Epigenetics meets endocrinology

Journal of Molecular Endocrinology

Volumn 46, Issue 1, 2011, Pages

  Zhang, Xiang ^a   Ho, Shuk Mei ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL; CELL NUCLEUS RECEPTOR; ENDOCRINE DISRUPTOR; MICRORNA; PEPTIDE HORMONE; RETINOIC ACID; STEROID HORMONE; THYROID HORMONE;

BIOSYNTHESIS; CPG ISLAND; DNA BINDING; DNA METHYLATION; DNA SEQUENCE; ENDOCRINE DISEASE; ENDOCRINE FUNCTION; ENVIRONMENTAL FACTOR; EPIGENETICS; GENE EXPRESSION; GENE IDENTIFICATION; GENOTYPE; HIGH THROUGHPUT SCREENING; HISTONE MODIFICATION; HORMONE RELEASE; HORMONE SYNTHESIS; HUMAN; IMMIGRATION; LIFESTYLE MODIFICATION; MONOZYGOTIC TWINS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVIEW; STEROIDOGENESIS;

ANIMALS; CALCITRIOL; DNA METHYLATION; ENDOCRINE DISRUPTORS; ENDOCRINE GLANDS; ENDOCRINE SYSTEM DISEASES; EPIGENESIS, GENETIC; GONADAL STEROID HORMONES; HISTONES; HUMANS; MICRORNAS; PEPTIDE HORMONES; PHENOTYPE; THYROID HORMONES; TRETINOIN;

EID: 79551715564     PISSN: 09525041     EISSN: 14796813     Source Type: Journal    
DOI: 10.1677/JME-10-0053     Document Type: Review

References (216)

1. Adams BD, Furneaux H & White BA 2007 The micro-ribonucleic acid (miRNA) miR-206 targets the human estrogen receptor-alpha (ERalpha) and represses ERalpha messenger RNA and protein expression in breast cancer cell lines. Molecular Endocrinology 21 1132-1147. (doi:10.1210/me.2007-0022)
2. Adlercreutz H 2002 Phytoestrogens and breast cancer. Journal of Steroid Biochemistry and Molecular Biology 83 113-118. (doi:10.1016/S0960-0760(02)00273- X)
3. Anway MD, Cupp AS, Uzumcu M & Skinner MK 2005 Epigenetic transgenerational actions of endocrine disruptors and male fertility. Science 308 1466-1469. (doi:10.1126/science.1108190)
4. Archey WB, McEachern KA, Robson M, Offit K, Vaziri SA, Casey G, Borg A & Arrick BA 2002 Increased CpG methylation of the estrogen receptor gene in BRCA1-linked estrogen receptor-negative breast cancers. Oncogene 21 7034-7041. (doi:10.1038/sj.onc.1205844)
5. Bannister AJ & Kouzarides T 2005 Reversing histone methylation. Nature 436 1103-1106. (doi:10.1038/nature04048)
6. Bateson P, Barker D, Clutton-Brock T, Deb D, D'Udine B, Foley RA, Gluckman P, Godfrey K, Kirkwood T, Lahr MM et al. 2004 Developmental plasticity and human health. Nature 430 419-421. (doi:10.1038/nature02725)
7. Benbrahim-Tallaa L, Waterland RA, Dill AL, Webber MM & Waalkes MP 2007 Tumor suppressor gene inactivation during cadmium-induced malignant transformation of human prostate cells correlates with overexpression of de novo DNA methyltransferase. Environmental Health Perspectives 115 1454-1459. (doi:10.1289/ehp.10207)
8. Berger SL, Kouzarides T, Shiekhattar R & Shilatifard A 2009 An operational definition of epigenetics. Genes and Development 23 781-783. (doi:10.1101/gad.1787609)
9. Betancourt AM, Eltoum IA, Desmond RA, Russo J & Lamartiniere CA 2010 In utero exposure to bisphenol A shifts the window of susceptibility for mammary carcinogenesis in the rat. Environmental Health Perspectives 118 1614-1619. (doi:10.1289/ehp.1002148)
10. Bird A 2007 Perceptions of epigenetics. Nature 447 396-398. (doi:10.1038/nature05913)
11. Blaustein JD 2010 The year in neuroendocrinology. Molecular Endocrinology 24 252-260. (doi:10.1210/me.2009-0350)
12. Bogdanovic O & Veenstra GJ 2009 DNA methylation and methyl-CpG binding proteins: developmental requirements and function. Chromosoma 118 549-565. (doi:10.1007/s00412-009-0221-9)
13. Boverhof DR, Kwekel JC, Humes DG, Burgoon LD & Zacharewski TR 2006 Dioxin induces an estrogen-like, estrogen receptor-dependent gene expression response in the murine uterus. Molecular Pharmacology 69 1599-1606. (doi:10.1124/mol.105.019638)
14. Bromer JG, Wu J, Zhou Y & Taylor HS 2009 Hypermethylation of homeobox A10 by in utero diethylstilbestrol exposure: an epigenetic mechanism for altered developmental programming. Endocrinology 150 3376-3382. (doi:10.1210/en.2009-0071)
15. Calafat AM, Ye X, Wong LY, Reidy JA & Needham LL 2008 Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004. Environmental Health Perspectives 116 39-44. (doi:10.1289/ehp.10753)
16. Cannell IG, Kong YW & Bushell M 2008 How do microRNAs regulate gene expression? Biochemical Society Transactions 36 1224-1231. (doi:10.1042/ BST0361224)
17. Carrell DT & Hammoud SS 2010 The human sperm epigenome and its potential role in embryonic development. Molecular Human Reproduction 16 37-47. (doi:10.1093/molehr/gap090)
18. Ceccatelli R, Faass O, Schlumpf M & Lichtensteiger W 2006 Gene expression and estrogen sensitivity in rat uterus after developmental exposure to the polybrominated diphenylether PBDE 99 and PCB. Toxicology 220 104-116. (doi:10.1016/j.tox.2005.12.004)
19. Champagne FA & Curley JP 2008 Maternal regulation of estrogen receptor alpha methylation. Current Opinion in Pharmacology 8 735-739. (doi:10.1016/j.coph.2008.06.018)
20. Chen J, Liufu C, Sun W, Sun X & Chen D 2010 Assessment of the neurotoxic mechanisms of decabrominated diphenyl ether (PBDE-209) in primary cultured neonatal rat hippocampal neurons includes alterations in second messenger signaling and oxidative stress. Toxicology Letters 192 431-439. (doi:10.1016/j.toxlet.2009.11.020)
21. Cheung P, Allis CD & Sassone-Corsi P 2000 Signaling to chromatin through histone modifications. Cell 103 263-271. (doi:10.1016/S0092-8674(00) 00118-5)
22. Chim CS, Wong SY, Pang A, Chu P, Lau JS, Wong KF & Kwong YL 2005 Aberrant promoter methylation of the retinoic acid receptor alpha gene in acute promyelocytic leukemia. Leukemia 19 2241-2246. (doi:10.1038/sj.leu.2403937)
23. Chun JY, Nadiminty N, Dutt S, Lou W, Yang JC, Kung HJ, Evans CP & Gao AC 2009 Interleukin-6 regulates androgen synthesis in prostate cancer cells. Clinical Cancer Research 15 4815-4822. (doi:10.1158/1078-0432.CCR-09-0640)
24. Clapier CR & Cairns BR 2009 The biology of chromatin remodeling complexes. Annual Review of Biochemistry 78 273-304. (doi:10.1146/annurev. biochem.77.062706.153223)
