Low dose effects of dichlorodiphenyltrichloroethane (DDT) on gene transcription and DNA methylation in the hypothalamus of young male rats: Implication of hormesis-like effects

Journal of Toxicological Sciences

Volumn 34, Issue 5, 2009, Pages 469-482

  Shutoh, Yasufumi ^a   Takeda, Makio ^a   Ohtsuka, Ryoichi ^a   Haishima, Atsuko ^a   Yamaguchi, Satoru ^a   Fujie, Hideaki ^a   Komatsu, Yutaka ^a   Maita, Keizo ^a,b   Harada, Takanori ^a  

^a INSTITUTE OF ENVIRONMENTAL TOXICOLOGY   (Japan)

^b Agrotox Inc   (Japan)

Author keywords

DDT; Hormesis like effect; Hypomethylation; Hypothalamus; Transcriptional down regulation; Young rats

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR 1; BRAIN PROTEIN; CHLORPHENOTANE; DNA METHYLTRANSFERASE 1; ECTODERMAL NEURAL CORTEX 1; GALANIN; GALECTIN RELATED INTERFIBER PROTEIN; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; MESSENGER RNA; PREALBUMIN; PREPROENKEPHALIN; SOMATOMEDIN B; SOMATOSTATIN; TRANSCRIPTION FACTOR MSX1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; DOWN REGULATION; GENE EXPRESSION; GENETIC SELECTION; GENETIC TRANSCRIPTION; HIPPOCAMPUS; HORMESIS; HYPOTHALAMUS; LIPID PEROXIDATION; MALE; MICROARRAY ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

RATTUS;

EID: 70349898602     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.34.469     Document Type: Article

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