메뉴 건너뛰기




Volumn 21, Issue 5, 2010, Pages 315-324

Partners in crime: Deregulation of AR activity and androgen synthesis in prostate cancer

Author keywords

[No Author keywords available]

Indexed keywords

ABIRATERONE ACETATE; ANDROGEN; ANDROGEN RECEPTOR; ANTIANDROGEN; BICALUTAMIDE; DOCETAXEL; DUTASTERIDE; FINASTERIDE; FLUTAMIDE; GONADORELIN AGONIST; HEPATOCYTE NUCLEAR FACTOR 3ALPHA; HYDROXYSTEROID DEHYDROGENASE; INDOMETACIN; KETOCONAZOLE; LEUPRORELIN; MDV 3100; NONSTEROID ANTIINFLAMMATORY AGENT; NUCLEAR RECEPTOR COACTIVATOR 2; NUCLEAR RECEPTOR COREPRESSOR; PARATHYROID HORMONE RELATED PROTEIN; PROSTATE SPECIFIC ANTIGEN; PROTEIN MDM2; RD 162; SOMATOMEDIN C; STEROID 17ALPHA MONOOXYGENASE; STEROID RECEPTOR COACTIVATOR 1; STEROID RECEPTOR COACTIVATOR 3; SUMO 1 PROTEIN; TOK 001; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 77952554163     PISSN: 10432760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tem.2010.01.002     Document Type: Review
Times cited : (244)

References (95)
  • 1
    • 41349099104 scopus 로고    scopus 로고
    • Cancer statistics
    • Jemal A., et al. Cancer statistics. CA Cancer J. Clin. 2008, 58:71-96.
    • (2008) CA Cancer J. Clin. , vol.58 , pp. 71-96
    • Jemal, A.1
  • 2
    • 57849151139 scopus 로고    scopus 로고
    • Outcomes for intermediate risk prostate cancer: Are there advantages for surgery, external radiation, or brachytherapy?
    • Klein E.A., et al. Outcomes for intermediate risk prostate cancer: Are there advantages for surgery, external radiation, or brachytherapy?. Urol. Oncol. 2009, 27:67-71.
    • (2009) Urol. Oncol. , vol.27 , pp. 67-71
    • Klein, E.A.1
  • 3
    • 33646026722 scopus 로고    scopus 로고
    • Combined androgen blockade: an update
    • v-vi
    • Klotz L. Combined androgen blockade: an update. Urol. Clin. North Am. 2006, 33:161-166. v-vi.
    • (2006) Urol. Clin. North Am. , vol.33 , pp. 161-166
    • Klotz, L.1
  • 4
    • 68049140791 scopus 로고    scopus 로고
    • Starving the addiction: new opportunities for durable suppression of AR signaling in prostate cancer
    • Knudsen K.E., Scher H.I. Starving the addiction: new opportunities for durable suppression of AR signaling in prostate cancer. Clin. Cancer Res. 2009, 15:4792-4798.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 4792-4798
    • Knudsen, K.E.1    Scher, H.I.2
  • 5
    • 34248169161 scopus 로고    scopus 로고
    • Initial hormonal management of androgen-sensitive metastatic, recurrent, or progressive prostate cancer: 2006 update of an American Society of Clinical Oncology practice guideline
    • Loblaw D.A., et al. Initial hormonal management of androgen-sensitive metastatic, recurrent, or progressive prostate cancer: 2006 update of an American Society of Clinical Oncology practice guideline. J. Clin. Oncol. 2007, 25:1596-1605.
    • (2007) J. Clin. Oncol. , vol.25 , pp. 1596-1605
    • Loblaw, D.A.1
  • 6
    • 34047181147 scopus 로고    scopus 로고
    • Drug insight: role of the androgen receptor in the development and progression of prostate cancer
    • Taplin M.E. Drug insight: role of the androgen receptor in the development and progression of prostate cancer. Nat. Clin. Pract. Oncol. 2007, 4:236-244.
    • (2007) Nat. Clin. Pract. Oncol. , vol.4 , pp. 236-244
    • Taplin, M.E.1
  • 7
    • 51449087794 scopus 로고    scopus 로고
    • Targeting the androgen receptor pathway in prostate cancer
    • Chen Y., et al. Targeting the androgen receptor pathway in prostate cancer. Curr. Opin. Pharmacol. 2008, 8:440-448.
    • (2008) Curr. Opin. Pharmacol. , vol.8 , pp. 440-448
    • Chen, Y.1
  • 8
    • 66149161780 scopus 로고    scopus 로고
    • Castration-resistant prostate cancer: locking up the molecular escape routes
    • Attar R.M., et al. Castration-resistant prostate cancer: locking up the molecular escape routes. Clin. Cancer Res. 2009, 15:3251-3255.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 3251-3255
    • Attar, R.M.1
  • 9
    • 58049196759 scopus 로고    scopus 로고
    • Mechanisms mediating androgen receptor reactivation after castration
    • Yuan X., Balk S.P. Mechanisms mediating androgen receptor reactivation after castration. Urol. Oncol. 2009, 27:36-41.