25. Clarkson TW 1995 Environmental contaminants in the food chain. American Journal of Clinical Nutrition 61 682S-686S.
26. Cnattingius S, Lundberg F, Sandin S, Gronberg H & Iliadou A 2009 Birth characteristics and risk of prostate cancer: the contribution of genetic factors. Cancer Epidemiology, Biomarkers & Prevention 18 2422-2426. (doi:10.1158/1055-9965.EPI-09-0366)
27. Cook JD, Davis BJ, Cai SL, Barrett JC, Conti CJ & Walker CL 2005 Interaction between genetic susceptibility and early-life environmental exposure determines tumor-suppressor-gene penetrance. PNAS 102 8644-8649. (doi:10.1073/pnas.0503218102)
28. Correa P, Rastad J, Schwarz P, Westin G, Kindmark A, Lundgren E, Akerstrom G & Carling T 1999 The vitamin D receptor (VDR) start codon polymorphism in primary hyperparathyroidism and parathyroid VDR messenger ribonucleic acid levels. Journal of Clinical Endocrinology andMetabolism84 1690-1694. (doi:10.1210/jc.84.5.1690)
29. Cosgrove MS, Boeke JD & Wolberger C 2004 Regulated nucleosome mobility and the histone code. Nature Structural and Molecular Biology 11 1037-1043. (doi:10.1038/nsmb851)
30. Crews D & McLachlan JA 2006 Epigenetics, evolution, endocrine disruption, health, and disease. Endocrinology 147 S4-S10. (doi:10.1210/en.2005- 1122)
31. Cui M, Wen Z, Yang Z, Chen J & Wang F 2009 Estrogen regulates DNA methyltransferase 3B expression in Ishikawa endometrial adenocarcinoma cells. Molecular Biology Reports 36 2201-2207. (doi:10.1007/s11033-008-9435-9)
32. Dannenberg LO & Edenberg HJ 2006 Epigenetics of gene expression in human hepatoma cells: expression profiling the response to inhibition of DNA methylation and histone deacetylation. BMC Genomics 7 181. (doi:10.1186/1471- 2164-7-181)
33. Davis SW, Castinetti F, Carvalho LR, Ellsworth BS, Potok MA, Lyons RH, Brinkmeier ML, Raetzman LT, Carninci P, Mortensen AH et al. 2009 Molecular mechanisms of pituitary organogenesis: in search of novel regulatory genes. Molecular and Cellular Endocrinology 323 4-19. (doi:10.1016/j.mce.2009.12.012)
34. Dekker FJ & Haisma HJ 2009 Histone acetyl transferases as emerging drug targets. Drug Discovery Today 14 942-948. (doi:10.1016/j.drudis.2009.06. 008)
35. Deladoey J, Vassart G & Van VG 2007 Possible non-Mendelian mechanisms of thyroid dysgenesis. Endocrine Development 10 29-42. (doi:10.1159/000106818)
36. Demura M & Bulun SE 2008 CpG dinucleotide methylation of the CYP19 I.3/II promoter modulates cAMP-stimulated aromatase activity. Molecular and Cellular Endocrinology 283 127-132. (doi:10.1016/j.mce.2007.12.003)
37. Denier X, Hill EM, Rotchell J & Minier C 2009 Estrogenic activity of cadmium, copper and zinc in the yeast estrogen screen. Toxicology in Vitro 23 569-573. (doi:10.1016/j.tiv.2009.01.006)
38. Dolinoy DC, Huang D & Jirtle RL 2007 Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development. PNAS 104 13056-13061. (doi:10.1073/pnas.0703739104)
39. Ehrlich S, Weiss D, Burghardt R, Infante-Duarte C, Brockhaus S, Muschler MA, Bleich S, Lehmkuhl U & Frieling H 2010 Promoter specific DNA methylation and gene expression of POMC in acutely underweight and recovered patients with anorexia nervosa. Journal of Psychiatric Research 44 827-833. (doi:10.1016/j.jpsychires.2010.01.011)
40. Ekbom A, Wuu J, Adami HO, Lu CM, Lagiou P, Trichopoulos D & Hsieh C 2000 Duration of gestation and prostate cancer risk in offspring. Cancer Epidemiology, Biomarkers and Prevention 9 221-223. (Pubitemid 30111948)
41. Esteller M 2005 Aberrant DNA methylation as a cancer-inducing mechanism. Annual Review of Pharmacology and Toxicology 45 629-656. (doi:10.1146/annurev. pharmtox.45.120403.095832)
42. Evans RM 1988 The steroid and thyroid hormone receptor superfamily. Science 240 889-895. (doi:10.1126/science.3283939)
43. Feinberg AP 2007 Phenotypic plasticity and the epigenetics of human disease. Nature 447 433-440. (doi:10.1038/nature05919)
44. Fraga MF, Ballestar E, Paz MF, Ropero S, Setien F, Ballestar ML, Heine-Suner D, Cigudosa JC, Urioste M, Benitez J et al. 2005 Epigenetic differences arise during the lifetime of monozygotic twins. PNAS 102 10604-10609. (doi:10.1073/pnas.0500398102)
45. Franceschi C, Olivieri F, Marchegiani F, Cardelli M, Cavallone L, Capri M, Salvioli S, Valensin S, De Benedictis G, Di Iorio A et al. 2005 Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians. Mechanisms of Ageing and Development 126 351-361. (doi:10.1016/j.mad.2004.08.028)
46. Fuks F 2005 DNA methylation and histone modifications: teaming up to silence genes. Current Opinion in Genetics and Development 15 490-495. (doi:10.1016/j.gde.2005.08.002)
47. Gale EA, Bingley PJ, Eisenbarth GS, Redondo MJ, Kyvik KO & Petersen JS 2001 Reanalysis of twin studies suggests that diabetes is mainly genetic. BMJ 323 997-998. (doi:10.1136/bmj.323.7319.997a)
48. Ganesan A, Nolan L, Crabb SJ & Packham G 2009 Epigenetic therapy: histone acetylation, DNA methylation and anti-cancer drug discovery. Current Cancer Drug Targets 9 963-981. (doi:10.2174/156800909790192428)
49. Gilman AG 1987 G proteins: transducers of receptor-generated signals. Annual Review of Biochemistry 56 615-649. (doi:10.1146/annurev.bi.56.070187. 003151)
50. Gluckman PD, Hanson MA, Buklijas T, Low FM & Beedle AS 2009 Epigenetic mechanisms that underpin metabolic and cardiovascular diseases. Nature Reviews. Endocrinology 5 401-408. (doi:10.1038/nrendo.2009.102)
51. Godfrey K 2006 The 'developmental origins' hypothesis: epidemiology. In Developmental Origins of Health and Disease, pp 6-32. Eds PD Gluckman & MA Hanson. Cambridge: Cambridge University Press.
