DNA methyltransferase 3B (DNMT3B) mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development, neurogenesis and immune function

Human Molecular Genetics

Volumn 17, Issue 5, 2008, Pages 690-709

  Jin, Bilian ^a   Tao, Qian ^b,c   Peng, Jinrong ^d   Soo, Hui Meng ^d   Wu, Wei ^d   Ying, Jianming ^b,c   Fields, C Robert ^a   Delmas, Amber I ^a   Liu, Xuefeng ^e   Qiu, Jingxin ^f   Robertson, Keith D ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^c Johns Hopkins Singapore   (Singapore)

^d INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^e WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA METHYLTRANSFERASE 3B; GENE PRODUCT; HISTONE; HISTONE H2; HISTONE H3; HOMEODOMAIN PROTEIN; POLYCOMB PROTEIN SUZ12; PROTEIN PRC2; UNCLASSIFIED DRUG;

ARTICLE; AUTOSOMAL RECESSIVE DISORDER; CELL LINE; CHROMATIN STRUCTURE; CONTROLLED STUDY; DNA METHYLATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE LOSS; GENE MUTATION; GENE REPRESSION; GENETIC ANALYSIS; GENETIC EPIGENESIS; GENETIC GAIN; HUMAN; HUMAN CELL; IMMUNE SYSTEM; IMMUNODEFICIENCY CENTROMERE INSTABILITY FACIAL ANOMALY SYNDROME; NERVOUS SYSTEM DEVELOPMENT; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN MODIFICATION; TRANSCRIPTION INITIATION; UPREGULATION;

ABNORMALITIES, MULTIPLE; ACETYLATION; AZACITIDINE; B-LYMPHOCYTES; CASE-CONTROL STUDIES; CELL LINE, TRANSFORMED; CELL TRANSFORMATION, VIRAL; CELLS, CULTURED; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; ENZYME INHIBITORS; EPIGENESIS, GENETIC; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, RECESSIVE; HISTONES; HUMANS; HYDROXAMIC ACIDS; IMMUNOLOGIC DEFICIENCY SYNDROMES; MALE; MENTAL RETARDATION; MUTATION; NEURONS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROMOTER REGIONS (GENETICS); TIME FACTORS;

EID: 39749152283     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddm341     Document Type: Article

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