    • (2009) Urol. Oncol. , vol.27 , pp. 36-41
    • Yuan, X.1    Balk, S.P.2
  • 10
    • 51549094259 scopus 로고    scopus 로고
    • Diverse roles of androgen receptor (AR) domains in AR-mediated signaling
    • Claessens F., et al. Diverse roles of androgen receptor (AR) domains in AR-mediated signaling. Nucl. Recept. Signal 2008, 6:e008.
    • (2008) Nucl. Recept. Signal , vol.6
    • Claessens, F.1
  • 11
    • 55049086227 scopus 로고    scopus 로고
    • The contribution of different androgen receptor domains to receptor dimerization and signaling
    • Centenera M.M., et al. The contribution of different androgen receptor domains to receptor dimerization and signaling. Mol. Endocrinol. 2008, 22:2373-2382.
    • (2008) Mol. Endocrinol. , vol.22 , pp. 2373-2382
    • Centenera, M.M.1
  • 12
    • 37349109417 scopus 로고    scopus 로고
    • Pre-receptor regulation of the androgen receptor
    • Penning T.M., et al. Pre-receptor regulation of the androgen receptor. Mol. Cell Endocrinol. 2008, 281:1-8.
    • (2008) Mol. Cell Endocrinol. , vol.281 , pp. 1-8
    • Penning, T.M.1
  • 13
    • 33846603663 scopus 로고    scopus 로고
    • Androgen receptor coregulators and their involvement in the development and progression of prostate cancer
    • Chmelar R., et al. Androgen receptor coregulators and their involvement in the development and progression of prostate cancer. Int. J. Cancer 2007, 120:719-733.
    • (2007) Int. J. Cancer , vol.120 , pp. 719-733
    • Chmelar, R.1
  • 14
    • 46749097609 scopus 로고    scopus 로고
    • Androgen receptor coactivators and prostate cancer
    • Agoulnik I.U., Weigel N.L. Androgen receptor coactivators and prostate cancer. Adv. Exp. Med. Biol. 2008, 17:245-255.
    • (2008) Adv. Exp. Med. Biol. , vol.17 , pp. 245-255
    • Agoulnik, I.U.1    Weigel, N.L.2
  • 16
    • 45849138558 scopus 로고    scopus 로고
    • Hormonal approaches in prostate cancer: application in the contemporary prostate cancer patient
    • Beekman K.W., Hussain M. Hormonal approaches in prostate cancer: application in the contemporary prostate cancer patient. Urol. Oncol. 2008, 26:415-419.
    • (2008) Urol. Oncol. , vol.26 , pp. 415-419
    • Beekman, K.W.1    Hussain, M.2
  • 17
    • 33750366075 scopus 로고    scopus 로고
    • Persistent prostate-specific antigen expression after neoadjuvant androgen depletion: an early predictor of relapse or incomplete androgen suppression
    • Ryan C.J., et al. Persistent prostate-specific antigen expression after neoadjuvant androgen depletion: an early predictor of relapse or incomplete androgen suppression. Urology 2006, 68:834-839.
    • (2006) Urology , vol.68 , pp. 834-839
    • Ryan, C.J.1
  • 18
    • 34547214787 scopus 로고    scopus 로고
    • A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth
    • Wang Q., et al. A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth. Mol. Cell 2007, 27:380-392.
    • (2007) Mol. Cell , vol.27 , pp. 380-392
    • Wang, Q.1
  • 19
    • 67650758019 scopus 로고    scopus 로고
    • Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer
    • Wang Q., et al. Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer. Cell 2009, 138:245-256.
    • (2009) Cell , vol.138 , pp. 245-256
    • Wang, Q.1
  • 20
    • 68049131467 scopus 로고    scopus 로고
    • Reactivation of androgen receptor-regulated TMPRSS2:ERG gene expression in castration-resistant prostate cancer
    • Cai C., et al. Reactivation of androgen receptor-regulated TMPRSS2:ERG gene expression in castration-resistant prostate cancer. Cancer Res. 2009, 69:6027-6032.
    • (2009) Cancer Res. , vol.69 , pp. 6027-6032
    • Cai, C.1
  • 21
    • 71249101060 scopus 로고    scopus 로고
    • Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer
    • Lin C., et al. Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer. Cell 2009, 39:1069-1083.
    • (2009) Cell , vol.39 , pp. 1069-1083
    • Lin, C.1
  • 22
    • 70849135782 scopus 로고    scopus 로고
    • Induced chromosomal proximity and gene fusions in prostate cancer
    • Mani R.S., et al. Induced chromosomal proximity and gene fusions in prostate cancer. Science 2009, 326:1230.
    • (2009) Science , vol.326 , pp. 1230
    • Mani, R.S.1
  • 23
    • 44649169622 scopus 로고    scopus 로고
    • Testosterone surge: rationale for gonadotropin-releasing hormone blockers?
    • van Poppel H., Nilsson S. Testosterone surge: rationale for gonadotropin-releasing hormone blockers?. Urology 2008, 71:1001-1006.
    • (2008) Urology , vol.71 , pp. 1001-1006
    • van Poppel, H.1    Nilsson, S.2
  • 24
    • 0344378213 scopus 로고    scopus 로고
    • Time to normalization of serum testosterone after 3-month luteinizing hormone-releasing hormone agonist administered in the neoadjuvant setting: implications for dosing schedule and neoadjuvant study consideration
    • Oefelein M.G. Time to normalization of serum testosterone after 3-month luteinizing hormone-releasing hormone agonist administered in the neoadjuvant setting: implications for dosing schedule and neoadjuvant study consideration. J. Urol. 1998, 160:1685-1688.