52. Goldberg AD, Allis CD & Bernstein E 2007 Epigenetics: a landscape takes shape. Cell 128 635-638. (doi:10.1016/j.cell.2007.02.006)
53. Gregory SG, Connelly JJ, Towers AJ, Johnson J, Biscocho D, Markunas CA, Lintas C, Abramson RK, Wright HH, Ellis P et al. 2009 Genomic and epigenetic evidence for oxytocin receptor deficiency in autism. BMC Medicine 7 62. (doi:10.1186/1741-7015-7-62)
54. Griswold MD & Kim JS 2001 Site-specific methylation of the promoter alters deoxyribonucleic acid-protein interactions and prevents follicle-stimulating hormone receptor gene transcription. Biology of Reproduction 64 602-610. (doi:10.1095/biolreprod64.2.602)
55. Gurrieri F & Neri G 2009 Defective oxytocin function: a clue to understanding the cause of autism? BMC Medicine 7 63. (doi:10.1186/1741-7015-7- 63)
56. Hansen RS, Wijmenga C, Luo P, Stanek AM, Canfield TK, Weemaes CM & Gartler SM 1999 The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome. PNAS 96 14412-14417. (doi:10.1073/pnas.96.25.14412)
57. Hayashi K, Yokozaki H, Goodison S, Oue N, Suzuki T, Lotan R, Yasui W & Tahara E 2001 Inactivation of retinoic acid receptor beta by promoter CpG hypermethylation in gastric cancer. Differentiation 68 13-21. (doi:10.1046/j.1432-0436.2001.068001013.x)
58. Heemers HV, Sebo TJ, Debes JD, Regan KM, Raclaw KA, Murphy LM, Hobisch A, Culig Z & Tindall DJ 2007 Androgen deprivation increases p300 expression in prostate cancer cells. Cancer Research 67 3422-3430. (doi:10.1158/0008-5472. CAN-06-2836)
59. Hermann A, Gowher H & Jeltsch A 2004 Biochemistry and biology of mammalian DNA methyltransferases. Cellular and Molecular Life Sciences 61 2571-2587. (doi:10.1007/s00018-004-4201-1)
60. Hillemacher T, Frieling H, Luber K, Yazici A, Muschler MA, Lenz B, Wilhelm J, Kornhuber J & Bleich S 2009 Epigenetic regulation and gene expression of vasopressin and atrial natriuretic peptide in alcohol withdrawal. Psychoneuroendocrinology 34 555-560. (doi:10.1016/j.psyneuen.2008.10.019)
61. Hiroi H, Christenson LK & Strauss JF III 2004 Regulation of transcription of the steroidogenic acute regulatory protein (StAR) gene: temporal and spatial changes in transcription factor binding and histone modification. Molecular and Cellular Endocrinology 215 119-126. (doi:10.1016/j.mce.2003.11.014)
62. Hitchins MP, Wong JJ, Suthers G, Suter CM, Martin DI, Hawkins NJ & Ward RL 2007 Inheritance of a cancer-associated MLH1 germ-line epimutation. New England Journal of Medicine 356 697-705. (doi:10.1056/NEJMoa064522)
63. Ho SM, Tang WY, Belmonte de Frausto J & Prins GS 2006 Developmental exposure to estradiol and bisphenol A increases susceptibility to prostate carcinogenesis and epigenetically regulates phosphodiesterase type 4 variant 4. Cancer Research 66 5624-5632. (doi:10.1158/0008-5472.CAN-06-0516)
64. Holliday R 1991 Mutations and epimutations in mammalian cells. Mutation Research 250 351-363. (doi:10.1016/0027-5107(91)90192-Q)
65. Houshdaran S, Cortessis VK, Siegmund K, Yang A, Laird PW & Sokol RZ 2007 Widespread epigenetic abnormalities suggest a broad DNA methylation erasure defect in abnormal human sperm. PLoS ONE 2 e1289. (doi:10.1371/journal.pone. 0001289)
66. Hsu PY, Deatherage DE, Rodriguez BA, Liyanarachchi S, Weng YI, Zuo T, Liu J, Cheng AS & Huang TH 2009 Xenoestrogen-induced epigenetic repression of microRNA-9-3 in breast epithelial cells. Cancer Research 69 5936-5945. (doi:10.1158/0008-5472.CAN-08-4914)
67. Hughes CL Jr 1988 Phytochemical mimicry of reproductive hormones and modulation of herbivore fertility by phytoestrogens. Environmental Health Perspectives 78 171-174. (doi:10.2307/3430517)
68. 3 in vivo and in vitro. Molecular Endocrinology 18 2660-2671. (doi:10.1210/me.2004-0116)
69. Hyman SJ, Novoa Y & Holzman I 2009 Perinatal endocrinology: common endocrine disorders in the sick and premature newborn. Endocrinology and Metabolism Clinics of North America 38 509-524. (doi:10.1016/j.ecl.2009.06.005)
70. Iliopoulos D, Malizos KN & Tsezou A 2007 Epigenetic regulation of leptin affects MMP-13 expression in osteoarthritic chondrocytes: possible molecular target for osteoarthritis therapeutic intervention. Annals of the Rheumatic Diseases 66 1616-1621. (doi:10.1136/ard.2007.069377)
71. Izawa M, Harada T, Taniguchi F, Ohama Y, Takenaka Y & Terakawa N 2008 An epigenetic disorder may cause aberrant expression of aromatase gene in endometriotic stromal cells. Fertility and Sterility 89 1390-1396. (doi:10.1016/j.fertnstert.2007.03.078)
72. Jaenisch R & Bird A 2003 Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nature Genetics 33 (Supplement) 245-254. (doi:10.1038/ng1089)
73. Jansen RP 1984 Endocrine response in the fallopian tube. Endocrine Reviews 5 525-551. (doi:10.1210/edrv-5-4-525)
74. Ji J, Zhang J, Huang G, Qian J, Wang X & Mei S 2009 Over-expressed microRNA-27a and 27b influence fat accumulation and cell proliferation during rat hepatic stellate cell activation. FEBS Letters 583 759-766. (doi:10.1016/j.febslet.2009.01.034)
75. Jiang G, Xu L, Song S, Zhu C, Wu Q, Zhang L & Wu L 2008 Effects of long-term low-dose cadmium exposure on genomic DNA methylation in human embryo lung fibroblast cells. Toxicology 244 49-55. (doi:10.1016/j.tox.2007.10.028)
76. Jin Z, Mori Y, Hamilton JP, Olaru A, Sato F, Yang J, Ito T, Kan T, Agarwal R & Meltzer SJ 2008a Hypermethylation of the somatostatin promoter is a common, early event in human esophageal carcinogenesis. Cancer 112 43-49. (doi:10.1002/cncr.23135)
77. Jin B, Tao Q, Peng J, Soo HM, Wu W, Ying J, Fields CR, Delmas AL, Liu X, Qiu J et al. 2008b DNA methyltransferase 3B (DNMT3B) mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development, neurogenesis and immune function. Human Molecular Genetics 17 690-709. (doi:10.1093/hmg/ddm341)
78. Jirtle RL & Skinner MK 2007 Environmental epigenomics and disease susceptibility. Nature Reviews. Genetics 8 253-262. (doi:10.1038/nrg2045)
79. Johnnidis JB, Harris MH, Wheeler RT, Stehling-Sun S, Lam MH, Kirak O, Brummelkamp TR, Fleming MD & Camargo FD 2008 Regulation of progenitor cell proliferation and granulocyte function by microRNA-223. Nature 451 1125-1129. (doi:10.1038/nature06607)
