2004 Mechanism of the pharmacokinetic interaction between methotrexate and benzimidazoles: potential role for breast cancer resistance protein in clinical drug-drug interactions Cancer Res. 64 5804 5811
33. H. Zeng L. J. Bain M. G. Belinsky G. D. Kruh 1999 Expression of multidrug resistance protein-3 (multispecific organic anion transporter-D) in human embryonic kidney 293 cells confers resistance to anticancer agents Cancer Res. 59 5964 5967
34. D. R. Adams 1992 Fine structure of the vomeronasal and septal olfactory epithelia and of glandular structures Microsc. Res. Tech. 23 86 97
35. K. K. Kandimalla. Carrier mediated transport of small molecules across bovine nasal mucosa: implications in nose-to-brain transport. Ph.D. thesis, University of Iowa, 2004.
36. B. P. Menco 1980 Qualitative and quantitative freeze-fracture studies on olfactory and nasal respiratory structures of frog, ox, rat, and dog. I. A general survey Cell Tissue Res. 207 183 209
37. M. C. Schmidt D. Simmen M. Hilbe P. Boderke G. Ditzinger J. Sandow S. Lang W. Rubas H. P. Merkle 2000 Validation of excised bovine nasal mucosa as in vitro model to study drug transport and metabolic pathways in nasal epithelium J. Pharm. Sci. 89 396 407
38. V. Longo A. Mazzaccaro F. Naldi P. G. Gervasi 1991 Drug-metabolizing enzymes in liver, olfactory, and respiratory epithelium of cattle J. Biochem. Toxicol. 6 123 128
39. P. Larsson H. Pettersson H. Tjalve 1989 Metabolism of aflatoxin B1 in the bovine olfactory mucosa Carcinogenesis 10 1113 1118
40. J. D. Allen S. C. van Dort M. Buitelaar O. van Tellingen A. H. Schinkel 2003 Mouse breast cancer resistance protein (Bcrp1/Abcg2) mediates etoposide resistance and transport, but etoposide oral availability is limited primarily by P-glycoprotein Cancer Res. 63 1339 1344
41. A. Collett N. B. Higgs E. Sims M. Rowland G. Warhurst 1999 Modulation of the permeability of H2 receptor antagonists cimetidine and ranitidine by P-glycoprotein in rat intestine and the human colonic cell line Caco-2 J. Pharmacol. Exp. Ther. 288 171 178
42. E. M. Fish B. A. Molitoris 1994 Alterations in epithelial polarity and the pathogenesis of disease states N. Engl. J. Med. 330 1580 1588
43. J. Kunta J. Yan V. D. Makhey P. J. Sinko 2000 Active efflux kinetics of etoposide from rabbit small intestine and colon Biopharm. Drug Dispos. 21 83 93
44. R. H. Stephens J. Tanianis-Hughes N. B. Higgs M. Humphrey G. Warhurst 2002 Region-dependent modulation of intestinal permeability by drug efflux transporters: in vitro studies in mdr1a(-/-) mouse intestine J. Pharmacol. Exp. Ther. 303 1095 1101
45. F. X. Tang K. Horie R. T. Borchardt 2002 Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa? Pharm. Res. 19 765 772
46. L. Illum 2000 Transport of drugs from the nasal cavity to the central nervous system Eur. J. Pharm. Sci. 11 1 18