    • (1998) J. Urol. , vol.160 , pp. 1685-1688
    • Oefelein, M.G.1
  • 25
    • 0036208492 scopus 로고    scopus 로고
    • Formation of the androgen receptor transcription complex
    • Shang Y., et al. Formation of the androgen receptor transcription complex. Mol. Cell 2002, 9:601-610.
    • (2002) Mol. Cell , vol.9 , pp. 601-610
    • Shang, Y.1
  • 26
    • 0033520806 scopus 로고    scopus 로고
    • Prostate cancer cell cycle regulators: response to androgen withdrawal and development of androgen independence
    • Agus D.B., et al. Prostate cancer cell cycle regulators: response to androgen withdrawal and development of androgen independence. J. Natl. Cancer Inst. 1999, 91:1869-1876.
    • (1999) J. Natl. Cancer Inst. , vol.91 , pp. 1869-1876
    • Agus, D.B.1
  • 27
    • 49649091112 scopus 로고    scopus 로고
    • Docetaxel in the management of prostate cancer: current standard of care and future directions
    • De Dosso S., Berthold D.R. Docetaxel in the management of prostate cancer: current standard of care and future directions. Expert Opin. Pharmacother. 2008, 9:1969-1979.
    • (2008) Expert Opin. Pharmacother. , vol.9 , pp. 1969-1979
    • De Dosso, S.1    Berthold, D.R.2
  • 28
    • 0035328474 scopus 로고    scopus 로고
    • Amplification and overexpression of androgen receptor gene in hormone-refractory prostate cancer
    • Linja M.J., et al. Amplification and overexpression of androgen receptor gene in hormone-refractory prostate cancer. Cancer Res. 2001, 61:3550-3555.
    • (2001) Cancer Res. , vol.61 , pp. 3550-3555
    • Linja, M.J.1
  • 29
    • 0035266404 scopus 로고    scopus 로고
    • Evaluation of androgen, estrogen (ER alpha and ER beta), and progesterone receptor expression in human prostate cancer by real-time quantitative reverse transcription-polymerase chain reaction assays
    • Latil A., et al. Evaluation of androgen, estrogen (ER alpha and ER beta), and progesterone receptor expression in human prostate cancer by real-time quantitative reverse transcription-polymerase chain reaction assays. Cancer Res. 2001, 61:1919-1926.
    • (2001) Cancer Res. , vol.61 , pp. 1919-1926
    • Latil, A.1
  • 30
    • 0141954183 scopus 로고    scopus 로고
    • Androgen receptor gene amplification and protein expression in recurrent prostate cancer
    • Ford O.H., et al. Androgen receptor gene amplification and protein expression in recurrent prostate cancer. J. Urol. 2003, 170:1817-1821.
    • (2003) J. Urol. , vol.170 , pp. 1817-1821
    • Ford, O.H.1
  • 31
    • 0042978480 scopus 로고    scopus 로고
    • Androgen receptor gene amplification and protein expression in hormone refractory prostate cancer
    • Edwards J., et al. Androgen receptor gene amplification and protein expression in hormone refractory prostate cancer. Br. J. Cancer 2003, 89:552-556.
    • (2003) Br. J. Cancer , vol.89 , pp. 552-556
    • Edwards, J.1
  • 32
    • 0036772932 scopus 로고    scopus 로고
    • Amplification of the androgen receptor gene in bone metastases from hormone-refractory prostate cancer
    • Brown R.S., et al. Amplification of the androgen receptor gene in bone metastases from hormone-refractory prostate cancer. J. Pathol. 2002, 198:237-244.
    • (2002) J. Pathol. , vol.198 , pp. 237-244
    • Brown, R.S.1
  • 33
    • 42349084869 scopus 로고    scopus 로고
    • Androgen receptor overexpression in prostate cancer linked to Pur alpha loss from a novel repressor complex
    • Wang L.G., et al. Androgen receptor overexpression in prostate cancer linked to Pur alpha loss from a novel repressor complex. Cancer Res. 2008, 68:2678-2688.
    • (2008) Cancer Res. , vol.68 , pp. 2678-2688
    • Wang, L.G.1
  • 34
    • 0035845558 scopus 로고    scopus 로고
    • Prostatic intraepithelial neoplasia in mice expressing an androgen receptor transgene in prostate epithelium
    • Stanbrough M., et al. Prostatic intraepithelial neoplasia in mice expressing an androgen receptor transgene in prostate epithelium. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:10823-10828.
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 10823-10828
    • Stanbrough, M.1
  • 35
    • 12844274300 scopus 로고    scopus 로고
    • Mutation of the androgen receptor causes oncogenic transformation of the prostate
    • Han G., et al. Mutation of the androgen receptor causes oncogenic transformation of the prostate. Proc. Natl. Acad. Sci. U. S. A. 2005, 102:1151-1156.
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 1151-1156
    • Han, G.1
  • 36
    • 1842612441 scopus 로고    scopus 로고
    • Molecular determinants of resistance to antiandrogen therapy
    • Chen C.D., et al. Molecular determinants of resistance to antiandrogen therapy. Nat. Med. 2004, 10:33-39.