80. Kaminsky ZA, Tang T, Wang SC, Ptak C, Oh GH, Wong AH, Feldcamp LA, Virtanen C, Halfvarson J, Tysk C et al. 2009 DNA methylation profiles in monozygotic and dizygotic twins. Nature Genetics 41 240-245. (doi:10.1038/ng.286)
81. Kaprio J, Tuomilehto J, Koskenvuo M, Romanov K, Reunanen A, Eriksson J, Stengard J & Kesaniemi YA 1992 Concordance for type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus in a population-based cohort of twins in Finland. Diabetologia 35 1060-1067. (doi:10.1007/BF02221682)
82. Kashyap V & Gudas LJ 2010 Epigenetic regulatory mechanisms distinguish retinoic acid-mediated transcriptional responses in stem cells and fibroblasts. Journal of Biological Chemistry 285 14534-14548. (doi:10.1074/jbc.M110.115345)
83. Kelce WR, Stone CR, Laws SC, Gray LE, Kemppainen JA & Wilson EM 1995 Persistent DDT metabolite p,p′-DDE is a potent androgen receptor antagonist. Nature 375 581-585. (doi:10.1038/375581a0)
84. 3-induced DNA methylation suppresses the human CYP27B1 gene. Molecular and Cellular Endocrinology 265-266 168-173. (doi:10.1016/j.mce. 2006.12.014)
85. Kim MS, Kondo T, Takada I, Youn MY, Yamamoto Y, Takahashi S, Matsumoto T, Fujiyama S, Shirode Y, Yamaoka I et al. 2009 DNA demethylation in hormone-induced transcriptional derepression. Nature 461 1007-1012. (doi:10.1038/nature08456)
86. Kinoshita H, Shi Y, Sandefur C, Meisner LF, Chang C, Choon A, Reznikoff CR, Bova GS, Friedl A & Jarrard DF 2000 Methylation of the androgen receptor minimal promoter silences transcription in human prostate cancer. Cancer Research 60 3623-3630. (Pubitemid 30482185)
87. Klinge CM 2009 Estrogen regulation of microRNA expression. Current Genomics 10 169-183. (doi:10.2174/138920209788185289)
88. Knower KC, To SQ, Simpson ER & Clyne CD 2010 Epigenetic mechanisms regulating CYP19 transcription in human breast adipose fibroblasts. Molecular and Cellular Endocrinology 321 123-130. (doi:10.1016/j.mce.2010.02.035)
89. Knudsen KE & Penning TM 2010 Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer. Trends in Endocrinology and Metabolism 21 315-324. (doi:10.1016/j.tem.2010.01.002)
90. Kondo Y 2009 Epigenetic cross-talk between DNA methylation and histone modifications in human cancers. Yonsei Medical Journal 50 455-463. (doi:10.3349/ymj.2009.50.4.455)
91. Kondo N, Toyama T, Sugiura H, Fujii Y & Yamashita H 2008 miR-206 Expression is down-regulated in estrogen receptor alpha-positive human breast cancer. Cancer Research 68 5004-5008. (doi:10.1158/0008-5472.CAN-08-0180)
92. Kong W, Zhao JJ, He L & Cheng JQ 2009 Strategies for profiling microRNA expression. Journal of Cellular Physiology 218 22-25. (doi:10.1002/jcp.21577)
93. Kuroda A, Rauch TA, Todorov I, Ku HT, Al-Abdullah IH, Kandeel F, Mullen Y, Pfeifer GP & Ferreri K 2009 Insulin gene expression is regulated by DNA methylation. PLoS ONE 4 e6953. (doi:10.1371/journal.pone.0006953)
94. Kuzawa CW & Quinn EA 2009 Developmental origins of adult function and health: evolutionary hypotheses. Annual Review of Anthropology 38 131-147. (doi:10.1146/annurev-anthro-091908-164350)
95. Lal G & Bromberg JS 2009 Epigenetic mechanisms of regulation of Foxp3 expression. Blood 114 3727-3735. (doi:10.1182/blood-2009-05-219584)
96. Latini G, Marcovecchio ML, Del VA, Gallo F, Bertino E & Chiarelli F 2009 Influence of environment on insulin sensitivity. Environment International 35 987-993. (doi:10.1016/j.envint.2009.03.008)
97. Lee LT, Tan-Un KC, Pang RT, Lam DT & Chow BK 2004 Regulation of the human secretin gene is controlled by the combined effects of CpG methylation, Sp1/Sp3 ratio, and the E-box element. Molecular Endocrinology 18 1740-1755. (doi:10.1210/me.2003-0461)
98. Lee DO, Jee BC, Ku SY, Suh CS, Kim SH, Choi YM, Moon SY & Kim JG 2008 Relationships between the insulin-like growth factor I (IGF-I) receptor gene G3174A polymorphism, serum IGF-I levels, and bone mineral density in postmenopausal Korean women. Journal of Bone and Mineral Metabolism 26 42-46. (doi:10.1007/s00774-007-0795-3)
99. Li LC & Dahiya R 2002 MethPrimer: designing primers for methylation PCRs. Bioinformatics 18 1427-1431. (doi:10.1093/bioinformatics/18.11.1427)
100. Li G, Luna C, Qiu J, Epstein DL & Gonzalez P 2009a Alterations in microRNA expression in stress-induced cellular senescence. Mechanisms of Ageing and Development 130 731-741. (doi:10.1016/j.mad.2009.09.002)
101. Li Y, Liu L, Andrews LG & Tollefsbol TO 2009b Genistein depletes telomerase activity through cross-talk between genetic and epigenetic mechanisms. International Journal of Cancer 125 286-296. (doi:10.1002/ijc.24398)
102. Ling C & Groop L 2009 Epigenetics: a molecular link between environmental factors and type 2 diabetes. Diabetes 58 2718-2725. (doi:10.2337/db09-1003)
103. Lintas C & Persico AM 2010 Neocortical RELN promoter methylation increases significantly after puberty. Neuroreport 21 114-118. (doi:10.1097/WNR.0b013e328334b343)
104. Lobato MN, Ordonez-Sanchez ML, Tusie-Luna MT & Meseguer A 1999 Mutation analysis in patients with congenital adrenal hyperplasia in the Spanish population: identification of putative novel steroid 21-hydroxylase deficiency alleles associated with the classic form of the disease. Human Heredity 49 169-175. (doi:10.1159/000022866)
105. Lv K, Guo Y, Zhang Y, Wang K, Jia Y & Sun S 2008 Allele-specific targeting of hsa-miR-657 to human IGF2R creates a potential mechanism underlying the association of ACAA-insertion/deletion polymorphism with type 2 diabetes. Biochemical and Biophysical Research Communications 374 101-105. (doi:10.1016/j.bbrc.2008.06.102)
106. Majid S, Dar AA, Shahryari V, Hirata H, Ahmad A, Saini S, Tanaka Y, Dahiya AV & Dahiya R 2010 Genistein reverses hypermethylation and induces active histone modifications in tumor suppressor gene B-Cell translocation gene 3 in prostate cancer. Cancer 116 66-76. (doi:10.1002/cncr.25488)
107. Martinez-Arguelles DB & Papadopoulos V 2010 Epigenetic regulation of the expression of genes involved in steroid hormone biosynthesis and action. Steroids 75 467-476. (doi:10.1016/j.steroids.2010.02.004)
108. Martinez-Arguelles DB, Culty M, Zirkin BR & Papadopoulos V 2009 In utero exposure to di-(2-ethylhexyl) phthalate decreases mineralocorticoid receptor expression in the adult testis. Endocrinology 150 5575-5585. (doi:10.1210/en.2009-0847)
109. Maywood ES, O'Neill JS, Reddy AB, Chesham JE, Prosser HM, Kyriacou CP, Godinho SI, Nolan PM & Hastings MH 2007 Genetic and molecular analysis of the central and peripheral circadian clockwork of mice. Cold Spring Harbor Symposia on Quantitative Biology 72 85-94. (doi:10.1101/sqb.2007.72.005)
110. McNamara P, Seo SB, Rudic RD, Sehgal A, Chakravarti D & FitzGerald GA 2001 Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock. Cell 105 877-889. (doi:10.1016/S0092-8674(01)00401-9)
111. Melzner I, Scott V, Dorsch K, Fischer P, Wabitsch M, Bruderlein S, Hasel C & Moller P 2002 Leptin gene expression in human preadipocytes is switched on by maturation-induced demethylation of distinct CpGs in its proximal promoter. Journal of Biological Chemistry 277 45420-45427. (doi:10.1074/jbc. M208511200)
112. Metzker ML 2010 Sequencing technologies - the next generation. Nature Reviews. Genetics 11 31-46. (doi:10.1038/nrg2626)
113. Michels KB & Xue F 2006 Role of birthweight in the etiology of breast cancer. International Journal of Cancer 119 2007-2025. (doi:10.1002/ijc.22004)
114. Miller WL 1988 Molecular biology of steroid hormone synthesis. Endocrine Reviews 9 295-318. (doi:10.1210/edrv-9-3-295)
115. Miller WL 2007 Steroidogenic acute regulatory protein (StAR), a novel mitochondrial cholesterol transporter. Biochimica et Biophysica Acta 1771 663-676. (doi:10.1016/j.bbalip.2007.02.012)
116. Miremadi A, Oestergaard MZ, Pharoah PD & Caldas C 2007 Cancer genetics of epigenetic genes. Human Molecular Genetics 16 R28-R49. (doi:10.1093/hmg/ddm021)
117. Missaghian E, Kempna P, Dick B, Hirsch A, Alikhani-Koupaei R, Jegou B, Mullis PE, Frey BM & Fluck CE 2009 Role of DNA methylation in the tissue-specific expression of the CYP17A1 gene for steroidogenesis in rodents. Journal of Endocrinology 202 99-109. (doi:10.1677/JOE-08-0353)
118. Moffat ID, Boutros PC, Celius T, Linden J, Pohjanvirta R & Okey AB 2007 microRNAs in adult rodent liver are refractory to dioxin treatment. Toxicological Sciences 99 470-487. (doi:10.1093/toxsci/kfm189)
119. Moiseeva EP & Manson MM 2009 Dietary chemopreventive phytochemicals: too little or too much? Cancer Prevention Research 2 611-616. (doi:10.1158/1940-6207.CAPR-08-0102)
120. Molinie B & Georgel P 2009 Genetic and epigenetic regulations of prostate cancer by genistein. Drug News and Perspectives 22 247-254. (doi:10.1358/dnp.2009.22.5.1378633)
121. Montanelli L & Tonacchera M 2010 Genetics and phenomics of hypothyroidism and thyroid dys- and agenesis due to PAX8 and TTF1 mutations. Molecular and Cellular Endocrinology 322 64-71. (doi:10.1016/j.mce.2010.03.009)
122. Montgomery RB, Mostaghel EA, Vessella R, Hess DL, Kalhorn TF, Higano CS, True LD & Nelson PS 2008 Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth. Cancer Research 68 4447-4454. (doi:10.1158/0008-5472.CAN-08-0249)
123. Mori Y, Cai K, Cheng Y, Wang S, Paun B, Hamilton JP, Jin Z, Sato F, Berki AT, Kan T et al. 2006 A genome-wide search identifies epigenetic silencing of somatostatin, tachykinin-1, and 5 other genes in colon cancer. Gastroenterology 131 797-808. (doi:10.1053/j.gastro.2006.06.006)
124. Muller HM, Fiegl H, Goebel G, Hubalek MM, Widschwendter A, Muller-Holzner E, Marth C & Widschwendter M 2003 MeCP2 and MBD2 expression in human neoplastic and non-neoplastic breast tissue and its association with oestrogen receptor status. British Journal of Cancer 89 1934-1939. (doi:10.1038/sj.bjc. 6601392)
125. Musri MM, Gomis R & Parrizas M 2007 Chromatin and chromatin-modifying proteins in adipogenesis. Biochemistry and Cell Biology 85 397-410. (doi:10.1139/O07-068)
126. Newell-Price J 2003 Proopiomelanocortin gene expression and DNA methylation: implications for Cushing's syndrome and beyond. Journal of Endocrinology 177 365-372. (doi:10.1677/joe.0.1770365)
127. Noer A, Sorensen AL, Boquest AC & Collas P 2006 Stable CpG hypomethylation of adipogenic promoters in freshly isolated, cultured, and differentiated mesenchymal stem cells from adipose tissue. Molecular Biology of the Cell 17 3543-3556. (doi:10.1091/mbc.E06-04-0322)
128. Novac N & Heinzel T 2004 Nuclear receptors: overview and classification. Current Drug Targets. Inflammation and Allergy 3 335-346. (doi:10.2174/1568010042634541)
129. Oakes CC, La SS, Smiraglia DJ, Robaire B & Trasler JM 2007 Developmental acquisition of genome-wide DNA methylation occurs prior to meiosis in male germ cells. Developmental Biology 307 368-379. (doi:10.1016/j.ydbio. 2007.05.002)
130. Ojeda SR, Lomniczi A, Sandau U & Matagne V 2010 New concepts on the control of the onset of puberty. Endocrine Development 17 44-51. (doi:10.1159/000262527)
131. Okano M, Bell DW, Haber DA & Li E 1999 DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99 247-257. (doi:10.1016/S0092-8674(00)81656-6)
132. Olsson M, Gustafsson O, Skogastierna C, Tolf A, Rietz BD, Morfin R, Rane A & Ekstrom L 2007 Regulation and expression of human CYP7B1 in prostate: overexpression of CYP7B1 during progression of prostatic adenocarcinoma. Prostate 67 1439-1446. (doi:10.1002/pros.20630)
133. Omdahl JL, Morris HA & May BK 2002 Hydroxylase enzymes of the vitamin D pathway: expression, function, and regulation. Annual Review of Nutrition 22 139-166. (doi:10.1146/annurev.nutr.22.120501.150216)
134. Ooi SK, O'Donnell AH & Bestor TH 2009 Mammalian cytosine methylation at a glance. Journal of Cell Science 122 2787-2791. (doi:10.1242/jcs.015123)
135. Patra SK & Bettuzzi S 2009 Epigenetic DNA-(cytosine-5-carbon) modifications: 5-aza-2′-deoxycytidine and DNA-demethylation. Biochemistry 74 613-619. (doi:10.1134/S0006297909060042)
136. Pearson RK, Anderson B & Dixon JE 1993 Molecular biology of the peptide hormone families. Endocrinology and Metabolism Clinics of North America 22 753-774.