    • (2004) Nat. Med. , vol.10 , pp. 33-39
    • Chen, C.D.1
  • 37
    • 65949113815 scopus 로고    scopus 로고
    • The role of androgen receptor mutations in prostate cancer progression
    • Brooke G.N., Bevan C.L. The role of androgen receptor mutations in prostate cancer progression. Curr. Genomics 2009, 10:18-25.
    • (2009) Curr. Genomics , vol.10 , pp. 18-25
    • Brooke, G.N.1    Bevan, C.L.2
  • 38
    • 0027203411 scopus 로고
    • Flutamide withdrawal syndrome: its impact on clinical trials in hormone-refractory prostate cancer
    • Scher H.I., Kelly W.K. Flutamide withdrawal syndrome: its impact on clinical trials in hormone-refractory prostate cancer. J. Clin. Oncol. 1993, 11:1566-1572.
    • (1993) J. Clin. Oncol. , vol.11 , pp. 1566-1572
    • Scher, H.I.1    Kelly, W.K.2
  • 39
    • 0029929794 scopus 로고    scopus 로고
    • The mutated androgen receptor and its implications for the treatment of metastatic carcinoma of the prostate
    • Middleman M.N., et al. The mutated androgen receptor and its implications for the treatment of metastatic carcinoma of the prostate. Pharmacotherapy 1996, 16:376-381.
    • (1996) Pharmacotherapy , vol.16 , pp. 376-381
    • Middleman, M.N.1
  • 40
    • 0037226103 scopus 로고    scopus 로고
    • Novel mutations of androgen receptor: a possible mechanism of bicalutamide withdrawal syndrome
    • Hara T., et al. Novel mutations of androgen receptor: a possible mechanism of bicalutamide withdrawal syndrome. Cancer Res. 2003, 63:149-153.
    • (2003) Cancer Res. , vol.63 , pp. 149-153
    • Hara, T.1
  • 41
    • 66249135684 scopus 로고    scopus 로고
    • Treatment-dependent androgen receptor mutations in prostate cancer exploit multiple mechanisms to evade therapy
    • Steinkamp M.P., et al. Treatment-dependent androgen receptor mutations in prostate cancer exploit multiple mechanisms to evade therapy. Cancer Res. 2009, 69:4434-4442.
    • (2009) Cancer Res. , vol.69 , pp. 4434-4442
    • Steinkamp, M.P.1
  • 42
    • 48549089747 scopus 로고    scopus 로고
    • Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance
    • Dehm S.M., et al. Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance. Cancer Res. 2008, 68:5469-5477.
    • (2008) Cancer Res. , vol.68 , pp. 5469-5477
    • Dehm, S.M.1
  • 43
    • 58249110391 scopus 로고    scopus 로고
    • Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer
    • Hu R., et al. Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer. Cancer Res. 2009, 69:16-22.
    • (2009) Cancer Res. , vol.69 , pp. 16-22
    • Hu, R.1
  • 44
    • 65549168746 scopus 로고    scopus 로고
    • A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth
    • Guo Z., et al. A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth. Cancer Res. 2009, 69:2305-2313.
    • (2009) Cancer Res. , vol.69 , pp. 2305-2313
    • Guo, Z.1
  • 45
    • 0028904382 scopus 로고
    • Identification of two transcription activation units in the N-terminal domain of the human androgen receptor
    • Jenster G., et al. Identification of two transcription activation units in the N-terminal domain of the human androgen receptor. J. Biol. Chem. 1995, 270:7341-7346.
    • (1995) J. Biol. Chem. , vol.270 , pp. 7341-7346
    • Jenster, G.1
  • 46
    • 33750316364 scopus 로고    scopus 로고
    • Post-translational modifications of steroid receptors
    • Faus H., Haendler B. Post-translational modifications of steroid receptors. Biomed. Pharmacother. 2006, 60:520-528.
    • (2006) Biomed. Pharmacother. , vol.60 , pp. 520-528
    • Faus, H.1    Haendler, B.2
  • 47
    • 40849113286 scopus 로고    scopus 로고
    • Phosphorylation of the androgen receptor is associated with reduced survival in hormone-refractory prostate cancer patients
    • McCall P., et al. Phosphorylation of the androgen receptor is associated with reduced survival in hormone-refractory prostate cancer patients. Br. J. Cancer 2008, 98:1094-1101.
    • (2008) Br. J. Cancer , vol.98 , pp. 1094-1101
    • McCall, P.1
  • 48
    • 51049107084 scopus 로고    scopus 로고
    • Site-specific androgen receptor serine phosphorylation linked to epidermal growth factor-dependent growth of castration-recurrent prostate cancer
    • Ponguta L.A., et al. Site-specific androgen receptor serine phosphorylation linked to epidermal growth factor-dependent growth of castration-recurrent prostate cancer. J. Biol. Chem. 2008, 283:20989-21001.
    • (2008) J. Biol. Chem. , vol.283 , pp. 20989-21001
    • Ponguta, L.A.1
  • 49
    • 58249122148 scopus 로고    scopus 로고
    • Androgen receptor and growth factor signaling cross-talk in prostate cancer cells
    • Zhu M.L., Kyprianou N. Androgen receptor and growth factor signaling cross-talk in prostate cancer cells. Endocr. Relat. Cancer 2008, 15:841-849.