137. Perera F, Tang WY, Herbstman J, Tang D, Levin L, Miller R & Ho SM 2009 Relation of DNA methylation of 5′-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma. PLoS ONE 4 e4488. (doi:10.1371/journal.pone.0004488)
138. Peterson CL & Laniel MA 2004 Histones and histone modifications. Current Biology 14 R546-R551. (doi:10.1016/j.cub.2004.07.007)
139. Pettitt DJ, Baird HR, Aleck KA, Bennett PH & Knowler WC 1983 Excessive obesity in offspring of Pima Indian women with diabetes during pregnancy. New England Journal of Medicine 308 242-245. (doi:10.1056/ NEJM198302033080502)
140. Pettitt DJ, Bennett PH, Saad MF, Charles MA, Nelson RG & Knowler WC 1991 Abnormal glucose tolerance during pregnancy in Pima Indian women. Long-term effects on offspring. Diabetes 40 (Supplement 2) 126-130.
141. Pietilainen KH, Naukkarinen J, Rissanen A, Saharinen J, Ellonen P, Keranen H, Suomalainen A, Gotz A, Suortti T, Yki-Jarvinen H et al. 2008 Global transcript profiles of fat in monozygotic twins discordant for BMI: pathways behind acquired obesity. PLoS Medicine 5 e51. (doi:10.1371/journal.pmed.0050051)
142. Plagemann A, Harder T, Brunn M, Harder A, Roepke K, Wittrock-Staar M, Ziska T, Schellong K, Rodekamp E, Melchior K et al. 2009 Hypothalamic proopiomelanocortin promoter methylation becomes altered by early overfeeding: an epigenetic model of obesity and the metabolic syndrome. Journal of Physiology 587 4963-4976. (doi:10.1113/jphysiol.2009.176156)
143. Platz EA, Giovannucci E, Rimm EB, Curhan GC, Spiegelman D, Colditz GA & Willett WC 1998 Retrospective analysis of birth weight and prostate cancer in the Health Professionals Follow-up Study. American Journal of Epidemiology 147 1140-1144. (Pubitemid 28285456)
144. Pozzi S, Rossetti S, Bistulfi G & Sacchi N 2006 RAR-mediated epigenetic control of the cytochrome P450 Cyp26a1 in embryocarcinoma cells. Oncogene 25 1400-1407. (doi:10.1038/sj.onc.1209173)
145. Prins GS 2008 Estrogen imprinting: when your epigenetic memories come back to haunt you. Endocrinology 149 5919-5921. (doi:10.1210/en.2008-1266)
146. Rakyan VK, Blewitt ME, Druker R, Preis JI & Whitelaw E 2002
147. Rakyan VK, Chong S, Champ ME, Cuthbert PC, Morgan HD, Luu KV & Whitelaw E 2003 Transgenerational inheritance of epigenetic states at the murine Axin(Fu) allele occurs after maternal and paternal transmission. PNAS 100 2538-2543. (doi:10.1073/pnas.0436776100)
148. Rampersaud E, Mitchell BD, Naj AC & Pollin TI 2008 Investigating parent of origin effects in studies of type 2 diabetes and obesity. Current Diabetes Reviews 4 329-339. (doi:10.2174/157339908786241179)
149. Reaven GM 1993 Role of insulin resistance in human disease (syndrome X): an expanded definition. Annual Review of Medicine 44 121-131. (doi:10.1146/annurev.me.44.020193.001005)
150. Rocha Monteiro PR, Reis-Henriques MA & Coimbra J 2000 Polycyclic aromatic hydrocarbons inhibit in vitro ovarian steroidogenesis in the flounder (Platichthys flesus L.). Aquatic Toxicology 48 549-559. (doi:10.1016/S0166- 445X(99)00055-7)
151. Rochester JR & Millam JR 2009 Phytoestrogens and avian reproduction: exploring the evolution and function of phytoestrogens and possible role of plant compounds in the breeding ecology of wild birds. Comparative Biochemistry and Physiology. Part A, Molecular and Integrative Physiology 154 279-288. (doi:10.1016/j.cbpa.2009.06.017)
152. Rodriguez A, Griffiths-Jones S, Ashurst JL & Bradley A 2004 Identification of mammalian microRNA host genes and transcription units. Genome Research 14 1902-1910. (doi:10.1101/gr.2722704)
153. Rodriguez-Antona C, Gomez A, Karlgren M, Sim SC & Ingelman-Sundberg M 2010 Molecular genetics and epigenetics of the cytochrome P450 gene family and its relevance for cancer risk and treatment. Human Genetics 127 1-17. (doi:10.1007/s00439-009-0748-0)
154. Rossignol DA 2009 Novel and emerging treatments for autism spectrum disorders: a systematic review. Annals of Clinical Psychiatry 21 213-236.
155. Rubello D, Giannini S, D'Angelo A, Nobile M, Carraio G, Rigotti P, Marchini F, Zaninotto M, Dalle CL, Sartori L et al. 2005 Secondary hyperparathyroidism is associated with vitamin D receptor polymorphism and bone density after renal transplantation. Biomedicine and Pharmacotherapy 59 402-407. (doi:10.1016/j.biopha.2004.09.015)
156. Rusiecki JA, Baccarelli A, Bollati V, Tarantini L, Moore LE & Bonefeld-Jorgensen EC 2008 Global DNA hypomethylation is associated with high serum-persistent organic pollutants in Greenlandic Inuit. Environmental Health Perspectives 116 1547-1552. (doi:10.1289/ehp.11338)
157. Ryan KK, Haller AM, Sorrell JE, Woods SC, Jandacek RJ & Seeley RJ 2010 Perinatal exposure to bisphenol-a and the development of metabolic syndrome in CD-1 mice. Endocrinology 151 2603-2612. (doi:10.1210/en.2009-1218)
158. Safe S & Wormke M 2003 Inhibitory aryl hydrocarbon receptor-estrogen receptor alpha cross-talk and mechanisms of action. Chemical Research in Toxicology 16 807-816. (doi:10.1021/tx034036r)
159. Saji S, Kawakami M, Hayashi S, Yoshida N, Hirose M, Horiguchi S, Itoh A, Funata N, Schreiber SL, YoshidaMet al. 2005 Significance of HDAC6 regulation via estrogen signaling for cell motility and prognosis in estrogen receptor-positive breast cancer. Oncogene 24 4531-4539. (doi:10.1038/sj.onc. 1208646)
160. Salay E & Garabrant D 2009 Polychlorinated biphenyls and thyroid hormones in adults: a systematic review appraisal of epidemiological studies. Chemosphere 74 1413-1419. (doi:10.1016/j.chemosphere.2008.11.031)
161. Sasaki M, Oh BR, Dharia A, Fujimoto S & Dahiya R 2000 Inactivation of the human androgen receptor gene is associated with CpG hypermethylation in uterine endometrial cancer. Molecular Carcinogenesis 29 59-66. (doi:10.1002/1098-2744(200010)29:2〈59::AID-MC2〉3.0.CO;2-6)
162. Sasaki M, Kaneuchi M, Fujimoto S, Tanaka Y & Dahiya R 2003 Hypermethylation can selectively silence multiple promoters of steroid receptors in cancers. Molecular and Cellular Endocrinology 202 201-207. (doi:10.1016/S0303-7207(03)00084-4)
163. Schayek H, Bentov I, Sun S, Plymate SR & Werner H 2010 Progression to metastatic stage in a cellular model of prostate cancer is associated with methylation of the androgen receptor gene and transcriptional suppression of the insulin-like growth factor-I receptor gene. Experimental Cell Research 316 1479-1488. (doi:10.1016/j.yexcr.2010.03.007)
164. Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, Duren WL, Erdos MR, Stringham HM, Chines PS, Jackson AU et al. 2007 A genomewide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316 1341-1345. (doi:10.1126/science.1142382)
165. Scully KM & Rosenfeld MG 2002 Pituitary development: regulatory codes inmammalian organogenesis. Science 295 2231-2235. (doi:10.1126/science.1062736)
166. Sharpe RM & Drake AJ 2010 Bisphenol A and metabolic syndrome. Endocrinology 151 2404-2407. (doi:10.1210/en.2010-0445)
167. Shi XB, Tepper CG & deVere White RW 2008a Cancerous miRNAs and their regulation. Cell Cycle 7 1529-1538.
168. Shi XB, Tepper CG & White RW 2008b MicroRNAs and prostate cancer. Journal of Cellular and Molecular Medicine 12 1456-1465. (doi:10.1111/j.1582- 4934.2008.00420.x)
169. Shutoh Y, Takeda M, Ohtsuka R, Haishima A, Yamaguchi S, Fujie H, Komatsu Y, Maita K & Harada T 2009 Low dose effects of dichlorodiphenyltrichloroethane (DDT) on gene transcription and DNA methylation in the hypothalamus of young male rats: implication of hormesis-like effects. Journal of Toxicological Sciences 34 469-482.
170. Siddiqi MA, Laessig RH & Reed KD 2003 Polybrominated diphenyl ethers (PBDEs): new pollutants-old diseases. Clinical Medicine and Research 1 281-290. (doi:10.3121/cmr.1.4.281)
171. Siedlecki P & Zielenkiewicz P 2006 Mammalian DNA methyltransferases. Acta Biochimica Polonica 53 245-256. (Pubitemid 44033922)
172. Sikka SC & Wang R 2008 Endocrine disruptors and estrogenic effects on male reproductive axis. Asian Journal of Andrology 10 134-145. (doi:10.1111/j.1745-7262.2008.00370.x)
173. Simmons RA 2009 Developmental origins of adult disease. Pediatric Clinics of North America 56 449-466. (doi:10.1016/j.pcl.2009.03.004)
174. Sinclair KD, Allegrucci C, Singh R, Gardner DS, Sebastian S, Bispham J, Thurston A, Huntley JF, Rees WD, Maloney CA et al. 2007 DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status. PNAS 104 19351-19356. (doi:10.1073/pnas.0707258104)
175. Smith JA, Fan CY, Zou C, Bodenner D & Kokoska MS 2007Methylation status of genes in papillary thyroid carcinoma. Archives of Otolaryngology - Head and Neck Surgery 133 1006-1011. (doi:10.1001/archotol.133.10.1006)
176. Sober S, Laan M & Annilo T 2010 MicroRNAs miR-124 and miR-135a are potential regulators of the mineralocorticoid receptor gene (NR3C2) expression. Biochemical and Biophysical Research Communications 391 727-732. (doi:10.1016/j.bbrc.2009.11.128)
177. Stein DJ 2009 Oxytocin and vasopressin: social neuropeptides. CNS Spectrums 14 602-606.
178. Stevens A, Begum G, Cook A, Connor K, Rumball C, Oliver M, Challis J, Bloomfield F & White A 2010 Epigenetic changes in the hypothalamic proopiomelanocortin and glucocorticoid receptor genes in the ovine fetus after periconceptional undernutrition. Endocrinology 151 3652-3664. (doi:10.1210/en.2010-0094)
179. Stoger R 2006 In vivo methylation patterns of the leptin promoter in human and mouse. Epigenetics 1 155-162. (doi:10.4161/epi.1.4.3400)
180. Stoger R, Kubicka P, Liu CG, Kafri T, Razin A, Cedar H & Barlow DP 1993 Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal. Cell 73 61-71. (doi:10.1016/0092-8674(93)90160-R)
181. Stouffs K, Vandermaelen D, Tournaye H, Liebaers I, Van SA & Lissens W 2009 Genetics and male infertility. Verhandelingen - Koninklijke Academie Voor Geneeskunde Van Belgie 71 115-139.
182. Sun LY & D'Ercole AJ 2006 Insulin-like growth factor-I stimulates histone H3 and H4 acetylation in the brain in vivo. Endocrinology 147 5480-5490. (doi:10.1210/en.2006-0586)
183. Tang WY & Ho SM 2007 Epigenetic reprogramming and imprinting in origins of disease. Reviews in Endocrine and Metabolic Disorders 8 173-182. (doi:10.1007/s11154-007-9042-4)
184. Tang WY, Newbold R, Mardilovich K, Jefferson W, Cheng RY, Medvedovic M & Ho SM 2008 Persistent hypomethylation in the promoter of nucleosomal binding protein 1 (Nsbp1) correlates with overexpression of Nsbp1 in mouse uteri neonatally exposed to diethylstilbestrol or genistein. Endocrinology 149 5922-5931. (doi:10.1210/en.2008-0682)
185. Tang X, Muniappan L, Tang G & Ozcan S 2009 Identification of glucose-regulated miRNAs from pancreatic {beta} cells reveals a role for miR-30d in insulin transcription. RNA 15 287-293. (doi:10.1261/rna.1211209)
186. Thompson RF & Einstein FH 2010 Epigenetic basis for fetal origins of age-related disease. Journal of Women's Health 19 581-587. (doi:10.1089/jwh. 2009.1408)
187. Thornton JW 2001 Evolution of vertebrate steroid receptors from an ancestral estrogen receptor by ligand exploitation and serial genome expansions. PNAS 98 5671-5676. (doi:10.1073/pnas.091553298)
188. Thornton JW, Need E & Crews D 2003 Resurrecting the ancestral steroid receptor: ancient origin of estrogen signaling. Science 301 1714-1717. (doi:10.1126/science.1086185)
189. Tilton SC, Orner GA, Benninghoff AD, Carpenter HM, Hendricks JD, Pereira CB & Williams DE 2008 Genomic profiling reveals an alternate mechanism for hepatic tumor promotion by perfluorooctanoic acid in rainbow trout. Environmental Health Perspectives 116 1047-1055. (doi:10.1289/ehp.11190)
190. Tiwari VK, McGarvey KM, Licchesi JD, Ohm JE, Herman JG, Schubeler D & Baylin SB 2008 PcG proteins, DNA methylation, and gene repression by chromatin looping. PLoS Biology 6 2911-2927. (doi:10.1371/journal.pbio.0060306)
191. Tobi EW, Lumey LH, Talens RP, Kremer D, Putter H, Stein AD, Slagboom PE & Heijmans BT 2009 DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific. Human Molecular Genetics 18 4046-4053. (doi:10.1093/hmg/ddp353)
192. Trasler JM 2009 Epigenetics in spermatogenesis. Molecular and Cellular Endocrinology 306 33-36. (doi:10.1016/j.mce.2008.12.018)
193. Vaag A & Poulsen P 2007 Twins in metabolic and diabetes research: what do they tell us? Current Opinion in Clinical Nutrition and Metabolic Care 10 591-596. (doi:10.1097/MCO.0b013e3282ab9ea6)
194. Vanselow J, Selimyan R & Furbass R 2008 DNA methylation of placenta-specific Cyp19 promoters of cattle and sheep. Experimental and Clinical Endocrinology and Diabetes 116 437-442. (doi:10.1055/s-2008-1058083)