    • (2008) Endocr. Relat. Cancer , vol.15 , pp. 841-849
    • Zhu, M.L.1    Kyprianou, N.2
  • 50
    • 69249203584 scopus 로고    scopus 로고
    • Castration-resistant prostate cancer: from new pathophysiology to new treatment targets
    • Chi K.N., et al. Castration-resistant prostate cancer: from new pathophysiology to new treatment targets. Eur. Urol. 2009, 56:594-605.
    • (2009) Eur. Urol. , vol.56 , pp. 594-605
    • Chi, K.N.1
  • 51
    • 33749445413 scopus 로고    scopus 로고
    • Regulation of androgen receptor activity by tyrosine phosphorylation
    • Guo Z., et al. Regulation of androgen receptor activity by tyrosine phosphorylation. Cancer Cell 2006, 10:309-319.
    • (2006) Cancer Cell , vol.10 , pp. 309-319
    • Guo, Z.1
  • 52
    • 70349754434 scopus 로고    scopus 로고
    • The neuroendocrine-derived peptide parathyroid hormone-related protein promotes prostate cancer cell growth by stabilizing the androgen receptor
    • DaSilva J., et al. The neuroendocrine-derived peptide parathyroid hormone-related protein promotes prostate cancer cell growth by stabilizing the androgen receptor. Cancer Res. 2009, 69:7402-7411.
    • (2009) Cancer Res. , vol.69 , pp. 7402-7411
    • DaSilva, J.1
  • 53
    • 57849133479 scopus 로고    scopus 로고
    • Oncogenic activation of androgen receptor
    • Kung H.J., Evans C.P. Oncogenic activation of androgen receptor. Urol. Oncol. 2009, 27:48-52.
    • (2009) Urol. Oncol. , vol.27 , pp. 48-52
    • Kung, H.J.1    Evans, C.P.2
  • 54
    • 70350036005 scopus 로고    scopus 로고
    • Androgen receptor phosphorylation and activity are regulated by an association with protein phosphatase 1
    • Chen S., et al. Androgen receptor phosphorylation and activity are regulated by an association with protein phosphatase 1. J. Biol. Chem. 2009, 284:25576-25584.
    • (2009) J. Biol. Chem. , vol.284 , pp. 25576-25584
    • Chen, S.1
  • 55
    • 63249104202 scopus 로고    scopus 로고
    • Regulation of androgen receptor transcriptional activity and specificity by RNF6-induced ubiquitination
    • Xu K., et al. Regulation of androgen receptor transcriptional activity and specificity by RNF6-induced ubiquitination. Cancer Cell 2009, 15:270-282.
    • (2009) Cancer Cell , vol.15 , pp. 270-282
    • Xu, K.1
  • 56
    • 44849104895 scopus 로고    scopus 로고
    • TRIM68 regulates ligand-dependent transcription of androgen receptor in prostate cancer cells
    • Miyajima N., et al. TRIM68 regulates ligand-dependent transcription of androgen receptor in prostate cancer cells. Cancer Res. 2008, 68:3486-3494.
    • (2008) Cancer Res. , vol.68 , pp. 3486-3494
    • Miyajima, N.1
  • 57
    • 13744257306 scopus 로고    scopus 로고
    • Regulation of androgen receptor and histone deacetylase 1 by Mdm2-mediated ubiquitylation
    • Gaughan L., et al. Regulation of androgen receptor and histone deacetylase 1 by Mdm2-mediated ubiquitylation. Nucleic Acids Res. 2005, 3:13-26.
    • (2005) Nucleic Acids Res. , vol.3 , pp. 13-26
    • Gaughan, L.1
  • 58
    • 61449247171 scopus 로고    scopus 로고
    • SUMO-specific protease 1 (SENP1) reverses the hormone-augmented SUMOylation of androgen receptor and modulates gene responses in prostate cancer cells
    • Kaikkonen S., et al. SUMO-specific protease 1 (SENP1) reverses the hormone-augmented SUMOylation of androgen receptor and modulates gene responses in prostate cancer cells. Mol. Endocrinol. 2009, 23:292-307.
    • (2009) Mol. Endocrinol. , vol.23 , pp. 292-307
    • Kaikkonen, S.1
  • 59
    • 69249110003 scopus 로고    scopus 로고
    • Normal and cancer-related functions of the p160 steroid receptor co-activator (SRC) family
    • Xu J., et al. Normal and cancer-related functions of the p160 steroid receptor co-activator (SRC) family. Nat. Rev. Cancer 2009, 9:615-630.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 615-630
    • Xu, J.1
  • 60
    • 0035361340 scopus 로고    scopus 로고
    • A mechanism for androgen receptor-mediated prostate cancer recurrence after androgen deprivation therapy
    • Gregory C.W., et al. A mechanism for androgen receptor-mediated prostate cancer recurrence after androgen deprivation therapy. Cancer Res. 2001, 61:4315-4319.