195. Vanselow J, Spitschak M, Nimz M & Furbass R 2010 DNA methylation is not involved in preovulatory down-regulation of CYP11A1, HSD3B1, and CYP19A1 in bovine follicles but may have a role in permanent silencing of CYP19A1 in large granulosa lutein cells. Biology of Reproduction 82 289-298. (doi:10.1095/ biolreprod.109.079251)
196. Veldhuis JD & Bowers CY 2003 Three-peptide control of pulsatile and entropic feedback-sensitive modes of growth hormone secretion: modulation by estrogen and aromatizable androgen. Journal of Pediatric Endocrinology and Metabolism 16 (Supplement 3) 587-605. (Pubitemid 37259073)
197. Venkataraman GM, Yatin M, Marcinek R & Ain KB 1999 Restoration of iodide uptake in dedifferentiated thyroid carcinoma: relationship to human Na+/I- symporter gene methylation status. Journal of Clinical Endocrinology and Metabolism 84 2449-2457. (doi:10.1210/jc.84.7.2449)
198. Vreugdenhil E, Verissimo CS, Mariman R, Kamphorst JT, Barbosa JS, Zweers T, Champagne DL, Schouten T, Meijer OC, de Kloet ER et al. 2009 MicroRNA 18 and 124a down-regulate the glucocorticoid receptor: implications for glucocorticoid responsiveness in the brain. Endocrinology 150 2220-2228. (doi:10.1210/en.2008- 1335)
199. Wang X & Wang X 2006 Systematic identification of microRNA functions by combining target prediction and expression profiling. Nucleic Acids Research 34 1646-1652. (doi:10.1093/nar/gkl068)
200. Wang Y, Fang MZ, Liao J, Yang GY, Nie Y, Song Y, So C, Xu X, Wang LD & Yang CS 2003 Hypermethylation-associated inactivation of retinoic acid receptor beta in human esophageal squamous cell carcinoma. Clinical Cancer Research 9 5257-5263. (Pubitemid 37413577)
201. Weaver IC, Champagne FA, Brown SE, Dymov S, Sharma S, Meaney MJ & Szyf M 2005 Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life. Journal of Neuroscience 25 11045-11054. (doi:10.1523/JNEUROSCI.3652-05. 2005)
202. Whitfield GK & Kourides IA 1985 Expression of chorionic gonadotropin alpha- and beta-genes in normal and neoplastic human tissues: relationship to deoxyribonucleic acid structure. Endocrinology 117 231-236. (doi:10.1210/endo- 117-1-231)
203. Widschwendter M, Siegmund KD, Muller HM, Fiegl H, Marth C, Muller-Holzner E, Jones PA & Laird PW 2004 Association of breast cancer DNA methylation profiles with hormone receptor status and response to tamoxifen. Cancer Research 64 3807-3813. (doi:10.1158/0008-5472.CAN-03-3852)
204. Wolfsberg TG 2010 Using the NCBI map viewer to browse genomic sequence data. Current Protocols in Bioinformatics Chapter 1 Unit 1.5.1-25. (doi:10.1002/0471250953.bi0105s29)
205. Wu Q, Ohsako S, Ishimura R, Suzuki JS & Tohyama C 2004 Exposure of mouse preimplantation embryos to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) alters the methylation status of imprinted genes H19 and Igf2. Biology of Reproduction 70 1790-1797. (doi:10.1095/biolreprod.103.025387)
206. Xing M, Usadel H, Cohen Y, Tokumaru Y, Guo Z,Westra WB, Tong BC, Tallini G, Udelsman R, Califano JA et al. 2003 Methylation of the thyroid-stimulating hormone receptor gene in epithelial thyroid tumors: a marker of malignancy and a cause of gene silencing. Cancer Research 63 2316-2321. (Pubitemid 36538643)
207. Xu GL, Bestor TH, Bourc'his D, Hsieh CL, Tommerup N, Bugge M, Hulten M, Qu X, Russo JJ & Viegas-Pequignot E 1999 Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene. Nature 402 187-191. (doi:10.1038/46214)
208. Yamagata Y, Asada H, Tamura I, Lee L, Maekawa R, Taniguchi K, Taketani T, Matsuoka A, Tamura H & Sugino N 2009 DNA methyltransferase expression in the human endometrium: downregulation by progesterone and estrogen. Human Reproduction 24 1126-1132. (doi:10.1093/humrep/dep015)
209. Yang NC, Castro AJ, Lewis M & Wong TW 1961 Polynuclear aromatic hydrocarbons, steroids and carcinogenesis. Science 134 386-387. (doi:10.1126/science.134.3476.386)
210. Yasui DH, Peddada S, Bieda MC, Vallero RO, Hogart A, Nagarajan RP, Thatcher KN, Farnham PJ & Lasalle JM 2007 Integrated epigenomic analyses of neuronal MeCP2 reveal a role for long-range interaction with active genes. PNAS 104 19416-19421. (doi:10.1073/pnas.0707442104)
211. Ye L, Li X, Kong X, Wang W, Bi Y, Hu L, Cui B, Li X & Ning G 2005 Hypomethylation in the promoter region of POMC gene correlates with ectopic overexpression in thymic carcinoids. Journal of Endocrinology 185 337-343. (doi:10.1677/joe.1.05963)
212. Yoshida T, Eguchi H, Nakachi K, Tanimoto K, Higashi Y, Suemasu K, Iino Y, Morishita Y & Hayashi S 2000 Distinct mechanisms of loss of estrogen receptor alpha gene expression in human breast cancer: methylation of the gene and alteration of trans-acting factors. Carcinogenesis 21 2193-2201. (doi:10.1093/carcin/21.12.2193)
213. Zama AM & Uzumcu M 2009 Fetal and neonatal exposure to the endocrine disruptor methoxychlor causes epigenetic alterations in adult ovarian genes. Endocrinology 150 4681-4691. (doi:10.1210/en.2009-0499)
214. Zhang X, Leung YK & Ho SM 2007 AP-2 regulates the transcription of estrogen receptor (ER)-beta by acting through a methylation hotspot of the 0N promoter in prostate cancer cells. Oncogene 26 7346-7354. (doi:10.1038/sj.onc. 1210537)
215. Zhao C, Lam EW, Sunters A, Enmark E, De Bella MT, Coombes RC, Gustafsson JA & Dahlman-Wright K 2003 Expression of estrogen receptor beta isoforms in normal breast epithelial cells and breast cancer: regulation by methylation. Oncogene 22 7600-7606. (doi:10.1038/sj.onc.1207100)
216. Zhu X, Leav I, Leung YK, Wu M, Liu Q, Gao Y, McNeal JE & Ho SM 2004 Dynamic regulation of estrogen receptor-beta expression by DNA methylation during prostate cancer development and metastasis. American Journal of Pathology 164 2003-2012. (Pubitemid 38669349)