    • (2001) Cancer Res. , vol.61 , pp. 4315-4319
    • Gregory, C.W.1
  • 61
    • 24744442616 scopus 로고    scopus 로고
    • Role of SRC-1 in the promotion of prostate cancer cell growth and tumor progression
    • Agoulnik I.U., et al. Role of SRC-1 in the promotion of prostate cancer cell growth and tumor progression. Cancer Res. 2005, 65:7959-7967.
    • (2005) Cancer Res. , vol.65 , pp. 7959-7967
    • Agoulnik, I.U.1
  • 62
    • 33846815520 scopus 로고    scopus 로고
    • Androgen receptor corepressors and prostate cancer
    • Burd C.J., et al. Androgen receptor corepressors and prostate cancer. Endocr. Relat. Cancer 2006, 13:979-994.
    • (2006) Endocr. Relat. Cancer , vol.13 , pp. 979-994
    • Burd, C.J.1
  • 63
    • 51849137775 scopus 로고    scopus 로고
    • Prohibitin and the SWI/SNF ATPase subunit BRG1 are required for effective androgen antagonist-mediated transcriptional repression of androgen receptor-regulated genes
    • Dai Y., et al. Prohibitin and the SWI/SNF ATPase subunit BRG1 are required for effective androgen antagonist-mediated transcriptional repression of androgen receptor-regulated genes. Carcinogenesis 2008, 29:1725-1733.
    • (2008) Carcinogenesis , vol.29 , pp. 1725-1733
    • Dai, Y.1
  • 64
    • 72549118242 scopus 로고    scopus 로고
    • Manipulating prohibitin levels provides evidence for an in vivo role in androgen regulation of prostate tumours
    • Dart D., et al. Manipulating prohibitin levels provides evidence for an in vivo role in androgen regulation of prostate tumours. Endocr. Relat. Cancer 2009, 16:1157-1169.
    • (2009) Endocr. Relat. Cancer , vol.16 , pp. 1157-1169
    • Dart, D.1
  • 65
    • 32044448683 scopus 로고    scopus 로고
    • Macrophage/cancer cell interactions mediate hormone resistance by a nuclear receptor derepression pathway
    • Zhu P., et al. Macrophage/cancer cell interactions mediate hormone resistance by a nuclear receptor derepression pathway. Cell 2006, 124:615-629.
    • (2006) Cell , vol.124 , pp. 615-629
    • Zhu, P.1
  • 66
    • 13444282183 scopus 로고    scopus 로고
    • Hey1, a mediator of notch signaling, is an androgen receptor corepressor
    • Belandia B., et al. Hey1, a mediator of notch signaling, is an androgen receptor corepressor. Mol. Cell Biol. 2005, 25:1425-1436.
    • (2005) Mol. Cell Biol. , vol.25 , pp. 1425-1436
    • Belandia, B.1
  • 67
    • 55749105296 scopus 로고    scopus 로고
    • EBP1, an ErbB3-binding protein, is decreased in prostate cancer and implicated in hormone resistance
    • Zhang Y., et al. EBP1, an ErbB3-binding protein, is decreased in prostate cancer and implicated in hormone resistance. Mol. Cancer Ther. 2008, 7:3176-3186.
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 3176-3186
    • Zhang, Y.1
  • 68
    • 33845394286 scopus 로고    scopus 로고
    • The cyclin D1b splice variant: an old oncogene learns new tricks
    • Knudsen K.E. The cyclin D1b splice variant: an old oncogene learns new tricks. Cell Div. 2006, 1:15.
    • (2006) Cell Div. , vol.1 , pp. 15
    • Knudsen, K.E.1
  • 69
    • 65049089363 scopus 로고    scopus 로고
    • Cyclin D1 splice variants: polymorphism, risk, and isoform-specific regulation in prostate cancer
    • Comstock C.E., et al. Cyclin D1 splice variants: polymorphism, risk, and isoform-specific regulation in prostate cancer. Clin. Cancer Res. 2009, 15:5338-5349.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 5338-5349
    • Comstock, C.E.1
  • 70
    • 0028173882 scopus 로고
    • Steroid 5α-reductase two genes/two enzymes
    • Russell D.W., Wilson J.D. Steroid 5α-reductase two genes/two enzymes. Annu. Rev. Biochem. 1994, 63:25-61.
    • (1994) Annu. Rev. Biochem. , vol.63 , pp. 25-61
    • Russell, D.W.1    Wilson, J.D.2
  • 71
    • 0029191661 scopus 로고
    • " Intracrinology" autonomy and freedom of peripheral tissues
    • Labrie F., et al. " Intracrinology" autonomy and freedom of peripheral tissues. Ann. Endocrinol. (Paris) 1995, 56:23-29.
    • (1995) Ann. Endocrinol. (Paris) , vol.56 , pp. 23-29
    • Labrie, F.1
  • 72
    • 0033852685 scopus 로고    scopus 로고
    • Intracrinology: role of the family of 17β-hydroxysteroid dehydrogenases in human physiology and disease
    • Labrie F., et al. Intracrinology: role of the family of 17β-hydroxysteroid dehydrogenases in human physiology and disease. J. Mol. Endocrinol. 2000, 25:1-16.
    • (2000) J. Mol. Endocrinol. , vol.25 , pp. 1-16
    • Labrie, F.1
  • 73
    • 33644881888 scopus 로고    scopus 로고
    • Aldo-keto reductase (AKR) 1C3: Role in prostate disease and the development of specific inhibitors
    • Penning T.M., et al. Aldo-keto reductase (AKR) 1C3: Role in prostate disease and the development of specific inhibitors. Mol. Cell Endocrinol. 2006, 248:182-191.
    • (2006) Mol. Cell Endocrinol. , vol.248 , pp. 182-191
    • Penning, T.M.1
  • 74
    • 51049098138 scopus 로고    scopus 로고
    • Androgen levels increase by intratumoral de novo steroidogenesis during the progression of castration-resistant prostate cancer
    • Locke J., et al. Androgen levels increase by intratumoral de novo steroidogenesis during the progression of castration-resistant prostate cancer. Cancer Res. 2008, 68:6407-6415.
    • (2008) Cancer Res. , vol.68 , pp. 6407-6415
    • Locke, J.1
  • 75
    • 49249119358 scopus 로고    scopus 로고
    • Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth
    • Montgomery R.B., et al. Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth. Cancer Res. 2008, 68:4447-4454.
    • (2008) Cancer Res. , vol.68 , pp. 4447-4454
    • Montgomery, R.B.1
  • 76
    • 33645056171 scopus 로고    scopus 로고
    • Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer
    • Stanbrough M., et al. Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer. Cancer Res. 2006, 66:2815-2825.
    • (2006) Cancer Res. , vol.66 , pp. 2815-2825
    • Stanbrough, M.1
  • 77
    • 0037812658 scopus 로고    scopus 로고
    • The influence of finasteride on the development of prostate cancer
    • Thompson I.M., et al. The influence of finasteride on the development of prostate cancer. N. Engl. J. Med. 2003, 349:215-224.
    • (2003) N. Engl. J. Med. , vol.349 , pp. 215-224
    • Thompson, I.M.1
  • 78
    • 65649090203 scopus 로고    scopus 로고
    • Development of a second-generation antiandrogen for the treatment of advanced prostate cancer
    • Tran C., et al. Development of a second-generation antiandrogen for the treatment of advanced prostate cancer. Science 2009, 324:787-790.
    • (2009) Science , vol.324 , pp. 787-790
    • Tran, C.1
  • 79
    • 61749092731 scopus 로고    scopus 로고
    • Finasteride does not increase the risk of high-grade prostate cancer: a bias-adjusted modeling approach
    • Redman M., et al. Finasteride does not increase the risk of high-grade prostate cancer: a bias-adjusted modeling approach. Cancer Prev. Res. 2008, 1:174-181.
    • (2008) Cancer Prev. Res. , vol.1 , pp. 174-181
    • Redman, M.1
  • 80
    • 42949151909 scopus 로고    scopus 로고
    • 5a-Reductase inhibitors in benign prostatic hyperplasia and prostate cancer risk reduction
    • Rittmaster R.S. 5a-Reductase inhibitors in benign prostatic hyperplasia and prostate cancer risk reduction. Best Pract. Res. Clin. Endocrinol. Metab. 2008, 22:389-402.
    • (2008) Best Pract. Res. Clin. Endocrinol. Metab. , vol.22 , pp. 389-402
    • Rittmaster, R.S.1
  • 81
    • 31444440675 scopus 로고    scopus 로고
    • Identification of the major oxidative 3α-hydroxysteroid dehydrogenase in human prostate that converts 5α-androstane-3α,17β-diol to 5α-dihydrotestosterone: A potential therapeutic target for androgen dependent disease
    • Bauman D.R., et al. Identification of the major oxidative 3α-hydroxysteroid dehydrogenase in human prostate that converts 5α-androstane-3α,17β-diol to 5α-dihydrotestosterone: A potential therapeutic target for androgen dependent disease. Mol. Endocrinol. 2006, 20:444-458.
    • (2006) Mol. Endocrinol. , vol.20 , pp. 444-458
    • Bauman, D.R.1
  • 82
    • 25844464558 scopus 로고    scopus 로고
    • Comparison of clinical trials with finasteride and dutasteride
    • Nickel J.C. Comparison of clinical trials with finasteride and dutasteride. Rev. Urol. 2004, 6(Suppl):S31-S39.
    • (2004) Rev. Urol. , vol.6 , Issue.SUPPL.
    • Nickel, J.C.1
  • 83
    • 34249989027 scopus 로고    scopus 로고
    • The effect of dutasteride on intraprostatic dihydrotestosterone concentrations in men with benign prostatic hyperplasia
    • Wurzel R., et al. The effect of dutasteride on intraprostatic dihydrotestosterone concentrations in men with benign prostatic hyperplasia. Prostate Cancer Prostatic Dis. 2007, 10:149-154.
    • (2007) Prostate Cancer Prostatic Dis. , vol.10 , pp. 149-154
    • Wurzel, R.1
  • 84
    • 7444233759 scopus 로고    scopus 로고
    • The backdoor pathway to dihydrotestosterone
    • Auchus R. The backdoor pathway to dihydrotestosterone. Trends Endocrinol. Metab 2004, 15:432-438.
    • (2004) Trends Endocrinol. Metab , vol.15 , pp. 432-438
    • Auchus, R.1
  • 85
    • 33847045552 scopus 로고    scopus 로고
    • Identification of the molecular switch that regulates access of 5alpha-DHT to the androgen receptor
    • Penning T.M., et al. Identification of the molecular switch that regulates access of 5alpha-DHT to the androgen receptor. Mol. Cell Endocrinol. 2007, 265-66:77-82.
    • (2007) Mol. Cell Endocrinol. , pp. 77-82
    • Penning, T.M.1
  • 86
    • 51049098138 scopus 로고    scopus 로고
    • Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer
    • Locke J.A., et al. Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer. Cancer Res. 2008, 68:6407-6415.
    • (2008) Cancer Res. , vol.68 , pp. 6407-6415
    • Locke, J.A.1
  • 87
    • 77952544169 scopus 로고    scopus 로고
    • Alterations in cholesterol regulation contribute to the production of intratumoral androgens during progression to castration-resistant prostate cancer in a mouse xenograft model. Prostate ()
    • Leon C.G. et al. (2009)Alterations in cholesterol regulation contribute to the production of intratumoral androgens during progression to castration-resistant prostate cancer in a mouse xenograft model. Prostate (). http://www3.interscience.wiley.com/journal/34304/home.
    • (2009)
    • Leon, C.G.1
  • 88
    • 77952549368 scopus 로고    scopus 로고
    • Arachidonic acid activation of intratumoral steroid synthesis during prostate cancer progression to castration resistance. Prostate ()
    • Locke J.A. et al. (2009)Arachidonic acid activation of intratumoral steroid synthesis during prostate cancer progression to castration resistance. Prostate (). http://www3.interscience.wiley.com/journal/34304/home.
    • (2009)
    • Locke, J.A.1
  • 89
    • 53749090666 scopus 로고    scopus 로고
    • Phase I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven
    • Attard G., et al. Phase I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven. J. Clin. Oncol. 2008, 26:4563-4571.
    • (2008) J. Clin. Oncol. , vol.26 , pp. 4563-4571
    • Attard, G.1
  • 90
    • 70449092013 scopus 로고    scopus 로고
    • Activity of dutasteride plus ketoconazole in csatration-refractory prostate cancer after progression on ketoconazole alone
    • Sartor O., et al. Activity of dutasteride plus ketoconazole in csatration-refractory prostate cancer after progression on ketoconazole alone. Clin. Genitourin. Cancer 2009, 7:E90-92.
    • (2009) Clin. Genitourin. Cancer , vol.7
    • Sartor, O.1
  • 91
    • 0029096372 scopus 로고
    • The molecular biology of androgenic 17β-hydroxysteroid dehydrogenases
    • Andersson S., et al. The molecular biology of androgenic 17β-hydroxysteroid dehydrogenases. J. Steroid Biochem. Mol. Biol. 1995, 53:37-39.
    • (1995) J. Steroid Biochem. Mol. Biol. , vol.53 , pp. 37-39
    • Andersson, S.1
  • 92
    • 0344819243 scopus 로고    scopus 로고
    • Molecular genetics and pathophysiology of 17β-hydroxysteroid dehydrogenase 3 deficiency
    • Andersson S.G., et al. Molecular genetics and pathophysiology of 17β-hydroxysteroid dehydrogenase 3 deficiency. J. Clin. Endocrinol. Metab. 1996, 81:130-136.
    • (1996) J. Clin. Endocrinol. Metab. , vol.81 , pp. 130-136
    • Andersson, S.G.1
  • 93
    • 37349047898 scopus 로고    scopus 로고
    • An indomethacin analogue, N-(4-chlorobenzoyl)-melatonin, is a selective inhibitor of aldo-keto reductase 1C3 (type 2 3alpha-HSD, type 5 17beta-HSD, and prostaglandin F synthase), a potential target for the treatment of hormone dependent and hormone independent malignancies
    • Byrns M., et al. An indomethacin analogue, N-(4-chlorobenzoyl)-melatonin, is a selective inhibitor of aldo-keto reductase 1C3 (type 2 3alpha-HSD, type 5 17beta-HSD, and prostaglandin F synthase), a potential target for the treatment of hormone dependent and hormone independent malignancies. Biochem. Pharmacol. 2008, 75:484-493.
    • (2008) Biochem. Pharmacol. , vol.75 , pp. 484-493
    • Byrns, M.1
  • 94
    • 53349101498 scopus 로고    scopus 로고
    • Androgen receptor inactivation contributes to antitumor efficacy of 17{alpha}-hydroxylase/17,20-lyase inhibitor 3beta-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene in prostate cancer
    • Vasaitis T., et al. Androgen receptor inactivation contributes to antitumor efficacy of 17{alpha}-hydroxylase/17,20-lyase inhibitor 3beta-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene in prostate cancer. Mol. Cancer Ther. 2008, 7:2348-2357.
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 2348-2357
    • Vasaitis, T.1
  • 95
    • 34547692874 scopus 로고    scopus 로고
    • Human aldo-keto reductases: Function, gene regulation, and single nucleotide polymorphism
    • Penning T.M., Drury J.E. Human aldo-keto reductases: Function, gene regulation, and single nucleotide polymorphism. Arch. Biochem. Biophys. 2007, 464:241-250.
    • (2007) Arch. Biochem. Biophys. , vol.464 , pp. 241-250
    • Penning, T.M.1    Drury, J.E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.